Thanks for the answers guys,
Dsade, would you mind just giving a brief summary on the research you are talking about regarding carnitine and the counter effects it has on ars? Thanks so much..
And just another thought.. Im very ignorant about all this stuff, but wouldn't the most sensitive place for ar's be in the brain in terms of effects on libido? And since this topical is being applied so close to that area it would make the chance for down-regulation of ar's to have a lot more of a pronounced effect even if it doesnt get that absorbed systemically?
It would be great if the rk's could be acting as adaptagens(sp?) in terms of only down-regulating androgen receptors in the presence of inflammation, in this case mpb...
Sorry if I sound pretty ignorant about all this, but any thoughts would be greatly appreciated..
For LCLT and androgen receptor response: Med Sci Sports Exerc. 2006 Oct;38(10):1861.
Androgenic responses to resistance exercise: effects of feeding and L-carnitine.
Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM.
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269-1110, USA.
[email protected]
PURPOSE: The purpose of this investigation was to determine the effects of 3 wk of L-carnitine L-tartrate (LCLT) supplementation and post-resistance-exercise (RE) feeding on hormonal and androgen receptor (AR) responses. METHODS: Ten resistance-trained men (mean+/-SD: age, 22+/-1 yr; mass, 86.3+/-15.3 kg; height, 181+/-11 cm) supplemented with LCLT (equivalent to 2 g of L-carnitine per day) or placebo (PL) for 21 d, provided muscle biopsies for AR determinations, then performed two RE protocols: one followed by water intake, and one followed by feeding (8 kcal.kg body mass, consisting of 56% carbohydrate, 16% protein, and 28% fat). RE protocols were randomized and included serial blood draws and a 1-h post-RE biopsy. After a 7-d washout period, subjects crossed over, and all experimental procedures were repeated. RESULTS: LCLT supplementation upregulated (P<0.05) preexercise AR content compared with PL (12.9+/-5.9 vs 11.2+/-4.0 au, respectively). RE increased (P<0.05) AR content compared with pre-RE values in the PL trial only. Post-RE feeding significantly increased AR content compared with baseline and water trials for both LCLT and PL. Serum total testosterone concentrations were suppressed (P<0.05) during feeding trials with respect to corresponding water and pre-RE values. Luteinizing hormone demonstrated subtle, yet significant changes in response to feeding and LCLT. CONCLUSION: In summary, these data demonstrated that: 1) feeding after RE increased AR content, which may result in increased testosterone uptake, and thus enhanced luteinizing hormone secretion via feedback mechanisms; and 2) LCLT supplementation upregulated AR content, which may promote recovery from RE.
Also, do not mistake application to the scalp with any possible entry THROUGH the Blood/Brain barrier to have profound neural effects. Proximity of scalp to brain doesn't mean the ingredient will soak straight through into the old noggin.
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