Virile Mane - Hair anyone?

[1HP]

Is this still gonna be available this week? I've got an order on hold whole week especially for this.. If it's gonna take a lot longer please let us know..

 

[1HP]

Is this still gonna be available this week? I've got an order on hold whole week especially for this.. If it's gonna take a lot longer please let us know..

lol fk, never mind, just noticed banish is now out of stock which was also included in my order that'll teach ya waiting for new products lol

 

[neoborn]

As per my original request long ago when you first mentioned this ....I would still love to beta test this for you...please.

 

[small_guy]

I am curious if this is out this week as well as I have an order that I want to place but more importantly I really WANT to try this product!!!

 

[1HP]

I am curious if this is out this week as well as I have an order that I want to place but more importantly I really WANT to try this product!!!

Yeah really

 

[Urban Monk]

As per my original request long ago when you first mentioned this ....I would still love to beta test this for you...please.

I think he'll have some beta's up for sale next week. Your experiences will be invaluable!

 

[dsade]

Nutra is going to run a presale for a few days...$30 special...while I package and ship everything. The beta run is quite small, while the production run will be large.

 

[Flyboy]

awesome price dsade... when will the presale be available on nutra? I've got cash waiting for both me and a friend! Think this might be the quickest selling product for RPN yet!

 

[dsade]

I sent them all the info, so I would say Monday it should be up..and they should have stock by Friday.

 

[evankyle]

DSADE when VM and JL are both availabe can you see if Nutra can do a package deal on all of the above including the Gut Health (all of the products are your with the exception of the Toco but I think PP would be cool with it)??? I would give it a shot for at least 3months on the whole stack to see if it can help. I have the type of thinning/shedding that is sounds like you have.....basically solid on the top but receeding hairline and overall kind of thin hair.

Mr.50

I am also interested in this package but I would prefer it without the Gut Health. I would prefer it with NOxidant.

 

[dsade]

I am also interested in this package but I would prefer it without the Gut Health. I would prefer it with NOxidant.

we will likely do a stack of NOxidant, Toco-8, Virile MAne, and Java Lustre.

Keep your eyes peeled for another Gut Health deal...to celebrate nutra's anniversary.

 

[evankyle]

we will likely do a stack of NOxidant, Toco-8, Virile MAne, and Java Lustre.

Keep your eyes peeled for another Gut Health deal...to celebrate nutra's anniversary.

when do you expect this stack to be available for sale

 

[dsade]

when do you expect this stack to be available for sale

I'm waiting to hear back from the PP guys on the Toco component.

 

[Flyboy]

write up coming dsade?

 

[CTDeuce]

as of 6am monday....none uploaded to Nutra yet

 

[Flyboy]

as of 6am monday....none uploaded to Nutra yet

sheesh... slackers. lol.

 

[dsade]

Writeup just getting some last FAQ polishing. SHould either be up today or tomorrow.

I'l try to, at minimum, get the short writeup posted.

 

[poison]

Git er up!!!! :banana:

 

[WebDesigner]

Finally, ill be happy with just the main product and the shampoo but ill consider the stack. Ill check back in a few hours.

 

[dsade]

Git er up!!!! :banana:

I'll have to trade you out formore of that awesome coffee of yours.

 

[poison]

Mmm, coffee.

Enticing?

 

[strategicmove]

Writeup just getting some last FAQ polishing. SHould either be up today or tomorrow.

I'l try to, at minimum, get the short writeup posted.

On the watch out for the ingredients!

 

[1HP]

On the watch out for the ingredients!

Yeah baby yeah

 

[poison]

WTF is going on in here?

 

[dsade]

WTF is going on in here?

Overload.

Still waiting on ONE ingredient for the carrier, which should have been here Yesterday.

Nothing showed up today, though tracking shows it was due yesterday as well.

Let me call and find out why.

 

[dsade]

RPN Presents: Virile Mane Hair Growth Stimulator

Before you even get a chance to introduce yourself, you have already been sized up. Though clothes can obscure or accentuate physique, nothing short of a hat or wig can hide a pathetic head of hair. Like it or not, a thick head of hair presents a strong, potent image of manhood.

Age, inflammation, hormonal milieu (both endogenous and exogenous), and other factors of modern life take a toll on a head of hair, leading to thin or even completely bald patches. Short of surgery, treatments previously available have been disappointing and even dangerous. Systemic DHT blockers take a massive toll on muscle growth and hardness, as well as sex drive. Previous topicals have been extremely limited in their effectiveness.

RPN, a company that has come to represent innovation of the highest degree, offers a solution - Virile Mane.

Formulated with scientifically supported ingredients, Virile Mane combines angles to flip a trigger switch that turns on the Anagen Follicle Growth phase, reduces inflammation, increases blood and nutrient flow to the scalp and follicles, and forces the follicle into overdrive. The results? Growth, baby...growth.

Presented in an extremely economical 6 ounce size (designed to last around 6 weeks) for an unbelievable price, Virile Mane finally delivers where other promises were....barren.

Brief scientific Intro:

The hair growth cycle consists of three distinct phases: Telogen, catagen, and Anagen. Active growth cycle is called Anagen, where the follicle – firmly rooted in the dermal layer – engages in active cell division that results in the formation and growth of the hair shaft. As long as this phase is active and unhindered, hair quality is thick and hearty. However, nature works in cycles and what goes up must come down. Anagen phase is followed by catagen phase (think catabolic as opposed to anabolic), and it is exactly what you think it is. The bulbous root drifts upwards and shrinks, losing the sheath that holds it tight. The final insult comes in the form of the telogen phase, where the once strong and proud hair is shed (exogen) , and the follicle goes dormant. Normally, this dormancy signals the scalp to recruit stem cells into development into a NEW follicle which eventually enters anagen phase and the whole happy process continues unabated.

This process is normally overlapping and continuously cycling, giving the perception of a constant unchanging hairline and thick crown…however sometimes things go horribly wrong.

The body, complicated as it is, sometimes gets things “wrong”. Sometimes this is caused by imbalance, dietary/nutrient limitation, haywire immune response, inflammation, excessive hormone activity/sensitivity…or it could be a conspiracy by RPN to sell you product. Yes, we are THAT powerful…fear us.

Humans, lacking sufficient instinct to perfectly guide our behaviours, fortunately possess intellect, reason, and an aesthetic ideal that, when combined, can allow us to short circuit undesired natural (and unnatural) consequences. While some don’t mind losing their hair, I have yet to meet someone that DESIRES a head that resembles a worn out sheepskin seat cover. And so we set to searching for the panacea.

While some of the treatments have been mildly effective, the “magic bullet” theory of treatment fails over and over again. In the end what we, in the supplement industry, have figured out is that subtle manipulations of systems and feedbacks can result in far more dramatic results than single approach treatments…which leads us to what you are all interested in seeing – the ingredient profile.

Virile Mane:

The goal when developing this product was to include ingredients that work effectively and synergistically, that have been tested on humans, and to include complementary supplement, nutrition, and lifestyle recommendations to maximize the prevention of hair loss and improve hair growth. Thus, the full writeup will include more thorough background information on the hair cycle, current options for stopping hair loss, and detailed mechanisms of how our product integrates with current research and exploits new and novel hair treatments. A topical delivery system was chosen in able to include effective ingredients that may negatively effect systemic milieu, but are effacious and safe in a local setting.

You may be wondering why our formula has so few ingredients compared to some other products. The reason is three fold: first, there is limited research on topical ingredients for hair growth in humans. Second, there are many regulators in the hair cycle and many remain relatively unexplored. And, because of this, there may be unknown interactions with ingredients that work in similar ways (more is not always better), or work in different ways attacking hair loss on multiple fronts, yet produce unexpected results. There are some examples of these in this writeup. Because of these unknowns, the ingredients we selected have solid research backing and are unlikely to negatively interact.

Despite a multi-billion dollar hair market, only two FDA approved products exist for hair loss: finasteride, and minoxidil. Surprisingly, even these are often not effective and not all of their molecular workings have been elucidated. Both will be explored further in this full writeup. In contrast, there sits human research on other substances that are rarely utilized in the hair market, that offer a similar or greater stimulation of hair growth for less expense.
To understand the causes of hair loss, one must first understand the mechanics of the complete hair cycle. Like most processes in the body, hair follicles follow a cycle of growth and regression. It should be noted, that many of the regulatory factors in the hair cycle are still unknown, and even finasteride and minoxidil were accidental
discoveries. However, recent insights into important molecular players allow us to
intervene in novel ways. Fortunately, many of these discoveries are natural
interventions, thus a over the counter formula like ours can rival or outperform current prescription options.

Ingredients:

Raspberry Ketone
The central and novel ingredient in the formula, Raspberry Ketone, works through the transient receptor potential vanilloid 1 (TRPV1). TRPV1 functions as an integrator of endogenous and exogenous nociceptive stimuli. The painful response from the
consumption of hot peppers, for example, is the result of TRPV1 activation. However,
TRPV1 exists nearly ubiquitously in the body, including skin tissue. The most researched ligand of this receptor is capsaicin, however many endogenous activators and sensitizers exist, such as heat, acidosis, derivatives of arachidonic acid, lipid peroxidation metabolites, and endocannabinoids. It is quite clear from these alone how nutrition and lifestyle can factor into this equation, and this will be further discussed later in the article. With the existance of TRPV1 in the epidermis, hair follicle, sebaceous gland, and some dermal cell populations, the next logical step was to find what it does in these areas.

The full writeup will detail mechanism and cite studies, but the gist of it is that Raspberry Ketones, applied topically in a VERY specific concentration (more is absolutely NOT better…but neither is too little) are able to activate TRPV1, induce CGRP without depleting it, and causing a rapid and pronounced increase in localized Insulinlike Growth Factor-1 (IGF-1) synthesis. In addition, RKs show a pronounced down-regulation of androgen receptors, as well as possibly increasing localized NO (resulting in enhanced blood flow and nutrient delivery). The effect is a pronounced and sustainable stimulation of hair growth.

Apple Polyphenols
The next ingredient(s) that have demonstrated exceptional results in research so far are certain polyphenols, specifically procyanidin oligomers are what are of most interest, which are commonly found in plants such as apples, grape seeds, and barley. They were chosen for this and for their unique mechanism and because there are an number of studies on them.
In 1998 and 1999, Takahashi et al. performed studies on over 1000 plant extracts for hair growth. They found that proanthocyanidins, constituents in grape seeds, induced anagen. The procyanidin oligomers (e.g. B-2) demonstrated better growth promotion than polymers and monomers. Also in 1999, they purified procyanidin B-2 from apples and performed a number of toxicological tests on animals. The tests suggested that irritation and toxicity in a topical test were not an issue even with a high dose.

Procyanidin B-2 was about 220% more effective than procyanidin C-1 at promoting
growth in epithelial cells in vitro, and about equally effective as Procyanidin B-1 and Procyanidin B-3 – which themselves were more effective than Minoxidil. In addition, stimulation of cAMP (and inhibition of PKC – a potent INDUCER of inflammation) are effective at stimulating Anagen phase. Forskolin is a possible future addition to the formula, but at present design dosage is unknown, and using too much would be more harmful than not using it at all.

RPN uses a potent 80% Apple polyphenol extract, standardized to contain a majority of Procyanidin b-2.

L-carnitine-L-tartrate
Last year, a study using carnitine (L-carnitine-L-tartrate) by Foitzik et al. in cultured hair follicles resulted in the downregulation of TGF-beta II, caspase 3 (creatine also does this) and 7 (which initiate apoptosis), and upregulated proliferation of keratinocytes. The theory is that it, like creatine, increases the energy supply to follicles in anagen. Carnitine is also important for mitochondrial health. A dose of approximately 3-4 grams of mixed carnitine salts is recommended for oral administration, however with in vivo evidence in humans supporting the addition in a topical formula, we included it in ours to hit hair growth from every angle.

Rooibos Tea Extract (35% polyphenols)
The next ingredient is commonly drunk as a tea, but its constituents have led to its use for promoting hair growth. One esoteric, unpublished study on humans exists but the mechanisms are also convincing. First, recall the previous antioxidative effects of the procyanidin oligomers and the effects of TGF-beta. Some rooibos tea constituents have similar activity to super oxide dismutase (SOD), one of the body's natural antioxidant enzymes. An independent lab (Dermascan, in France) performed a study for Cosmetochem International using a rooibos preparation. The trial was on 10 women for 90 days and used 5ml of a 10% rooibos lotion versus a placebo. There was a increase in hair growth speed in 89% of subjects. Questionnaire results showed that most subjects saw an improvement: 67% stated hair loss as zero or low, and 78% indicated that they had an improvement of hair growth. While SOD and its mineral components/peptides are patented for hair growth, Rooibos tea is not.

Emu Oil
The last ingredient doubles as an emulsifying agent to thicken the preparation and has evidence for hair growth promotion. Emu oil, also trademarked Kalaya oil, was studied in 1996 by Michael Holick and colleagues at Boston University Medical Center. The mouse model C57 BL/6 was applied with .1 ml of Emu oil for 14 days. The results of this pilot study suggested that there was follicle proliferation to anagen state from telogen.

Virile Mane is the result of 4 years of design work, and an immense amount of thorough research and design by myself and Colby Vorland. Combined with Java Lustre Hair Support Shampoo, and stacked with oral supplements such as Toco-8 by Primordial Performance (a rich source of both mixed tocopherols, as well as the rarer and potent Tocotrienols) and NOxidant by RPN (systemic anti-oxidant formula), Virile Mane promises not only to protect the precious hair you have, but to bring back your long lost friends.

In this age of hormonal manipulation, shoddy poisoning convenience diets, environmental toxins, and constant stress barrages, we need every weapon in our arsenal to reach our aesthetic ideals.

Virile Mane is available in a 6 ounce dispenser tipped bottle, which should last the average user around 6 weeks.

Active ingredients:

Raspberry Ketones
Apple Polyphenol Complex (standardized for 80% BioActive Procyanidins)
L-Carnitine-L-Tartarate
Rooibos Tea
Emu Oil
Menthol

 

[Urban Monk]

1. Which ingredient in here acts has the same MOA as Minoxidil?

2. Are any of these consider topical DHT blockers?

3. Is the carrier for the ingredients included in this write up?

4. Would it be MORE effective combined w/ anything else (minoxidil, spirolactone, fluridil, etc), or better by itself?

 

[dsade]

1. Which ingredient in here acts has the same MOA as Minoxidil?

Both the RKs and Procyanidins cause shifting back towards anagen phase. Minoxidil weakly inhibits catagen induction and slightly prolongs catagen indirectly.

2. Are any of these consider topical DHT blockers?

We considered using an antiandrogen (which the research just couldn't justify at the moment) and Saw Palmetto (again, topically the evidence is shaky), but decided against it. The apparent paradoxical effect of the LCLT in scalp tissue (as opposed to the rest of the body, where evidence is pointing to both increase in density AND sensitivity of ARs) reduces the effects of androgens.

3. Is the carrier for the ingredients included in this write up?

No. The carrier right now is proprietary, as this is also sort of a key to the effective transport of the ingredients just to, but not beyond, the follicle.

4. Would it be MORE effective combined w/ anything else (minoxidil, spirolactone, fluridil, etc), or better by itself?

Spironolactone, perhaps...I would not use other treatments for the reasons stated in the writeup (either limited effectiveness or systemic side effects.)

 

[max silver]

Is virile mane likely to be effective for hair regrowth on it's own, or is the stack you suggest in the writeup going to be necessary? I am all for regaining some lost hair, but not if it's going to cost me in the neighborhood of 100 dollars a month, I don't like my hair that much.

 

[dsade]

Is virile mane likely to be effective for hair regrowth on it's own, or is the stack you suggest in the writeup going to be necessary? I am all for regaining some lost hair, but not if it's going to cost me in the neighborhood of 100 dollars a month, I don't like my hair that much.

It will be effective on it's own...the rest of the products are just ideal.

In order of effectiveness (most to least), I would recommend:

VM
NOxidant closely followed by
Toco-8
Java Lustre

 

[dsade]

Go ahead and post any questions. It's gym time (tonight is the long workout) but I will be back later.

 

[pmiller383]

This is a localized formula correct?
So if I have the george costanza look going on I can just apply to the top of my head to get the desired results?

 

[Urban Monk]

So minoxidil would just be repetitive? Or would it "deepen" the effect, like say starting w/ rogaine foam, and then putting VM on.

 

[poison]

Killer!!!! I LIKE the profile!


Smell? You show menthol, is it a strong smell?

Is it a twice a day application?

 

[johnny gunz]

what website do i order it from?

 

[Mr.50]

DSADE,

We have talked about this before but I want to be clear....will this be very effective for those of us with a receeding hairline and generalized thin hair strands without much balding on the top of the head? I was always looking at trying Rogaine but supposedly it only works for balding on the top of the head?

Also does VM need to be combined with the shampoo you were also planning on coming out with? Is it out yet and what is the name?

Thanks.

Mr.50

 

[TMack40]

Perhaps the full write it up will shine some light on the question, but could you please elaborate just a bit on why too high of a concentration of RKs could be negative?

 

[Flyboy]

what form of menthol (hopefully not synthetic)? I assume you are aware peppermint oil has actually been shown to be anti-androgenic also? I believe through interference with the androgen receptor (on which note tea tree oil would also be a nice potential addition?). I only ask because you mention in response to one of the questions that you don't have any topical anti androgens.

What is to stop the rooibos from oxidising (as anti-oxidants love to do) while in solution? I have seen a lot of promise from research on the use of topical ECGC (green tea extract specifically i believe) yet the problem is the solution doesn't stay viable for long.

The RK's, AP's, emu oil and LC LT are awesome to have in one product, the rest is icing on the cake for me. Thanks for the quick write up and I'll definately be among the first in line to give this stuff a go.


Just a side note adding my opinions - anyone on minox that drops it for this might be in for a rough ride for a couple of months. Minox dependant hairs will shed when you stop and even this stuff is unlikely to be able to stop that (the only thing in there that could theoretically is the RK's but i've yet to see evidence of anything that actually will)... they may well grow back just as thick with the help of virile mane but it would unlikely be quick enough to counter the shedding. It might be wise to figure out some sort of phasing in/out process.

 

[dsade]

what form of menthol (hopefully not synthetic)? I assume you are aware peppermint oil has actually been shown to be anti-androgenic also? I believe through interference with the androgen receptor (on which note tea tree oil would also be a nice potential addition?). I only ask because you mention in response to one of the questions that you don't have any topical anti androgens.

Menthol (yes, we are using peppermint oil) triggers CGRP release from different types of nerve fibers via activation of a slightly different receptor type as well as shifting the action potential to trigger release at lower noxious stimulus (lower concentration required), though there is slight overlap. This will allow higher levels of IGF-1 over a longer period of time with less risk of depleting CGRP, thus causing a rapid DROP in IGF-1. We are shooting for a steady rise and elevated levels maintained over a greater period of time. The other properties are just a bonus, but were not used for that purpose. Tea Tree can go systemic too easily and is MUCH too potent in its anti-androgenic/estrogenic effects. Menthol is also a potent penetration enhancer through the stratum corneum.

What is to stop the rooibos from oxidising (as anti-oxidants love to do) while in solution? I have seen a lot of promise from research on the use of topical ECGC (green tea extract specifically i believe) yet the problem is the solution doesn't stay viable for long.

This was actually very tricky. The key here was to limit water content of the carrier as much as possible. The first alternative was a high alcohol content carrier, but there was some serious side effects (mass irritatione, skin dryness, dermatitis, risk to eyes). Most of the development time in this product has been fine tuning a carrier that will limit oxidation of the polyphenols, optimize penetration without going too systemic, conditioning scalp and keeping it soft, and being able to transport to active compounds in.

The RK's, AP's, emu oil and LC LT are awesome to have in one product, the rest is icing on the cake for me. Thanks for the quick write up and I'll definately be among the first in line to give this stuff a go.

Sorry I didn't have a chance to get back to you about your PM..you were right on target pretty much.

Just a side note adding my opinions - anyone on minox that drops it for this might be in for a rough ride for a couple of months. Minox dependant hairs will shed when you stop and even this stuff is unlikely to be able to stop that (the only thing in there that could theoretically is the RK's but i've yet to see evidence of anything that actually will)... they may well grow back just as thick with the help of virile mane but it would unlikely be quick enough to counter the shedding. It might be wise to figure out some sort of phasing in/out process.

 

[dsade]

Perhaps the full write it up will shine some light on the question, but could you please elaborate just a bit on why too high of a concentration of RKs could be negative?

CGRP is a finite peptide that can easily be depleted before it can be resynthesized. Steady release of CGRP equates to a steady rise in IGF-1 levels. Too much release would cause CGRP to be depleted, and IGF-1 levels to collapse.

 

[dsade]

DSADE,

We have talked about this before but I want to be clear....will this be very effective for those of us with a receeding hairline and generalized thin hair strands without much balding on the top of the head? I was always looking at trying Rogaine but supposedly it only works for balding on the top of the head?

Also does VM need to be combined with the shampoo you were also planning on coming out with? Is it out yet and what is the name?

Thanks.

Mr.50

As the full writeup (complete with quite dramatic pictures from the studies cited) show, growth is on the FULL landscape of the head, not just the crown area.

VM doesn't NEED to be combined with the shampoo, but we were asked to develop a full range regimen to optimize the different approaches. I snuck something into the shampoo that is kind of cool, and we are waiting on feedback for that. It has to do with melanin deposition in the newly formed hairs, thus giving the appearance of thicker hair faster.

 

[dsade]

what website do i order it from?

Nutraplanet should be holding a presale this week, with product availability looking like NEXT week.

 

[Mr.50]

As the full writeup (complete with quite dramatic pictures from the studies cited) show, growth is on the FULL landscape of the head, not just the crown area.

VM doesn't NEED to be combined with the shampoo, but we were asked to develop a full range regimen to optimize the different approaches. I snuck something into the shampoo that is kind of cool, and we are waiting on feedback for that. It has to do with melanin deposition in the newly formed hairs, thus giving the appearance of thicker hair faster.

Much appreciate for the response. Sorry I missed the bit in the write up about "the whole head not just the crowne".

Approximately when might the shampoo be available too?

Thanks.

Mr.50

 

[dsade]

Much appreciate for the response. Sorry I missed the bit in the write up about "the whole head not just the crowne".

Approximately when might the shampoo be available too?

Thanks.

Mr.50

Awaiting the final supplies ( a thickener) for this one, as well as the lids (for some reason they sent the bottles and lids separately.)

 

[Flyboy]

Top stuff dsade - cheers for the response.

Eager to give this a go, I'll throw in some of the shampoo for fun too.

 

[Urban Monk]

Bump to this Q. Also, would you apply VM first, and then spiro, additionals, or after?

So minoxidil would just be repetitive? Or would it "deepen" the effect, like say starting w/ rogaine foam, and then putting VM on.

 

[poison]

Awesome stuff, dsade!! I can't wait!

 

[small_guy]

great! I am not going to pretend that I understand all that it is said but more that I trust dsade and his products.

 

[EIC]

Very nice, Dsade. You have definitely piqued my interest. Any chance we can get a look at the inactive ingredients (I am mainly curious about parabens)?

Also, it seems like this product, specifically with the Raspberry Ketones and menthol, has the potential to interfere with the androgen receptor in the scalp. Does this mean that VM might help stave off hairloss while on a cycle of non-DHT androgens (e.g., 1-androsterone)?

Lastly, is it possible to get some signal in this thread that the pre-sale is underway on Nutra? I definitely want to be in the first go around of VM.

 

[1HP]

Hey dsade, any estimate when it'll be available to buy at NP? If it'll take another week I'm gonna order it seperately lol, need my other goodies