Formex MCPE - Coming soon!

[nattydisaster]

I didn't know Form had an effect of Free T and SHBG. This is good. Do other AI's have this same effect.

I haven't done as much research on other forms of AI's and SHBG, but the fact that formestane lowers SHBG came up in numerous studies. The mechanism behind this is mainly from the fact it has its own anabolic/androgenic properties, which other AI's lack.

Some other AI's, such as ATD, have actually been shown to compete for the AR

 

[LakeMountD]

Yeah, it is interesting to note that only oral formestane was found to effect SHBG levels, another advantage over TD. There are a couple of studies regarding this, but I found it to be an interesting anomaly in all of the data on formestane. james1, yes it is, but I am leaving it at that.

 

[celc5]

Some other AI's, such as ATD, have actually been shown to compete for the AR

I believe this to be true with trione as well. A while back, someone (I believe it was SomewhatGifted) posted some nice links to independent trione studies. The participants "felt" great, had strength gains, and showed elevated total test. But there was no evidence of lean mass gains.

That study is congruent with my experience with trione. Leaning, strength, enhanced libido, but ZERO lean mass gains. In comparison, I sort of lean toward thinking that I MAY have had some lean mass gains with formestane. I'd assume the super mild 4oht ph aspect is what makes the difference. I'll be using calipers throughout my log so I hope to have actual evidence, one way or the other, in terms of formestane's potential for gaining lean mass even while stripping away fat.

 

[nattydisaster]

Yeah, it is interesting to note that only oral formestane was found to effect SHBG levels, another advantage over TD. There are a couple of studies regarding this, but I found it to be an interesting anomaly in all of the data on formestane. james1, yes it is, but I am leaving it at that.

Yup, in the studies I found with regular formestane injected, the SHBG was unaffected, which would be the same case if used transdermally.

But in the studies where they tested it orally, SHBG was lowered.

 

[nattydisaster]

I believe this to be true with trione as well. A while back, someone (I believe it was SomewhatGifted) posted some nice links to independent trione studies. The participants "felt" great, had strength gains, and showed elevated total test. But there was no evidence of lean mass gains.

That study is congruent with my experience with trione. Leaning, strength, enhanced libido, but ZERO lean mass gains. In comparison, I sort of lean toward thinking that I MAY have had some lean mass gains with formestane. I'd assume the super mild 4oht ph aspect is what makes the difference. I'll be using calipers throughout my log so I hope to have actual evidence, one way or the other, in terms of formestane's potential for gaining lean mass even while stripping away fat.

Sounds like a good plan. I thought trione blocked the AR as well but I wasn't sure, so thanks for bringing the info!

 

[ohiostate2827]

sub

 

[chainsaw]

Yeah, it is interesting to note that only oral formestane was found to effect SHBG levels, another advantage over TD. There are a couple of studies regarding this, but I found it to be an interesting anomaly in all of the data on formestane. james1, yes it is, but I am leaving it at that.

What was the oral dose amount? How much of your product would one have to use to get said effect.

 

[mattikus]

Formex almost sounds too good to be true. I am dyin' to try this one out. Nice writeup btw.

 

[Steveoph]

Formex almost sounds too good to be true. I am dyin' to try this one out. Nice writeup btw.

Agreed. LMD is the correct structure the one below, except the OCH3 grp on the pentyl group on the far right?

 

[LakeMountD]

The correct structure is:

Sorry had to draw it . Also if you are ever trying to search for info on it you have to search IBE Formex not just Formex because there is two companies that already have those domain names, one of which sells flotation devices for boat docks lol.

 

[nattydisaster]

What was the oral dose amount? How much of your product would one have to use to get said effect.

I'll find this out for you asap . I do know a bottle will last a month.

Formex almost sounds too good to be true. I am dyin' to try this one out. Nice writeup btw.

You just wait and see! We are always bringing innovative products to the table. Report back with your experience after you try it.

The correct structure is:

Sorry had to draw it . Also if you are ever trying to search for info on it you have to search IBE Formex not just Formex because there is two companies that already have those domain names, one of which sells flotation devices for boat docks lol.

They do have some nice boat docks though

 

[jmh80]

I'm buying 2 noa.

 

[nattydisaster]

I'm buying 2 noa.

How do you plan on using it JMH?

 

[Ev52]

I already purchased some myself. Couldn't wait for nutra because of timeframe.

 

[warnerve]

when you guys have a chance, could you post up the info about oral intake and shgb effect? I only ask cause that's what intrigues me most about this. Thanks

 

[Iron Lungz]

I already purchased some myself. Couldn't wait for nutra because of timeframe.

Wait, so it's In Stock at certain places? :think:

 

[strategicmove]

Wait, so it's In Stock at certain places? :think:

That was going to be my question, too!

 

[chainsaw]

when you guys have a chance, could you post up the info about oral intake and shgb effect? I only ask cause that's what intrigues me most about this. Thanks

I am in for the SHBG as well.

Doesn't Form increase IGF-1 as well?

 

[jmh80]

That was going to be my question, too!

Google mate.

 

[jmh80]

How do you plan on using it JMH?

Awesomely! LOL

Eh - just wanna sea wat it does honestly. Haven't ever used Form. Am a few months from my next cycle. Not on anything special now.

 

[nattydisaster]

Sounds good man. Awesomely is the best way to do everything in life haha

 

[LakeMountD]

Just so you guys have them, here are the two snippets from studies:

"Formestane, when given by the intramuscular route,
leads to no significant changes in luteinizing hormone
(LH), follicle-stimulating hormone (FSH), or sex
hormone-binding globulin (SHBG) concentrations, which
are indices of androgenic or oestrogenic activity. It is of
only academic interest that SHBG concentrations are
decreased when formestane is given by the oral route"

"Notably, while given by the oral route, formestane expressed androgenic side effects to a variable extent. While formestane administered the i.m. rout in doses up to 500mg weekly was found to have no influence on plasma SHBG levels, formestane given orally was found to suppress plasma SHBG in a dose-dependent manner. "

 

[warnerve]

very interesting lake, thanks for that. I'm convinced to give it a try

 

[Steveoph]

The correct structure is:

Sorry had to draw it . Also if you are ever trying to search for info on it you have to search IBE Formex not just Formex because there is two companies that already have those domain names, one of which sells flotation devices for boat docks lol.

Ah that makes alot more sense; I was thinking a methyl ether right on the 5C ring would only be a tiny modification. :thumbsup:

With all the interest in the product, I wonder if it will kick off Epistane on our IBE Best-Seller List . It might be hard-pressed to beat the X-Dreams/X-Force stack this is selling so well.

 

[rxp1997]

Just so you guys have them, here are the two snippets from studies:

"Formestane, when given by the intramuscular route,
leads to no significant changes in luteinizing hormone
(LH), follicle-stimulating hormone (FSH), or sex
hormone-binding globulin (SHBG) concentrations, which
are indices of androgenic or oestrogenic activity. It is of
only academic interest that SHBG concentrations are
decreased when formestane is given by the oral route"

"Notably, while given by the oral route, formestane expressed androgenic side effects to a variable extent. While formestane administered the i.m. rout in doses up to 500mg weekly was found to have no influence on plasma SHBG levels, formestane given orally was found to suppress plasma SHBG in a dose-dependent manner. "

so would it be unadvisable to run this with Divanex/ActivateExtreme due to the SHBG suppression?

 

[AZMIDLYF]

LM D, you stated that Form given orally was found to suppress SHBG...dose dependent. What dose amount was that and I would assume you guys have that covered.

 

[nattydisaster]

so would it be unadvisable to run this with Divanex/ActivateExtreme due to the SHBG suppression?

You would not need to run Divanex/Activate Extreme, as Formex will lower SHBG (this is a good thing )

 

[nattydisaster]

LM D, you stated that Form given orally was found to suppress SHBG...dose dependent. What dose amount was that and I would assume you guys have that covered.

Yes we have that covered. The studies used 125mg and 250mg oral, regular formestane. Take into GREAT consideration that regular formestane taken orally has VERY POOR bio-availability, yet still there was a very significant decrease in SHBG.

The Formex caps contain 25mg of Formestane-MCPE. 60 caps/bottle, with 50mg/day being the normal dose

 

[AZMIDLYF]

I have read alot about some older lifters running low dose Form on a continual basis. Can this be used in that way too? Say I dose it on w/o days only? If done this way, how long could I stay on this?

 

[chainsaw]

You would not need to run Divanex/Activate Extreme, as Formex will lower SHBG (this is a good thing )

If running Formex as natty test booster, what would you advise to stack with it, if Divanil is not needed.

 

[nattydisaster]

If running Formex as natty test booster, what would you advise to stack with it, if Divanil is not needed.

As far as "test boosting" supplements go, you wouldn't need to stack anything with it to further increase testosterone boosting capabilities, or to eliminate any more estrogen, etc. It is basically an all-in-one compound. Ton's of benefits.

So stacking things with it would be pretty much goal-dependent. If you're cutting and want to stack a fat burner with it, go for it. If you bulking and want to stack your powdered mixes with it, go for it.

If you are just cruising along on TRT or something, you could stack it with Reverse to greatly increase the anti-aging benefits of the stack.

 

[nattydisaster]

I have read alot about some older lifters running low dose Form on a continual basis. Can this be used in that way too? Say I dose it on w/o days only? If done this way, how long could I stay on this?

One could easily stay on 25mg-50mg/day, without having to "cycle" it.

I am currently on TRT, and will be using formex year round because I have elevated estrogen from the TRT, raised DHT from the TRT, and while my testosterone levels are high, I would like to see my free testosterone higher, since this is the bio-available form of test. Formex will do all for that, as well as increase the bodies total natural testosterone production.

Bottles are 60 caps of 25mg capsules. "Normal" dose will be 25mg-50mg.

I will probably cruise on 25mg/day year round, and if I get serious or want to be really dedicated bump it up to 50mg (the normal dose everyone will be using).

 

[TexasLifter89]

So you would recommend 50 mg as daily dosage? I went as high ass I think around 200mg previously on oral Form.

 

[nattydisaster]

So you would recommend 50 mg as daily dosage? I went as high ass I think around 200mg previously on oral Form.

Yea, 50mg will be the standard dose everyone will be running. 50mg of Formex will be more potent than 200mg of regular oral formestane for sure. The active life of that stuff was about 2 hours!

 

[Steveoph]

Azmid the study he referenced was http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBD-4B716FF-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e1664fce0126bd9233cae0de63e8d30d I believe. It talks about SHBG Suppression using 25mg/day of Exemestane, Did more digging but couldnt find any doses of formestane mentioned.

 

[stxnas]

Would there not be "synergy" in using a divanil product with Formex? If I'm reading everything correctly, Formex will lower SHBG in the body. Why not add something else that will render some of the remaining SHBG useless? What are the upsides, if any, to having SHBG in the body?

I might have to rethink my current stash now because I have A LOT of divanil based products.

<Opens stash and looks at Divanex x 2, JW x 2, Mass FX, Bulk Powder, and AX>

 

[nattydisaster]

Bah, I can't get access to the full text, but it seems like there's a study done on eplileptic men that showed no SHBG change for an oral dose, http://www.ingentaconnect.com/content/ftd/ern/2005/00000005/00000001/art00016 . (What got me interested was the text caught by Google, http://scholar.google.ca/scholar?hl=en&lr=&scoring=r&q=Formestane+SHBG&as_ylo=2004&btnG=Search ) Probably nothing, just frustrating not getting the article to see what they're saying, although there's plenty of other articles that verify the SHBG-Formestane relationship.

Azmid the study he referenced was http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBD-4B716FF-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e1664fce0126bd9233cae0de63e8d30d I believe. It talks about SHBG Suppression using 25mg/day of Exemestane, Did more digging but couldnt find any doses of formestane mentioned.

Theres a number of studies showing oral formestane lowering SHBG. Let me round them up, i got studies all over the place right now . In the full text version of the study in exemestane you posted, it talks about the oral formestane supressing SHBG, if it's the same study I read.

 

[nattydisaster]

Would there not be "synergy" in using a divanil product with Formex? If I'm reading everything correctly, Formex will lower SHBG in the body. Why not add something else that will render some of the remaining SHBG useless? What are the upsides, if any, to having SHBG in the body?

I might have to rethink my current stash now because I have A LOT of divanil based products.

<Opens stash and looks at Divanex x 2, JW x 2, Mass FX, Bulk Powder, and AX>

I am not sure the mechanism of divanyl so I can't say whether it would provide any synergy or not. If they worked through different mechanisms, which they may, their could certainly be some added benefit. Def. wouldnt hurt though.

 

[nattydisaster]

Steveoph, here is a simple abstract with mention. Most of the studies where the SHBG effects are seen don't have it in the abstracts, but in the full texts, some of which arn't formestane studies but studies on other AI's being compared to formestane.

Again, we didn't find this in just one study and then make the claim.

http://www.ncbi.nlm.nih.gov/pubmed/1591054

 

[EasyEJL]

One could easily stay on 25mg-50mg/day, without having to "cycle" it.

I am currently on TRT, and will be using formex year round because I have elevated estrogen from the TRT, raised DHT from the TRT, and while my testosterone levels are high, I would like to see my free testosterone higher, since this is the bio-available form of test. Formex will do all for that, as well as increase the bodies total natural testosterone production.

Bottles are 60 caps of 25mg capsules. "Normal" dose will be 25mg-50mg.

I will probably cruise on 25mg/day year round, and if I get serious or want to be really dedicated bump it up to 50mg (the normal dose everyone will be using).

hmmm thats pretty interesting

 

[stxnas]

I am not sure the mechanism of divanyl so I can't say whether it would provide any synergy or not. If they worked through different mechanisms, which they may, their could certainly be some added benefit. Def. wouldnt hurt though.

Okay, let me rephrase this, as maybe I will still be able to hang onto my DVTHF

Does Formex bind to SHBG rendering it useless or does it actually reduce the amount of SHBG in the body?

The fact that Formex acts on SHBG, boosts test, and lowers estrogen does make it sound very worthy of being ran as a standalone though.

 

[LakeMountD]

Bah, I can't get access to the full text, but it seems like there's a study done on eplileptic men that showed no SHBG change for an oral dose, http://www.ingentaconnect.com/content/ftd/ern/2005/00000005/00000001/art00016 . (What got me interested was the text caught by Google, http://scholar.google.ca/scholar?hl=en&lr=&scoring=r&q=Formestane+SHBG&as_ylo=2004&btnG=Search ) Probably nothing, just frustrating not getting the article to see what they're saying, although there's plenty of other articles that verify the SHBG-Formestane relationship.

Azmid the study he referenced was http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBD-4B716FF-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e1664fce0126bd9233cae0de63e8d30d I believe. It talks about SHBG Suppression using 25mg/day of Exemestane, Did more digging but couldnt find any doses of formestane mentioned.

Okay, enough is enough. For the record everyone steveoph is doing this because NP is getting some formestane powder in. I just want to let everyone know that because steveoph doesn't want to say it in our thread. But I am saying it for him so that everyone knows now.

Now that we got that out of the way you are not going to convince me or anyone else for that matter that TD is better than Formex. Plus if you are going to try and make a point about your product over ours then I suggest you do some better researching.

First off I looked at both of those links you posted. The first is more of a theoretical abstract about various therapies in epileptic men, in which they even talk about a 'single' case where letrazole helped, nothing about shbg in the study. I have the full text. A single case study? N=1 isn't exactly definitive. But aside from that is the fact that what you saw in the Google search is COMPLETELY wrong. Here is what you saw:
"tane and formestane, and have ... hormone bind- ing globulin (SHBG) was normal ... "

In Google when you see periods like "...." it means that the text occurs later in the article and the text is not continuous. It could be the next page, could be 25 pages further. Therefore, SHBG normal could be talking about the subjects beforehand, could be talking about what happens when letrozole was given, etc. We have a few references that show that SHBG is only lowered with oral use and unless you would like to post a supplementary comment to the journal of where it was published saying that you feel otherwise, it is a bit hard to question it.

Okay now back on subject.

 

[LakeMountD]

stxnas, the references all use the word "reduce". So the levels are reduced, not just antagonist ability.

 

[stxnas]

This is awesome b/c I can't think of a single product on the market that can make that claim and back it up! I know some might claim this, but try finding a single study to back the claims of their ingredients...just sayin'...

It sounds like you guys definitely have a winner on your hands!

 

[Iron Lungz]

This is awesome b/c I can't think of a single product on the market that can make that claim and back it up! I know some might claim this, but try finding a single study to back the claims of their ingredients...just sayin'...

It sounds like you guys definitely have a winner on your hands!

Formex will put the antediluvian Bulk powder in the grave for sure. (In my opinion)

 

[stxnas]

Sounds like it! I'm excited to start seeing the logs

Congrats on yet another Innovative product! (Pun Intended)

 

[Ev52]

Wait, so it's In Stock at certain places? :think:

Yes, as LMD mentioned, it is in-stock at certain places.

 

[somewhatgifted]

Ah that makes alot more sense; I was thinking a methyl ether right on the 5C ring would only be a tiny modification. :thumbsup:

With all the interest in the product, I wonder if it will kick off Epistane on our IBE Best-Seller List . It might be hard-pressed to beat the X-Dreams/X-Force stack this is selling so well.

What do you think about stacking x-dreams with Formex?......:scared: :dl:

 

[Resolve]

Personally, I'd think a Reverse/Formex stack would be very effective.

 

[stxnas]

Have all of you seen the logger opportunity? Sorry if it's already been posted here, but the entry deadline is tonight and another entry or two couldn't hurt anything: http://anabolicminds.com/forum/company-promotions/119073-sponsored-ibe-formex.html