Nice write-up, but what exactly is the MOA?
Looks like a phyto-anabolic, e.g. a plant extract that mimics testosterone's anabolic and sexual properties, but doesn't display the androgenic properties...
Administration of extract resulted in weight gain in treated animals. Testes and epididymal
weights were also increased significantly, while a moderate but insignificant increase in
prostate weight was also observed. The increase in body and organ weights was
comparable with testosterone (Table 1). Since androgenic effect is attributable to
testosterone levels in the blood, it is likely that the plant extracts may have a role in
testosterone secretion allowing better availability of hormone to gonads [3].
A significant
anabolic effect upon administration of extracts was observable as compared to the control
group, which was comparable to that of the administration of testosterone suggesting a
testosterone type action of the extracts. The experiment clearly suggests anabolic
steroidal effect of A. pyrethrum. The enhancement of sexual activity has been directly
correlated to the enhancement of sexual pleasure. Penile erection index is important for
evaluating the effect of administration of extract on erectile function [18]. The aqueous
extract of A. pyrethrum increased the penile erection of male rats, similar to the increase in
penile erection index observed by administration of testosterone. An increase in PEI was
observed in treated groups, indicating the involvement of nitrous oxide (NO) based
intervention [19].The effect in A. pyrethrum aqueous extract treated group (100 mg/Kg) is
much more pronounced when compared to the administration of testosterone.
Administration of extract (50 and100 mg/Kg b. w.) modified both the orientation as well as
sexual behavior, conclusively suggesting a better sexual performance after administration
of the extracts. This activity was also validated by the histopathological studies on testis
section of various groups. The results thus confirm that, the drug extracts can be useful in
enhancement of overall sexual performance of male rats. Drug also shows prolonged and
sustained effect in overall sexual performance conducted during this study. Sexual desire
may be affected directly by increasing serum testosterone level or by having testosterone
like effect. This may be due to the change in neurotransmitter level or their action in the
cell could also changed sexual behavior [7, 20]. Spermatogenesis involves a complex
interplay between the structural element of testis and the endocrine system [15].
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