Q and A for Olympus labs TR3ST

MrKleen73 said:
I can see Stano in the cycle increasing DHT since TR3st does not convert to DHT. Extra DHT could help by binding to AR receptors in the breast tissue so that you are less likely to get gyno. Other than that I don't know that there would be a lot of benefit. You will get plenty androgens from the TR3ST and it also converts to Estro so you will have enough estro to grow optimally and keep a libido. Only thing is to control aromatization for optimal levels of estro, you don't want to completely crush it.

I don't think the stano would dry you out because the TR3st is going to do the opposite. Stano is a dry compound but it doesn't dry you out the lack of estro once you shut down is what makes you dry out when on it. However you would be taking the TR3ST so that would not happen unless you use an AI heavily and i don't recommend crushing estro you just get less out of the cycle with it crushed. Plus it is not enjoyable....
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Absolutely! Hard to crush the weights on cycle when your joints feel like you've got rheumatoid arthritis!
 
MrKleen73 said:
I can see Stano in the cycle increasing DHT since TR3st does not convert to DHT. Extra DHT could help by binding to AR receptors in the breast tissue so that you are less likely to get gyno. Other than that I don't know that there would be a lot of benefit. You will get plenty androgens from the TR3ST and it also converts to Estro so you will have enough estro to grow optimally and keep a libido. Only thing is to control aromatization for optimal levels of estro, you don't want to completely crush it. I don't think the stano would dry you out because the TR3st is going to do the opposite. Stano is a dry compound but it doesn't dry you out the lack of estro once you shut down is what makes you dry out when on it. However you would be taking the TR3ST so that would not happen unless you use an AI heavily and i don't recommend crushing estro you just get less out of the cycle with it crushed. Plus it is not enjoyable....
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Ty sir. Good explanation.
 
808bigdog said:
Totally off the subject of Stano but Could I add LMG to my cycle?
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I do not remember everything you were planning to run off the top of my head but there is no reason you could not add Max-LMG to your cycle. Only thing I recommend is a good AI especially if you are running LMG on top of TR3ST. If you add it in how high will you run it?
 
I'm going to be running...
DYMETHAZ9NE-40/40/40/40/40/60
TR3ST-50/75/75/75/75/75
I don't know what dosage to run the LMG at. That's why I was asking if it would be ok. If it is what would you guys recommend? And would I start it 2 week before the other PH's so the LMG would be kicked in by then?
 
When stacked, 75mg of LMG is a good starting point..
But like Kleen said - better have a good AI on hand!
 
808bigdog said:
I'm going to be running...
DYMETHAZ9NE-40/40/40/40/40/60
TR3ST-50/75/75/75/75/75
I don't know what dosage to run the LMG at. That's why I was asking if it would be ok. If it is what would you guys recommend? And would I start it 2 week before the other PH's so the LMG would be kicked in by then?
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Just like GH said 75 -ish is a good starting point. You could definitely run LMG for 8 weeks if you want to start it earlier. However I think you would see the effects in the 6 week range but 8 would obviously be more gains. I think I would be more likely to just run the LMG 2 weeks after not 2 weeks before though to help cement the gains.
 
I'd probably continue taking trest with LMG because odds are that after dropping a "feel good" compound like trest you'll be ready to start PCT.
 
Does anyone know why formeron is so god damn good? I swear to god it's one of the best OTC ais I've ever used.
 
EatMoar said:
Does anyone know why formeron is so god damn good? I swear to god it's one of the best OTC ais I've ever used.
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It has an extremely high affinity to the aromatase enzyme so it binds to it well before the enzyme can attach to the androgens. It locks the enzyme up until the enzyme dies off. It also does not have a high affinity on the AR so it does not compete with androgens for the AR receptors. That leaves your natural or "supplemented" levels of DHT or other androgens a far better likelihood of the androgens binding to the AR. Obviously androgens can not exact their effect if they can not bind to the AR so formestane not competing with the androgens for a spot on the AR allows more androgens to bind to the AR and produce the desired effects.
 
MrKleen73 said:
It has an extremely high affinity to the aromatase enzyme so it binds to it well before the enzyme can attach to the androgens. It locks the enzyme up until the enzyme dies off. It also does not have a high affinity on the AR so it does not compete with androgens for the AR receptors. That leaves your natural or "supplemented" levels of DHT or other androgens a far better likelihood of the androgens binding to the AR. Obviously androgens can not exact their effect if they can not bind to the AR so formestane not competing with the androgens for a spot on the AR allows more androgens to bind to the AR and produce the desired effects.
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Actually, the hormone formestane converts into binds to the AR very strongly and for a long period of time...
 
g0hardorgohom said:
You want to stay anabolic for the biggest part of the day. That's why it's better to spread those doses evenly throughout the day.

At 75mg/day I'd probably dose them this way: 25mg 8:30m AM, 25mg 3:30 PM and 25mg 10:30 PM

It has short half life but it's fat soluble compound like all steroids are. Blood levels won't vary that much once you're therapeutic.
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When something has a 40 minute halflife, and you go 7 hours between doses as you suggested, then you are completely incorrect. Regardless of lipophilicity, a 40 minute TERMINAL halflife means that he is getting a peak and a FULL TROUGH (levels of zero trestolone) after each dose. There's really no arguing this, it's like first day of class pharmacokinetics.
 
mr.cooper69 said:
When something has a 40 minute halflife, and you go 7 hours between doses as you suggested, then you are completely incorrect. Regardless of lipophilicity, a 40 minute TERMINAL halflife means that he is getting a peak and a FULL TROUGH (levels of zero trestolone) after each dose. There's really no arguing this, it's like first day of class pharmacokinetics.
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Thanks for the info.I speak only from my own experience - when I ran oral trestolone, I spread it to three doses. Never noticed any kind of "crash" like I may do if I pin short esters E3D or something like that.
 
mr.cooper69 said:
When something has a 40 minute halflife, and you go 7 hours between doses as you suggested, then you are completely incorrect. Regardless of lipophilicity, a 40 minute TERMINAL halflife means that he is getting a peak and a FULL TROUGH (levels of zero trestolone) after each dose. There's really no arguing this, it's like first day of class pharmacokinetics.
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So what are you suggesting cooper?
 
Honestly, book and forum knowledge is only a starting point. You can only find out what steroid and dosing works for you by trying it.
 
mr.cooper69 said:
Actually, the hormone formestane converts into binds to the AR very strongly and for a long period of time...
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I know that Formestane can convert into 4-hydroxytestosterone and that that can bind to the AR receptor pretty strongly. However my understanding is that the conversion to 4-htest is pretty low and a typical AI dose should not be causing much conversion. SOunds like you may be educated in the matter do you know what the conversion rate is? I beleive the 4-hydroxytestosterone is a second step conversion not a direct one which is part of the reason I have believed it to be a low conversion rate. At least if the 4-hydroxytestosterone does bind though there is actually some steroidal activity although it is less than 50% as strong as test. One of the other benefits of formestane is a rise in IGF-1 in the muscles which helps with promote anabolism.
 
mr.cooper69 said:
When something has a 40 minute halflife, and you go 7 hours between doses as you suggested, then you are completely incorrect. Regardless of lipophilicity, a 40 minute TERMINAL halflife means that he is getting a peak and a FULL TROUGH (levels of zero trestolone) after each dose. There's really no arguing this, it's like first day of class pharmacokinetics.
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Would a transdermal application increase the halflife?
 
Initial consumer and personal feedback on our Trestolone clone is looking very good.
 
koi1214 said:
Would a transdermal application increase the halflife?
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Basically it would just lengthen the time of administration but not that actual halflife once it was in the system. We are working on esters to increase the halflife though. We have just not released them yet. As of right now TD is probably going to be the best bet for having any sustained levels. However not all effects of the steriods stop once the hormone binds to the AR, once it is bound to the AR it does it's thing. With a really short half life it is going to bind a lot faster to the receptors and be put to work. So it isn't like you are not going to see increases from a drug with a short half life.
 
Right now with a lack of more anecdotal evidence spacing them out evenly is probably a good bet but definitely take one close to your workout considering that during and just after is when you will want to be the most anabolic. I am still looking for the exact half life but it seems to elude me. Perhaps one of the other reps or the big man himself can shed the light on that for sure.
 
MrKleen73 said:
Right now with a lack of more anecdotal evidence spacing them out evenly is probably a good bet but definitely take one close to your workout considering that during and just after is when you will want to be the most anabolic. I am still looking for the exact half life but it seems to elude me. Perhaps one of the other reps or the big man himself can shed the light on that for sure.
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This has been the hardest to figure out in terms of best way to dose and half life.

Spacing them seems right but than people say half life is extremely short. So idk what to think of it. I was thinking maybe? An hour before workout and post workout than maybe another 4 hours after or so?

Big man should chime in
 
halfhuman said:
This has been the hardest to figure out in terms of best way to dose and half life. Spacing them seems right but than people say half life is extremely short. So idk what to think of it. I was thinking maybe? An hour before workout and post workout than maybe another 4 hours after or so? Big man should chime in
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Keep the dosing constant. Honestly I would do every 3ish hours. But find what works for you man. It's perso specific. Take your highest doses in the morning, to mimic natural testosterone rhythm, and taper the dose throughout the day. I did this with multiple hormones and didn't shutdown /minimal shutdown.
 
EatMoar said:
Honestly, book and forum knowledge is only a starting point. You can only find out what steroid and dosing works for you by trying it.
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In this case, there is a human trial. And a very good human trial. Most AAS don't have this, hence why user feedback is so valuable. But for trestolone, we have a rare case of the realest and most applicable information you can find.Yes, making trestolone transdermal would allow once a day application since TDs absorb over the course of 8+ hours.
 
MrKleen73 said:
I know that Formestane can convert into 4-hydroxytestosterone and that that can bind to the AR receptor pretty strongly. However my understanding is that the conversion to 4-htest is pretty low and a typical AI dose should not be causing much conversion. SOunds like you may be educated in the matter do you know what the conversion rate is? I beleive the 4-hydroxytestosterone is a second step conversion not a direct one which is part of the reason I have believed it to be a low conversion rate. At least if the 4-hydroxytestosterone does bind though there is actually some steroidal activity although it is less than 50% as strong as test. One of the other benefits of formestane is a rise in IGF-1 in the muscles which helps with promote anabolism.
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I don't believe anyone knows the conversion rate, but my point was that the lack of AR binding is not the reason formestane is so good. Many AIs share this quality, except for the obvious ones like ATD. Formestane is good because it is a suicidal inhibitor. Even if it's not terribly potent, if you dose it long enough you can get equivalent aromatase inhibition to clinical AIs. And since it takes much longer for this to occur, it is typically devoid of side effects
 
mr.cooper69 said:
In this case, there is a human trial. And a very good human trial. Most AAS don't have this, hence why user feedback is so valuable. But for trestolone, we have a rare case of the realest and most applicable information you can find.Yes, making trestolone transdermal would allow once a day application since TDs absorb over the course of 8+ hours.
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I NEED LINKS COOP I NEEEEEED!!!
 
looking for feedback for those who have used the TR3ST. Thus far all the logs show it to be working amazingly, and from personal experience I'm loving it as well the way it is.
 
Olympus Labs said:
looking for feedback for those who have used the TR3ST. Thus far all the logs show it to be working amazingly, and from personal experience I'm loving it as well the way it is.
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Just started 4 days ago with tr3st and furaza. You can follow my progress here.

Invalid Link Removed
 
Thanks for the input Coop! I would like to see a link to the study you referred to just to see if I can muddle through it. Some are way to technical even in the abstract or summary.
 
808bigdog said:
edje007 what you dosing TR3ST at? Would 75mg be good?
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I'm using 50mg and I love it. I take my halodrol 3 times daily and the TR3ST first thing in the AM and pre workout (early evening). I feel phenomenal all day long which is huge since last time I ran halodrol I felt like utter garbage after the first week and had to stop.
 
Thanks Coop! That abstract was actually an easy read too.
 
From looking at the study my bro-science stance would be that with a 40 minute half life you are basically bursting the androgens with each dose there is not any way to keep the levels stable orally until the longer ester version comes out. That being the case I would take it based around your workout for certain and depending on dose you are taking perhaps one pre and one post and the rest spread out. If only doing 50 then probably one in AM and one pre or post workout.

Now I do not know this for sure about androgens and the AR, but with natural GH the half life is short to but the effects once bound set off a cascade of effects that last over 3 hours. It would be my "ASSUMPTION" that there is also an extended period of anabolic activity once the TR3ST binds to the AR. IF that is true then the half life is not quite as important in this scenario as binding affinity to the receptors. Since MENT does not bind to SHBG most of it should be binding directly to the AR.

Again that is BroScience which I am sure could be backed up or refuted with a little research but right now it is just a hypothesis based on knowledge related to other hormonal activity.
 
Nice point kleen.

That's exactly what I figured to on dosing before.

Pre, post and maybe another 4 hours post workout.
 
GH lasts for hours because GH isn't the hormone with intrinsic activity...it induces IGF-1 release which has a halflife that is much much longer.

Androgens don't share this characteristic. But I do think there are some "lasting" changes that can occur from strong AR stimulation.

Halflife is important in this case because it's the terminal halflife. This means this is the halflife once the ARs have already been bound and equilibrium is achieved. So I don't think that second part about AR affinity holds true.
 
mr.cooper69 said:
GH lasts for hours because GH isn't the hormone with intrinsic activity...it induces IGF-1 release which has a halflife that is much much longer. Androgens don't share this characteristic. But I do think there are some "lasting" changes that can occur from strong AR stimulation. Halflife is important in this case because it's the terminal halflife. This means this is the halflife once the ARs have already been bound and equilibrium is achieved. So I don't think that second part about AR affinity holds true.
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Interesting, but what dosage scheme you think is most optimal?

From what you posted dosing around workout is best. As me and kleen stated probably pre, post and maybe a few hours after post dosage. That's how I've been dosing it as of late.
 
mr.cooper69 said:
GH lasts for hours because GH isn't the hormone with intrinsic activity...it induces IGF-1 release which has a halflife that is much much longer.

Androgens don't share this characteristic. But I do think there are some "lasting" changes that can occur from strong AR stimulation.

Halflife is important in this case because it's the terminal halflife. This means this is the halflife once the ARs have already been bound and equilibrium is achieved. So I don't think that second part about AR affinity holds true.
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Very interesting, I knew that the GH caused muscular IGF-1 production, among other hormonal responses in the body.

After responding earlier I took the time to research it a little bit since I knew there was a cascading effect but not the technical term for it or how exactly it worked but I knew there was a process kicked off protein synthesis at a supernatural level.

As far as the affinity not being a factor, I am not so sure that isn't the case. I am sure you know this info but the action of a steroid binding to the AR is to cross the cell barrier, bind to the AR receptor, once bound move into the nucleus of the cell and signal for (mRNA) production, the mRNA calls for extra proteins to be created IE... extra muscle. That process is called Translation, and it is this process that I assume continues well after the steroid has bound to the AR. (That is my simplified version of the stuff I was reading)

That is why I was speaking to the affinity for the AR and faster binding is very important considering the half life of TR3ST is very short. If the binding affinity is high then more of the androgen will bind during the short halflife. Once bound the growth is already set in place for however long the Translation process takes. For the product to have such great results for people even with a 40 minute half life they must be getting a lot of binding at the AR.

So what i meant to say originally is not that affinity is more important than halflife, but that the short halflife dictates that maintaining constant levels of TR3ST via oral administration without an ester is impossible without taking a dose ever 20-30 minutes... However the affinity is high enough in this case and the steroid strong enough that it works quite well even though it is only available in the blood stream for a very short period.

That being said with it having short half life I would take it surrounding any anabolic activity and at times when you are fed well. You definitely want fuel for the building. As far as avoiding TR3ST in the evening with a 40 minute halflife there is not really any reason to do that. Just take it maybe an hour or so before bed or whatever. Should be basically out of your system when you go to sleep. At night your body checks the negative feedback loop to see how many androgens you have running around to see if it should make more or not. Since this is so short half life i wouldn't see any reason why it couldn't be dosed in the evening without any negative affects. However bottom line is the TR3ST is gonna shut you down anyway, and you do a lot of your growth while sleeping so why not dose close to bed and have heightened protein synthesis while you sleep.
 
You're not far off, but the AR is a transcription factor. It goes to the nucleus and induces transcription. Transcription products then last up to 90 minutes before translation has occurred, but it's usually much less. Once translation has occurred, the protein is made and the job is done.

I agree with the second part though. You can see changes with trest because it is so powerful, even in that, say, 3 hour window when you're exposed during the day. I'm just saying TD and IM would change things, as would a new ester
 
mr.cooper69 said:
You're not far off, but the AR is a transcription factor. It goes to the nucleus and induces transcription. Transcription products then last up to 90 minutes before translation has occurred, but it's usually much less. Once translation has occurred, the protein is made and the job is done.I agree with the second part though. You can see changes with trest because it is so powerful, even in that, say, 3 hour window when you're exposed during the day. I'm just saying TD and IM would change things, as would a new ester
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Got ya then we are in agreement and thanks for validating my thoughts on that part of it. Knowing the estimated timing of the process still does not provide a dosing pattern to keep levels more stabil. However it illustrates that dosing this particular compound is about what you want to have happening in the next 90 minutes or so. For me I wiould use it around training and around large feedings like mentioned before mr.cooper69 the good news is we are working on a longer estered version that will increase the half life of the oral. We are also working on a good TD app for it as well. SO this won't be a point of consideration then. Will be interesting to see the combinations that arise from that. I can see people running the longer Ester at a reasonably high dose then pulsing the current version pre-workout for that extra kick.
 
MrKleen73 said:
I can see people running the longer Ester at a reasonably high dose then pulsing the current version pre-workout for that extra kick.
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This is exactly what I would like to do and is why I'm saving my current bottles of trest to combined with the long ester version. Whenever that is!! Hopefully within the year!
 
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