New Muscle Gainer!

There is a between the the hormone neuropeptide Y, and LPL levels which play a role in appetite.

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this usually occurs in the morning (from what i learned in school).

Neuropeptide Y certainly plays an important role in appetite regulation. My original querry related to your assertion regarding high LPL levels in fasted states.

obviously insulin plays a role in this NPY and LPL levels, anf after fasting and ingesting a high carbohydrate meal (like a breakfast cereal or something with a lot of sugar) your body over secretes insulin to deal with this amount of sugar (again something i learned while in school) this in turn is why id rather not have my carbs in the morning.

Insulin response to carbohydrate consumption is a metabolic activity that is certainly not restricted to morning (carbohydrate) meals alone. It is the body's default response to carbohydrate intake, irrespective of time of day, assuming no dysfunction in pancreatic beta-cell activity.
It is, in fact, reasonable to expect a more effective macronutrient absorption in the mornings, as the body is in an optimal state for nutrient uptake, a state termed by some as an "Anabolic Window of Opportunity".

...then again theres a lot of interaction between LPL NPY and Leptin, When NPY is low HSL is higher which helps with FFA metabolism

It might help to examine some concepts and relationships more closely, in order to promote targeted understanding of certain assertions.

Now, abundantly available in the fat-cell membrane, hormone-sensitive lipase (HSL) is actually a crucial enzyme in the hydrolysis of triacylglycerol (TAG) [to diacyglycerol (DAG) and free fatty acids (FFA)] and degradation of cholesteryl ester (into free cholesterol for the production of steroid hormones), in different tissues, including adipocytes. HSL is regulated via reversible phosphorylation on four residues. When the body’s energy needs rise, the secretion of hormone-sensitive lipase is stimulated. The activation of HSL leads to the breakdown of triglycerides (made up of fatty acids and glycerol), and the release of fatty acids for the production of adenosine triphosphate (ATP). HSL shows a synergistic relationship with glucagon, cathecholamines, and adrenocorticotropic hormone (ACTH), but responds negatively to insulin. In fact, down-regulation of hormone-sensitive lipase inhibits adipogenesis and obesity.

Now to leptin. The adipocytokine leptin is an adipocyte protein. Leptin is involved in the inhibition of appetite and regulates the enzymes involved in the synthesis of fatty acids. Now, let’s introduce neuropeptide Y (NPY). Appetite regulation is broadly governed by two hypothalamic neuronal groups.
The first is the so-called neuropeptide Y/Agouti-related protein or Agouti-related peptide (NPY/AgRP) group. When these neurons are activated, NPY and AgRP are released, leading to the stimulation of appetite. Leptin suppresses the expression of these neurons. In effect, low levels of leptin leads to a high hypothalamic concentration of NPY/AgRB, leading to appetite stimulation and potential fat accumulation. Something else: Hypothalamic insulin receptors inhibit NPY secretion; furthermore, PYY3-36 (a gastro-intestinal-tract appetite-stimulating hormone) down-regulates appetite by inhibiting the secretion of NPY/AgRP; while Ghrelin (an appetite-stimulating peptide secreted in fasting states) stimulates NPY activity.
The other group of hypothalamic neuronal hormones is the so-called pro-opiomelanocortin/cocaine and amphetamine-regulated transcript (POMC/CART) group. The stimulation of these neurons eventually leads to the inhibition of appetite. Leptin stimulates the expression of these neurons.

however i do understand that malonyl CoA inhibits lipolysis, but i have not learned much about that in my short semester in bio chem.

this was a decent read tho.
Malonyl-CoA is the first committed step in the synthesis of fatty acids, and does not inhibit lipolysis.

EDIT: should have worded my words better in the original post with carb craving...

Agree. Tight terminology helps a lot! :D
 
Seems like Glycobol would lend itself better to bodybuilding/size routines more so than strength routines. Would you guys agree? If so, is there any specific type of routine you recommend?

I'm looking to switch it up...have been doing a 5x5/strength routine for awhile now.
 
Damn Ike, you sound like my biochem textbook :D One thing though as for "Malonyl-CoA is the first committed step in the synthesis of fatty acids, and does not inhibit lipolysis. " , I believe it inhibits Carnitine AcylTranferase 1, which is req'd to move the Fatty-Acid - Carnitine across the IMM to the matrix, where we get B-Oxidation/Lipolysis. I jumped in at the end here though, so my point may be out of context.
 
Neuropeptide Y certainly plays an important role in appetite regulation. My original querry related to your assertion regarding high LPL levels in fasted states.



Insulin response to carbohydrate consumption is a metabolic activity that is certainly not restricted to morning (carbohydrate) meals alone. It is the body's default response to carbohydrate intake, irrespective of time of day, assuming no dysfunction in pancreatic beta-cell activity.
It is, in fact, reasonable to expect a more effective macronutrient absorption in the mornings, as the body is in an optimal state for nutrient uptake, a state termed by some as an "Anabolic Window of Opportunity".



It might help to examine some concepts and relationships more closely, in order to promote targeted understanding of certain assertions.

Now, abundantly available in the fat-cell membrane, hormone-sensitive lipase (HSL) is actually a crucial enzyme in the hydrolysis of triacylglycerol (TAG) [to diacyglycerol (DAG) and free fatty acids (FFA)] and degradation of cholesteryl ester (into free cholesterol for the production of steroid hormones), in different tissues, including adipocytes. HSL is regulated via reversible phosphorylation on four residues. When the body’s energy needs rise, the secretion of hormone-sensitive lipase is stimulated. The activation of HSL leads to the breakdown of triglycerides (made up of fatty acids and glycerol), and the release of fatty acids for the production of adenosine triphosphate (ATP). HSL shows a synergistic relationship with glucagon, cathecholamines, and adrenocorticotropic hormone (ACTH), but responds negatively to insulin. In fact, down-regulation of hormone-sensitive lipase inhibits adipogenesis and obesity.

Now to leptin. The adipocytokine leptin is an adipocyte protein. Leptin is involved in the inhibition of appetite and regulates the enzymes involved in the synthesis of fatty acids. Now, let’s introduce neuropeptide Y (NPY). Appetite regulation is broadly governed by two hypothalamic neuronal groups.
The first is the so-called neuropeptide Y/Agouti-related protein or Agouti-related peptide (NPY/AgRP) group. When these neurons are activated, NPY and AgRP are released, leading to the stimulation of appetite. Leptin suppresses the expression of these neurons. In effect, low levels of leptin leads to a high hypothalamic concentration of NPY/AgRB, leading to appetite stimulation and potential fat accumulation. Something else: Hypothalamic insulin receptors inhibit NPY secretion; furthermore, PYY3-36 (a gastro-intestinal-tract appetite-stimulating hormone) down-regulates appetite by inhibiting the secretion of NPY/AgRP; while Ghrelin (an appetite-stimulating peptide secreted in fasting states) stimulates NPY activity.
The other group of hypothalamic neuronal hormones is the so-called pro-opiomelanocortin/cocaine and amphetamine-regulated transcript (POMC/CART) group. The stimulation of these neurons eventually leads to the inhibition of appetite. Leptin stimulates the expression of these neurons.

dont get the first part of what i bolded, but i understand ghrelin. so essentially, Ghrelin is raised in fasted states leading to an increase in NPY which causes a rise in LPL?


Malonyl-CoA is the first committed step in the synthesis of fatty acids, and does not inhibit lipolysis.



Agree. Tight terminology helps a lot! :D

bolded and uhmm

TOUCHE
 
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Glycobol

Sorry about that

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I have a very weak stomach..will this product give me bad stomach aches or anything like that?

For example, while i was taking cell tech hardcore i would get diarrhea after nearly every dosage i had.

But for some other products, i don't experience anything.
 
No way to say 100% for sure. You say 1 product gives you trouble but no other ones. I would think you would be fine.
 
So what exactly is this product? (creatine, amino acid, protein, carb, etc etc)

I'm really interested in trying it out.

Also i have another question, I have an injured shoulder, which prevents me from doing shoulder workouts, chest workouts, and trap workouts, would i still be able to take this product and have it be beneficial if i do all my other muscle groups besides chest, and shoulders? Also will it increase the risk of getting injured again?
 
I have a very weak stomach..will this product give me bad stomach aches or anything like that?

For example, while i was taking cell tech hardcore i would get diarrhea after nearly every dosage i had.

But for some other products, i don't experience anything.

I ocassionally get stomach discomfort (assplosions) from Yellow Gold, but I don't get it from Glycobol at all.

Nutraplanet has a trial bottle for $9.99 if you want to give it a try before buying a full bottle: Invalid Link Removed

So what exactly is this product? (creatine, amino acid, protein, carb, etc etc)

I'm really interested in trying it out.

Also i have another question, I have an injured shoulder, which prevents me from doing shoulder workouts, chest workouts, and trap workouts, would i still be able to take this product and have it be beneficial if i do all my other muscle groups besides chest, and shoulders? Also will it increase the risk of getting injured again?

Anabolic Innovations Presents: Glycobol

Glycobol works, not like typical muscle gainers, but primarily by it’s ability to mimic and boost insulin. On it’s own, insulin is a powerful growth peptide, but it also plays a critical role in the action of androgens. Just like insulin, androgens are another fundamental class of endocrine hormones. Studies show that androgens fail to sustain a positive muscle nitrogen balance in the absence of insulin, emphasizing the critical role of insulin as a potential limiting factor to the anabolic capacity of androgens. Therefore, Glycobol could be combined with any of the commercially available androgens to optimize and exaggerate gains by it’s essential synergistic contribution.


* Promotes muscle mass, strength and endurance.
* Encourages fat loss and prevents fat accumulation.
* Improves recovery time by rapid glycogen resynthesis.
* Provides lasting “pump”, hardness and vascularity.
* Drives amino acid and creatine uptake in muscle.
* Increases muscle protein synthesis and inhibits breakdown.
* Controls blood sugar and maximizes nutrient utilization.
* Potent synergism with endogenous endocrine hormones.
* Strong anti-oxidant protects liver, lipid and cardio health.

Insulin also interacts synergistically with GH, IGF and thyroid hormones to compound growth effects, even when these endocrine co-factors are only present at average physiological levels. Therefore, Glycobol can be used to achieve impressive natural muscle gains and body recomposition as an effective stand-alone agent too.

You asked for something Innovative, now you’ve got it!

Glycobol Blend:

Sodium R-Lipoate (Na-r-ALA)
ALA is naturally produced in the body as a mitochondrial enzyme cofactor. It is important to aerobic metabolism. ALA has been shown to increase cellular uptake of glucose to cell membranes by recruiting the glucose transporter GLUT4. ALA improves skeletal muscle glucose transport, resulting in desirable blood glucose disposal and increased muscle glycogen concentrations. (1) Studies also indicate that in muscle, ALA is a potent anti-oxidant which protects cells from oxidative stress-induced insulin resistance. (2) The ALA used in this formula is chemically stabilized and of the highest quality. It’s the most active isomer and the highest potency salt commercially available. ALA is an invaluable addition that offers a multitude of benefits plus countless extras for any serious athlete.

Bottom Line: Best way to describe this effect is that it almost adds a filter to the muscle fibers; Taking in what it needs to prepare for growth.

Trigonella Seed isolate (standardized to 10% 4-hydroxyisoleucine)
Fenugreek has been successfully applied for thousands of years to improve health. It corrects blood sugar problems and improves cholesterol scores. Modern research also shows that it improves endurance and lowers blood lactate concentrations dramatically. Treatment with fenugreek seed can also significantly decreases fat accumulation. These results suggest that this improvement in endurance and reduction in body fat is caused by an increase in the utilization of fatty acids as an energy source. (3) Fenugreek supplements high in 4-HIL have also been demonstrated to increase post-exercise glycogen resynthesis in athletes, which promotes rapid recovery and helps prevent training fatigue. (4) The visible results of this glycogenic effect are big, pumped muscles that look extremely full and vascular.

Bottom Line: Helps you use fatty acids as an energy source, rather than store them as Fat!

Phellodendron extract (standardized to 90% berberine)
Phellodendron is one of the highly valued traditional Chinese herbs, used medicinally to treat a variety of health conditions. It is reported that some subjects show improved strength, lower blood pressure, and lower blood sugar in response to Phellodendron isolates. Laboratory studies suggest that one of these alkaloidal isolates called berberine may accomplish these benefits by enhancing insulin production. (5) There are also many studies that suggest berberine can reduce total serum cholesterol, dangerous LDL-cholesterol, and unhealthy triglycerides, which would obviously contribute greatly to increased athletic performance and good over-all health. (6) Improved health and increased physical performance translates into greater strength and muscle gains in the gym.

Bottom Line: Increased performance translates into greater strength and muscle gains.

Cinnamon Bark 20:1 extract (standardized for 16% flavonoids)
Cinnamon is a common spice used all over the world, but it’s not commonly known that the spice has significant therapeutic value. Cinnamon contains the element chromium, which is needed for proper glucose metabolism, and also compounds called flavonoids. Flavinoids are potent anti-oxidants which are known to provide protection against cancer and heart disease. The specific flavonoids found in cinnamon bark are shown to stimulate glucose uptake and glycogen synthesis similar to insulin. These flavonoids may activate receptors by direct insulin mimicking action, or indirect insulin potentiation, or both. (7) Studies also show that cinnamon improves lipid profiles for some subjects. (8) If you train consistently and have a healthy diet, your big muscular improvements from this powerful little cinnamon extract might surprise you.

Bottom Line: Insulin is very anabolic, so the insulin boosting action of cinnamon extract will be bigger, stronger muscles.

Bis(Maltolato)Oxovanadium (BMOV)
BMOV is an organic form of the mineral vanadium. Although elemental vanadium and inorganic salts of vanadium show significant biological potential, it has a poor therapeutic index due to low gastrointestinal absorbance. BMOV is recognized as safer, more absorbable, and able to deliver a therapeutic effect up to 50% greater than the inorganic forms. (9) Vanadium is one of the rare microelements that can promote a profound boost in endurance and strongly support anabolism. BMOV can give muscles a hardness like you have never experience before. The form of vanadium used in this formula is one of the very best you can find, if not the best.

*Bottom Line: Makes your Muscle harder than ever, increases vascularity!
 
It was offered by itself as well and was a week's worth. I'll check and see if there will be more trial sizes sent out.

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i'm on my 2nd bottle and am loving it. should i cycle this or is that not necessary?

As long as you eating carbs, it is fine to continue use, remember its a nutrient partritioner, so extra nutrients is always welcomed. I have been running it for 3 moths straight, and do not plan on stopping any time soon.
 
As long as you eating carbs, it is fine to continue use, remember its a nutrient partritioner, so extra nutrients is always welcomed. I have been running it for 3 moths straight, and do not plan on stopping any time soon.

awesome. i got sick last month and dropped over 10lbs and with glycobol i'm almost back to where i was. and pretty cut still too thanks to that and DCP.. but stupid nutraplanet has to be out of DCP aaaaagain
 
As long as you eating carbs, it is fine to continue use, remember its a nutrient partritioner, so extra nutrients is always welcomed. I have been running it for 3 moths straight, and do not plan on stopping any time soon.

How has your body composition changed?
 
How has your body composition changed?

If you refer to pg.20 of this thread you will see pics, as for what exactly went down, was improved vascularity, improved muscle fullness, lost bf%, gained slow but constant strength, better mood, better sleep, better recovery.
 
Sorry if it's already been asked but is this product similar to Anabolic Pump?

If I could offer you my opinion I might do so in a very tactful and honest manner, being extremely careful not to compromise the truth, while also being as gracious and diplomatic as possible. However, I have never personally tried AP, plus do not want to give any impression of unfair bias, so I don't feel qualified to compare the two products.

If I did criticize or offer advise on a product I'd never even tried before (especially a competitor's product), that would make me a pathetic loser and I'd have no choice but to kick my own a** for being such a lil' b*****. :)
 
If I could offer you my opinion I might do so in a very tactful and honest manner, being extremely careful not to compromise the truth, while also being as gracious and diplomatic as possible. However, I have never personally tried AP, plus do not want to give any impression of unfair bias, so I don't feel qualified to compare the two products.

If I did criticize or offer advise on a product I'd never even tried before (especially a competitor's product), that would make me a pathetic loser and I'd have no choice but to kick my own a** for being such a lil' b*****. :)

:laugh::cheers:
 
Whenever possible, I try find cheap add-ins to increase the effectiveness of different supplements. Cinnamon caps are pretty cheap. Would taking them with Glycobol increase the effect?
 
If I could offer you my opinion I might do so in a very tactful and honest manner, being extremely careful not to compromise the truth, while also being as gracious and diplomatic as possible. However, I have never personally tried AP, plus do not want to give any impression of unfair bias, so I don't feel qualified to compare the two products.

If I did criticize or offer advise on a product I'd never even tried before (especially a competitor's product), that would make me a pathetic loser and I'd have no choice but to kick my own a** for being such a lil' b*****. :)

Great post! :thumbsup:
 
Whenever possible, I try find cheap add-ins to increase the effectiveness of different supplements. Cinnamon caps are pretty cheap. Would taking them with Glycobol increase the effect?

I do too! :)

Yes, possibly. One of cinnamon's strongest benefits appears to be it's ability to increase phosphatidylinositol 3-kinase activity (an insulin signaling pathway with predominately anabolic results) so as long as you're not dieting, additional cinnamon might potentiating the effectiveness of Glycobol.
 
Vanadium is one of the rare microelements that can promote a profound boost in endurance and strongly support anabolism. BMOV can give muscles a hardness like you have never experience before. The form of vanadium used in this formula is one of the very best you can find, if not the best.


DR.D could u elaborate on this, how dose is support anabolism and increase endurance
 
Vanadium is one of the rare microelements that can promote a profound boost in endurance and strongly support anabolism. BMOV can give muscles a hardness like you have never experience before. The form of vanadium used in this formula is one of the very best you can find, if not the best.


DR.D could u elaborate on this, how dose is support anabolism and increase endurance

Sure. Micros like Vanadium are essential to anabolic processes, especially in athletes. Dehydration is common, and it cause severe depletion in many athletes. These elements are limiting factors that have detrimental consequences on strength and performance (vigor they call it), as evidenced in particular by the negative cardiovascular consequences associated with their deficiency. Plus, Vanadium has shown not only to sensitize the system for insulin, but to act independent of insulin as well, so it doesn't even matter if you're dieting. It works with or without carbs! It's a really nice bonus that it lowers cholesterol and triglycerides too. Many people now realize they are zinc deficient and supplement other micros too, but they continue to overlook Vanadium and it's necessity to optimal lipid and carbohydrate homeostasis. Here's a few little abstracts that may shed some light...


Trace elements in nutrition.
Med J Aust.; Dreosti IE.; 9 Aug 1980; 2(3):117-23.

Advances in trace element research over the last decade have done much to elucidate the function of these nutrients at the biochemical level. Five new trace elements have been identified and the general relevance of microelements in human nutrition has undergone reassessment. Deficiencies of iodine, iron and fluorine remain important problems and necessitate supplementation. Suboptimal nutrition in chromium, copper, selenium, zinc and possibly vanadium has been suggested, and these elements are generally acknowledged to be of concern in human nutrition. Genetic factors and other "conditioning" agents have been implicated in the etiology of a number of trace element deficiencies in apparently well nourished communities. Tissues under anabolic stress have been recognized to be especially sensitive to trace element deficits, and the particular vulnerability of the fetus has been demonstrated on a number of occasions. In practical dietary terms, the loss of microelements during the refining and processing of food has been widely illustrated. Also, the generally lower levels of trace elements in plant material and the lower availability of minerals from these food sources has been well established. Of the newer trace element deficiencies, zinc impoverishment appears to be especially important, as a state of physiological zinc deficiency rapidly follows dietary insufficiency, and the consequences on all growing tissues are particularly serious. In general, recent developments suggest that marginal deficiencies of microelements are more widespread in human nutrition than was previously appreciated. Greater attention to trace element status seems to be indicated in circumstances in which physical condition and vigor are unaccountably poor and especially in situations accompanied by active anabolism.


Effect of several microelements contained in drinking water on the development of atherosclerosis.

Probl Khig.; Novakova S, Nikolchev G, Mautner G, Angelieva R, Dinoeva S.; 1983; 8:121-31.

During his whole life man drinks water - about 2 liters in 24 hours for an adult in the countries with moderate climate. Usually, drinking water contains many microelements. Their type and concentration depend mainly on the geochemical characteristic of the earth layers. The pollution of waters by industrial enterprises has, very likely, an effect on the content of microelements. According to literature data, in epidemiological studies information was collected, providing grounds to admit that some microelements have an effect ion atherosclerosis advancement. The results obtained are not convincing enough to judge if a casual relationship exists between the microelements in the drinking water and atherosclerosis advancement. In order to supplement the existing studies, the authors carried out investigations to elucidate the role of some microelement in the progress of experimental atherosclerosis. The results obtained provided grounds to claim that the microelements chromium, zinc, lead, cadmium, vanadium stimulate or restrict the advancement of experimental atherosclerosis.


Urinary excretion of microelements in endurance-trained volunteers during restriction of muscular activity and chronic rehydration.
Biol Trace Elem Res.; Zorbas YG, Federenko YF, Naexu KA.; Mar 1994; 40(3):189-202.

The objective of this investigation was to determine the effect of daily intake of fluid and salt supplementation (FSS) on increased urinary losses of microelements that developed during hypokinesia (decreased number of walking steps/d). The studies were performed on 30 endurance-trained male volunteers aged 23-26 yr, with an averaged maximum oxygen uptake of 65 mL/kg/min during 364 d of hypokinesia (HK). All volunteers were divided into three equal groups: Ten volunteers were placed continuously under an average of 10,000 running steps/d (14.2 km/d) (control subjects), ten volunteers subjected continuously to HK without the use of FSS (hypokinetic subjects), and ten volunteers were continuously submitted to HK and consumed daily FSS (hyperhydrated subjects). For the simulation of the hypokinetic effect the hypokinetic and hyperhydrated volunteers were kept under an average of 3,000 walking steps/d (2.7 km/d) for 364 d. Prior to their exposure to HK the volunteers were on an average of 10,000 running steps/d (14.2 km/d). During the prehypokinetic period of 60 d and during the hypokinetic period of 364 d were determined renal excretion of microelements responses of endurance-trained volunteers. In the hyperhydrated volunteers urinary excretion of iron, zinc, copper, manganese, cobalt, nickel, lead, tin, chromium, aluminum, molybdenum, and vanadium decreased, whereas in the hypokinetic volunteers it increased significantly. It was concluded that chronic hyperhydration may be used to attenuate urinary excretion of microelements in endurance-trained volunteers during prolonged restriction of muscular activity.


Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) in rat model of non-insulin-dependent-diabetes.
Indian J Exp Biol.; Shinde UA, Mehta AA, Goyal RK; Sep 2001; 39(9):864-70.

Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) (BMOV) was studied in streptozotocin (STZ)-induced neonatal non-insulin-dependent-diabetic (NIDDM) rats. Intraperitoneal injection of STZ (90 mg kg(-1)) in Wistar rat pups (day 2 old) produced mild hyperglycemia, impaired glucose tolerance and insulin resistance at the age of 3 months. Treatment with BMOV (0.23 mM kg(-1)) in drinking water for 6 weeks produced a significant decrease in elevated serum glucose levels without any significant change in serum insulin levels in diabetic rats. BMOV treatment significantly decreased integrated area under the glucose curve without any significant change in integrated area under the insulin curve indicating improved glucose tolerance. Treatment also significantly increased K(ITT) value of diabetic rats indicating increased insulin sensitivity. BMOV treatment significantly reduced hypercholesterolemia in diabetic rats. Treatment also significantly decreased serum triglyceride levels in both diabetic and non-diabetic rats. The data suggest that chronic BMOV treatment improves glucose and lipid homeostasis. These effects appear to be due to the insulin sensitizing action of vanadium.
 
wow since im diabetic this would really help me out

It could possibly help out BUT dont put all your eggs in one basket this should probably be discussed with your Doctor before you use it and before you think about cutting out your diabetic medicine insulin? (if thats what your thinking)...You dont just wanna jump into this hoping it will help you....:wave2:
 
It could possibly help out BUT dont put all your eggs in one basket this should probably be discussed with your Doctor before you use it and before you think about cutting out your diabetic medicine insulin? (if thats what your thinking)...You dont just wanna jump into this hoping it will help you....:wave2:

Yes sir, exactly correct. This may be a healthy adjunctive for the Non-IDD, but it would be tricky for IDDs.

Also, athletes are reporting great fat loss with this product and I'm not surprised. However, real diabetics and consumers that don't exercise regularly may not get the same 'dieting' benefits of this product. Lipolysis may be a challenge in such people, or it might not.
 
Yes sir, exactly correct. This may be a healthy adjunctive for the Non-IDD, but it would be tricky for IDDs.

Also, athletes are reporting great fat loss with this product and I'm not surprised. However, real diabetics and consumers that don't exercise regularly may not get the same 'dieting' benefits of this product. Lipolysis may be a challenge in such people, or it might not.

I am one of those athlete that Dr.D mentioned, great fat loss with muscle added over it, on the real.
 
Yes sir, exactly correct. This may be a healthy adjunctive for the Non-IDD, but it would be tricky for IDDs.

Also, athletes are reporting great fat loss with this product and I'm not surprised. However, real diabetics and consumers that don't exercise regularly may not get the same 'dieting' benefits of this product. Lipolysis may be a challenge in such people, or it might not.

I have good news. I have been testing with two people who do not exercise and have not for many years. Both have gotten leaner with no change in diet nor any exercise.

I am NOT saying this is a diet pill and you do not need to exercise just reporting what I have observed.

They dose as follows. 1 -2 capsules with every meal and 1 at bedtime for a total of 4 per day. Quantity they say they just play it by ear and use 2 if they will be eating more and 1 if they are eating less.
 
I have good news. I have been testing with two people who do not exercise and have not for many years. Both have gotten leaner with no change in diet nor any exercise.

I am NOT saying this is a diet pill and you do not need to exercise just reporting what I have observed.

They dose as follows. 1 -2 capsules with every meal and 1 at bedtime for a total of 4 per day. Quantity they say they just play it by ear and use 2 if they will be eating more and 1 if they are eating less.

I plan on using this as a part of my recomp, and I was wondering how pertinent you think it would be to add the 1 prior to bedtime?
 
I do not think it is absolutely necessary.

But I do think it does help a good amount.
I really like it myself because falling to sleep is very quick for me and the deep sleep I get is great.
 
I have good news. I have been testing with two people who do not exercise and have not for many years. Both have gotten leaner with no change in diet nor any exercise. ...

I'm not surprised. It makes sense that improved carbohydrate metabolism and correction of insulin resistance would promote fat loss all by itself, and exercise could greatly exaggerate those results.
 
Dr. D, I'm sure this has been asked already, but I didn't read the whole thread, AADD. Can I add this to my current 3-AD cycle? I'm in at 1 1/2 weeks of a 6 weeks cycle.
 
Glycobol should increase the efficacy of a PH due to the shuttling of nutrients.

There will definitely be a synergy at play when using Glycobol with a PH :thumbsup:

I have to give it to D, he seems to have come through with a great Innovative product in that of Glycobol!!!
 
... Can I add this to my current 3-AD cycle? I'm in at 1 1/2 weeks of a 6 weeks cycle.

Hey Jim! I've never tried 3AD so I can't vouch for compatibility or synergy with G-bol, but just looking at the ingredients, I don't see why not.
 
Yeah, it really shined for me before bed. I never needed to dose more than one at time to have seen the great results I got, making it very cost effective.
 
as long as you're not dieting, additional cinnamon might potentiating the effectiveness of Glycobol.

Can you explain?
 
I'm not surprised. It makes sense that improved carbohydrate metabolism and correction of insulin resistance would promote fat loss all by itself, and exercise could greatly exaggerate those results.

How could somebody that doesn't lift weights maximize Glycobol usage in order to lose weight ?

IE, My wife doesn't lift weights, but does like to run, jog, and hit the elliptical. Can somebody like this use Glycobol too? If so, should they use it any differently than you or I use it?

Thanks in advance!!!
 
Can you explain?

Don't get me wrong. I'm trying to be fair and offer both sides of the coin, because cinnamon potentiates insulin, and insulin does inhibit lipolysis. That's why I made the statement. Since you asked though, I'll tell you how I personally feel. ;) I've read many, many studies that demonstrate strong lipolytic properties for cinnamon! And lots of other desirable properties too.

To begin with, cinnamon improves postprandial (after you eat) blood glucose response by reducing the rate of gastric emptying, so it has a fundamental, mechanical mechanism for it's beneficial effects on carbohydrate metabolism.

Cinnamon demonstrates the ability to reduce fasting glucose levels, total cholesterol, LDL cholesterol and systolic BP. In a 12wk study that used the same cinnamon species and extract concentration found in G-bol, it also increased lean muscle mass (+1.1%) and reduced total fat mass (-0.7%), so additional cinnamon could be helpful whether dieting or not.

Cinnamon also improves the anti-oxidant status of subjects with 'metabolic syndrome'. Everybody knows that a high fructose diet can promote this syndrome which is growing ever more common, even in kids (too damn many sodas, lol.) Well cinnamon is shown to prevent induction of metabolic syndrome in animals fed experimental high fructose diets!

Cinnamon has some wonderful polyphenols in it. The polyphenols found in cinnamon activate insulin receptors by increasing tyrosine phosphorylation activity and by decreasing phosphatase activity (which inactivate insulin receptors.) These polyphenols increase insulin receptors (the B isoform) and the GLUT-4 transporter too. They increases glycogen synthase and glycogen accumulation, while decreasing glycogen synthase kinase-3b.

These polyphenols also increase the anti-inflammatory protein tristetraprolin, the same weight loss mechanism as green tea! Tristetraprolin accumulation may be the best explanation for the improvement of metabolic syndrome and reversal of insulin resistance seen with cinnamon, by it's down-regulating effect on pro-inflammatory cytokines. This means it boosts the immune system too.

While I'm on that subject, I'll also point out that one of cinnamon's metabolites called Sodium Benzoate (also a fairly common preservative used in some foods) has been shown to reduce levels of the pro-inflammatory cytokines IL-1b and IL-6, which inhibits the clinical symptoms and severity of cytokine storms by preventing the infiltration of mononuclear cells and subsequent demyelination! Or in other words, this could be a great supp if you ever contracted a hardcore influenza strain like H5N1, the Chicken Flu. ;)

So nevermind, go ahead and take extra cinnamon if you like, lol. I recommend you stick to the good 20:1 high potency stuff with the high polyphenol content. It might or might not help to conserve G-bol dosing, but it probably won't hurt to stack it.
 
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