Sure...Glucosamine forms the base of the end product of glucose/sucrose traveling through the Hexosamine pathway (this will be covered in the new writeups, and is extensively covered in Par Deus Leptin series), which is a nutrient sensing pathway. Glucosamine is something lean individuals can take to mimic elevated carbohydrate intake, and increase Leptin levels, but can also induce Leptin resistance, exactly the opposite of what Epitome is trying to accomplish.
http://advances.nutrition.org/content/3/5/736.full
" Preliminary studies show that activation of the HBP can cause leptin resistance and increase phosphorylation of hypothalamic STAT3 in a manner similar to that seen in sucrose-fed rats. Glucosamine entry into the HBP is not regulated and rats receiving continuous high doses of glucosamine from i.p. miniosmotic pumps for 2 d were resistant to a peripheral injection of leptin. In a second study, rats were i.v. infused with glucosamine. The infusion elevated blood glucose, indicative of the development of insulin insensitivity. After 150 min, the rats were injected with leptin and hypothalamic tissue was collected 30 min later. Similar to the effects of sucrose consumption, glucosamine infusion significantly increased PSTAT3 levels in the nonstimulated state in the hypothalamus. Further investigation is required to directly associate development of leptin resistance in sucrose-fed rats with activity of the HBP and to determine how O-linked glycosylation of specific proteins interferes with leptin signaling. "