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Dexaprine 3rd Party Test

Royd The Noyd

Royd The Noyd

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If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone.

I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.


A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.

AuthorsVenhuis B, et al. Show all Journal
Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]

Affiliation
Abstract
Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
 
I tried but came up empty
 
Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
 
Geoforce said:
Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
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I'm not sure. Hard to keep up. This is the label currently on their website for XR which matches what this analysis found.

Invalid Link Removed
 
Royd The Noyd said:
If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone. I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. AuthorsVenhuis B, et al. Show all Journal Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print] Affiliation Abstract Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as ?-methyl-?-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
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Just bought mine and have some left over as well.

Pea's are pretty damn cool. Especially with an Mao b inhibitor and a couple added goodies. For the purpose of going out
 
Royd The Noyd said:
If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone.

I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.


A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.

AuthorsVenhuis B, et al. Show all Journal
Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]

Affiliation
Abstract
Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
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Everything they listed is a constituent of natural extracts which we use. This witch hunt is going strong.
 
VaughnTrue said:
not a clue sorry man
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Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
 
PuZo said:
Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
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Do you have the full text? 98% of studies on specific supplements like this do not list the actual name of the supplement in the abstract. I'm surprised they even included "Dexaprine" in the abstract.
 
Royd The Noyd said:
Do you have the full text? 98% of studies on specific supplements like this do not list the actual name of the supplement in the abstract. I'm surprised they even included "Dexaprine" in the abstract.
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I do not. It's more alarmist propaganda. Everything they found was as listed on the label so it comes to question if whoever made this study has some sort of an agenda.

This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances
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Everything they found was declared... so...:bsflag:
 
PuZo said:
I do not. It's more alarmist propaganda. Everything they found was as listed on the label so it comes to question if whoever made this study has some sort of an agenda.



Everything they found was declared... so...:bsflag:
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Alarmist propaganda? Lol you cannot be serious. Do you know what a peer reviewed journal is?

How do you know if everything they found was declared if you don't even know which version of Dexaprine they tested?
 
Geoforce said:
Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
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Correct. I still have some v1 and 3 bottles of v2 i bought on ebay 2 months ago at 20$ each lol...
 
PuZo said:
Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
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FYI - reading an abstract does not equal reading a study.

The point of the thread is to see if someone has access to the text so he can see if it is mentioned in thr study.


PuZo said:
It's more alarmist propaganda.
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A few people had bad reactions to a product. In an industry that is notorious for spiking products they figured they would test the pills and see if there was anything extra in it. They list what they would which if it is XR then there wasnt anything extra.

How is this alarmist propaganda?

Showing that a product meets label claims and isnt spiked (assuming it was xr) is alarmist propaganda?
 
Royd The Noyd said:
Alarmist propaganda? Lol you cannot be serious. Do you know what a peer reviewed journal is?

How do you know if everything they found was declared if you don't even know which version of Dexaprine they tested?
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JudoJosh said:
A few people had bad reactions to a product. In an industry that is notorious for spiking products they figured they would test the pills and see if there was anything extra in it. They list what they would which if it is XR then there wasnt anything extra.

How is this alarmist propaganda?

Showing that a product meets label claims and isnt spiked (assuming it was xr) is alarmist propaganda?
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I was speaking in part due to the comment at the end:

This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances
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What undeclared active substances did they find? The propaganda is you're scaring the general public by spreading misinformation. There are 2 point of views from this abstract. You have the one that says everything found in their test was listed on the ingredient panel, and then you have the other stating undeclared active substances... so which is it?
 
PuZo said:
I was speaking in part due to the comment at the end:



What undeclared active substances did they find? The propaganda is you're scaring the general public by spreading misinformation. There are 2 point of views from this abstract. You have the one that says everything found in their test was listed on the ingredient panel, and then you have the other stating undeclared active substances... so which is it?
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They tested the product and indicated something in it was undeclared. There is nothing in the abstract that states everything they found was listed in the ingredient panel. They are spreading factual information based on their findings. Just bc the abstract doesn't list the undeclared ingredient doesn't mean there wasn't one in there.
 
All I know about dexaprine XR is that that **** had me shaking worse than clenbuterol. Made me hot and jittery with chills. Thoroughly unpleasant.
 
I still have a bunch of the original. I'll pass it out at work and see what everybody has to say, haha.
I liked it when I tried it. :)
 
Could they be talking about the β-methyl-β-phenylethylamines when they say "undeclared".
 
haiz69 said:
Could they be talking about the β-methyl-β-phenylethylamines when they say "undeclared".
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Well, considering that is most likely in reference to acacia rigidula, then probably not:

Invalid Link Removed
 
BamBam0319 said:
All I know about dexaprine XR is that that **** had me shaking worse than clenbuterol. Made me hot and jittery with chills. Thoroughly unpleasant.
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Same here! I had to bin the bottle - the worst stim I have ever taken. I'm not bashing iFroce, because I do use some of their other products, but this one felt dangerous.
 
PuZo said:
Well, considering that is most likely in reference to acacia rigidula, then probably not:

Invalid Link Removed
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I only say that because since the label only list Acacia and not what it is standardized for, that when they found the phenethylamines, that they would consider them "unlabeled".
 
Royd The Noyd said:
I think this is exactly what we will come to find out. Maybe...
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That would be my guess, especially considering all the hoopla over different forms of B-PEA's being structurally similar to amphetamine. Of course, we know that they don't act that way secondary to varied metabolism, but most won't dig that deep.
 
haiz69 said:
I only say that because since the label only list Acacia and not what it is standardized for, that when they found the phenethylamines, that they would consider them "unlabeled".
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And that's the issue we face. Are these authors familiar with DSHEA, in it's entirety, and what is allowed to be labelled.
 
Royd The Noyd said:
DSHEA is a USA law. Not the same as the European Commission regulations.
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Very well then. Are the authors familiar with the European Commission regulations?
 
I briefly looked over the full study (4 pages).. their main gripe is that they want active's to be listed on the label.
They also claim unnaturally high levels of theophylline.. which doesn't really make sense...

That's like saying a 5g serving of creatine mono contains "unnaturally" high levels of creatine that you can't find in nature.
 
PuZo said:
I briefly looked over the full study (4 pages).. their main gripe is that they want active's to be listed on the label.
They also claim unnaturally high levels of theophylline.. which doesn't really make sense...

That's like saying a 5g serving of creatine mono contains "unnaturally" high levels of creatine that you can't find in nature.
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They may be saying that the theophylline content exceeds that which is naturally extractable from the plant.
 
mr.cooper69 said:
They may be saying that the theophylline content exceeds that which is naturally extractable from the plant.
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They are most definitely saying that. They also claim it is cheaper to use synthetic forms rather than naturally extracting said substances(in a negative connotation).
 
PuZo said:
I briefly looked over the full study (4 pages).. their main gripe is that they want active's to be listed on the label. They also claim unnaturally high levels of theophylline.. which doesn't really make sense...That's like saying a 5g serving of creatine mono contains "unnaturally" high levels of creatine that you can't find in nature.
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mind sharing the FT?
 
Can't get this in Australia anymore :( We only had the powder version, not the pills - I think the pills had yohimbine which is banned here.

I can't post the link but article text from the newspaper:

One person has been hospitalised after consuming a sports drink with an amphetamine-like substance and illegal levels of caffeine.

The energy drink, Dexaprine XR Green Apple, has illegal levels of caffeine and an amphetamine-like substance, and on Thursday was recalled by the manufacturer.

One Australian has required hospitalisation after drinking Dexaprine XR Green Apple, which is sold in sports supplement stores in ACT, NSW, Victoria, Queensland, South Australia, Western Australia and online.

In a statement on Thursday, ACT Health said the product contained prohibited levels of caffeine, prescription-only substances and an amphetamine-like substance.

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An ACT Health spokeswoman said one ACT business, with three outlets in Canberra, had been identified as a distributor, as well as an unknown number of online outlets.

"The health detection service inspected the ACT outlet and determined there was no product present in that outlet," she said.

"The business reports the stock of the product has not been received or sold."

She said the official national product recall had been issued by Food Standards Australia and NZ on May 6.

ACT Health said consumers should not drink the product and return it for a full refund at the place of purchase.

It is sold as a powder in a 120 gram plastic tub, with an expiry date of November 2018, and has been made by Kings Sports Industries Pty Ltd
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Personally, I never had any problems with it and probably another case of a person using it stupidly. That said, I did have a bit of a gripe that the nutrition label says 1 scoop = 1 serve but in actual fact, 1 scoop = closer to 2 serves so it could be quite easy to unknowingly use more of the product than is intended.
 
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