EvoMuse Defuse Writeup

mcgeier said:
Whats a dgat inhibitor? And whats the best stack to prevent excess calories to be stored as fat?
Defuse, Recompadrol and AAV2?
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Diacylglycerol Acyltransferase...transfers the final acyl group to form a triglyceride. Salvia Miltiorrhiza is a DGAT inhibitor, and is included in the formula.
 
dsade said:
Diacylglycerol Acyltransferase...transfers the final acyl group to form a triglyceride. Salvia Miltiorrhiza is a DGAT inhibitor, and is included in the formula.
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From the man himself

Corosolic acid seems to have that property some what as well
 
I'm thinking of going 2 caps prior to post workout meal and 4 prior to another meal. Then the regular 4 cap doses on non training days.. Is it stupid to only use two caps at a dose?
 
chedapalooza said:
I'm thinking of going 2 caps prior to post workout meal and 4 prior to another meal. Then the regular 4 cap doses on non training days.. Is it stupid to only use two caps at a dose?
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No, not at all. Partial inhibition will still lessen the damage.
 
criticalbench said:
Is this a tolerance issue? Also, pointless when dieting? I dont mean cheat meals, reg days.
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I think Matt has said try giving it a whirl at a lower dosage on reg days. I'm going to run it at 2 caps with my biggest meal of the day and only go up to max dosage when I'm really cheating or having a massive meal.

He can correct me if I'm mistaken, but that's how I will be running my bottle.
 
Geoforce said:
I think Matt has said try giving it a whirl at a lower dosage on reg days. I'm going to run it at 2 caps with my biggest meal of the day and only go up to max dosage when I'm really cheating or having a massive meal.

He can correct me if I'm mistaken, but that's how I will be running my bottle.
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Good to no, appreciated!

Mike
 
I think you should stick to Matt's limit. The glycyrrhetinic acid is notorious for causing electrolyte disturbances/hypertension if used for too long or at too high a dose. I believe Matt's dosing protocol is grounded in the fact that he wants your body to return to homeostasis as far as fluid balance is concerned.
 
mr.cooper69 said:
I think you should stick to Matt's limit. The glycyrrhetinic acid is notorious for causing electrolyte disturbances/hypertension if used for too long or at too high a dose. I believe Matt's dosing protocol is grounded in the fact that he wants your body to return to homeostasis as far as fluid balance is concerned.
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Hmm.. good to no! As always, appreciated. Do you no the cause of htn from glycyrrgetnic acid? From electrolyte disturbances, I'm thinking a fluid overload state?
 
criticalbench said:
Hmm.. good to no! As always, appreciated. Do you no the cause of htn from glycyrrgetnic acid? From electrolyte disturbances, I'm thinking a fluid overload state?
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Wikipedia has a nice writeup:

"3-β-D-(monoglucuronyl)-18-β-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of active cortisol to inactive cortisone in the kidneys. This occurs via inhibition of the enzyme by inhibiting the enzyme 11-β-hydroxysteroid dehydrogenase. As a result, cortisol levels are high within the collecting duct of the kidney. Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct. Hypertension develops due to this mechanism of sodium retention. People often have high blood pressure with a low renin and low aldosterone blood level. The increased amounts of cortisol binds to the unprotected, unspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemia, high blood pressure and inhibition of the renin-angiotensin-aldosterone system. Therefore licorice should not be given to patients with a known history of hypertension in doses sufficient to inhibit 11-β-hydroxysteroid dehydrogenase."
 
mr.cooper69 said:
Wikipedia has a nice writeup:

"3-?-D-(monoglucuronyl)-18-?-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of active cortisol to inactive cortisone in the kidneys. This occurs via inhibition of the enzyme by inhibiting the enzyme 11-?-hydroxysteroid dehydrogenase. As a result, cortisol levels are high within the collecting duct of the kidney. Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct. Hypertension develops due to this mechanism of sodium retention. People often have high blood pressure with a low renin and low aldosterone blood level. The increased amounts of cortisol binds to the unprotected, unspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemia, high blood pressure and inhibition of the renin-angiotensin-aldosterone system. Therefore licorice should not be given to patients with a known history of hypertension in doses sufficient to inhibit 11-?-hydroxysteroid dehydrogenase."
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So, if I'm i am taking away the main idea of this, should one watch their sodium intake with this?
 
mr.cooper69 said:
Wikipedia has a nice writeup:

"3-β-D-(monoglucuronyl)-18-β-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of active cortisol to inactive cortisone in the kidneys. This occurs via inhibition of the enzyme by inhibiting the enzyme 11-β-hydroxysteroid dehydrogenase. As a result, cortisol levels are high within the collecting duct of the kidney. Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct. Hypertension develops due to this mechanism of sodium retention. People often have high blood pressure with a low renin and low aldosterone blood level. The increased amounts of cortisol binds to the unprotected, unspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemia, high blood pressure and inhibition of the renin-angiotensin-aldosterone system. Therefore licorice should not be given to patients with a known history of hypertension in doses sufficient to inhibit 11-β-hydroxysteroid dehydrogenase."
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Ahhh.. I have an idea about what this is about.. Thanks bro!

Mike
 
Been using this prior to my largest meals for a couple weeks. Still too hard to dial everything in with as much travel as I've had, so things haven't been quite as to my general routine, but have noticed I don't feel as bad post-feeding.
 
21 days was a success coming off EC and using this 2-4 caps before 2 large meals. Gonna take a couple weeks off and saved some caps for a planned OFF week. Great product. Will buy again.
 
Are there any logs/reviews floating around for Defuse?

chedapalooza could you summarise your experience with defuse and let us know your dosing protocol etc. I'd be interested to know whether defuse has decent effects to prevent fat gain with just dosing prior to a heavy meal or if you need to dose continuously leading up to a heavy meal. When I say heavy meal I'm really talking stomach bursting binge style, but generally within a short time period (few hours). Also do you see an improvement in effects over time?

Thanks for the info,

Joe
 
pluckjoe said:
Are there any logs/reviews floating around for Defuse?

chedapalooza could you summarise your experience with defuse and let us know your dosing protocol etc. I'd be interested to know whether defuse has decent effects to prevent fat gain with just dosing prior to a heavy meal or if you need to dose continuously leading up to a heavy meal. When I say heavy meal I'm really talking stomach bursting binge style, but generally within a short time period (few hours). Also do you see an improvement in effects over time?

Thanks for the info,

Joe
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I would rather preload a supplement like that to continuously inhibit sreb1 acc PPARy ect. The more you repress the protein the less likely to put on more fat.

It works,
 
pluckjoe said:
Are there any logs/reviews floating around for Defuse?

chedapalooza could you summarise your experience with defuse and let us know your dosing protocol etc. I'd be interested to know whether defuse has decent effects to prevent fat gain with just dosing prior to a heavy meal or if you need to dose continuously leading up to a heavy meal. When I say heavy meal I'm really talking stomach bursting binge style, but generally within a short time period (few hours). Also do you see an improvement in effects over time?

Thanks for the info,

Joe
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I used it for 21 days at 6-8 caps a day. I dosed it twice daily. I noticed reduced appetite over the course of the time and subtle leaning effects. On days where I ate that I felt I went "overboard" slightly (all clean food) I still wasnt affected by it and actually woke up leaner. It's a great product and I think it's worth a shot to use and see if u personally like it. I will absolutely be using the remainder of the bottle and buying more
 
chedapalooza said:
I used it for 21 days at 6-8 caps a day. I dosed it twice daily. I noticed reduced appetite over the course of the time and subtle leaning effects. On days where I ate that I felt I went "overboard" slightly (all clean food) I still wasnt affected by it and actually woke up leaner. It's a great product and I think it's worth a shot to use and see if u personally like it. I will absolutely be using the remainder of the bottle and buying more
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Glad to hear that, brother.
 
chedapalooza said:
I used it for 21 days at 6-8 caps a day. I dosed it twice daily. I noticed reduced appetite over the course of the time and subtle leaning effects. On days where I ate that I felt I went "overboard" slightly (all clean food) I still wasnt affected by it and actually woke up leaner. It's a great product and I think it's worth a shot to use and see if u personally like it. I will absolutely be using the remainder of the bottle and buying more
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Awesome man, solid feedback!

Mike
 
Production is not going to make it in time. We had to resend one of the ingredients for a third time.
 
Bumping this up....we BLASTED through the entire last run in a matter of a few weeks. Trying to get this restocked before the Holiday Season gets underway.
 
mr.cooper69 said:
I think you should stick to Matt's limit. The glycyrrhetinic acid is notorious for causing electrolyte disturbances/hypertension if used for too long or at too high a dose. I believe Matt's dosing protocol is grounded in the fact that he wants your body to return to homeostasis as far as fluid balance is concerned.
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i hate this stuff, it was inside a sleeping supplement i got from the supermarket here. got Hypertension and messsed up electrolytes had no idea what was going on really scary stuff. hands were all weird i was so worried, couldn't figure out what was wrong with me, thought it was ArA or Calcium. learnt my lesson lol, stay right away from that chit.

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Defuse should be part of everyone's holiday avoid the fat stack.
 
Just now reading about this product...right up my alley all year with my typical dietary discipline, especially from Thanksgiving to new year's...will be grabbing some of this

Ordered today - noob question as I am just now familiarizing myself with this...can we take this post workout?? Will that hinder teh gainzzz at all?? I eat the vast majority of my calories shortly after my workout.
 
warnerve said:
Just now reading about this product...right up my alley all year with my typical dietary discipline, especially from Thanksgiving to new year's...will be grabbing some of this

Ordered today - noob question as I am just now familiarizing myself with this...can we take this post workout?? Will that hinder teh gainzzz at all?? I eat the vast majority of my calories shortly after my workout.
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Should be fine to take anytime.
 
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