NOTE: Glucagon like peptide-1 is NOT glucagon. It ACTUALLY stimulates the secretion of insulin and INHIBITS the release of glucagon. GLP-1 is a derivative of the proglucagon molecule. Proglucagon is the precursor to both glucagon and GLP-1. Both of which have opposing actions.
I had to look up the above since I never head of GLP-1 before but knew it wasnt the samething as str8 glucagon.
The question you must ask yourself is this: Does dietary intake of protein release glucagon?
The answer is it would be biochemical counterintuitive to release a catabolic hormone when the desirved activity is anabolism.
Remember when i said glucagon and insulin oppose each other? Well if they oppose each other, they will not be released simultaneously. This will cause the body to both store and to degrade simultaneously. This is a no go. Either the body is storing the food it has taken in, or it is trying to produce energy in from stored reserves.
Again GLP-1 will be released at the same time as insulin b/c it is a potent scretagogue of insulin and will potentiate its release.
See now you got me reading and I was right in the fact that High protein meals do cause a release in glucagon. Everywhere I look I find the same result regarding that. A simple search for high protein meal and glucagon release will pull up tons of articles and studies.
One interesting thing I found is that Glucagon has no effect on skeletal muscle. So in that aspect it is not catabolic, also Glucagon and Insulin reside in the body at all times. They don't oppose each other in the aspect that they can't be in the body at the same time but they oppose each other in that they create a balance with one another.
I would have to go directly to PubMed for some other searches if needed but this is the best explanation I have found. It is quite a read but explains the insulin / glucagon balance, the different things that cause secretion of both and how they have effects on each other. Has a lot of good graphs and tables in it explaining the differences on different aspects of physiology and metabolism.
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So we are both correct in our understanding of the process however not how they interract with one another. One interesting though comes tomind after reading this. A high protein meal causes a release in glucagon the glucagon increases insulin sensitivity. So I wonder if without fasting one could use a high protein meal void of carbs to increase glucagon increasing lypolsis and insulin sensitivy then eat a high carb containing meal and take advantage of the increase insulin sensitivity as if they had fasted most of the day. Reason I wonder this is maybe just maybe a meal of pure protien after my morning workout would supply my muscle with plenty of aminos since Glut 4 transport is increaed via muscle activity even in the absence of adequate levels of insulin, which would be the case in that situation.
Another consideration is that during physical activity the insulin release is lowered and the glucagon release is increased. Which would explain why they say not to take in carbs during your workout. It also explains why in another thread it was mentioned that studies showed that a 10-20 gram of protein meal before cardio actually increases the amount of fat burned during the session. Well if the glucagon is already elevated from the protein the hormonally you are already set to burn fat before even stepping on the treadmill then you increase the energy expenditure and glucagon release during the activity which in turn further enhances the lipolsys.
Anyway I am to excited about some of the revalations that this article has brought to my attention about other things I have been learning recently. Please go have a look at the article and let me know what you think.
Also this one just has a few references that mention that high protein causes a release in Glucagon.
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Look down toward the bottom you will see a Section saying Control of Glucagon Secretion where it again referes to protein, high amino content in the blood prompting the release of glucagon.
Is it just me or is the spelling of lypolsis just elusive? I feel I spelled it wrong in at least 3 different ways through out the post.
Andres let me know if that article goes along with your current knowledge. I am assuming that it will.