Its also hard to know whats really in the stuff thats available because at least on the label it states that its a plant extract.
But there is no Urolithin B in any plant on earth. Its a human metabolite. So either the labels are a lie or the ingredient is not present.
This isnt to badger OL, just the facts.
This also means that whatever the dose is on the label you will get VASTLY less in reality because if its a metabolite you will only get a tiny fraction of the original extract because, of course its not 100% conversion and its not at all 100% urolithin b conversion. Id be surprised if there was 5% of the original extract that became urolithin b.
Its like taking a prohormone supp that has 7 prohormones each that have a tiny conversion % and then labeling that 100% of the total original substance is one of the metabolites.
Invalid Link Removed 2006 Nov 15;54(23):8956-61.
Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers.
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Abstract
The intake of polyphenols has been demonstrated to have health-promoting and disease-preventive effects. The pomegranate (Punica granatum L.), which is rich in several polyphenols, has been used for centuries in ancient cultures for its medicinal purposes. The potential health benefits of pomegranate polyphenols have been demonstrated in numerous in vitro studies and in vivo experiments. This study investigated the absorption and antioxidant effects of a standardized extract from pomegranate in healthy human volunteers after the acute consumption of 800 mg of extract. Results indicate that ellagic acid (EA) from the extract is bioavailable, with an observed C(max) of 33 ng/mL at t(max) of 1 h.
The plasma metabolites urolithin A, urolithin B, hydroxyl-urolithin A, urolithin A-glucuronide, and dimethyl ellagic acid-glucuronide were identified by HPLC-MS. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 32% after 0.5 h, whereas the generation of reactive oxygen species (ROS) was not affected. The inflammation marker interleukin-6 (IL-6) was not significantly affected after 4 h after the consumption of the extract. Overall, this study demonstrated the absorbability of EA from a pomegranate extract high in ellagitannin content and its ex vivo antioxidant effects.
PMID: 17090147 DOI:
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[Indexed for MEDLINE]