Anyone interested in us doing a GH product?

CompEdgeLabs

CompEdgeLabs

Board Sponsor
I have gotten some emails and pm's of some people wanting to see us do a product of this type, so I wanted to post a thread and see what the demand would really be like.

I would love to hear some opinions of what people would like to see in one and if we do decide to do one, if anyone throws out a name we go with, it'll be worth a free bottle when it comes out.
 
I`d be interested for sure. Ghen X. Something that would promote GH secretion as well as the fat loss properties of real GH WITHOUT any stims. Maybe combine a mild PH(Furaz, Halovar, Epi, etc) and make a super gh/hardener.
 
HELL YEAH, there aren't too many of them out there; good quality ones that is. And the ones out there need some good competition. So they can step their game (formulas) up.
 
I've always been interested in trying a GH product...I would definitely be interested in a CEL GH product...quality
 
testosteronet said:
For one, safed musli does absolutely nothing for gh, maybe to raise test, but not gh...secondly, it raises prolactin, which to me is very undesirable...
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Thanks. Let me clarify that as you can probably see, this is a category of products that I am not too familiar with, so its a learning process for me.

The Safed seems to be a main constituent in the AN product, so I was curious on that. I hadnt seen anyone complain about prolactin issues with it, but as I said I havent had time to fully look into it yet.

manofmany said:
I haven't read that writeup but it's been theorized that green tea can help l-dopa cross the BBB.
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Thank you.

matt352 said:
I've always been interested in trying a GH product...I would definitely be interested in a CEL GH product...quality
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Thanks. If we do a product like this, we plan on doing it right. I am doing my best to research the best ways to do this type product, and also will be consulting with some people that have a far better knowledge level on this subject than myself.
 
GH products are great, atleast the one's i've tried, they might not add crazy amounts of muscle like some ppl want, but they keep my strength up while leaning out a bit which i love.....the thing about most of them is the price, they are a bit pricey compared to other supplements...name...CompetitiveGH
 
Gh isn't for massive muscle gain. LBM is where it shines. With the right doses and ingredients it would be awesome. Any update?
 
testosteronet said:
For one, safed musli does absolutely nothing for gh, maybe to raise test, but not gh...secondly, it raises prolactin, which to me is very undesirable...
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I don't know much about safed musli (and don't have time to look it up), but l-dopa has pretty potent anti-prolactin properties, so the combination (if beneficial in terms of test and/or GH effects) may not be causing much in the way of prolactin issues.

I know a lot of people use l-dopa or alternatively dopamine agonists to reduce prolactin on "tren" cycles since it has a knack for causing a pain-in-the@$$ gyno "syndrome" (sad lol).

I know wikipedia isn't a source, but it cites sources (lol), and it says the following well:

Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. [16] Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin.
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Not wikipedia:):

Biochem Pharmacol. 2005 May 15;69(10):1523-31.

Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies.

Chen D, Wang CY, Lambert JD, Ai N, Welsh WJ, Yang CS.

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA.

(-)-Epigallocatechin-3-gallate (EGCG) is the major polyphenol present in green tea. We previously demonstrated that EGCG was both a substrate and potent inhibitor of human liver cytosolic catechol-O-methyltransferease (COMT). We now report the structure-activity relationship for the inhibition of COMT-catalyzed O-methylation of catecholestrogens in human liver cytosol by tea catechins and some of their metabolites. The most potent inhibitors were catechins with a galloyl-type D-ring, including EGCG (IC(50)=0.07 microM), 4''-O-methyl-EGCG (IC(50)=0.10 microM), 4',4''-di-O-methyl-EGCG (4',4''-DiMeEGCG) (IC(50)=0.15 microM), and (-)-epicatechin-3-gallate (ECG) (IC(50)=0.20 microM). Catechins without the D-ring showed two to three orders of magnitude less inhibitory potency. Enzyme kinetic analyses revealed that EGCG behaved as a mixed inhibitor, whereas 4',4''-di-O-methyl-EGCG exhibited competitive kinetics for the S-adenosylmethionine (SAM), and noncompetitive kinetics for the catechol binding site. These compounds may represent a new type of COMT inhibitor. In silico molecular-modeling studies using a homology model of human COMT were conducted to aid in the understanding the catalytic and inhibitory mechanisms. Either D-ring or B-ring of EGCG could be accommodated to the substrate binding pocket of human COMT. However, the close proximity (2.6A) of 4''-OH to the critical residue Lys144, the higher acidity of the hydroxyl groups of the D-ring, and the hydrophobic interactions between the D-ring and residues in the binding pocket greatly facilitated the interaction of the D-ring with the enzyme, and resulted in increased inhibitory potency. These results provide mechanistic insight into the inhibition of COMT by commonly consumed tea catechins.

PMID: 15857617.
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So there is some basis for green tea extract (about 4 studies in humans) having an inhibitory effect on COMT in the liver. But:

COMT is, however, a relatively minor metabolizing enzyme for L-Dopa as opposed to aromatic acid decarboxylase (AADC). A two-pronged pharmaceutical approach has been developed in which entacapone (a COMT inhibitor) and carbidopa are combined with L-Dopa to increase brain L-Dopa levels in Parkinson's Disease patients. Only inhibiting COMT, however, will likely have minimal effects on L-Dopa metabolism.
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I don't know how safed fits into the picture, but I do know that maca puriens + l-dopa extract combos are popular as prolactin antagonists in the supp world. So perhaps the combo increases blood-brain-barrier penetration by l-dopa (which should control prolactin to some extent). How this all adds up to boosting GH, I sure as hell don't know.
 
testosteronet said:
Couple more things, leave GABA out since ai put it in theirs and don't give us no proprietary blend...
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Why would you want us to leave something out just because another company puts it in their product? Designing products is about providing the best product, not using or not using what someone else is.

Are you saying you dont think GABA is effective?

Young Gotti said:
GH products are great, atleast the one's i've tried, they might not add crazy amounts of muscle like some ppl want, but they keep my strength up while leaning out a bit which i love.....the thing about most of them is the price, they are a bit pricey compared to other supplements...name...CompetitiveGH
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Thanks for the input. Would you mind letting me know which ones that you have tried that you are pleased with? Trying to collect all the ideas that I can.

MrBigPR said:
Gh isn't for massive muscle gain. LBM is where it shines. With the right doses and ingredients it would be awesome. Any update?
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Agree completely.

Any input on what ingredients people would like to see in one would be appreciated.
 
Regarding GABA and GH, does anyone remember when GNC used to sell "Blue Nitro" (liquid GHB, aka the evil date rape drug)?

I never tried it out, but I knew some kids in college that loved the stuff and always called it Blue Nitro as homage to its dietary supplement name, lol.

Now, GHB is CI, except for the special distribution procedure, CIII brand of GHB called Xyrem(R) and used for insomnia.

Who knows; if there weren't so many got-no-game rapists out there, perhaps the drug wouldn't have gotten such an extremely bad rep (and penalties such as up to 20 years for possession...)

Anyway, I think the idea is that GHB not only gave a deeper, more refreshing sleep, but it was also purported to boost GH secretion at night.

I guess GABA consequently makes sense in a GH product, but then again, some people take some hefty doses of GABA as a standalone already. I wonder how much is needed to have a beneficial effect on GH levels?

I don't know about Phenibut (gaba-b agonist), but its future isn't clear, and I found it to be too strong of a sedative personally. I don't know if it has any GH benefits, but I kind of doubt it.
 
dumbhick3 said:
Regarding GABA and GH, does anyone remember when GNC used to sell "Blue Nitro" (liquid GHB, aka the evil date rape drug)?

I never tried it out, but I knew some kids in college that loved the stuff and always called it Blue Nitro as homage to its dietary supplement name, lol.

Now, GHB is CI, except for the special distribution procedure, CIII brand of GHB called Xyrem(R) and used for insomnia.

Who knows; if there weren't so many got-no-game rapists out there, perhaps the drug wouldn't have gotten such an extremely bad rep (and penalties such as up to 20 years for possession...)

Anyway, I think the idea is that GHB not only gave a deeper, more refreshing sleep, but it was also purported to boost GH secretion at night.

I guess GABA consequently makes sense in a GH product, but then again, some people take some hefty doses of GABA as a standalone already. I wonder how much is needed to have a beneficial effect on GH levels?

I don't know about Phenibut (gaba-b agonist), but its future isn't clear, and I found it to be too strong of a sedative personally. I don't know if it has any GH benefits, but I kind of doubt it.
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GHB was the most relaxed I've ever felt, and the best sleep I have ever had.

I love Phenibut for sleep, but wouldnt compare it at all to GHB.
 
I'd love to see CEL make a GH product! I currently use a GH product and really like it. Key benefits for me are as follows: improved sleep, recovery, getting leaner. I don't expect it to make me grow that much, which is fine.
 
CompEdgeLabs said:
GHB was the most relaxed I've ever felt, and the best sleep I have ever had.

I love Phenibut for sleep, but wouldnt compare it at all to GHB.
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Relaxed or comatose:D
I remember when i used to buy it in the 12oz bottle back in the early /mid 90s:tongue2:.....
 
I'll be interested in anything you guys come out with. I've had great results with many of your products.
 
mvrk1 said:
I'd love to see CEL make a GH product! I currently use a GH product and really like it. Key benefits for me are as follows: improved sleep, recovery, getting leaner. I don't expect it to make me grow that much, which is fine.
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Which one are you using?

IBE said:
3-OH-GABA (GABOB) is the best for GH and also maybe GHRP-6 in a delivery system
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Thanks for the input.

mw1 said:
Relaxed or comatose:D
I remember when i used to buy it in the 12oz bottle back in the early /mid 90s:tongue2:.....
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GHB Or Phenibut?

GHB makes (woops, meant made ;) ) me relaxed.

Phenibut doesnt knock me out, but helps keep me asleep.

Swim said:
I'll be interested in anything you guys come out with. I've had great results with many of your products.
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Thanks. I appreciate that. I hope that most everyone will be pleased with the new items. I regret that they are taking so long to bring out, but we want to make sure we do it right.
 
CompEdgeLabs said:
Thanks. I appreciate that. I hope that most everyone will be pleased with the new items. I regret that they are taking so long to bring out, but we want to make sure we do it right.
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Now that I think about it, and how the market is saturated (nearly) with non-hormonal supps (lots of garbage, some good stuff, etc), it doesn't surprise me that it would take a lot longer to come out with some truly useful non-hormonal supplements compared to PH/DS which seem to hinge mainly on supplier quality and availability. Could be wrong, but if it takes longer to make something high-quality, then don't rush perfection:).
 
mw1 said:
Relaxed or comatose:D
I remember when i used to buy it in the 12oz bottle back in the early /mid 90s:tongue2:.....
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About the 12oz bottle, was it "Blue Nitro", or a high quality clone?:silly:

I don't remember if the original "innovater" was the Blue Nitro brand or not of course:).
 
dumbhick3 said:
Now that I think about it, and how the market is saturated (nearly) with non-hormonal supps (lots of garbage, some good stuff, etc), it doesn't surprise me that it would take a lot longer to come out with some truly useful non-hormonal supplements compared to PH/DS which seem to hinge mainly on supplier quality and availability. Could be wrong, but if it takes longer to make something high-quality, then don't rush perfection:).
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There is definately alot more involved in coming out with these items than it was ph's. Alot more raw materials to source, and also some of the products are flavored, so its getting the tastes right, etc.

Some people have expressed impatience with us, but the important thing to us is doing it right.

dumbhick3 said:
About the 12oz bottle, was it "Blue Nitro", or a high quality clone?:silly:

I don't remember if the original "innovater" was the Blue Nitro brand or not of course:).
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We have to quit talking about GHB. It's making me sad lol
 
Guess I gotta spread some rep around.

(A) Patience is virtue. You guys don't slack when it comes to business OR quality. Give impatient people a product that you don't think is ready to market yet and then they'll just be impatient + disillusioned, even if it is just as good as other products in the same class. You guys have a stellar reputation; there is no need to tarnish it to attempt to satiate a few people. I think ppl expect great things from you guys, BUT great things take time, esp going from PHs which are really just a small slice of the overall supp market IMO to non-hormonals which are the lion's share. I mean, how can you expect to compete with the Muscletechs and Nitrocraps of the world? (LMAO) Seriously though, keep up the good work. Put out quality and ppl will buy it, no question.

(B) About the flavor-just don't make something that tastes like the early batches of Cycle Support. I've heard phrases like "baby vomit flavor", etc.

(C) LOL about the GHB. I will say no more since it is off the potential GH product ingredient list by default anyway:).
 
dumbhick3 said:
Guess I gotta spread some rep around.

(A) Patience is virtue. You guys don't slack when it comes to business OR quality. Give impatient people a product that you don't think is ready to market yet and then they'll just be impatient + disillusioned, even if it is just as good as other products in the same class. You guys have a stellar reputation; there is no need to tarnish it to attempt to satiate a few people. I think ppl expect great things from you guys, BUT great things take time, esp going from PHs which are really just a small slice of the overall supp market IMO to non-hormonals which are the lion's share. I mean, how can you expect to compete with the Muscletechs and Nitrocraps of the world? (LMAO) Seriously though, keep up the good work. Put out quality and ppl will buy it, no question.

(B) About the flavor-just don't make something that tastes like the early batches of Cycle Support. I've heard phrases like "baby vomit flavor", etc.

(C) LOL about the GHB. I will say no more since it is off the potential GH product ingredient list by default anyway:).
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Thanks. That is the way I feel as well. I have been surprised with the amount of impatience and frustration that we have been met with. I think sometimes people get so wrapped up in the forum stuff that they forget that we are a business, and we have to focus on doing things the right way.

We will not put out a product that tastes bad.
 
1,4 BD is legal now since this new case law stating it is not an analog of GHB they found it is an alcohol and not an acid.I never really liked BD anyways
 
IBE said:
1,4 BD is legal now since this new case law stating it is not an analog of GHB they found it is an alcohol and not an acid.I never really liked BD anyways
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I'm not familiar with that compound or at least not with that abbreviation.
 
Hey CEL !

What do you think about a HGH Stacked with a PH?
A bottle with these two componds will be nice. and of course.....with yours wesome prices hehe!

I will use 2 bottles off 11-sterone + homano growth (labrada). do you think that stack will be nice? i will get more gains ?

PEACE
 
felost said:
Hey CEL !

What do you think about a HGH Stacked with a PH?
A bottle with these two componds will be nice. and of course.....with yours wesome prices hehe!

I will use 2 bottles off 11-sterone + homano growth (labrada). do you think that stack will be nice? i will get more gains ?

PEACE
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I am not familiar enough with the effectiveness of the Labrada product to give an opinion on that.
 
I'd love to see CEL make a GH product! I currently use a GH product and really like it. Key benefits for me are as follows: improved sleep, recovery, getting leaner. I don't expect it to make me grow that much, which is fine.
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Bump on the "Which product are you using?" question. I think I've seen more than one mention of someone liking the various GH products (or a particular one), but no one seems to be sharing the name(s) of which GH supps they are taking. Are they all good or am I missing something?:yo:

I'm just curious to see what is working for people b/c I've always seen that product segment as iffy due to the pricing and the multitude of products available and I haven't bothered to look for any logs/non-sponsored reviews/etc. They are definitely growing in popularity, but the golden rule of the supplement market states that X% of them are absolute garbage.:suspect:

I guess I need to do some research...or I'll just wait for CEL's product to come out and grab it (LOL). Withholding potentially useful info won't slow down CEL's product development process (IMO), but it won't speed up the process either!
 
HOOOOOOOOO CEL !!!

I REALLY love HGH boosters.

PLEASE, check yhis trhead: Invalid Link Removed

look my post and you will see my opinion about HGH boosters.

if you do this type pf product you can be sure that i'll try.

i trust in CEL.
 
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