From PA's blog on Rikkunsh!to "Two chemical constituents of Rikkunsh!to proposed to be responsible for these effects are Hesperidin and Atractylodin. Hesperidin is thought to increase Ghrelin secretion via antagonizing a subtype serotonin receptor known as the 5-HT2b/2c receptor. Atractylodin is believed to sensitize the ghrelin receptor, thereby amplifying the physiological effects of the increased ghrelin secreted into the bloodstream."
Intradesting
I have been talking to one of the guys who ran a study on rikkun****o and its actually VERY interesting.
The best rikkun****o is Tsumura CO rikkun****o. Its prescription drug in Japan actually.
It will make your appetite go thru then roof.
Used for :
Persons with weak digestion, no appetite, (anorexia)fullness and epigastric distress, lack of stamina, anemia, cold hands and feet, gastritis, gastric catarrh, indigestion, stomachache, and vomiting.
In the original rikkun****o its 8 ingredients.
And one of the sides can be low potassium ..
Rikkun****o contains Glycyrrhiza, which is a plant (used agains stomach problems, one of the benefits of Rikkun****o).
Side effects of this plant are - if you are overdosing (using more than 50g per day) over four weeks - a possible differentiation of the electrolyte-concentration in the body and a "Hypokaliämie" (too low level on potassium, which is caused by the flavonides) or a "Hypernatriumämie" (too much sodium/natrium which can cause water retention and high blood pressure).