BBB Permeability, target tissues, safety concerns.
Thanks C. I understand the safety concerns regarding DAA, but with respect to N-Methyl-D-aspartic acid, would you advise using one over the other?
BBB Permeability, target tissues, safety concerns.
the study done was on DAA supplementation not NMDA... plus less concern taking DAA compared to NMDAThanks C. I understand the safety concerns regarding DAA, but with respect to N-Methyl-D-aspartic acid, would you advise using one over the other?
i dont know of any evidence that shows oral administration of nmda is toxic. or not toxicOK thanks guys. That is what I gathered, that there was no safe dosage for NMDA and that it could be dangerous at certain dosages. You would figure if you took enough DAA that could be harmful as well, but maybe not......
PA, with this being said, how do you feel about iForce's new NMDA product, Intimidate?i dont know of any evidence that shows oral administration of nmda is toxic. or not toxic
PA, with this being said, how do you feel about iForce's new NMDA product, Intimidate?
first couple of logs:
anabolicminds.com/forum/supplement-reviews-logs/188523-get-intimidated-tomahawk.html
anabolicminds.com/forum/supplement-reviews-logs/188517-intimidate-u-ready.html
anabolicminds.com/forum/supplement-reviews-logs/188514-napalms-sponsored-iforce.html
sorry about bunk links, still a noob in the eyes of AM
I didn't realise the ingredient had been announced.PA, with this being said, how do you feel about iForce's new NMDA product, Intimidate?
first couple of logs:
anabolicminds.com/forum/supplement-reviews-logs/188523-get-intimidated-tomahawk.html
anabolicminds.com/forum/supplement-reviews-logs/188517-intimidate-u-ready.html
anabolicminds.com/forum/supplement-reviews-logs/188514-napalms-sponsored-iforce.html
sorry about bunk links, still a noob in the eyes of AM
Clear you inbox please SP.None of this sounds positive. Lol.
Done my friend.Clear you inbox please SP.
correct, I think its more assumption than actual fact. Seems to be a lot of NMDA toxicity articles on the net though for some reason.i dont know of any evidence that shows oral administration of nmda is toxic. or not toxic
Seems to be a lot of NMDA toxicity articles on the net though for some reason.
must they be so negative? and scare us? or could they study they brain without the scary stuff?there are a ton of NMDA related articles on the internet because it is an important tool in studying the brain
Yes you should.i have never heard of it. should i get all excited and stop what i am doing and read up on it?
Yes I am sure. The logs have already started.I didn't realise the ingredient had been announced.
There was a competition on a UK forum to guess the ingredient and he who guessed NMDA did not win. Are you sure?
I would advise DAA over NMDA, with the two primary reasons being:Thanks C. I understand the safety concerns regarding DAA, but with respect to N-Methyl-D-aspartic acid, would you advise using one over the other?
You need to do more reading.This is all so very confusing and the consensus is, there is no consensus.What I've been able to gather so far regarding NMDA, is that it does more harm than good.
Well if I need to do more reading, then so do many others in this thread, as it seems there are conflicting opinions on the long term impact of the ndma. No need to get defensive, which seems to be reflexive for you, take a step back for once in your life and look at it from the consumer's POV. We're all just trying to learn as much as we can and make informed decisions. Damn you are a sensitive guy sometimes.You need to do more reading.
Any of the supposed "harm" that NMDA causes it when it's applied directly directly to brain matter. You plan on removing your skull and applying liberally? LOL nope
Everyone had concerns when DAA came out, and then everyone realized they were wayyyy overblown.
Same is here.
iForce's new INTIMIDATE is pure NMDA and is going to make quite a few people happy with some impressive results.
for real, I guess we should just use DAA for now......at least until the pure NMDA supps come around (as mentioned by one poster, that his company is releasing one).....I notice muscle warfare's NMDA is conglomeration of a dozen supplements, and whats worse I can't even figure out what mg amount of the first listed blend is ACTUALLY NMDA....I'd at least want a pure product where I know the ingredients exact dosage.This is all so very confusing and the consensus is, there is no consensus.
iforce will be using 30mg nmda per serving.for real, I guess we should just use DAA for now......at least until the pure NMDA supps come around (as mentioned by one poster, that his company is releasing one).....I notice muscle warfare's NMDA is conglomeration of a dozen supplements, and whats worse I can't even figure out what mg amount of the first listed blend is ACTUALLY NMDA....I'd at least want a pure product where I know the ingredients exact dosage.
That was pretty straight forward. :yeah:iforce will be using 30mg nmda per serving.
This is Intimidate right?? Is it out yet??iforce will be using 30mg nmda per serving.
How is this supposed to compare results wise to 3 grams DAA per day? Or is the point of the logs that I have seen popping up to find that out...iforce will be using 30mg nmda per serving.
Subscribe to the logsHow is this supposed to compare results wise to 3 grams DAA per day? Or is the point of the logs that I have seen popping up to find that out...
Not out yet. Beta logs are just starting.This is Intimidate right?? Is it out yet??
Had a feeling you would say that lolSubscribe to the logs
The full write up hasn't been released yet, but I'm trying to find out as much as I can. Trust me I want to know just as much as you.Had a feeling you would say that lol
Yeah, understood. I didnt know if you had some knowledge of the write up since you are a rep. Just curious if the company had any "theoretical" data to estimate gains compared to DAA. Looks like logs are the best we have available right now so Ill be sure to follow some of them.The full write up hasn't been released yet, but I'm trying to find out as much as I can. Trust me I want to know just as much as you.
I agree. If you want to use it then use it. If your worried about the sides then don't use it. Sh!t I started this thread back in march, lolthe bad part is that despite the fact the stuff is gonna work, since we already know big brother will work just as good and probably better than little brother.....but again, no way we will know long term sides....and the short term sides will be similar to DAA of course. So I doubt we learn much new info other than I am certain the loggers results should be superior to DAA.
yeah I think it dropped down the page's pretty far, but I found it and bumped it back to the top a few days back, and then it was on again for another half dozen pages hahahaha!!!I agree. If you want to use it then use it. If your worried about the sides then don't use it. Sh!t I started this thread back in march, lol
It's all good. I have no shame in bumping a thread back from the dead if the information is relative.yeah I think it dropped down the page's pretty far, but I found it and bumped it back to the top a few days back, and then it was on again for another half dozen pages hahahaha!!!
I can just as easily say: "I can give people placebo and get a significantly higher proportion that will say DAA is making them anxious I bet". (In other words, neither of us has a clue). I personally tend to experience anxiety whenever something makes me feel unusual, as I did with DAA. It's just my body's way of saying "hang on, something might be wrong here". Once my system is used to whatever feels different, though, this tends to subside. So it might with DAA.i can give people placebo and get the same proportion of people that will say the stuff is making them anxious i bet
but you are right, you still count it. thats why drug companies have placebo arms in their studies to account for these things
u are correct in that the enzyme which makes it from l-aspartic acid is localized in specific parts of the body. Still though it circulates in plasma.There are some unanswered questions about D-aspartic acid: What is the rate of production in the body and what is the rate of methylation to N-methyl-D-asparic acid. In the body it is produced in the locals wher e it is used. In so fart as I know it does not go into general circulation. On the other hand when it is ingested it goes everywhere.
I can just as easily say: "I can give people placebo and get a significantly higher proportion that will say DAA is making them anxious I bet". (In other words, neither of us has a clue). I personally tend to experience anxiety whenever something makes me feel unusual, as I did with DAA. It's just my body's way of saying "hang on, something might be wrong here". Once my system is used to whatever feels different, though, this tends to subside. So it might with DAA.
.
Yeah, when I had a colonoscopy and the anasthesia started kicking in, I freaked out for a moment feeling as though I was dying, then the sedative component kicked in and I was very calm ... next thing I know, I'm waking up. The more I think about it, the more I'm convinced this is what's going on for me. I actually felt pretty good at first after having 3 g of DAA, then it got a bit weird and I think some adrenaline kicked in. I'd almost forgotten that the first time I had Creatine, I felt "hyped" and on edge. I actually thought it contained ephedra, but that's illegal in Australia and it was a well known brand, so I doubt it (?). It was probably also an initial change to the body. If DAA acts throgh the hypothalamus to affect test and LH, then you're going to feel a bit different. I'm just very attuned to physiological/mental changes and I know a lot of peole are not so attuned (often I wish I wasn't). I think I'll go with 0.5 g and just look to nudge it up to 1 g and take it from there. No rule that says it has to be 3 g.i was given general anesthesia ... It didnt relax me though it freaked me out. cuz it made me feel weird and then i thought i was gonna die or something ...
Any other feelings on this, and/or your thoughts on potential risk?possible role of NMDA receptors in muscle nerve transmission?
Muscle Nerve. 2011 Dec;44(6):987-9. doi: 10.1002/mus.22250.
[h=1]NMDA receptors at the endplate of rat skeletal muscles: Precise postsynaptic localization.[/h]Malomouzh AI, Nurullin LF, Arkhipova SS, Nikolsky EE.
[h=3]Source[/h]Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia. [email protected].
[h=3]Abstract[/h]In this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction.Muscle Nerve, 2011.
Copyright © 2011 Wiley Periodicals, Inc.
PMID: 22102472 [PubMed - in process]
This is EXACTLY what I suspect is happening in those reporting anxiety.I can just as easily say: "I can give people placebo and get a significantly higher proportion that will say DAA is making them anxious I bet". (In other words, neither of us has a clue). I personally tend to experience anxiety whenever something makes me feel unusual, as I did with DAA. It's just my body's way of saying "hang on, something might be wrong here". Once my system is used to whatever feels different, though, this tends to subside. So it might with DAA.
Yeah, when I had a colonoscopy and the anasthesia started kicking in, I freaked out for a moment feeling as though I was dying, then the sedative component kicked in and I was very calm ... next thing I know, I'm waking up. The more I think about it, the more I'm convinced this is what's going on for me. I actually felt pretty good at first after having 3 g of DAA, then it got a bit weird and I think some adrenaline kicked in. I'd almost forgotten that the first time I had Creatine, I felt "hyped" and on edge. I actually thought it contained ephedra, but that's illegal in Australia and it was a well known brand, so I doubt it (?). It was probably also an initial change to the body. If DAA acts throgh the hypothalamus to affect test and LH, then you're going to feel a bit different. I'm just very attuned to physiological/mental changes and I know a lot of peole are not so attuned (often I wish I wasn't). I think I'll go with 0.5 g and just look to nudge it up to 1 g and take it from there. No rule that says it has to be 3 g.
i see nothing in that abstract which brings up the thoughts of riskAny other feelings on this, and/or your thoughts on potential risk?
mocking inane advice, or offering it? hopefully the former.just breathe. inhale, exhale. everything is gonna be ok
lol
Going to this post waaay back on p. 9 -- I can concur with the semen analysis, and I get this effect with around 0.5 g per day and within a very short time (making me wonder whether 3 g is really necessary for any effects that are to be seen). I also agree with the disposition you seem to express toward standard medical 'controlled experiments'; and I say this as someone with a fair bit of expertise in statistical analysis, much of which I consider rubbish. I can't say about results, I need to give that one a bit longer.What I can say is that semen analysis (of course there is some exoticness to what I do, but understand it is no brain biopsy) did show increased quantity and quality (judging from motility factors and anatomic reconstruct.). What I can say is a whole bunch of subjective stuff that mimics that which many have already plagued this thread with and many others across the internet and so on. What I can say is...it is far better from many herbal nonsensical preps that people rave over from an objective standpoint.
D_
Were you whacking it more?I'm 24 and after all the people saying how good daa is I used a bottle of tcf1 3 grams per day for a month I noticed absolutley nothing no strength gains or muscle or libido ... If anything the only thing I got from daa was my left arm and bicep kept shaking muscle spasym.
I won't use daa ever again and will stick to activate xtreme .
What can we say? We are all the modern day Jesus. (Woman laughs) What? You think Mary gave birth to a human? (Kid laughs hysterically to the point of physical discomfort...Pointing at him with a fully extended right arm, turned hip, and index finger firmly flexed...) Shoosh child! Let me preach! Mary gave birth to anabolicminds, which later, spawned an abundance of reps, members, and some of the most intelligent humans on earth to bring....not bread and wine...but valuable information...(epic music slowly rises) So hear me when I say, damn it, people! If you have a question, a concern, NAY...a request! GO to anabolicminds! (Raises fist) Let your voice be heard!!!!! (Rips shirt off and all see an i-Force tattoo with a bottle of intimidate on his chest) (silence) (whispers....) and let your body be loved...(huge uproar and clapping until a random spectator comes on stage and kills the young man and announces his name as Mission1.) The end.I just spent about an hour reading all 25 pages of this thread.
Now I'm more tired than I would be following a hard leg workout! :rofl:
It's cool that we have so many educated and well-informed members around here.
Good job.
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