I believe Matt was going to be giving the finalized product a shot, tonight (if I'm not mistaken).
Good night, sweet prince.
Good night, sweet prince.
Giggity giggity.I believe Matt was going to be giving the finalized product a shot, tonight (if I'm not mistaken).
Good night, sweet prince.
What's the verdict Beast?! Update?I believe Matt was going to be giving the finalized product a shot, tonight (if I'm not mistaken).
Good night, sweet prince.
Haven't heard from Matt -- I assume he's pulling a Rip Van Winkle lol.What's the verdict Beast?! Update?
- Valdez
Dosage experiment was a success. Everything adjusted perfectly.Haven't heard from Matt -- I assume he's pulling a Rip Van Winkle lol.
That's great to hear! Moving along nicely!Dosage experiment was a success. Everything adjusted perfectly.
Our sleeping beauty is awake! Prince Tony must have given him a big smooch! :kiss:Dosage experiment was a success. Everything adjusted perfectly.
Are we getting closer?Dosage experiment was a success. Everything adjusted perfectly.
I can't recall the exact time line of this in relation to the other product releases off the top of my head, but it is in fact much closer than when we'd been discussing it in this thread, last.Are we getting closer?
Loving the sound of this.I can't recall the exact time line of this in relation to the other product releases off the top of my head, but it is in fact much closer than when we'd been discussing it in this thread, last.
Good things to come, here.
It's like a stack of a lullabye and spooning.Matt, is Sleephoria equivalent to one of your lullabies? Your lullabies always knock me out.
Hey dewster!! You better keep your eyes peeled. We have some unique products in the works.I'm a little late, but definitely looking forward to seeing the whole formula!
First ingredient reveal:
J Ethnopharmacol. 2005 Jan 15;96(3):365-70.
Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze.
Emamghoreishi M, Khasaki M, Aazam MF.
Source
Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. [email protected]
Abstract
The clinical applications of benzodiazepines as anxiolytics are limited by their unwanted side effects. Therefore, the development of new pharmacological agents is well justified. Among medicinal plants, Coriandrum sativum L. has been recommended for relief of anxiety and insomnia in Iranian folk medicine. Nevertheless, no pharmacological studies have thus far evaluated its effects on central nervous system. Therefore, the aim of this study was to examine if the aqueous extract of Coriandrum sativum seed has anxiolytic effect in mice. Additionally, its effect on spontaneous activity and neuromuscular coordination were evaluated. The anxiolytic effect of aqueous extract (10, 25, 50, 100 mg/kg, i.p.) was examined in male albino mice using elevated plus-maze as an animal model of anxiety. The effects of the extract on spontaneous activity and neuromuscular coordination were assessed using Animex Activity Meter and rotarod, respectively. In the elevated plus-maze, aqueous extract at 100 mg/kg showed an anxiolytic effect by increasing the time spent on open arms and the percentage of open arm entries, compared to control group. Aqueous extract at 50, 100 and 500 mg/kg significantly reduced spontaneous activity and neuromuscular coordination, compared to control group. These results suggest that the aqueous extract of Coriandrum sativum seed has anxiolytic effect and may have potential sedative and muscle relaxant effects.
PMID:
15619553
[PubMed - indexed for MEDLINE]
Double the GABA A double the fun lol! What's oral bioavailability like with these. I saw the one was administered intra peritoneal. Do these readily cross the BBB?Love me some GABA-A activation.
Sleephoria will have a full 25mg of 80% magnolol Magnolia extract. This ingredient is incredibly finicky (as the whole formula is). I'm making this formula 2 caps (even though it would fit into 1) so that you can adjust your dosage to 1, 2, or 3 caps.
Neuropharmacology. 2012 Nov;63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. Epub 2012 Jul 4.
Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM.
Source
Department of Pharmacology, Fudan University, Shanghai, 200032, PR China.
Abstract
Magnolol (6,6',7,12-tetramethoxy-2,2'-dimethyl-1-beta-berbaman, C(18)H(18)O(2)), an active ingredient of the bark of Magnolia officinalis, has been reported to exert potent anti-epileptic effects via the GABA(A) receptor. The receptor also mediates sleep in humans and animals. The aim of this study was to determine whether magnolol could modulate sleep behaviors by recording EEG and electromyogram in mice. The results showed that magnolol administered i.p. at a dose of 5 or 25 mg/kg could significantly shorten the sleep latency, increase the amount of non-rapid eye movement (non-REM, NREM) and rapid eye movement (REM) sleep for 3 h after administration with an increase in the number of NREM and REM sleep episodes. Magnolol at doses of 5 and 25 mg/kg increased the number of bouts of wakefulness but decreased their duration. On the other hand, magnolol increased the number of state transitions from wakefulness to NREM sleep and subsequently from NREM sleep to wakefulness. Immunohistochemical study showed that magnolol increased c-Fos expression in the neurons of ventrolateral preoptic area, a sleep center in the anterior hypothalamus, and decreased c-Fos expression in the arousal tuberomammillary nucleus, which was located in the caudolateral hypothalamus. The sleep-promoting effects and changes in c-Fos induced by magnolol were reversed by flumazenil, an antagonist at the benzodiazepine site of the GABA(A) receptor. These results indicate that magnolol increased NREM and REM sleep via the GABA(A) receptor.
Copyright © 2012 Elsevier Ltd. All rights reserved.
PMID:
22771461
[PubMed - indexed for MEDLINE]
That sounds rough bro lol.Double the GABA A double the fun lol! What's oral bioavailability like with these. I saw the one was administered intra peritoneal. Do these readily cross the BBB?
I'm excited for this man been waiting for a long time to see it reach the light of day.
P.S.that Ambien Walrus is no joke. One night after taking it I apparently went down checked the mail (approximately 50ft away from the swimming pool), came back up hid my chicks car keys, and ate two pounds of salami falling asleep while snuggling the packaging LMAO
Double the GABA A double the fun lol! What's oral bioavailability like with these. I saw the one was administered intra peritoneal. Do these readily cross the BBB?
I'm excited for this man been waiting for a long time to see it reach the light of day.
P.S.that Ambien Walrus is no joke. One night after taking it I apparently went down checked the mail (approximately 50ft away from the swimming pool), came back up hid my chicks car keys, and ate two pounds of salami falling asleep while snuggling the packaging LMAO
I bet you have some stories my man[/B]
Having a 60s flashback here. Lol
Lol...which decadeI bet you have some stories my man
I laughed pretty hard at this, man; particularly snuggling with the wrapper lol.Double the GABA A double the fun lol! What's oral bioavailability like with these. I saw the one was administered intra peritoneal. Do these readily cross the BBB?
I'm excited for this man been waiting for a long time to see it reach the light of day.
P.S.that Ambien Walrus is no joke. One night after taking it I apparently went down checked the mail (approximately 50ft away from the swimming pool), came back up hid my chicks car keys, and ate two pounds of salami falling asleep while snuggling the packaging LMAO
I was guessing we'd see lemon balm. I remember you talking about it way back.Neurochem Res. 2011 Feb;36(2):250-7. doi: 10.1007/s11064-010-0312-2. Epub 2010 Nov 13.
Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus.
Yoo DY, Choi JH, Kim W, Yoo KY, Lee CH, Yoon YS, Won MH, Hwang IK.
Source
Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Abstract
Lemon balm, leaves of Melissa officinalis L., has been used for anti-anxiety and spasmolytics. We observed the extract of Melissa officinalis L. (MOE) on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG) of middle-aged mice (12 months of age) using Ki67 and doublecortin (DCX), respectively. We also observed changes in corticosterone, GAD67 and GABA-transaminase (GABA-T) to check their possible mechanisms related to neurogenesis. We administered 50 or 200 mg/kg MOE to the animals once a day for 3 weeks. For labeling of newly generated cells, we also administered 5-bromodeoxyuridine (BrdU) twice a day for 3 days from the day of the first MOE treatment. Administration of 50 or 200 mg/kg MOE dose-dependently increased Ki67 positive nuclei to 244.1 and 763.9% of the vehicle-treated group, respectively. In addition, 50 or 200 mg/kg MOE significantly increased DCX positive neuroblasts with well-developed (tertiary) dendrites. Furthermore, MOE administration significantly increased BrdU/calbindin D-28 k double labeled cells (integrated neurons into granule cells in the DG) to 245.2% of the vehicle-treated group. On the other hand, administration of MOE reduced corticosterone levels in serum and decreased GABA-T levels in the DG homogenates. These results suggest that MOE increases cell proliferation, neuroblast differentiation and integration into granule cells by decreasing serum corticosterone levels as well as by increasing GABA levels in the mouse DG.
PMID:
21076869
[PubMed - indexed for MEDLINE]
I can't wait to have this one in the arsenal. It will be a great fit with my lifestyle for the next year or so.Just keeps getting better.
Same here. I've had my eye on this one myself for a while now.I can't wait to have this one in the arsenal. It will be a great fit with my lifestyle for the next year or so.
Sleephoria is going to keep them closed!Same here. I've had my eye on this one myself for a while now.
We are waiting for one more compound to arrive. Ahhhhhh!How close are we?
How's that compound coming? Any news? I'm ready to sleep.We are waiting for one more compound to arrive. Ahhhhhh!
This is the compound that got lost in transit. Replacement material is finally on the way...How's that compound coming? Any news? I'm ready to sleep.
You had me at hello.Sleephoria is that feeling of euphoria you get when you wake up from an incredible night of sleep. Sleep, as we well know, is essential to ideal performance, recovery, growth, and optimal performance. The Sleephoria formula has been painstakingly tested and researched to provide a flawless night of sleep, allowing the body and mind to restore itself, without any residual hangover or difficulty waking up the next morning.
Sleephoria...Arise and Conquer.
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