It Is Here- AN's Write-Up for 2009's Biggest Product!!!!!!

[Enigma76]

RMS can you go into further detail about the biochemical processes around this molecule?

The writeup is confusing to me. I understand that this compound is an oxime derivative of DHT. From the writeup, however, it suggests that this compound converts into DHT but, due to the oxime addition, is not metabolized by 3a-HSD. It is continually compared to DHT regarding effects, binding properties and elimination.

To finally clarify and clear up these PH/designer steroid questions. When someone takes "The One", does it undergo any enzymatic changes in the body prior to activation? If yes, via what enzyme? Or is it metabolically active in its current form, and simply needs to survive the first-pass hepatic metabolism to bind and activate AR gene transcription?

I know it was postulated that 1-AD had intrinsic effects (binding to the AR prior to conversion to 1-T) as well as enzymatic conversion to 1-T which has its own binding properties. So it is possible for a compound to have both its own intrinsic activity and activity through its metabolites.



To those confused about this, and any other, product being a PH/PS/DS. If the molecule requires conversion prior to being active, it should be termed a prohormone or prosteroid (interchangable for all intents and purposes in this setting, though not all hormones are steroids). The pro- prefix denotes that it is a precursor to something else active. If it does not require conversion, it should be termed a "designer steroid" or some derivation thereof.

 

[ShakesAllDay]

The ONE is a PH. It is an analog/derivative of DHT.

So, it does convert to an active compound?

Pro-hormone = conversion to target hormone necessary for activity

(Designer) Steroid = active with no conversion to anything

Just stating that to be clear on my interpretation of the terms PH and DS.



edit: Enigma hit the nail on the head. A lot of cross-talk or miscommunication, it seems. If it is active on its own, let's please call a duck a duck.

 

[OzzY SluGGa]

Let me put it this way: If you have never used anything hormonal before and purchase a product and then start using it with no idea of what you're really doing (which MANY people do), or having researched and planned your cycle, then it would NOT be safe. However, if you have never used anything hormonal before, but research anything you are interested in thoroughly and make yourself aware of everything, and cover ALL your bases on AND off cycle to make sure that you are as safe as possible, and then purchase a product and use it, then you SHOULD be relatively safe in using it (the term relatively because you never know how you will react to something that you've never used before, etc.).

Now THAT is concise and perfectly understandable to me. Thank you. Damn this girls good:thumbsup:

 

[donorrell]

So, it does convert to an active compound?

Pro-hormone = conversion to target hormone necessary for activity

(Designer) Steroid = active with no conversion to anything

Just stating that to be clear on my interpretation of the terms PH and DS.



edit: Enigma hit the nail on the head. A lot of cross-talk or miscommunication, it seems. If it is active on its own, let's please call a duck a duck.

It's a Pro-hormone, but converts to a unique target hormone. I'll have to have RMS answer this one if more details are needed...

 

[rms80]

I had the same thoughts regarding a formal recommendation of a SERM for PCT, however you see countless posts from reps of companies with hormonal products in which SERMs are recommended for PCT.

At some point, someone in the know should outline the safest possible PCT plan for the supplement (given their unique knowledge of the proprietary compound they are using). I realize this was already done in the original post, I'm just not sure if a SERM was omitted from their suggestions for legal/PR reasons or if it is genuinely not needed. Unfortuantely, my own knowledge of chemical compounds is virtually non-existant so I couldn't take much more than an educated guess regarding the true PCT needs for a supplement like this.

honestly- I omitted it b/c I am not a huge fan of them- you can do PCT in a lot of different ways- SERMs are not necessarily the end-all be-all of PCT- lot of different ways to skin a cat....

 

[rms80]

Are they Pro hormones? I have been trying to research all this the last 2 days and just get more confused. Especially since It's all abbreviations, wich is frustrating if you dont know the full word!
And I cant help but notice the AN reps use terms like "relatively safe" or "you should be ok" etc, if you know what I mean. Doesnt exactly fill a man with confidence. No one has outlined in black and white EXACTLY what you must take and do after you do your "the one" cycle. Its mentioned here an there but nothing comprehensive in plain english. And I have to agree with the guy that asks why such a large, reputable company didnt have extensive bloodwork before, during and after.
Now before I get blasted, i realize i am speaking from relative ignorance(so AN boys an girls go easy) it just seems they have every answer bout product except what to do after....

The write-up and its recommendations are pretty black and white, don't you think? I tell you how to take The One, what supplements to include along with it, what to eat, how to train, and what to take for PCT- as for blood work- we are working on it- just need a little extra time....

 

[Enigma76]

It's a Pro-hormone, but converts to a unique target hormone. I'll have to have RMS answer this one if more details are needed...

No not needed. But I am curious...

 

[rms80]

Its being called a pro hormone by everyone involved, but my classification of it, the way Ive always understood the differences, Im calling it a designer steroid. Everything Ive ever read states that a pro hormone has to utilize something in the body to convert it into the steroid, where The One has no need to convert as its a designer steroid.

But I remember reading a post in one of the 3 threads where it was explained that the classifications and differences are debatable, so this is just my interpretation. I think AN would like for it to be referred to as a PH, probably for marketing purposes. That will make it more easily related to by the general public, because the term "designer steroid" sounds a lot more harsh to the average supp shopper.

Not that Im trying to speak for AN.

it depends on how you classify the compound, at what stage that you classify it, and what form- honestly- even testosterone is a prohormone of DHT in the nervous system- so yes, it is a prohormone....

 

[rms80]

That's why I'm confused. The wording/explanation is somewhat contradictory in my mind. So, it doesn't convert to DHT, rather it is an analog to DHT? I know how exogenous DHT effects my body, and I'm trying to compare that to this compound, but it doesn't seem applicable i

methyl-1-test compared to 1-test
DHT+3-hydroxyimine compared to DHT

Maybe we could start referring to it as a DS, if that's what it actually is. The PH term really throws me off.

edit: btw, I'm not just stirring the pot. I've taken MMv2, which supposedly converts to DHT, and I very much enjoyed my time on it. So, I'm just trying to make comparisons, if/where they exist.

I think you are over-thinking this Yes- it is a derivation of DHT- and it does eventually hydrolyze to DHT- but not right away- the effects are not the same as taking straight DHT, because the molecule is actually protected from some of the "usual suspects" that metabolize DHT to 5-aa....this is why the effects are different from other analogs such as mestanolone and mesterolone (both are fairly weak in terms of lean body mass increases)- they are both DHT analogs, but MUCH closer to actual DHT than this compound. Methyldrostanolone (SD) is also a DHT deriv., but it has effects that are nothing like mestanolone or mesterolone- proof that one small molecular change can make all the difference in the world when in comes to these compounds- mestanolone is 17aa DHT- that is, a DHT base molecule with alkylation at the 17th carbon to make it more bioavaliable. Mesterolone is DHT deriv. that has an extra methyl at carbon 1 but no alpha alkylation at carbon 17. Methydrostanolone has an extra methyl @ carbon 2, and is 17aa. Mesterolone is a prohormone of DHT and 5-aa- it becomes DHT, then 5-aa- mestanolone is a prohormone of DHT and 5-aa, testosterone is a prohormone of DHT and estrogen, nandrolone is a prohormone of DBN and progesterone- my point is, it is all relative...

 

[Mr.50]

RMS can you go into further detail about the biochemical processes around this molecule?

The writeup is confusing to me. I understand that this compound is an oxime derivative of DHT. From the writeup, however, it suggests that this compound converts into DHT but, due to the oxime addition, is not metabolized by 3a-HSD. It is continually compared to DHT regarding effects, binding properties and elimination.

To finally clarify and clear up these PH/designer steroid questions. When someone takes "The One", does it undergo any enzymatic changes in the body prior to activation? If yes, via what enzyme? Or is it metabolically active in its current form, and simply needs to survive the first-pass hepatic metabolism to bind and activate AR gene transcription?

I know it was postulated that 1-AD had intrinsic effects (binding to the AR prior to conversion to 1-T) as well as enzymatic conversion to 1-T which has its own binding properties. So it is possible for a compound to have both its own intrinsic activity and activity through its metabolites.



To those confused about this, and any other, product being a PH/PS/DS. If the molecule requires conversion prior to being active, it should be termed a prohormone or prosteroid (interchangable for all intents and purposes in this setting, though not all hormones are steroids). The pro- prefix denotes that it is a precursor to something else active. If it does not require conversion, it should be termed a "designer steroid" or some derivation thereof.

Hey, not to be a prick, but what does the distinction between ph/ps/ds/aas or anything else matter besides to raise the interest of the DEA or FDA???? If we know if the compound is legal or illegal, and we know the mechanism of action and possible side effects, as well as the correct chemical structure (all for health reasons besides the legal status) what is the difference if it is called a ph, ps, ds, aas etc. All this can do, even if you are right and it is a DS, is raise the interest of the DEA or FDA even more. I think this is a classification best left alone.

Mr.50

 

[rms80]

RMS can you go into further detail about the biochemical processes around this molecule?

The writeup is confusing to me. I understand that this compound is an oxime derivative of DHT. From the writeup, however, it suggests that this compound converts into DHT but, due to the oxime addition, is not metabolized by 3a-HSD. It is continually compared to DHT regarding effects, binding properties and elimination.

To finally clarify and clear up these PH/designer steroid questions. When someone takes "The One", does it undergo any enzymatic changes in the body prior to activation? If yes, via what enzyme? Or is it metabolically active in its current form, and simply needs to survive the first-pass hepatic metabolism to bind and activate AR gene transcription?

I know it was postulated that 1-AD had intrinsic effects (binding to the AR prior to conversion to 1-T) as well as enzymatic conversion to 1-T which has its own binding properties. So it is possible for a compound to have both its own intrinsic activity and activity through its metabolites.



To those confused about this, and any other, product being a PH/PS/DS. If the molecule requires conversion prior to being active, it should be termed a prohormone or prosteroid (interchangable for all intents and purposes in this setting, though not all hormones are steroids). The pro- prefix denotes that it is a precursor to something else active. If it does not require conversion, it should be termed a "designer steroid" or some derivation thereof.

see my above post- it is compared to DHT b/c it is a derivation of DHT- with a DHT backbone- and yes, it eventually hydrolyzes to DHT and to 5-aa. At what point, I cannot say for sure- that is why the write-up may not answer all of your questions- I am not going to sit here and make something up or make false conclusions.

The compound will eventually have to undergo some sort of enzymatic change to actively bind to the AR, at what point, and when, I can't say, because it is a novel compound and I can only ascertain from studies that I do have on other DHT derivs., immunoassay studies, pathways, and gestrogen studies that have used 3-oxime to control binding proteins - it may get hydrolyzed by 3-alpha HSD in the muscle, but once again, I am not absolutely sure when....

 

[rms80]

Hey, not to be a prick, but what does the distinction between ph/ps/ds/aas or anything else matter besides to raise the interest of the DEA or FDA???? If we know if the compound is legal or illegal, and we know the mechanism of action and possible side effects, as well as the correct chemical structure (all for health reasons besides the legal status) what is the difference if it is called a ph, ps, ds, aas etc. All this can do, even if you are right and it is a DS, is raise the interest of the DEA or FDA even more. I think this is a classification best left alone.

Mr.50

thank you :thumbsup:

 

[Maverick60]

Hey, not to be a prick, but what does the distinction between ph/ps/ds/aas or anything else matter besides to raise the interest of the DEA or FDA???? If we know if the compound is legal or illegal, and we know the mechanism of action and possible side effects, as well as the correct chemical structure (all for health reasons besides the legal status) what is the difference if it is called a ph, ps, ds, aas etc. All this can do, even if you are right and it is a DS, is raise the interest of the DEA or FDA even more. I think this is a classification best left alone.

Mr.50

I agree. To me, it really doesnt matter what you call it. As long as we know how it works and what to expect. Im sure we will better know what to expect from logs and reviews soon enough. I was just stating what I would have thought of it as based on my understanding. Right or wrong. Wrong judging by Rms' explanation. lol. I can live with that.

 

[rms80]

I agree. To me, it really doesnt matter what you call it. As long as we know how it works and what to expect. Im sure we will better know what to expect from logs and reviews soon enough. I was just stating what I would have thought of it as based on my understanding. Right or wrong. Wrong judging by Rms' explanation. lol. I can live with that.

....I will try to answer all of your questions to the best of my ability- but I am not going to make things up as I go along- I will give you the best plausible theory, but if the data doesn't exist, I can't just play interpretive/pseudo-biology, LOL

 

[bolt10]

Interesting not something i would have in mind but its good to see some companies at least coming out with more innovative things rather than just clones(and it seems they are looking for safer routes as well)

good luck with this and i look forward to w/e Applied has in store next! :thumbsup:

 

[Trauma1]

I told you bro...this is going to be a big hit. I'll be running this one myself and will start my log back up when I run my cycle. I plan on doing something a bit different with my cycle as well. .

Dirk and Don....my boy T1 should be on the short list for testers! He's one of the best reviewers out there and knows his sh*t.

Cheers Brutha Man!:cheers:

Thanks, sean! I try to give sufficient detail, as well as encourage an informative and interactive learning experience that benefits all involved.

Make sure to link me when you get this going!

It really does look like a very impressive and interesting compound. Very nice work AN.

 

[OzzY SluGGa]

The write-up and its recommendations are pretty black and white, don't you think? I tell you how to take The One, what supplements to include along with it, what to eat, how to train, and what to take for PCT- as for blood work- we are working on it- just need a little extra time....

They are indeed RMS. I guess I just dont understand alot of the technical talk, and abbreviations in Regards to P/H's(been a lifter 9 years now but no P/H experience) So when I read all the posts things are not always clear to me. My problem obviously not yours, but research is NOT my strong suit mate. I end up getting even more confused
But yeah, It was clear as you say, i merely need a better understanding obviously. thanks for your patience.
PS Guejsn seems to have a way of putting things that my simple mind can understand!:icon_lol:
PPS Are they Amstaffs in your Avatar? God damn I love them dogs.

 

[ShakesAllDay]

Thank you for further explanation, rms80. I don't care whether you want to call it a PH, DS, etc., I just needed clarification because those terms denote certain properties to me.

btw, good point on test being a "pro-hormone"... something I hadn't really thought about.

 

[Rosie Chee]

Now THAT is concise and perfectly understandable to me. Thank you. Damn this girls good:thumbsup:

...

PS Guejsn seems to have a way of putting things that my simple mind can understand!:icon_lol:

No worries, mate. Glad you're getting something. I'm only here to help

 

[OzzY SluGGa]

No worries, mate. Glad you're getting something. I'm only here to help

Well, after spending ALL day on various forums and all over google can you help me with this? : Everyone(rough term maybe 8/10) posters on other sites do nothing but bag P/H's in the sense they have all the sides of "real gear" with less effect. So their contension is why use them when Gear is way more affective with the same sides?
And just your personal opinion in how you think "the one" goes in the sides stakes compared to other common P/H's?
PS Onw thing bout P/H's is they are new and no one can really conclusively determine long term affects as appose to roids. All so interesting, is exhausting reading people abuse each other on forums all day LOL

 

[Rosie Chee]

Well, after spending ALL day on various forums and all over google can you help me with this? : Everyone(rough term maybe 8/10) posters on other sites do nothing but bag P/H's in the sense they have all the sides of "real gear" with less effect. So their contension is why use them when Gear is way more affective with the same sides?

Yes, they tend to do that. Many posters have no actual idea what they're talking about. And most of those that do are probably basing their opinions on heresay and not actual experience. (Just a general observation).

And just your personal opinion in how you think "the one" goes in the sides stakes compared to other common P/H's?

For me to give an "opinion" on The ONE and associated sides I would have to have used it AND other PH's to make a comparison. However, personally, I have never used anything hormonal, so asking me about sides seems pointless (AND they would affect a female in a COMPLETELY different way than a male - i.e. virilization).

Sides associated with PH and DS are vast, ranging from acne, loss of libido, and hair loss, to testicular shrinkage and gynecomastia, etc. However, the guys who did the testing with The ONE noted a slight increase in acne by way of sides, but nothing too much more than that.

Dirk is really the one to ask about this.

PS Onw thing bout P/H's is they are new and no one can really conclusively determine long term affects as appose to roids. All so interesting, is exhausting reading people abuse each other on forums all day LOL

PH have similar, if not the same, effects as steroids, just usually to a lesser extent (and note that it also depends on the individual). Therefore it might be assumed that they have similar long-term effects as steroids as well (with chronic usage).

 

[EasyEJL]

And just your personal opinion in how you think "the one" goes in the sides stakes compared to other common P/H's?

its among the lowest sides of any. It can depend on what you classify as side effects, for instance hunger is way up on The One, and its difficult to sleep if you take it much later than 3 or 4 in the afternoon. As far as common hormonal sides, I ended up starting 2 or 3 pimples on my face which easy came under control with OTC products, that was it. Interestingly, none on my biceps or back.

 

[donorrell]

Well, after spending ALL day on various forums and all over google can you help me with this? : Everyone(rough term maybe 8/10) posters on other sites do nothing but bag P/H's in the sense they have all the sides of "real gear" with less effect. So their contension is why use them when Gear is way more affective with the same sides?
And just your personal opinion in how you think "the one" goes in the sides stakes compared to other common P/H's?
PS Onw thing bout P/H's is they are new and no one can really conclusively determine long term affects as appose to roids. All so interesting, is exhausting reading people abuse each other on forums all day LOL

I applaud your exhaustive research and efforts to educate yourself. More people should do so. You're our favorite kind of customer...the more you know about supplements, the more you'll appreciate what we do as opposed to other companies.

I think now you've reached an "information overload" point. Take a step back and don't overthink this. You've assimilated a lot of facts and a lot of "broscience". (Hmmm another topic...?) Here are a few basic considerations that you should think about here:

1. Less is more. Low / moderate doses often work as well as higher doses but with far less side effects.

2. Take long breaks between cycles. This allows your receptors to refresh and your body to cleanse any free radicals that may have resulted from your cycle.

3. Use your head. Healthy diet, exercise, refrain form alcohol.

4. Remember that even many of the strongest steroids were/are approved by the FDA/TGA for medical purposes. That means that these compounds were deemed safe enough by the government to be administered commercially to the public under a doctor's supervision. Revert to items 1-3; that's what your doctor would say. "Everything in moderation, my friend..."

5. Most steroids are illegal, but you can buy The One virtually anywhere (once launched). OK, except maybe in Australia.

My 2 cent's worth.

:good:

 

[EasyEJL]

Everyone(rough term maybe 8/10) posters on other sites do nothing but bag P/H's in the sense they have all the sides of "real gear" with less effect.

everyone in 1490 thought the earth was flat too.

 

[ShakesAllDay]

everyone in 1490 thought the earth was flat too.

It's not?

:wtf:

 

[Ubiyca]

Would this be less supressive than H-drol (which is already very low supression) I am 21 and I want to try the safest and least androgenic steroid out there

Is it less androgenic than Havoc?

 

[rms80]

They are indeed RMS. I guess I just dont understand alot of the technical talk, and abbreviations in Regards to P/H's(been a lifter 9 years now but no P/H experience) So when I read all the posts things are not always clear to me. My problem obviously not yours, but research is NOT my strong suit mate. I end up getting even more confused
But yeah, It was clear as you say, i merely need a better understanding obviously. thanks for your patience.
PS Guejsn seems to have a way of putting things that my simple mind can understand!:icon_lol:
PPS Are they Amstaffs in your Avatar? God damn I love them dogs.

Gotcha- something I gotta work on- Rosie does explain things well My goal is to make you guys as educated/informed as possible when it comes to diet, training, and supplementation in general- I want you to love our products and use them in the most effective manner.....


American Bulldogs- real similar- they are really fun dogs- they love to wrestle and play tug-of-war

 

[rms80]

Would this be less supressive than H-drol (which is already very low supression) I am 21 and I want to try the safest and least androgenic steroid out there

Is it less androgenic than Havoc?

not sure on whether or not it would be more or less suppressive than H-drol- if you run it as recommended (4-5 weeks maximum), follow good nutrition, training, rest, and PCT, suppression should only be a limited issue

It is slightly more androgenic than Havoc

 

[LilPsychotic]

Epistane in probrably the most powerful oral steroid I have ever used. Saying that the One "could" give me a 6-fold increase in lean mass by comparasin, is a pretty bold statement. Somehow I just don't see it in terms of its structure and ratings. I've also never seen an N-OH group on the 3 position before, but it seems that the interaction with SHGB is mostly theoretical. We will see how this pans out.

 

[steveironman]

As i said i am very intersted in seeing the reults of this product. Given the responses above i do think it prudent to establish a few things
1- most ph/ps products do have alot of the associated sides of aas ,many to the exact same extent as aas without equal benefit when it comes to building muscle. Thats a fact. Will this product be different...it would be nice. If so it would be huge if it was as even with aas usually effectiveness has a fairly direct correlation to side effects in alot of instances. Re: primobloan has low associated side effects...it also doesnt come close to building the muscle that trenbolne does .Same analogy re: anavar and anadrol etc.... At any rate i see other ph with similar chem stuctures(p plex)but this structure is def unique to this product.
2- I too wonder about certain effects based on chem structure BUT lets see....as with aas chem structure doesnt aways dictate true effects. Again im curious but i also think its important to be honest and realistic about ph/ps products ..what they are ,what they do ,and their comparisons to aas (sides and reulsts)
3-Also IMO it is prudent based on sides observed to handle pct appropraitely ...the manu in this case has been honest(which is nice to see) about saying that hey it doesnt appear harsh but we dont know yet...this is what we recommend for pct...they arent gonna say use clomid and nolva...but i think as end user and consumers we need to be intelligent enough and in tune with effects enough to determine what we may or may not need after product usage. I am a firm believer in serm pct protocols...but thats me. Exercise good common sense whether using aas or ps/ph products.

Again i am very intrigued by this product and look forward to seeing its results and effectiveness determined.

 

[Noto]

In the warning section it says do not consume alcohol.... Is this a suggestion for best results or are you putting yourself at a health risk? I workout hard, eat right but like a few drinks a couple times a week. I'm not going out getting smashed, but maybe 3 or 4 beers twice a week. I've been on RPM/DRIVE/IGF-2, and continued to moderately drink on the occasion and still have seen great results...

 

[Ubiyca]

In the warning section it says do not consume alcohol.... Is this a suggestion for best results or are you putting yourself at a health risk? I workout hard, eat right but like a few drinks a couple times a week. I'm not going out getting smashed, but maybe 3 or 4 beers twice a week. I've been on RPM/DRIVE/IGF-2, and continued to moderately drink on the occasion and still have seen great results...

Hell no, don't drink on it, are you crazy? :trout:

 

[Maverick60]

In the warning section it says do not consume alcohol.... Is this a suggestion for best results or are you putting yourself at a health risk? I workout hard, eat right but like a few drinks a couple times a week. I'm not going out getting smashed, but maybe 3 or 4 beers twice a week. I've been on RPM/DRIVE/IGF-2, and continued to moderately drink on the occasion and still have seen great results...

Its because products like this are already hard enough on your liver, alcohol would just make your liver have to work that much harder to function. Alcohol will inhibit muscle growth as well, so if youre going to the extreme of using a PH you should be more focused than to need to drink anyway. If you cant go a month without a drink, you probably shouldnt be running PH or AAS.

But mainly for the sake of your liver.

 

[Noto]

:think::think:

Its because products like this are already hard enough on your liver, alcohol would just make your liver have to work that much harder to function. Alcohol will inhibit muscle growth as well, so if youre going to the extreme of using a PH you should be more focused than to need to drink anyway. If you cant go a month without a drink, you probably shouldnt be running PH or AAS.

But mainly for the sake of your liver.

No not crazy, just not educated. That's why I have you guys! And as I said, lI ike the drinks but can easily hold them off for a product like this. Haven't tried an AN product yet I didnt love, anxious for the "ONE" that's gonna have the biggest impact!

 

[OzzY SluGGa]

Gotcha- something I gotta work on- Rosie does explain things well My goal is to make you guys as educated/informed as possible when it comes to diet, training, and supplementation in general- I want you to love our products and use them in the most effective manner.....


American Bulldogs- real similar- they are really fun dogs- they love to wrestle and play tug-of-war

Na Mate, you dont have to work on it. Your answers are awesome. Just my knowledge isnt up to speed with them. Maybe Rosie has brothers and knows how to talk to dumb guys Plus she's Kiwi, wich is almost Aussie!:nutkick:

 

[OzzY SluGGa]

I applaud your exhaustive research and efforts to educate yourself. More people should do so. You're our favorite kind of customer...the more you know about supplements, the more you'll appreciate what we do as opposed to other companies.

I think now you've reached an "information overload" point. Take a step back and don't overthink this. You've assimilated a lot of facts and a lot of "broscience". (Hmmm another topic...?) Here are a few basic considerations that you should think about here:

1. Less is more. Low / moderate doses often work as well as higher doses but with far less side effects.

2. Take long breaks between cycles. This allows your receptors to refresh and your body to cleanse any free radicals that may have resulted from your cycle.

3. Use your head. Healthy diet, exercise, refrain form alcohol.

4. Remember that even many of the strongest steroids were/are approved by the FDA/TGA for medical purposes. That means that these compounds were deemed safe enough by the government to be administered commercially to the public under a doctor's supervision. Revert to items 1-3; that's what your doctor would say. "Everything in moderation, my friend..."

5. Most steroids are illegal, but you can buy The One virtually anywhere (once launched). OK, except maybe in Australia.

My 2 cent's worth.

:good:

That was a wicked post cheers( do Americans use that term?)
Your right, way too much info. And even worse, way too much conflicting opinions! I have to sort through 10 pages of **** to find one good post cause everyone wants to talk tough over a keyboard.
I am far more interested in PCT, because I only wanna run one cycle. I am ten years in the game and over 100kg(bout 230pnd) and round 12%. If I put another 4 kg on I would be stoked and wont want anymore. So my perspective approaching The One is to do 1 good cycle and thats it.
As far as sides, i dont care bout anything....as LONG as its temporary, you know acne etc. Cant understand why people would complain bout things while there in cycle? (hello, your testosterone is up!)
BUT i am petrified of man boobs down track or after! Or ANY kind of sexual disfunction.
What do you guys think bout a much lower dose but for a longer time? Does that work the same? Or is it a massie oversimplification? "pulsing" one of the terms i learnt on my information hunt

 

[donorrell]

That was a wicked post cheers( do Americans use that term?)
BUT i am petrified of man boobs down track or after! Or ANY kind of sexual disfunction.
What do you guys think bout a much lower dose but for a longer time? Does that work the same? Or is it a massie oversimplification? "pulsing" one of the terms i learnt on my information hunt

Ozzie,

Man boobs: No worries. This product does not aromatize (convert to estrogen) so your nipples are safe.

Sex Drive: Our testers said they learned a new meaning for the term "pile-driver" :lol:

Low, long dose: Don't do it. Too low will give you diminished benefits and loo long increases the chance of shutdown.

Take it for 4-5 weeks, do your PCT, and you'll be thrilled. The only thing I can't guarantee is that you'll only do it once!:thumbsup:

 

[OzzY SluGGa]

Ozzie,

Man boobs: No worries. This product does not aromatize (convert to estrogen) so your nipples are safe.

Sex Drive: Our testers said they learned a new meaning for the term "pile-driver" :lol:

Low, long dose: Don't do it. Too low will give you diminished benefits and loo long increases the chance of shutdown.

Take it for 4-5 weeks, do your PCT, and you'll be thrilled. The only thing I can't guarantee is that you'll only do it once!:thumbsup:

Yeah mate, 1 cycle will be all I will need or want. As far as man boobs, I thought they came after a cycle? when you stop all the artificial test raising and your estrogen remains high? But I guess thats what the PCT is for. Hope I can get all the needed PCT stuff here in Aus....sounds like so many pills! Is there a PCT supp you can just take rather than 3 or 4 diff things? That would be so much easier.
5 LEAN kilo's (bout 12 pound) that I KEEP and I will be over the moon man. Thats all i want! maybe help me in some stubborn spots like upper chest.
Anyway as always you been a big help:thumbsup:
Now lets get this **** down Aus ya'll! ASAP:head:

 

[Irish Cannon]

Yeah mate, 1 cycle will be all I will need or want. As far as man boobs, I thought they came after a cycle? when you stop all the artificial test raising and your estrogen remains high? But I guess thats what the PCT is for. Hope I can get all the needed PCT stuff here in Aus....sounds like so many pills! Is there a PCT supp you can just take rather than 3 or 4 diff things? That would be so much easier.
5 LEAN kilo's (bout 12 pound) that I KEEP and I will be over the moon man. Thats all i want! maybe help me in some stubborn spots like upper chest.
Anyway as always you been a big help:thumbsup:
Now lets get this **** down Aus ya'll! ASAP:head:

I don't know how heavy this compound is, but CEL's Post Cycle Assist or Anabolic Innovations Stoked are both great PCT products. AIs + SERM properties in both. Check them out on NutraPlanet.

 

[rms80]

In the warning section it says do not consume alcohol.... Is this a suggestion for best results or are you putting yourself at a health risk? I workout hard, eat right but like a few drinks a couple times a week. I'm not going out getting smashed, but maybe 3 or 4 beers twice a week. I've been on RPM/DRIVE/IGF-2, and continued to moderately drink on the occasion and still have seen great results...

prolly not going to hurt you- but heavier consumption (daily and more than 4 drinks) is probably not wise- just use common sense

 

[rms80]

Epistane in probrably the most powerful oral steroid I have ever used. Saying that the One "could" give me a 6-fold increase in lean mass by comparasin, is a pretty bold statement. Somehow I just don't see it in terms of its structure and ratings. I've also never seen an N-OH group on the 3 position before, but it seems that the interaction with SHGB is mostly theoretical. We will see how this pans out.

I have used both- I can say 60 mg/day of The One is stronger than 30-40 mg/day of epi- gains are much faster from The One, but the gains from epi really manifest themselves later in the response curve- I didn't see appreciable gains from Epistane until about the beginning of the 3rd week, but once they started, they really got going quickly....The graph is over a 2 week period (the first two weeks of the cycle) on the comparsion- and it is for commercially recommended doses (those indicated on the bottle). Mg for mg, I think the potencies are actually similar, but I have never gone up to 60 mg/day of epi....the 3-oxime interaction with SHBG has been pretty well documented in several studies- look up some of the immunoassay and gestrogen studies that I listed- they have some pretty good data on the topic

Read Progestins and Antiprogestins in Clinical Practice by Sitruk-Ware and Mishell- discusses the topic in depth....

 

[Rosie Chee]

Na Mate, you dont have to work on it. Your answers are awesome. Just my knowledge isnt up to speed with them. Maybe Rosie has brothers and knows how to talk to dumb guys Plus she's Kiwi, wich is almost Aussie!:nutkick:

I only have one brother, and he's 6 years YOUNGER than me. However, 99% of my friends are males. And I have learnt to 'dumb it down' when trying to explain to people (something that you have to do as a personal trainer); it's actually quite hard to do sometimes.

 

[OzzY SluGGa]

I only have one brother, and he's 6 years YOUNGER than me. However, 99% of my friends are males. And I have learnt to 'dumb it down' when trying to explain to people (something that you have to do as a personal trainer); it's actually quite hard to do sometimes.

OI! Are you calling me dumb?:FUfinger: hahaha, Kidding, I do need the dumbing down in regards to P/H's for sure! Im being schooled by a 5 '2 Kiwi chick!! someone help me! LOL

 

[Rosie Chee]

OI! Are you calling me dumb?:FUfinger: hahaha, Kidding, I do need the dumbing down in regards to P/H's for sure! Im being schooled by a 5 '2 Kiwi chick!! someone help me! LOL

No, not saying that at all. What I meant was that when one talks in scientific terms or jargon the general population just say "whaaat???", so you have to find a way to say it so they understand it.

And there's nothing wrong with "being schooled" by a female; some of us actually DO know things males don't :nutkick:

 

[steveironman]

I have used both- I can say 60 mg/day of The One is stronger than 30-40 mg/day of epi- gains are much faster from The One, but the gains from epi really manifest themselves later in the response curve- I didn't see appreciable gains from Epistane until about the beginning of the 3rd week, but once they started, they really got going quickly....The graph is over a 2 week period (the first two weeks of the cycle) on the comparsion- and it is for commercially recommended doses (those indicated on the bottle). Mg for mg, I think the potencies are actually similar, but I have never gone up to 60 mg/day of epi....the 3-oxime interaction with SHBG has been pretty well documented in several studies- look up some of the immunoassay and gestrogen studies that I listed- they have some pretty good data on the topic

Read Progestins and Antiprogestins in Clinical Practice by Sitruk-Ware and Mishell- discusses the topic in depth....

and in retrospect the shbg makes sense as it is a characteristic associated with dht compounds...and another intriguing thing im curious to is the potential anti prosgestin/progesterone effects (theoretical in some cases) also associated with dht based compounds... anyway good info for consideration...

 

[Enigma76]

Hey, not to be a prick, but what does the distinction between ph/ps/ds/aas or anything else matter besides to raise the interest of the DEA or FDA???? If we know if the compound is legal or illegal, and we know the mechanism of action and possible side effects, as well as the correct chemical structure (all for health reasons besides the legal status) what is the difference if it is called a ph, ps, ds, aas etc. All this can do, even if you are right and it is a DS, is raise the interest of the DEA or FDA even more. I think this is a classification best left alone.

Mr.50

No offense taken. I honestly don't know if a difference in classification means anything to the DEA/FDA. PH/PS/DS/AAS...all the same in my eyes in the end and I assume so for them as well. Why would the classification make any difference, other than the psychology of calling it a "steroid" versus a "hormone"? The psychology of the classification might influence the general public, but then again who cares about the general public, most are completely misinformed by the media anyways and will never get wind of this product.

I made the post because others prior to me in this thread were also confused. I personally am interested in the biochemistry, which RMS explained to the best of his knowledge (and thank you for not conjecturing RMS...I really do respect it when people say that they don't know the exact truth and don't attempt to label it as something otherwise. I figured as much about its metabolism, seeing as the compound is novel. I'd much rather a company say "we don't exactly know everything, but this is what we do know". Props to you). I was especially interested since the compound is novel. And I'm not alone, as I've gotten quite a few reputation points and private messages from people expressing their confusion as well.

Writeups will never please everyone. For some, it is information overload. For others like myself, it is never enough (just always interested in learning personally). For even more still, a writeup might not emphasize the information they are looking for or are particularly interested in.

While I disagree that changing its classification would raise the FDA's vigilance more, I do see your point. I'm not trying to be a cynic looking to rip apart a company's product like many do. I'm simply trying to learn about it. Hope you can see my point of view as well.

 

[OzzY SluGGa]

No, not saying that at all. What I meant was that when one talks in scientific terms or jargon the general population just say "whaaat???", so you have to find a way to say it so they understand it.

And there's nothing wrong with "being schooled" by a female; some of us actually DO know things males don't :nutkick:

I know you didnt mean I was dumb i was playing. Kiwi's! sheesh!:lol:

 

[AdelV]

legal in australia?

 

[Rosie Chee]

legal in australia?

Wouldn't count your odds, mate, given the TGA.

 

[Mr Barlow]

This does look an interesting product! I plan on using it for a pulse in a month of two, what would AN recommend in terms of dosing? Could you guys put up some sample doses? perhaps on for a no PCT pulse method like Dr.D did for epistane if that is possible? and possibly another one for a pulse method with light PCT?