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EvoMuse Presents: Epitome™

Easy...you take it as long as you want to easily maintain those low levels of bodyfat. Normalized Leptin levels will prevent some of the major metabolic damage/slowing, as well as preventing those psychotic junk cravings.

I would definitely incorporate some cheat days in here, though, especially sub 10.
 
dsade said:
Easy...you take it as long as you want to easily maintain those low levels of bodyfat. Normalized Leptin levels will prevent some of the major metabolic damage/slowing, as well as preventing those psychotic junk cravings. I would definitely incorporate some cheat days in here, though, especially sub 10.
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This sounds amazing every time u write something. It sure is hard maintaining low bf (sub10%)

How long does a bottle last?
 
halfhuman said:
This sounds amazing every time u write something. It sure is hard maintaining low bf (sub10%)

How long does a bottle last?
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30 days.
 
dsade said:
Easy...you take it as long as you want to easily maintain those low levels of bodyfat. Normalized Leptin levels will prevent some of the major metabolic damage/slowing, as well as preventing those psychotic junk cravings.

I would definitely incorporate some cheat days in here, though, especially sub 10.
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You had me at cheat days, emphasis on the plural. I can't wait for the full BMP release. Do you have rough timing? I would love to log the BMP to pick up off the beta I ran, maybe incorporate epitome too.
 
There is probably a strong chance this question has already been addressed but excuse my laziness and not wanting to read through all the various pages but with the focus of this product being the signaling pathway of AMPk, is there any concern with induced muscle loss due to the product?
 
AMPK isn't the primary, but the secondary, mechanism of action.

Queen Bee Acid is a highly potent AMPK activator, which is why I restricted dosage to twice per day instead of 3 times (plus the Leptin balancing action is sufficient at twice per day.)
 
dsade said:
AMPK isn't the primary, but the secondary, mechanism of action.

Queen Bee Acid is a highly potent AMPK activator, which is why I restricted dosage to twice per day instead of 3 times (plus the Leptin balancing action is sufficient at twice per day.)
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So when exactly did you take it then? I like the ideology behind this supplement. My concern is the inhibition of mTOR via the Epitome activation of AMPK, so I could see this being highly beneficial for fat loss but preservation of muscle/ building muscle I'm not so sure. What would say be the half life of the the active ingredients in the Epitome that activate AMPK? In a sense, maybe one could keep it to certain times of the day where this would be more advantageous like say the morning around cardio and then back off the dosage around night when one might train.
 
Dosage recommendation for standard shift people is about 10 am and 3pm, assuming either a before work workout or after work....either accounts for any detrimental effects. People who work out at odd times will have to adjust.
 
Sure...Glucosamine forms the base of the end product of glucose/sucrose traveling through the Hexosamine pathway (this will be covered in the new writeups, and is extensively covered in Par Deus Leptin series), which is a nutrient sensing pathway. Glucosamine is something lean individuals can take to mimic elevated carbohydrate intake, and increase Leptin levels, but can also induce Leptin resistance, exactly the opposite of what Epitome is trying to accomplish.

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" Preliminary studies show that activation of the HBP can cause leptin resistance and increase phosphorylation of hypothalamic STAT3 in a manner similar to that seen in sucrose-fed rats. Glucosamine entry into the HBP is not regulated and rats receiving continuous high doses of glucosamine from i.p. miniosmotic pumps for 2 d were resistant to a peripheral injection of leptin. In a second study, rats were i.v. infused with glucosamine. The infusion elevated blood glucose, indicative of the development of insulin insensitivity. After 150 min, the rats were injected with leptin and hypothalamic tissue was collected 30 min later. Similar to the effects of sucrose consumption, glucosamine infusion significantly increased PSTAT3 levels in the nonstimulated state in the hypothalamus. Further investigation is required to directly associate development of leptin resistance in sucrose-fed rats with activity of the HBP and to determine how O-linked glycosylation of specific proteins interferes with leptin signaling. "
 
dsade said:
Sure...Glucosamine forms the base of the end product of glucose/sucrose traveling through the Hexosamine pathway (this will be covered in the new writeups, and is extensively covered in Par Deus Leptin series), which is a nutrient sensing pathway. Glucosamine is something lean individuals can take to mimic elevated carbohydrate intake, and increase Leptin levels, but can also induce Leptin resistance, exactly the opposite of what Epitome is trying to accomplish.

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" Preliminary studies show that activation of the HBP can cause leptin resistance and increase phosphorylation of hypothalamic STAT3 in a manner similar to that seen in sucrose-fed rats. Glucosamine entry into the HBP is not regulated and rats receiving continuous high doses of glucosamine from i.p. miniosmotic pumps for 2 d were resistant to a peripheral injection of leptin. In a second study, rats were i.v. infused with glucosamine. The infusion elevated blood glucose, indicative of the development of insulin insensitivity. After 150 min, the rats were injected with leptin and hypothalamic tissue was collected 30 min later. Similar to the effects of sucrose consumption, glucosamine infusion significantly increased PSTAT3 levels in the nonstimulated state in the hypothalamus. Further investigation is required to directly associate development of leptin resistance in sucrose-fed rats with activity of the HBP and to determine how O-linked glycosylation of specific proteins interferes with leptin signaling. "
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Side note: still cannot wait for this one to roll out. Giddy on up!
 
I need this in my life. Starting a hard core cut and this is going to be a part of it. Now hurry it here boss :)
 
dsade said:
Sure...Glucosamine forms the base of the end product of glucose/sucrose traveling through the Hexosamine pathway (this will be covered in the new writeups, and is extensively covered in Par Deus Leptin series), which is a nutrient sensing pathway. Glucosamine is something lean individuals can take to mimic elevated carbohydrate intake, and increase Leptin levels, but can also induce Leptin resistance, exactly the opposite of what Epitome is trying to accomplish.

Invalid Link Removed

" Preliminary studies show that activation of the HBP can cause leptin resistance and increase phosphorylation of hypothalamic STAT3 in a manner similar to that seen in sucrose-fed rats. Glucosamine entry into the HBP is not regulated and rats receiving continuous high doses of glucosamine from i.p. miniosmotic pumps for 2 d were resistant to a peripheral injection of leptin. In a second study, rats were i.v. infused with glucosamine. The infusion elevated blood glucose, indicative of the development of insulin insensitivity. After 150 min, the rats were injected with leptin and hypothalamic tissue was collected 30 min later. Similar to the effects of sucrose consumption, glucosamine infusion significantly increased PSTAT3 levels in the nonstimulated state in the hypothalamus. Further investigation is required to directly associate development of leptin resistance in sucrose-fed rats with activity of the HBP and to determine how O-linked glycosylation of specific proteins interferes with leptin signaling. "
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Great info. Thanks brother
 
I should be finding out tomorrow what day next week Epitome will be done!
 
enhanced said:
None of the youngsters probably remember that one.
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I'd agree with you if it weren't for the Katy Perry halftime show at the Super Bowl this year.

Speaking of...

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Left Shark approves of Epitome.
 
Looks like it'll be here on Friday, but with the Arnold Classic being next week, I will probably go ahead and set up a presale on Wednesday and start shipping on Monday.
 
blurryimage said:
Do you know the price point yet? I need to make sure I have plenty of cash flow next week.
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Waiting for the final production invoice, but it will be less than $27.
 
Excited. My BF is finally dropping to the point where I can use this stuff in 2-3 months!
 
dsade said:
I'll have to see how many shirts I have left.
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Would love an evomuse shirt only cool supp shirts i got are a pes one, athletix one, want one of all my favorite company's lol. maybe do it so you can order the epitome and slintensity pack x amount of times, and 1 shirt per order so then you don't need to give out 10 shirts haha
 
Auslifter said:
Would love an evomuse shirt only cool supp shirts i got are a pes one, athletix one, want one of all my favorite company's lol.
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I hear you, man. This one, my new PES one and an oooolllldddd APS one are the only ones I really wear that are comfy. Of any of the others, I'd just gut the sleeves and wear them as cut-offs. These ones I'll actually wear around. Oh, and the new USP ones, too.
 
I was going to post up the link with the writeup, but I'm still polishing up the final touches.
 
dsade said:
I was going to post up the link with the writeup, but I'm still polishing up the final touches.
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Just bought a bottle of Epitom, but do have a couple questions..

How long should you use it for..? 1 month, 2, etc...?

Should it be cycled..?

When are you picking the loggers...?
 
Interesting this contains Queen Bee Acid. Antaeus Labs just released this solo. I wonder if stacking that product with this for extra QBA would "bee" useful?
 
vujade said:
Just bought a bottle of Epitom, but do have a couple questions..

How long should you use it for..? 1 month, 2, etc...?

Should it be cycled..?

When are you picking the loggers...?
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Depends...if you are one of the super lean, you can use it indefinitely to maintain (combined, eventually, with BASIC). If you are endomorph or >25% then you use it until you are back at your setpoint, somewhere in the teens. Your body will tell you when it's no longer effective, and you can switch up to a PPAR/Adrenergic approach to fat loss.

I will pick the loggers tomorrow.
 
dsade said:
Depends...if you are one of the super lean, you can use it indefinitely to maintain (combined, eventually, with BASIC). If you are endomorph or >25% then you use it until you are back at your setpoint, somewhere in the teens. Your body will tell you when it's no longer effective, and you can switch up to a PPAR/Adrenergic approach to fat loss.

I will pick the loggers tomorrow.
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sounds good bro.. thx
 
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