1) What compound am I (common name will suffice)? Begamottin (6,7,- dihydroxybergamottin) (DHB)
2) What FINAFLEX product is it in? Finaflex 1-Andro
3) What is its purpose or use? Improve bio-availability and absorption of 1-andro
4) Where can this compound be found naturally occurring? Grapefruit
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).1↗ It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.2↗,1↗ However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
1 Edwards, D.J., Bellevue, F.H.I., Woster, P.M.. Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos 24(12) 1287-1290 (1996).
2 Bellevue, F.H.I., Woster, P.M., Edwards, D.J., et al. Synthesis and biological evalution of 6',7'-dihydroxybergamottin (6,7-DHB), a naturally occurring inhibitor of cytochrome P450 3A4. Bioorg Med Chem Lett 7(20) 2593-2598 (1997).