a little update guys.
biotin directly activates guanylate cyclase in hepatocytes . The resulting production cGMP acts to increase the expression of glucokinase, and decrease that of phosphoenolpyruvate carboxykinase, two enzymes of key importance in the regulation of gluconeogenesis. High-dose biotin (3 mg t.i.d.) has been reported to lower fasting glucose in type 2 diabetics and in type-1 diabetics temporarily withdrawn from insulin. It also can improve glycemic control in diabetic or pre-diabetic rodents, and can retard weight gain in obesity-prone rats (presumably because it reduces insulin secretion).
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