MYRICETIN CYCLODEXTRIN COMPLEX
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables, fruits, nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Myrecetin is an exceptionally potent flavonoid with a host of beneficial effects on health but for our purposes we are specifically concerned with its ability to help us lose bodyfat.
Myricetin is a POTENT GLP-1 agonist comparable in strength and effects to the prescriprion GLP-1 agonist Liraglutide (REF 1.) And showed more potent effects on insulin and fat loss than injected GLP-1.
QUOTE"the rats injected with myricetin exhibited better glucose tolerance in this single-dose injection experiment than those treated with GLP-1. The treatment with myricetin resulted in blood glucose levels that were main-tained at 7.5–8.5 mM over 8 h, and these results were similar to those after liraglutide administration. Additionally, myricetin seemed to exhibit a similar glucoregulatory duration(0–8 h), which suggests that myricetin might possess a half-life similar to that of liraglutide (11.3 h) "
It would appear that Myricetin is an exceptionally potent GLP-1 agonist, as effective as prescription drugs of this type and more potent than GLP-1 itself at managing insulin but there is more.
DPP-4
Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal (Peptide Bond) dipeptides from a variety of substrates, including cytokines, growth factors, neuropeptides, and the incretin hormones. Expression of DPP4 is substantially dysregulated in a variety of disease states including inflammation, cancer, obesity, and diabetes. Since the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), are major regulators of post-prandial insulin secretion, inhibition of DPP4 by the gliptin family of drugs has gained considerable interest for the therapy of type 2 diabetics. DPP-4 inhibitors prevent the N-terminal cleavage and the destruction of the Incretins GLP-1 and GIP. Myricetin is a potent DPP-4 inhibitor so on top of its ability to increase the secretion of GLP-1 it also prevents its destruction which is part of why Myricetin is shown to be more powerful than GLP-1 itself!
GIP
Glucose-dependent insulinotropic polypeptide (more commonly known earlier as gastric inhibitory polypeptide or gastric inhibitory peptide), abbreviated as GIP, is an inhibiting hormone of the secretin family of hormones. While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion. Recently the pharamaceutical industry has been working hard to improve on the already extremely effective GLP-1 agonist. In 2022 Eli Lily announced the next generation of these far burning drugs with Mountjaro. The first Combination GLP-1 and GIP agonist. This combination has been shown to decrease weight by significantly more than semaglutide and other GLP-1 agonists.
Weight reduction: 11.2 kg (24.7 lb., Mounjaro 15 mg), 6.9 kg (15.2 lb., injectable semaglutide 1 mg) and 0 kg (placebo), p<0.001
Fat mass reduction: 9.7 kg (21.4 lb., Mounjaro 15 mg) and 5.9 kg (13.0 lb., injectable semaglutide 1 mg), p=0.002
Keep in mind neither of these drugs have the added DDP-4 inhibitor so we have even more power in Incinderine.
ok so we have Massive potential as a GLP-1 and GIP inhibitor coupled with DPP-4 inhibition but thats just the beginning.
Myricetin also increases insulin sensitivity which further accentuates the weight loss potential of the previously discussed mechanisms as GLP-1 agonists. GIP agonists and DPP-4 inhibitors all help boost insulin.
Myricetin also activates
BAT (brown adipose tissue AKA brown fat) and Beige Fat by upregulating thermogenic protein expression and activating mitochondrial biogenesis, eventually increasing heat dissipation and calorie expenditure. This is exceptionally important for those of us looking to burn body fat. In order to demonstrate why we need a bit of education regarding the different types of fat.
There are different types of fat in your body. Each type is identified by its color and function, including:
White fat: This is the type of fat we want to get rid of.
Most of the fat in your body is white fat. White fat stores energy in various places around your body. White fat insulates your organs. Too much white fat leads to obesity.
Brown fat: This is the type we want.
Brown fat is smaller than white fat. It stores energy and burns that energy to regulate your body temperature. Brown fat helps you burn calories by creating heat right before your body starts to shiver (thermogenesis). It also helps regulate sugar (glucose) and fat metabolism.
Beige fat: This type is also beneficial because it is basically white fat preparing to convert to the brown fat.
Beige fat is a combination of white and brown fat cells. These cells burn calories to regulate body temperature by converting white fat cells to brown.
Converting our white fat to brown fat is massively important to getting super us shredded. Brown fat is not fat like we would think of it. Its an absolute lean physique shredding powerhouse that instead of storing the calories we eat it burns them off like a furnace. So we want as much of this as possible. Increasing the conversion rate of white fat to beige and brown causes the body utilize excess calories and burn them off vs storing them.
For the sake of brevity I will just quickly mention some additional benefits.
Myricetin is a relatively potent aromatase inhibitor and the reduction in estrogen will assist in reducing bodyfat and water retention. Myricetin is a PDE inhibitor, reduces LDL and my favorite, increases the release of endorphins which really helps push through when you are training to failure and dieting. It also has a host of antiaging and general health benefits.
Myricetin has one drawback....it has a roughly 10% oral bioavailability. Studies indicate that complexing myricetin with specific cylodextrins can increase oral bioavailability by 900%. So our Myricetin cyclo complex is 900% more potent than plain myricetin and Incinderine also employs Biox which increases bioavailability and reduces metabolism in vivo even further.
REF
1. Myricetin: a potent approach for the treatment of type2 diabetes as a natural class B GPCR agonist
2. Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice
Purpose Myricetin, a dietary flavonoid, is effective in the treatment of obesity and insulin resistance by increasing glucose transport and lipogenesis in adipocyte and diminishing systemic inflammation in obesity. However, it has not been revealed yet whether myricetin is associated with brown...
link.springer.com
3. Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein
Dipeptidyl peptidase-4 (DPP-4) is a proteolytic enzyme responsible for the rapid degradation of Glucagon-like peptide 1 (GLP-1) that is required for the secretion of insulin. DPP-4 also influences activation of node like receptor family, pyrin domain ...
www.ncbi.nlm.nih.gov
4. Myricetin attenuates hyperinsulinemia-induced insulin resistance in skeletal muscle cells
Previous studies have shown that hyperinsulinemia is not only a marker of insulin resistance, but also the causative factor of peripheral tissue insulin resistance. It also has been suggested that prolonged high-dose insulin treatment can mimic the effects of hyperinsulinemia and exacerbate...
link.springer.com
