FWIW towards the conversation I am just finishing up a 5 week run of PP's Dermacrine. I have had no issues of gyno or gyno related symptoms.
whats the daily dose of DHEA in it?FWIW towards the conversation I am just finishing up a 5 week run of PP's Dermacrine. I have had no issues of gyno or gyno related symptoms.
Since its a transdermal I am sure it varies but roughly ???mg's/application is my understanding.whats the daily dose of DHEA in it?
how many applications are recommended in a day?Since its a transdermal I am sure it varies but roughly 700mg's/application is my understanding.
One daily dose contains 56mg DHEA and 21 mg pregnenolone.how many applications are recommended in a day?
smart move because that study has never been duplicated and is considered to be an anomalyThere are studies that show 1600mg being used for prolonged periods of time by men with no ill effects at all and excellent repartitioning too, would you prefer I put heavily weighted studies like that in here?! I would be guilty of cherry picking studies just like the op was, so no, I won't do that.
Pat,
If your suggesting that supplementing with DHEA will cause gyno, make you fat and block your muscle gains, that is flat out wrong. Out of the hundreds of users of Dermacrine, which probably has a dose comparable to a 700mg/oral dose of DHEA, we’ve maybe had 1-2 complaints about “sore nipples”… the rest of the feedback was from guys that reduced BF, increased their lifts, and found a new untapped energy source.
DHEA converts to many more hormones besides 5-Adiol. (BTW, 5-Adiol is great for the immune system) Consider the metabolites 4-Adiol, Triol, Adione, Stanedione, Stanediole, Test, 7-alpha DHEA, 7-oxo DHEA, ect. This is only part of a whole hormone milieu from DHEA which encourages muscle gain, fat loss and sexual function.
As I explained in my previous post, in-vitro studies with cancer-cell lines often have little to do with the real-world effects with supplements. Especially studies using irrelevant super-physiological doses in isolated cell-lines.
-Pp
everyone should know that this is a famous study and has been discussed in great detail. that is because it was never duplicated.http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=2961787&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Fair enough Jason, but I'm telling you, you really have to try it to know. All these studies can provide guidelines but that's about it.
I really hope SDNG does not contain a healthly dose of DHEA, Because i've read that you don't need a serm!supplementing dhea can cause gyno. it won't make you fat and its effects on muscle probably are neutral.
dhea in large dosages will cause a strong estrogenic effect in the male - the research is clear on this.
many of these studies are not related to cancer and all taken together give a convincing argument that males should avoid high dosages or at least take them with a SERM
5-ad is by far the largest metabolite of dhea. the other ones you mention are minor in comparison
caveat emptor
Same to you..
I asked a question about SDNG... I was hopeing to get an educational response.
Actually here is another study showing a decrease in fat mass and an increase in strength in men – (hardly an “estrogenic effect")everyone should know that this is a famous study and has been discussed in great detail. that is because it was never duplicated.
FYI, 30% absorbed with a topical is very possible with current technology. Look at this study on a transdermal delivery system, which performed 3x better than androgel (30% absorbed after curve) We believe our topical technology is even a step beyond this, which gives us an edge on the competition with about 40% estimated delivery rate.most transdermal steroid products average no more than 10-20% bioavailability. So whatever dose is in the transdermal, divide by 5-10
Well I try to make this a 'side effect' of practically every supp I develop (including ng) but sure, I can make one specifically for that if ya like. I will need testers, of course.Dr. D shoudnt you be in the lab working on 69-AD our new pleasure pleaser supplement ? Oh whoooops thats privelaged info isnt it
Man oh man make it to work on womenz my wife needs a double dose ....man she would kick my a$$ for thatWell I try to make this a 'side effect' of practically every supp I develop (including ng) but sure, I can make one specifically for that if ya like. I will need testers, of course.
FYI, 30% absorbed with a topical is very possible with current technology. Look at this study on a transdermal delivery system, which performed 3x better than androgel (30% absorbed after curve) We believe our topical technology is even a step beyond this, which gives us an edge on the competition with about 40% estimated delivery rate.
Pharmacokinetics of a new transdermal testosterone delivery
system, TDS-testosterone, in healthy subjects
Chik Z, Johnston A, Tucker A, Chew SL, Michaels L, Alam CA
Br J Clin Pharm 2006; 61: 275-279
Considering oral DHEA is absorbed at about 3% and our topical is absorbed by at least 30% the dose in Dermacrine could actually be considered about 10x more powerful than the equivalent dose taken orally. AND, that isn’t even taking into account the increased steroidogenic activity in the skin and increased conversion to DHEA’s metabolites.
Truce?
-Pp
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