2nd GEAR™
[size=+2]2nd Gear™[/size]
INGREDIENTS:
6-BROMODIONE (6-BROMO-ETIOALLOCHAN-4-ENE-3,17-DIONE 50% ALPHA/ 50% BETA)
MILK THISTLE (SILYMARIN)
AVENA SATIVA 10:1
INDOLE-3-CARBINOL
6-BROMODIONE INFORMATION:
Activity: Aromatase Inhibitor
Ki (inhibition constant) Value: 6a-Bromo- 3.4 nM
6b-Bromo- 0.8 nM
Characteristics:
• Halogenated Androgen with Anti-Aromatase Characteristics- bromide added at C-6
• Two isomers, Alpha and Beta
• Alpha Isomer- rapid-acting competitive aromatase inhibitor. Prevents the aromatization of androgens to estrogen, normalizing estrogen while testosterone production returns to normal.
• Beta Isomer- suicide inhibitor of aromatase, meaning that it is irreversible and mechanism-based- the bromodione molecule binds to the aromatase enzyme, but does not release, and is then excreted out of the body
• C-6 "front" side of the androgen molecule allows for binding the aromatase active site- allowing for Active-site-directed inactivation of aromatase by 6-Bromodione
Data:
ADMINISTRATION/DOSAGE:
• For PCT, use 50 mg/day
• Oral administration only
• Can be taken with or without food
• Take for 3-5 weeks post-cycle as part of PCT
• For anabolic purposes, use 100 mg/day
• Can be used in conjunction with other anabolic products or PCT products
EFFECTS:
• Lowered conversion of testosterone to estrogen
• Can increase testosterone levels
• Lowered water retention
• Faster recovery of HPTA post-cycle
• Effective as an aromatase-inhibitor during a cycle
• Effective for increasing testosterone as a stand-alone or in conjunction with non-steroidal anabolics
MILK THISTLE INFORMATION:
CHARACTERISTICS AND EFFECTS:
• Strong anti-oxidant and liver protectant
• Lowers cholesterol
• Increases liver content of GSH (glutathione)
• Glutathione serves to detoxify many compounds in the body
• Also shown to have membrane stabilizing action, and can prevent cellular damage
• Increases ribosomal protein synthesis
• Stimulates the formation and growth of new hepatocytes
DOSAGE:
• Oral administration only
• Dosage per day: 200-600 mg
AVENA SATIVA INFORMATION:
CHARCTERISTICS AND EFFECTS
• Shown to bind and eliminate SHBG (steroid hormone binding globulin)
• SHBG binds free testosterone, making it inactive and unusable
• Increases free testosterone levels
• Lowers cholesterol and can normalize LDL/HDL levels
• Enhances libido
DOSAGE:
• Oral administration only
• Dosage per day: 100-300 mg
INDOLE-3-CARBINOL INFORMATION:
CHARCTERISTICS AND EFFECTS
• Shown to be an effective anti-estrogenic agent
• Derived from cruciferous vegetables
• Powerful anti-oxidant and cellular membrane-protectant
• Protects DNA structure
• Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol
DOSAGE:
• Oral administration only
• Dosage per day: 100-200 mg
POST CYCLE: TIPS TO MAXIMIZE RECOVERY, KEEPING GAINS AND GROWTH
2nd GEAR™, 1 per day
• Aromatase Inhibitor
• Increases free testosterone
• Liver protectant
• Normalizes cholesterol
BIO-MEND™ and COMPLETE BALANCE™ as directed on labels
• Prevent calcium leakage from Sarcoplasmic Reticulum
• Helps to maintain cell membrane integrity
• Helps to maintain healthy HDL/LDL levels
• Helps to protect mRNA and DNA
• Helps to keep adequate nutrient profile
OMEGA ESSENTIALS™ as directed on label
• Increases cell membrane strength
• Helps establish/maintain healthy lipid profiles
• Increases insulin sensitivity
DRIVE™ as directed on label
• Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
• Increases free testosterone
• Increases thyroid output
• Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response
IGF-2® as directed on label
• Increases free testosterone
• Increases GH output
STUDIES/CLINICAL INFORMATION:
Mitsuteru Numazawa, Wakako Handa and Keiko Yamada, “Synthesis and Biochemical Properties of 6-Bromoandrostenedione Derivatives with a 2,2-Dimethyl or 2-Methyl Group as Aromatase Inhibitors”, Biol. Pharm. Bull., Vol. 27, 1878-1882 (2004) .
Covey D. F., “Steroid Biosynthesis Inhibitors: Pharmaceutical and Agrochemical Aspects,” Chap. 12, eds. by Berg D., Plemel M., Ellis Horwood Ltd., Chichester, 1988, pp. 534—571.
Oh S. S., Robinson C. H., Mechanism of human placental aromatase: a new active site model. J. Steroid Biochem. Mol. Biol., 44, 389—397 (1993).
Osawa Y, Osawa Y, Coon MJ. Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione. Endocrinology. 1987 Sep;121(3):1010-6.
Numazawa M, Yamada K. Reaction of androst-5-en-17-one with hypobromous acid and its use for synthesis of 19-oxygenated 5-ene and 4-en-6-one steroids. Steroids. 1998 Feb;63(2):62-9.
Klein H, Bartsch W, Niemand A, Stürenburg HJ, Voigt KD. Inhibition of human placental aromatase in a perfusion model. Comparison with kinetic, cell-free experiments. J Steroid Biochem. 1988 Feb;29(2):161-9.
Tan L, Rousseau P. The aromatase active site: the C-6 "front" side of the androgen molecule is required for binding. Biochem Biophys Res Commun. 1987 Sep 30;147(3):1259-67.
Numazawa M, Yoshimura A, Oshibe M. Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase. Biochem J. 1998 Jan 1;329 ( Pt 1):151-6.
Bradlow HL, et al. 2- Hydroxyextrone: the “good” estrogen, J Endocrinol 1996; 150: S259-S265.
Ho GH, et al. Using 2/16 alpha hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein 3 and a potential biomarker of breast cancer risk. Ann Acad Med Singapore 1998; 27: 294-299.
Kali MA, Vang O, Klausen J. Effects of dietary broccoli on human drug metabolizing activity. Cancer Letters 1997; 114: 169-170, and Effects of dietary broccoli on human vivo drug metabolizing enzymes. Carcinogenesis 1996; 17: 793-799.
Bradlow HL et al. Indole-3-carbinol: A novel approach to breast cancer prevention. Ann NY Acad Sci 1996; 768: 180-200.
Jellinck PH et al. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol 1993; 45:1129-1136.
Lawrence, Valerie MD, MSc et al. (2000). "Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects". AHRQ Publication No. 01-E025.
Angulo P, Patel T, Jorgensen RA, Therneau TM, Lindor KD (2001). "Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid". Hepatology. 2001 Feb;33(2):483-4. 32: 897.
Grubbs CJ et al, Chemo-prevention of chemically induced mammary carcinogenesis by indole-3-carbinol, Anticancer Research 1995; 15: 709-716.
.American Botanical Council (2007). "Intravenous Milk Thistle Compound Used to Save Victims of Poisonous Mushrooms". HerbalGram (74): 16.
Lieber CS, Leo MA, Cao Q, Ren C, DeCarli LM. (2003). "Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons". Journal of Clinical Gastroenterology. 2003 Oct;37(4):336-9..
National Center for Complementary and Alternative Medicine. General information on milk thistle
Rambaldi A, Jacobs BP, Iaquinto G, Gluud C (2005). "Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials". Am. J. Gastroenterol. 100 (11): 2583–91.
Sur R, Nigam A, Grote D, Liebel F, Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch Dermatol Res. 2008 Nov;300(10):569-74. Epub 2008 May 7
Guo W, Wise ML, Collins FW, Meydani M. Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med. 2008 Feb 1;44(3):415-29. Epub 2007 Oct
Schöttner M, Gansser D, Spiteller G.Interaction of lignans with human sex hormone binding globulin (SHBG). Z Naturforsch [C]. 1997 Nov-Dec;52(11-12):834-43.
Schöttner M, Spiteller G, Gansser D. Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin. J Nat Prod. 1998 Jan;61(1):119-21.
Adlercreutz H, Höckerstedt K, Bannwart C, Bloigu S, Hämäläinen E, Fotsis T, Ollus A. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem. 1987;27(4-6):1135-44.
WARNING: This product is only intended to be consumed by healthy adult males 21 years of age or older. Not for use by women. Before using this product, consult with your physician if you are using any prescription or over the counter medicine or if you are unaware of your current medical condition. Do not use this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, high cholesterol, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking and MAO-B inhibitor or any other medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Possible androgenic side effects including but not limited to acne, increased risk of male pattern baldness and gynecomastia (males), may occur. Do not consume alcohol while taking this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Note: This product may contain ingredients which are banned by some athletic or government associations (including military).
[size=+2]2nd Gear™[/size]
INGREDIENTS:
6-BROMODIONE (6-BROMO-ETIOALLOCHAN-4-ENE-3,17-DIONE 50% ALPHA/ 50% BETA)
MILK THISTLE (SILYMARIN)
AVENA SATIVA 10:1
INDOLE-3-CARBINOL
6-BROMODIONE INFORMATION:
Activity: Aromatase Inhibitor
Ki (inhibition constant) Value: 6a-Bromo- 3.4 nM
6b-Bromo- 0.8 nM
Characteristics:
• Halogenated Androgen with Anti-Aromatase Characteristics- bromide added at C-6
• Two isomers, Alpha and Beta
• Alpha Isomer- rapid-acting competitive aromatase inhibitor. Prevents the aromatization of androgens to estrogen, normalizing estrogen while testosterone production returns to normal.
• Beta Isomer- suicide inhibitor of aromatase, meaning that it is irreversible and mechanism-based- the bromodione molecule binds to the aromatase enzyme, but does not release, and is then excreted out of the body
• C-6 "front" side of the androgen molecule allows for binding the aromatase active site- allowing for Active-site-directed inactivation of aromatase by 6-Bromodione
Data:
ADMINISTRATION/DOSAGE:
• For PCT, use 50 mg/day
• Oral administration only
• Can be taken with or without food
• Take for 3-5 weeks post-cycle as part of PCT
• For anabolic purposes, use 100 mg/day
• Can be used in conjunction with other anabolic products or PCT products
EFFECTS:
• Lowered conversion of testosterone to estrogen
• Can increase testosterone levels
• Lowered water retention
• Faster recovery of HPTA post-cycle
• Effective as an aromatase-inhibitor during a cycle
• Effective for increasing testosterone as a stand-alone or in conjunction with non-steroidal anabolics
MILK THISTLE INFORMATION:
CHARACTERISTICS AND EFFECTS:
• Strong anti-oxidant and liver protectant
• Lowers cholesterol
• Increases liver content of GSH (glutathione)
• Glutathione serves to detoxify many compounds in the body
• Also shown to have membrane stabilizing action, and can prevent cellular damage
• Increases ribosomal protein synthesis
• Stimulates the formation and growth of new hepatocytes
DOSAGE:
• Oral administration only
• Dosage per day: 200-600 mg
AVENA SATIVA INFORMATION:
CHARCTERISTICS AND EFFECTS
• Shown to bind and eliminate SHBG (steroid hormone binding globulin)
• SHBG binds free testosterone, making it inactive and unusable
• Increases free testosterone levels
• Lowers cholesterol and can normalize LDL/HDL levels
• Enhances libido
DOSAGE:
• Oral administration only
• Dosage per day: 100-300 mg
INDOLE-3-CARBINOL INFORMATION:
CHARCTERISTICS AND EFFECTS
• Shown to be an effective anti-estrogenic agent
• Derived from cruciferous vegetables
• Powerful anti-oxidant and cellular membrane-protectant
• Protects DNA structure
• Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol
DOSAGE:
• Oral administration only
• Dosage per day: 100-200 mg
POST CYCLE: TIPS TO MAXIMIZE RECOVERY, KEEPING GAINS AND GROWTH
2nd GEAR™, 1 per day
• Aromatase Inhibitor
• Increases free testosterone
• Liver protectant
• Normalizes cholesterol
BIO-MEND™ and COMPLETE BALANCE™ as directed on labels
• Prevent calcium leakage from Sarcoplasmic Reticulum
• Helps to maintain cell membrane integrity
• Helps to maintain healthy HDL/LDL levels
• Helps to protect mRNA and DNA
• Helps to keep adequate nutrient profile
OMEGA ESSENTIALS™ as directed on label
• Increases cell membrane strength
• Helps establish/maintain healthy lipid profiles
• Increases insulin sensitivity
DRIVE™ as directed on label
• Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
• Increases free testosterone
• Increases thyroid output
• Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response
IGF-2® as directed on label
• Increases free testosterone
• Increases GH output
STUDIES/CLINICAL INFORMATION:
Mitsuteru Numazawa, Wakako Handa and Keiko Yamada, “Synthesis and Biochemical Properties of 6-Bromoandrostenedione Derivatives with a 2,2-Dimethyl or 2-Methyl Group as Aromatase Inhibitors”, Biol. Pharm. Bull., Vol. 27, 1878-1882 (2004) .
Covey D. F., “Steroid Biosynthesis Inhibitors: Pharmaceutical and Agrochemical Aspects,” Chap. 12, eds. by Berg D., Plemel M., Ellis Horwood Ltd., Chichester, 1988, pp. 534—571.
Oh S. S., Robinson C. H., Mechanism of human placental aromatase: a new active site model. J. Steroid Biochem. Mol. Biol., 44, 389—397 (1993).
Osawa Y, Osawa Y, Coon MJ. Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione. Endocrinology. 1987 Sep;121(3):1010-6.
Numazawa M, Yamada K. Reaction of androst-5-en-17-one with hypobromous acid and its use for synthesis of 19-oxygenated 5-ene and 4-en-6-one steroids. Steroids. 1998 Feb;63(2):62-9.
Klein H, Bartsch W, Niemand A, Stürenburg HJ, Voigt KD. Inhibition of human placental aromatase in a perfusion model. Comparison with kinetic, cell-free experiments. J Steroid Biochem. 1988 Feb;29(2):161-9.
Tan L, Rousseau P. The aromatase active site: the C-6 "front" side of the androgen molecule is required for binding. Biochem Biophys Res Commun. 1987 Sep 30;147(3):1259-67.
Numazawa M, Yoshimura A, Oshibe M. Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase. Biochem J. 1998 Jan 1;329 ( Pt 1):151-6.
Bradlow HL, et al. 2- Hydroxyextrone: the “good” estrogen, J Endocrinol 1996; 150: S259-S265.
Ho GH, et al. Using 2/16 alpha hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein 3 and a potential biomarker of breast cancer risk. Ann Acad Med Singapore 1998; 27: 294-299.
Kali MA, Vang O, Klausen J. Effects of dietary broccoli on human drug metabolizing activity. Cancer Letters 1997; 114: 169-170, and Effects of dietary broccoli on human vivo drug metabolizing enzymes. Carcinogenesis 1996; 17: 793-799.
Bradlow HL et al. Indole-3-carbinol: A novel approach to breast cancer prevention. Ann NY Acad Sci 1996; 768: 180-200.
Jellinck PH et al. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol 1993; 45:1129-1136.
Lawrence, Valerie MD, MSc et al. (2000). "Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects". AHRQ Publication No. 01-E025.
Angulo P, Patel T, Jorgensen RA, Therneau TM, Lindor KD (2001). "Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid". Hepatology. 2001 Feb;33(2):483-4. 32: 897.
Grubbs CJ et al, Chemo-prevention of chemically induced mammary carcinogenesis by indole-3-carbinol, Anticancer Research 1995; 15: 709-716.
.American Botanical Council (2007). "Intravenous Milk Thistle Compound Used to Save Victims of Poisonous Mushrooms". HerbalGram (74): 16.
Lieber CS, Leo MA, Cao Q, Ren C, DeCarli LM. (2003). "Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons". Journal of Clinical Gastroenterology. 2003 Oct;37(4):336-9..
National Center for Complementary and Alternative Medicine. General information on milk thistle
Rambaldi A, Jacobs BP, Iaquinto G, Gluud C (2005). "Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials". Am. J. Gastroenterol. 100 (11): 2583–91.
Sur R, Nigam A, Grote D, Liebel F, Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch Dermatol Res. 2008 Nov;300(10):569-74. Epub 2008 May 7
Guo W, Wise ML, Collins FW, Meydani M. Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med. 2008 Feb 1;44(3):415-29. Epub 2007 Oct
Schöttner M, Gansser D, Spiteller G.Interaction of lignans with human sex hormone binding globulin (SHBG). Z Naturforsch [C]. 1997 Nov-Dec;52(11-12):834-43.
Schöttner M, Spiteller G, Gansser D. Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin. J Nat Prod. 1998 Jan;61(1):119-21.
Adlercreutz H, Höckerstedt K, Bannwart C, Bloigu S, Hämäläinen E, Fotsis T, Ollus A. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem. 1987;27(4-6):1135-44.
WARNING: This product is only intended to be consumed by healthy adult males 21 years of age or older. Not for use by women. Before using this product, consult with your physician if you are using any prescription or over the counter medicine or if you are unaware of your current medical condition. Do not use this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, high cholesterol, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking and MAO-B inhibitor or any other medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Possible androgenic side effects including but not limited to acne, increased risk of male pattern baldness and gynecomastia (males), may occur. Do not consume alcohol while taking this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Note: This product may contain ingredients which are banned by some athletic or government associations (including military).