cortisol supp

GQNemesis said:
good to hear, stacking it with something ?
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My current stack is:

Reduce XT
SNS ALCAR
Metabolic BioShock
Beverly Proteins
Peak Beta+
Accelerant
Alpha Max
BioForge
Anavite
Recompadrol

That and some fish oil, magnesium, a few general health supps like Lipid Stabil. All seems to be helping out quite well, I'm 240 and staying lean enough to see my abs.
 
I've been getting a lot of good feedback from lean fx. One of my friends have shredded up nicely on it.

The only cort control product I've personally had experience with was the old IBE X-Lean. I did remember liking it.
 
mr.cooper69 said:
It depends on the MOA, See below of 11b-HSD1. Transdermal 7-keto is best for a cut due to its effects on liver enzymes (of the thermogenic variety)



Alright, but your recommendation is poor then. Cortisol stimulates lipolysis fat loss, and reduce xt inhibits cortisol production in 11b-HSD1 sensitive tissues like adipose, but not in muscle tissue. Cortisol also promotes adipogenesis. So an 11b-HSD1 inhibitor would be best taken when in a pro-adipogenic state, and it would be less effective or even counterintuititive in a deficit.
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So Reduce XT would be best used during a bulk (to lessen cortisol-promoted-adipogenesis)? In other words, adipogenesis can only occur in a caloric surplus, so bulking is the only time you would want to prevent cortisol from promoting the extra adipogenesis? (A bit confused.)

Which cortisol supplements function to preserve muscle (by inhibiting cortisol production in muscle tissue)?


Sorry, I've never really found the need to post until now--as this conversation is very relevant to my supp. usage.
 
Abliterate IMO.. drastically noticable results real fast. For at least 8 weeks in every contest prep it's included.. love it!

Mike
 
Would Abliderate AMMO work in a similar fashion and be best in a cut? Picked some up on Black Friday and wondering when is best to run it
 
I cycle erase pro for the cortisol benefits. I also dose Ashwagandha 3-5 times throughout the day and drink a protein shake with dextrose during my workout (Layne Norton tip).

I've heard of Reduce XT, but I'm saving it for a bulk or lean mass gain phase.

Are there any other supps/methods to reduce cortisol? (besides meditation)
 
The Engineer said:
I cycle erase pro for the cortisol benefits. I also dose Ashwagandha 3-5 times throughout the day and drink a protein shake with dextrose during my workout (Layne Norton tip).

I've heard of Reduce XT, but I'm saving it for a bulk or lean mass gain phase.

Are there any other supps/methods to reduce cortisol? (besides meditation)
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Don't fear cortisol. People overly fear whereas it actually serves a very important purpose.

From ZiR:

Take a look, cortisol was associated with changes in type II fiber CSA and LBM.

It may actually be the link between why people gain muscle signficantly faster when they are on hormones and training vs. just on hormones.






Eur J Appl Physiol. 2012 Jul;112(7):2693-702. Epub 2011 Nov 22.

Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training.

West DW, Phillips SM.
Source

Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, Hamilton, ON, L8S 4K1, Canada.

Abstract

The purpose of this study was to investigate associations between acute exercise-induced hormone responses and adaptations to high intensity resistance training in a large cohort (n = 56) of young men. Acute post-exercise serum growth hormone (GH), free testosterone (fT), insulin-like growth factor (IGF-1) and cortisol responses were determined following an acute intense leg resistance exercise routine at the midpoint of a 12-week resistance exercise training study. Acute hormonal responses were correlated with gains in lean body mass (LBM), muscle fibre cross-sectional area (CSA) and leg press strength. There were no significant correlations between the exercise-induced elevations (area under the curve-AUC) of GH, fT and IGF-1 and gains in LBM or leg press strength. Significant correlations were found for cortisol, usually assumed to be a hormone indicative of catabolic drive, AUC with change in LBM (r = 0.29, P < 0.05) and type II fibre CSA (r = 0.35, P < 0.01) as well as GH AUC and gain in fibre area (type I: r = 0.36, P = 0.006; type II: r = 0.28, P = 0.04, but not lean mass). No correlations with strength were observed. We report that the acute exercise-induced systemic hormonal responses of cortisol and GH are weakly correlated with resistance training-induced changes in fibre CSA and LBM (cortisol only), but not with changes in strength.
 
antihero said:
Exceptional stuff. But for doses to show a dramatic physical impact, its just not cost effective. Although it does have some excellent cognitive benefits at an affordable dose.
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That's what I was going to say. It as the literature to support it, but isn't the most economically feasible cortisol reduction supplement.
 
Driven2lift said:
Would Abliderate AMMO work in a similar fashion and be best in a cut? Picked some up on Black Friday and wondering when is best to run it
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It could be used on a cut or a lean bulk. Some users have reported appetite suppression on the morning dose, but honestly I haven't found it super strong in that regard when I ran it.
 
On the AMMO bottle it warns against using stimulants with it, I assume most people do anyways? I always have a stim/burner in my cuts.

Is it only saying that because of cortisol rise from stim use? Because my goal is to offset that
 
Driven2lift said:
On the AMMO bottle it warns against using stimulants with it, I assume most people do anyways? I always have a stim/burner in my cuts.

Is it only saying that because of cortisol rise from stim use? Because my goal is to offset that
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That would be my assumption as well.
 
Driven2lift said:
On the AMMO bottle it warns against using stimulants with it, I assume most people do anyways? I always have a stim/burner in my cuts. Is it only saying that because of cortisol rise from stim use? Because my goal is to offset that
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Hopefully a rep can chime in on that. I'm not concerned with the subsequent rise in cortisol from stimulant usage.
 
aaronuconn said:
Hopefully a rep can chime in on that. I'm not concerned with the subsequent rise in cortisol from stimulant usage.
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Exactly my thoughts. I assume the only reason stims are listed is that they would to some extent conflict with the effects.
 
I started my reduce xt today. I took 1.cap at 9am. At 930 i had a banana and some avocado, and at 945 i just started up at the gym. When i took the cap at 9, i took it with 1gram agmatine, potassium nitrate, and a scoop of creatine. Took 2nd cap at 1 pm and will take the 3rd before bed with zma.

Anyone see any issues with this or suggest a better way of dosing?
 
srocco112 said:
I started my reduce xt today. I took 1.cap at 9am. At 930 i had a banana and some avocado, and at 945 i just started up at the gym. When i took the cap at 9, i took it with 1gram agmatine, potassium nitrate, and a scoop of creatine. Took 2nd cap at 1 pm and will take the 3rd before bed with zma.

Anyone see any issues with this or suggest a better way of dosing?
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i could be wrong but have been told not to take cortisol lowering supps pre workout, you want cortisol to help you push through the workout.
 
rhoadx said:
i could be wrong but have been told not to take cortisol lowering supps pre workout, you want cortisol to help you push through the workout.
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Since it looks like he trains close to when he wakes up, I think he's okay to dose at 9AM, which I'm assuming is upon waking.
 
Well usually i wake up at about 430-5 am and go to the gym but i was off of work the day i woke up at 9.

Either way, i always go close to waking up
 
Great, thanks!

What are some of the effects that you will "feel" from lowered cortisol? Or is it more so what u will "see"?
 
If too low, moody, stagnant training, loss of appetite.

Visually, if lowered just enough, lower abdominal definition
 
Reduce XT doesn't lower systemic cortisol so those side effects won't manifest. It lowers cortisol in brain, liver, and adipose, specfically
 
mr.cooper69 said:
Reduce XT doesn't lower systemic cortisol so those side effects won't manifest. It lowers cortisol in brain, liver, and adipose, specfically
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Reduce XT is a 7oh product right? My understanding is that 7OH converts to 7-oxo(and 7oxo to 7oh) using the enzyme 11betaHSD1. While this enzyme is busy doing That it does not convert the inert cortisone to cortisol. This should not be site specific. What I don't understand from your post is how it lowers cortisol only in brain, liver and fat. Can you explain please?
 
Rostam said:
Reduce XT is a 7oh product right? My understanding is that 7OH converts to 7-oxo(and 7oxo to 7oh) using the enzyme 11betaHSD1. While this enzyme is busy doing That it does not convert the inert cortisone to cortisol. This should not be site specific. What I don't understand from your post is how it lowers cortisol only in brain, liver and fat. Can you explain please?
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Why does you say it's not site-specific? All it takes is mapping of the 11b-HSD1 enzyme in the body, and sure enough, it's in the 3 tissues I listed chiefly.
 
Rostam said:
Reduce XT is a 7oh product right? My understanding is that 7OH converts to 7-oxo(and 7oxo to 7oh) using the enzyme 11betaHSD1. While this enzyme is busy doing That it does not convert the inert cortisone to cortisol. This should not be site specific. What I don't understand from your post is how it lowers cortisol only in brain, liver and fat. Can you explain please?
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it's only expressed heavily in those 3 places
 
Being heavily expressed in these 3 sites doesn't mean 7oh will reduce the cortisol only at these sites.
 
What info? I'm just saying it will probably reduce cortisol where ever the enzyme is. Even if it's mainly expressed in the 3 mentioned sites. Sin' that true?
 
Rostam said:
What info? I'm just saying it will probably reduce cortisol where ever the enzyme is. Even if it's mainly expressed in the 3 mentioned sites. Sin' that true?
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So if 99% of the enzyme is in those 3 tissues (hypothetical), then yes, the extra 1% in the body will be inhibited, which contributes to virtually no cortisol production for those organs and is thus negligible.
 
EBF_2356 said:
If too low, moody, stagnant training, loss of appetite.

Visually, if lowered just enough, lower abdominal definition
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Hmm i was hoping to steer clear of the moody side effect. Dosing reduce xt at a 1-1-1 daily routine seems to be on the lower side of what the bottle calls for. Do you thi k that at this dose i should be ok and not have to worry about cortisol being "too" low?
 
srocco112 said:
Hmm i was hoping to steer clear of the moody side effect. Dosing reduce xt at a 1-1-1 daily routine seems to be on the lower side of what the bottle calls for. Do you thi k that at this dose i should be ok and not have to worry about cortisol being "too" low?
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Just be on the look out for any side effects, but Mr. Cooper explained Reduce XT's effects very well.
 
Well today is day 3. I do feel my work outs and mood have been a bit draggy, but relate that to the fact i cut out my pre workout stims. Figured 2.5 days is not lonh enough for any neg sides from.the reduce xt
 
srocco112 said:
Well today is day 3. I do feel my work outs and mood have been a bit draggy, but relate that to the fact i cut out my pre workout stims. Figured 2.5 days is not lonh enough for any neg sides from.the reduce xt
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It does sound that it's mostly due to cutting out the stims. If sides do occur, you could try dropping down to dosing 2 per day.
 
Beside the fat loss in low stomach - any other areas known to see fat loss or other physical changes/recomp?
 
Interesting

How would this stuff fair for someone who has adrenal exhaustion? Contraindicated?

I originally would have assumed yes, but given some of these recent posts, perhaps one could still use it for fat loss /fat gain prevention w/o it adversely affecting systemically low cort levels (adrenal fatigue)

mr.cooper69 said:
Reduce XT doesn't lower systemic cortisol so those side effects won't manifest. It lowers cortisol in brain, liver, and adipose, specfically
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Whacked said:
Interesting

How would this stuff fair for someone who has adrenal exhaustion? Contraindicated?

I originally would have assumed yes, but given some of these recent posts, perhaps one could still use it for fat loss /fat gain prevention w/o it adversely affecting systemically low cort levels (adrenal fatigue)
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There is no such thing as adrenal fatigue induced by stimulant use. If you have an actual medical condition, there are worthwhile drugs to look into.
 
Not by "just" stim use, from the stresses of life, LOL

mr.cooper69 said:
There is no such thing as adrenal fatigue induced by stimulant use. If you have an actual medical condition, there are worthwhile drugs to look into.
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Thx coop

mr.cooper69 said:
Yeah I got ya. Still, your body should be able to handle stress without hormone depletion. If anything, cortisol levels will be higher from the stresses of life, not lower
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Well i couldnt hold out any longer. I know it is suggested to lay off of stims when using reduce xt but i have gone only 3 days without my pre workout and i feel so dull and unmotivated in the gym. I wake up at 430 am to hit the gym so that morning jolt is really needed. I decided to have a coffee today (which i think is a bit better than an actual pre wo) it was drank about an hour after my reduce xt dose and about 45 mins prior to gym, taken with my kno3 and agmatine. I think ill continue like this because man, waking up.at 430 and trying to kill it in the gym with no boost is pretty hard.
 
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