Delta-Sleep-Inducing-Peptide
DSIP (Delta Sleep-inducing Peptide) is a neuropeptide found in the hypothalamus,
pituitary, and adrenal glands. Its isolation has allowed for extensive research
which has found several possible primary and peripheral roles of this peptide.
First, DSIP has been shown to induce sleep [1]. Second, it has been used
successfully to treat opiate and alcohol withdrawal [2]. Third, it has been
shown to work as an analgesic in treatment of chronic pain, sometimes as an
adjunct treatment [3]. Fourth, DSIP has been shown to block ACTH release and
decrease levels of ACTH, stimulate LH release, and act as an inhibitor of the
secretion of somatostatin [4]. The source of production of DSIP is yet unknown;
it may be produced in the central nervous system or in a peripheral organ. It is
thought to pass through the blood-brain barrier (BBB) more easily than most
known neuropeptides. As mentioned, DSIP has shown positive results in inducing
slow-wave EEG (sleep). It has been shown to help treat narcolepsy and restore
disturbed sleep patterns to normal sleep rhythms. [5]
DSIP Amino Acid
Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu