TexasLifter89
Well-known member
here ya go guys: Invalid Link Removed
2009's biggest product is here- a sneak preview from AN :)
- Thread starter rms80
- Start date
russianstar
Well-known member
Droool
Outside Backer
Well-known member
well thanks for your honesty
i guess if you see no difference in those 2 photos then maybe your just to hard o impress
no worries. My wife doesnt impress very well either
all in good fun
but someone asked for photos i posted them so that was my .02
:bb3:
DreamWeaver
Legend
Hormonal... yah that makes more sense. I will have to bow out for now then...
freakdego21
New member
any u guys test prime out? If so some feed back would be awsome. Like is it worth gettin?
TexasLifter89
Well-known member
please keep that to a prime thread....this is not the right place for that. Also there are plenty of feedback threads on it.
rolandajoint
Well-known member
donorrell
Board Sponsor
You have to be kidding me
donorrell
Board Sponsor
For your convenience here it is in this thread P.1 of 5
OK, without further ado....
[size=+3]The ONE™[/size] by Invalid Link Removed
Invalid Link Removed
Name: 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine
Standard: Testosterone
Androgenic: 140
Anabolic: 380
Estrogenic Activity: none
Progestational Activity: none
Derivation/Analog of: Dihydrotestosterone
Brief History:
• Dihydrotestosterone (DHT) was first synthesized in 1935.
• Primary active ingredient (17a-methyl-etioallocholan-17b-ol-3-hydroxyimine) was first described by Z. Cekan and B. Pelc, Effects of 1-alkyl substitution on the biological action in a series of androstanes. Steroids 8,209 (1966).
• Never commercially produced – A COMPLETELY NOVEL MOLECULE.
Product Characteristics:
• The One is an oral prohormone of Dihydrotestosterone (DHT), a compound that produces effects 3 to 5 times more potent than testosterone on the androgen receptor.
• The One can inhibit the action of estrogens by acting as a competitive antagonist and/or decreasing the mRNA-induced transcription of estrogenic effects post-binding.
• The One can also act like an aromatase inhibitor, disallowing the conversion of androgens to estrogen.
• The One activates GLUT-4 receptors in skeletal muscle, increasing glycogen uptake of 17-alpha alkylated molecules for greater oral bioavailability.
• The One can significantly lower SHBG levels, allowing for more active product to reach skeletal muscle.
Effects Related to Physique Enhancement:
• Rapid lean body mass gains - typical users report 0.75 lb./day gains for first 2-3 weeks
• Overall hardening effect to physique
• Increased vascularity
• Increased strength
• Dramatically enhanced neural function (coordination) as DHT is the predominant androgen in neural function
• Mood-enhancing effect
• Lipolytic effect (increases fat metabolism)
ADMINISTRATION/DOSAGE:
• Effective dose: 67.5 - 90 mg/day (3-4 capsules) ; DO NOT EXCEED 90 MG/DAY
• Can be taken with or without food; preferably in the AM
• Oral Administration Only
• 4-5 week administration period; do not exceed 5 weeks duration
OK, without further ado....
[size=+3]The ONE™[/size] by Invalid Link Removed
Invalid Link Removed
Name: 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine
Standard: Testosterone
Androgenic: 140
Anabolic: 380
Estrogenic Activity: none
Progestational Activity: none
Derivation/Analog of: Dihydrotestosterone
Brief History:
• Dihydrotestosterone (DHT) was first synthesized in 1935.
• Primary active ingredient (17a-methyl-etioallocholan-17b-ol-3-hydroxyimine) was first described by Z. Cekan and B. Pelc, Effects of 1-alkyl substitution on the biological action in a series of androstanes. Steroids 8,209 (1966).
• Never commercially produced – A COMPLETELY NOVEL MOLECULE.
Product Characteristics:
• The One is an oral prohormone of Dihydrotestosterone (DHT), a compound that produces effects 3 to 5 times more potent than testosterone on the androgen receptor.
• The One can inhibit the action of estrogens by acting as a competitive antagonist and/or decreasing the mRNA-induced transcription of estrogenic effects post-binding.
• The One can also act like an aromatase inhibitor, disallowing the conversion of androgens to estrogen.
• The One activates GLUT-4 receptors in skeletal muscle, increasing glycogen uptake of 17-alpha alkylated molecules for greater oral bioavailability.
• The One can significantly lower SHBG levels, allowing for more active product to reach skeletal muscle.
Effects Related to Physique Enhancement:
• Rapid lean body mass gains - typical users report 0.75 lb./day gains for first 2-3 weeks
• Overall hardening effect to physique
• Increased vascularity
• Increased strength
• Dramatically enhanced neural function (coordination) as DHT is the predominant androgen in neural function
• Mood-enhancing effect
• Lipolytic effect (increases fat metabolism)
ADMINISTRATION/DOSAGE:
• Effective dose: 67.5 - 90 mg/day (3-4 capsules) ; DO NOT EXCEED 90 MG/DAY
• Can be taken with or without food; preferably in the AM
• Oral Administration Only
• 4-5 week administration period; do not exceed 5 weeks duration
donorrell
Board Sponsor
Page 2 of 5
Test Data:
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Invalid Link Removed
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TIME-DEPENDANT COMPARISON TO OTHER NON-AROMATIZING ORAL PRODUCTS IN TERMS OF LEAN BODY MASS GAINS DURING THE FIRST TWO WEEKS OF USAGE:
Invalid Link Removed
Binding of Oximes by Steroid Hormone Globulin (SHBG) Compared to Other Compounds:
Invalid Link Removed
Test Data:
Invalid Link Removed
Invalid Link Removed
Invalid Link Removed Invalid Link Removed
TIME-DEPENDANT COMPARISON TO OTHER NON-AROMATIZING ORAL PRODUCTS IN TERMS OF LEAN BODY MASS GAINS DURING THE FIRST TWO WEEKS OF USAGE:
Invalid Link Removed
Binding of Oximes by Steroid Hormone Globulin (SHBG) Compared to Other Compounds:
Invalid Link Removed
donorrell
Board Sponsor
Page 3 of 5
ON CYCLE: TIPS TO MAXIMIZE GROWTH
• Take Complete Balance™ Multi-Vitamin/Multi-Mineral
o Ensures that all essential vitamins and minerals are being taken in daily
• Take Omega Essentials™ EFA/DHA at 3-5 grams per day
o Strengthens cell membranes
o Enhances insulin sensitivity
o Synergistic with the GLUT-4 translocating ability of The One
o Enhances healthy HDL/LDL profiles
• Take Bio-Mend™ Anti-Oxidant formula
o High ORAC Value
o Protects cellular membrane
o Protects transcriptional factors (mRNA and DNA)
• Milk Thistle
o Hepatoprotectant – protects liver health
• In general, maintain a healthy diet and lifestyle:
o Drink Plenty of water- at least 64 oz. per day
o Ingest at least 1 gram of protein per lb. of body weight daily
o Sleep at least 7 hours per night
o Eat lots of fruits and vegetables
o Eat lots of complex carbs
o Eat 5-6 smaller protein and carb-rich meals throughout the day
o Increase calories to at least 500 Kcal/day over your normal intake
o BCAAs and Creatine will be helpful
o Avoid alcohol and tobacco
TRAINING
• 8-15 rep sets- 75-85% of 1RM Max for maximal hypertrophy
• Train 3-5 days per week
• Use Heavy Compound Exercises and Variations
• Squats
• Deadlifts
• Pull-Ups w/ multiple grips
• Bench Press
POST CYCLE: TIPS TO MAXIMIZE RECOVERY & MAINTAIN GAINS
6-BROMODIONE, 50 mg/day
• Aromatase Inhibitor
• Increases free testosterone with minimal endocrine suppression
BIO-MEND™ and COMPLETE BALANCE™ as directed on labels
• Prevent calcium leakage from Sarcoplasmic Reticulum
• Helps to maintain cell membrane integrity
• Helps to maintain healthy HDL/LDL levels
• Helps to protect mRNA and DNA
• Helps to keep adequate nutrient profile
OMEGA ESSENTIALS™ as directed on label
• Increases cell membrane strength
• Helps establish/maintain healthy lipid profiles
• Increases insulin sensitivity
DRIVE™ as directed on label
• Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
• Increases free testosterone
• Increases thyroid output
• Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response
IGF-2® as directed on label
• Increases free testosterone
• Increases GH output
ON CYCLE: TIPS TO MAXIMIZE GROWTH
• Take Complete Balance™ Multi-Vitamin/Multi-Mineral
o Ensures that all essential vitamins and minerals are being taken in daily
• Take Omega Essentials™ EFA/DHA at 3-5 grams per day
o Strengthens cell membranes
o Enhances insulin sensitivity
o Synergistic with the GLUT-4 translocating ability of The One
o Enhances healthy HDL/LDL profiles
• Take Bio-Mend™ Anti-Oxidant formula
o High ORAC Value
o Protects cellular membrane
o Protects transcriptional factors (mRNA and DNA)
• Milk Thistle
o Hepatoprotectant – protects liver health
• In general, maintain a healthy diet and lifestyle:
o Drink Plenty of water- at least 64 oz. per day
o Ingest at least 1 gram of protein per lb. of body weight daily
o Sleep at least 7 hours per night
o Eat lots of fruits and vegetables
o Eat lots of complex carbs
o Eat 5-6 smaller protein and carb-rich meals throughout the day
o Increase calories to at least 500 Kcal/day over your normal intake
o BCAAs and Creatine will be helpful
o Avoid alcohol and tobacco
TRAINING
• 8-15 rep sets- 75-85% of 1RM Max for maximal hypertrophy
• Train 3-5 days per week
• Use Heavy Compound Exercises and Variations
• Squats
• Deadlifts
• Pull-Ups w/ multiple grips
• Bench Press
POST CYCLE: TIPS TO MAXIMIZE RECOVERY & MAINTAIN GAINS
6-BROMODIONE, 50 mg/day
• Aromatase Inhibitor
• Increases free testosterone with minimal endocrine suppression
BIO-MEND™ and COMPLETE BALANCE™ as directed on labels
• Prevent calcium leakage from Sarcoplasmic Reticulum
• Helps to maintain cell membrane integrity
• Helps to maintain healthy HDL/LDL levels
• Helps to protect mRNA and DNA
• Helps to keep adequate nutrient profile
OMEGA ESSENTIALS™ as directed on label
• Increases cell membrane strength
• Helps establish/maintain healthy lipid profiles
• Increases insulin sensitivity
DRIVE™ as directed on label
• Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
• Increases free testosterone
• Increases thyroid output
• Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response
IGF-2® as directed on label
• Increases free testosterone
• Increases GH output
donorrell
Board Sponsor
page 4 of 5
Mechanism of Action/Function:
Absorption
• User ingests compound orally
• Digestion occurs in roughly 20-30 minutes (as with most encapsulated products)
• Compound is absorbed by the duodenum and jejunum of the small intestine, and then is displaced into the hepatic portal vein, (a special blood vessel leading from the digestive tract to the liver) where the compound must undergo the “first pass” through the liver and survive hepatic metabolism.
• Methylation allows the compound to survive the first pass through the liver, protecting the molecule from hepatic enzymatic degradation.
• After first pass, the compound is distributed into the inferior vena cava, and then to the heart for systemic distribution.
Distribution
• The heart pumps the active compound into all different areas of the body during the distribution phase. As is the case with most compounds, SHBG (steroid hormone binding globulin) can remove active compounds from systemic distribution before they reach their target organ (in this case, skeletal muscle).
• Binding proteins such as SHBG are rendered fairly inactive in this situation with the active ingredient in The One, because it is one of only a few compounds that does not carry an actual 3-keto group; it carries a 3-oxime group instead.
• Research has dictated that oximes have little or no binding affinity to SHBG in the blood stream, allowing for more free active substrate to reach their target (the androgen receptor (AR) in skeletal muscle). In essence, the 3-oxime “protects” the molecule from being bound (see graph below) leaving more active substrate in the blood to target skeletal muscle.
Metabolism
• Once The One reaches skeletal muscle, it must interact with specific target androgen receptors to exert the desired effect of increased protein synthesis and increased nitrogen retention.
• Under normal circumstances, DHT is quickly deactivated in the blood by 3a-HSD into 5alpha-androstan-3a,17b-diol, a weak androgen, and its access to target skeletal muscle tissue is restricted.
• There is some evidence that the 3-oxime substituted for 3-keto group may slow this deactivation, allowing for greater binding of the molecule to the AR.
• Oximes are a group of compounds with the general formula R¹R²CNOH, where R1 constitutes an organic side chain, and R2 is another organic group. This forms a ketoxime.
• Oximes exist as two geometric stereoisomers: a syn-isomer and an anti-isomer.
• Oximes are formed by the action of hydroxylamine on ketones.
Receptor Binding
• Because the evidence suggests that active DHT may not be metabolized by 3a-HSD into the weaker 5-alpha-androstan-3a,17b-diol within the skeletal muscle because of the oxime, there is a very good chance that fairly large amounts of DHT will actually bind to the AR in skeletal muscle.
• DHT has a 3 to 5 times greater binding potency on the androgen receptor than testosterone, so the resulting effect from The One is a very powerful growth stimulus on skeletal muscle.
• Androgens can act in a genomic (transcriptive, from direct AR binding) or non-genomic (non-AR binding) fashion on target cells.
• Some examples of non-genomic effects: increased IGF-1 expression, displacement of estrogen and progesterone from receptor sites, displacement of aromatase, and increased uptake of calcium in the sarcoplasmic reticulum.
Genomic Effects and MOA:
• The AR has four functional regions: a hinge region containing a nuclear localization signal, a carboxy-terminal ligand-binding domain (AF-2 site), an amino terminal regulatory domain (AF-1 site) and a DNA-binding domain composed of two zinc fingers.
• ARs that are not ligated are located primarily in the cytoplasm, and are bound to heat shock proteins (HSPs). HSPs stabilize the tertiary structure of the AR, permitting androgen binding.
• When The One binds the AR, there is a resulting dissociation of HSPs from the AR, allowing for dimerization (to be held together by molecular force) of the AR and subsequent tyrosine kinase phosphorylation, resulting in translocation (movement) of the AR to the nucleus.
• When the AR translocates inside the nucleus, it binds androgen response elements located in the enhancer and promoter areas of target genes. This results in the consequential assembly of regulatory proteins, and the creation of an active complex for transcription.
• The regulatory proteins form a cross-bridge with the AR, the RNA polymerase, and the pre-initiation complex. Specific coactivators begin transcription by recruiting protein clusters to DNA that change the chromatin scaffolding to a form that is more active for transcription.
• The resulting activated transcription results in synthesis of mRNA, which is signaled by ribosomes to produce specific proteins. Changes in specific cell proteins follow, which in turn mediate growth responses, nitrogen balance, and protein synthesis, among other things.
Excretion
• The Compound is removed from the body via excretion, through the kidneys via glomelular filtration.
WARNING: This product is only intended to be consumed by healthy adult males 21 years of age or older. Not for use by women. Before using this product, consult with your physician if you are using any prescription or over the counter medicine or if you are unaware of your current medical condition. Do not use this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, high cholesterol, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking and MAO-B inhibitor or any other medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Possible androgenic side effects including but not limited to acne, increased risk of male pattern baldness, testicular atrophy and gynecomastia (males), may occur. Do not consume alcohol while taking this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Note: This product may contain ingredients which are banned by some athletic or government associations (including military).
Mechanism of Action/Function:
Absorption
• User ingests compound orally
• Digestion occurs in roughly 20-30 minutes (as with most encapsulated products)
• Compound is absorbed by the duodenum and jejunum of the small intestine, and then is displaced into the hepatic portal vein, (a special blood vessel leading from the digestive tract to the liver) where the compound must undergo the “first pass” through the liver and survive hepatic metabolism.
• Methylation allows the compound to survive the first pass through the liver, protecting the molecule from hepatic enzymatic degradation.
• After first pass, the compound is distributed into the inferior vena cava, and then to the heart for systemic distribution.
Distribution
• The heart pumps the active compound into all different areas of the body during the distribution phase. As is the case with most compounds, SHBG (steroid hormone binding globulin) can remove active compounds from systemic distribution before they reach their target organ (in this case, skeletal muscle).
• Binding proteins such as SHBG are rendered fairly inactive in this situation with the active ingredient in The One, because it is one of only a few compounds that does not carry an actual 3-keto group; it carries a 3-oxime group instead.
• Research has dictated that oximes have little or no binding affinity to SHBG in the blood stream, allowing for more free active substrate to reach their target (the androgen receptor (AR) in skeletal muscle). In essence, the 3-oxime “protects” the molecule from being bound (see graph below) leaving more active substrate in the blood to target skeletal muscle.
Metabolism
• Once The One reaches skeletal muscle, it must interact with specific target androgen receptors to exert the desired effect of increased protein synthesis and increased nitrogen retention.
• Under normal circumstances, DHT is quickly deactivated in the blood by 3a-HSD into 5alpha-androstan-3a,17b-diol, a weak androgen, and its access to target skeletal muscle tissue is restricted.
• There is some evidence that the 3-oxime substituted for 3-keto group may slow this deactivation, allowing for greater binding of the molecule to the AR.
• Oximes are a group of compounds with the general formula R¹R²CNOH, where R1 constitutes an organic side chain, and R2 is another organic group. This forms a ketoxime.
• Oximes exist as two geometric stereoisomers: a syn-isomer and an anti-isomer.
• Oximes are formed by the action of hydroxylamine on ketones.
Receptor Binding
• Because the evidence suggests that active DHT may not be metabolized by 3a-HSD into the weaker 5-alpha-androstan-3a,17b-diol within the skeletal muscle because of the oxime, there is a very good chance that fairly large amounts of DHT will actually bind to the AR in skeletal muscle.
• DHT has a 3 to 5 times greater binding potency on the androgen receptor than testosterone, so the resulting effect from The One is a very powerful growth stimulus on skeletal muscle.
• Androgens can act in a genomic (transcriptive, from direct AR binding) or non-genomic (non-AR binding) fashion on target cells.
• Some examples of non-genomic effects: increased IGF-1 expression, displacement of estrogen and progesterone from receptor sites, displacement of aromatase, and increased uptake of calcium in the sarcoplasmic reticulum.
Genomic Effects and MOA:
• The AR has four functional regions: a hinge region containing a nuclear localization signal, a carboxy-terminal ligand-binding domain (AF-2 site), an amino terminal regulatory domain (AF-1 site) and a DNA-binding domain composed of two zinc fingers.
• ARs that are not ligated are located primarily in the cytoplasm, and are bound to heat shock proteins (HSPs). HSPs stabilize the tertiary structure of the AR, permitting androgen binding.
• When The One binds the AR, there is a resulting dissociation of HSPs from the AR, allowing for dimerization (to be held together by molecular force) of the AR and subsequent tyrosine kinase phosphorylation, resulting in translocation (movement) of the AR to the nucleus.
• When the AR translocates inside the nucleus, it binds androgen response elements located in the enhancer and promoter areas of target genes. This results in the consequential assembly of regulatory proteins, and the creation of an active complex for transcription.
• The regulatory proteins form a cross-bridge with the AR, the RNA polymerase, and the pre-initiation complex. Specific coactivators begin transcription by recruiting protein clusters to DNA that change the chromatin scaffolding to a form that is more active for transcription.
• The resulting activated transcription results in synthesis of mRNA, which is signaled by ribosomes to produce specific proteins. Changes in specific cell proteins follow, which in turn mediate growth responses, nitrogen balance, and protein synthesis, among other things.
Excretion
• The Compound is removed from the body via excretion, through the kidneys via glomelular filtration.
WARNING: This product is only intended to be consumed by healthy adult males 21 years of age or older. Not for use by women. Before using this product, consult with your physician if you are using any prescription or over the counter medicine or if you are unaware of your current medical condition. Do not use this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, high cholesterol, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking and MAO-B inhibitor or any other medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Possible androgenic side effects including but not limited to acne, increased risk of male pattern baldness, testicular atrophy and gynecomastia (males), may occur. Do not consume alcohol while taking this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Note: This product may contain ingredients which are banned by some athletic or government associations (including military).
donorrell
Board Sponsor
Page 5 of 5
STUDIES/CLINICAL INFORMATION:
• Kuhnz W, Fritzemeier KH, Hegele-Hartung C, Krattenmacher R. Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Contraception. 1995 Feb;51(2):131-9.
• Li QG, Li DZ. Analysis of anti-implantational action of norethisterone-3-oxime. Contraception. 1987 Dec;36(6):667-76.
• Li DZ, Fu GM, Zuo MD, Zhou MY, Zhao XL, Wang GP, Wei ZN. Pharmacokinetic studies of norethisterone-3-oxime and norethisterone-3-oxime acetate in rhesus monkey. J Tongji Med Univ. 1991;11(2):81-7.
• Li QG. Aromatization and hydrolysis of norethisterone-3-oxime in rabbit. J Steroid Biochem Mol Biol. 1994 Jun;49(2-3):227-31.
• Hammerstein J. Prodrugs: advantage or disadvantage? Am J Obstet Gynecol. 1990 Dec;163(6 Pt 2):2198-203.
• Shrivastav TG, Basu A, Kariya KP. One step enzyme linked immunosorbent assay for direct estimation of serum testosterone. J Immunoassay Immunochem. 2003;24(2):205-17.
• Tripathi V, Nara S, Chaube SK, Rangari K, Saroha A, Kariya KP, Singh H, Shrivastav TG. J Development of rapid and sensitive one-step direct enzyme linked immunosorbent assay for 17-alpha-OH-progesterone in serum. Immunoassay Immunochem. 2008; 29(2):117-27.
• Nara S, Tripathi V, Chaube SK, Rangari K, Singh H, Kariya KP, Shrivastav TG. A novel enzyme-linked immunosorbent assay for cortisol using a long-chain biotinylated cortisol-3-CMO derivative. J Immunoassay Immunochem. 2008;29(4):390-405.
• Sinnecker G, Köhler S Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test. J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200.
• Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984 Jun;114(6):2100-6.
• Tóth M, Zakár T. Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. J Steroid Biochem. 1982 Dec;17(6):653-60.
• Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA (December 2006). "International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors". Pharmacol. Rev. 58 (4): 782–97.
• Hammond GL, Abrams LS, Creasy GW, Natarajan J, Allen JG, Siiteri PK.
• Serum distribution of the major metabolites of norgestimate in relation to its
• pharmacological properties. Contraception. 2003 Feb;67(2):93-9.
• Juchem M, Pollow K, Elger W, Hoffmann G, Möbus V. Receptor binding of norgestimate--a new orally active synthetic progestational compound. Contraception. 1993 Mar;47(3):283-94.
• Ouyang G, Chen Z, Cai XJ, Song BA, Bhadury PS, Yang S, Jin LH, Xue W, Hu DY, Zeng S. Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group. Bioorg Med Chem. 2008 Nov 15;16(22):9699-707. Epub 2008 Oct 2.
• Shrivastav TG, Kanaujia PK. Direct radioimmunoassay for the measurement of serum testosterone using 3H as label. J Immunoassay Immunochem. 2007;28(2):127-36.
• Basu A, Shrivastav TG One step enzyme linked immunosorbent assay for direct estimation of serum cortisol. J Immunoassay. 2000 Feb;21(1):39-50.
• Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, and Ryuichi Ajisaka Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Am J Physiol Endocrinol Metab 294: E961-E968, 2008.
• Davison SL, Bell R (April 2006). "Androgen physiology". Semin. Reprod. Med. 24 (2): 71–7.
• Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency.
• Cailleux-Bounacer A, Rohmer V, Lahlou N, Lefebvre H, Roger M, Kuhn JM.
• Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men. Int J Androl. 2007 Oct 11.
• Kunelius P, Lukkarinen O, Hannuksela ML, Itkonen O, Tapanainen. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. JSJ Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.
• de Lignieres B. Transdermal dihydrotestosterone treatment of 'andropause'. Ann Med. 1993 Jun;25(3):235-41.
• Sakhri S, Gooren LJ. Safety aspects of androgen treatment with 5alpha-dihydrotestosterone. Andrologia. 2007 Dec;39(6):216-22.
• Boada LD, Fernández L, Zumbado M, Luzardo OP, Chirino R, Díaz-Chico BN.
• Identification of a specific binding site for the anabolic steroid stanozolol in male rat liver microsomes. J Pharmacol Exp Ther. 1996 Dec;279(3):1123-9.
• Fernández L, Chirino R, Boada LD, Navarro D, Cabrera N, del Rio I, Díaz-Chico BN. Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes. Endocrinology. 1994 Mar;134(3):1401-8.
• Guillon G. Experiment with mesterolone in male fertility disorders Z Hautkr. 1975 Apr 1;50(7):293-7.
• Szöllösi J, Falkay GY, Sas M. Mesterolone treatment of patients with pathospermia. Int Urol Nephrol. 1978;10(3):251-6.
• Nikkanen V. Plasma cholesterol, triglycerides, FSH and testosterone levels of normolipemic male patients with decreased fertility treated with mesterolone. Andrologia. 1979 Jan;11(1):33-6.
• Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD.
• The hormone response to a synthetic androgen (mesterolone) in oligospermia.
• Clin Endocrinol (Oxf). 1977 May;6(5):339-45.
• Christiansen, K. in Testosterone Action, Deficiency, and Substitution, Nieschlag, E. and Behre, H.M. eds. Springer-Verlag, New York, 107-142, 1998.
STUDIES/CLINICAL INFORMATION:
• Kuhnz W, Fritzemeier KH, Hegele-Hartung C, Krattenmacher R. Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Contraception. 1995 Feb;51(2):131-9.
• Li QG, Li DZ. Analysis of anti-implantational action of norethisterone-3-oxime. Contraception. 1987 Dec;36(6):667-76.
• Li DZ, Fu GM, Zuo MD, Zhou MY, Zhao XL, Wang GP, Wei ZN. Pharmacokinetic studies of norethisterone-3-oxime and norethisterone-3-oxime acetate in rhesus monkey. J Tongji Med Univ. 1991;11(2):81-7.
• Li QG. Aromatization and hydrolysis of norethisterone-3-oxime in rabbit. J Steroid Biochem Mol Biol. 1994 Jun;49(2-3):227-31.
• Hammerstein J. Prodrugs: advantage or disadvantage? Am J Obstet Gynecol. 1990 Dec;163(6 Pt 2):2198-203.
• Shrivastav TG, Basu A, Kariya KP. One step enzyme linked immunosorbent assay for direct estimation of serum testosterone. J Immunoassay Immunochem. 2003;24(2):205-17.
• Tripathi V, Nara S, Chaube SK, Rangari K, Saroha A, Kariya KP, Singh H, Shrivastav TG. J Development of rapid and sensitive one-step direct enzyme linked immunosorbent assay for 17-alpha-OH-progesterone in serum. Immunoassay Immunochem. 2008; 29(2):117-27.
• Nara S, Tripathi V, Chaube SK, Rangari K, Singh H, Kariya KP, Shrivastav TG. A novel enzyme-linked immunosorbent assay for cortisol using a long-chain biotinylated cortisol-3-CMO derivative. J Immunoassay Immunochem. 2008;29(4):390-405.
• Sinnecker G, Köhler S Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test. J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200.
• Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984 Jun;114(6):2100-6.
• Tóth M, Zakár T. Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. J Steroid Biochem. 1982 Dec;17(6):653-60.
• Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA (December 2006). "International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors". Pharmacol. Rev. 58 (4): 782–97.
• Hammond GL, Abrams LS, Creasy GW, Natarajan J, Allen JG, Siiteri PK.
• Serum distribution of the major metabolites of norgestimate in relation to its
• pharmacological properties. Contraception. 2003 Feb;67(2):93-9.
• Juchem M, Pollow K, Elger W, Hoffmann G, Möbus V. Receptor binding of norgestimate--a new orally active synthetic progestational compound. Contraception. 1993 Mar;47(3):283-94.
• Ouyang G, Chen Z, Cai XJ, Song BA, Bhadury PS, Yang S, Jin LH, Xue W, Hu DY, Zeng S. Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group. Bioorg Med Chem. 2008 Nov 15;16(22):9699-707. Epub 2008 Oct 2.
• Shrivastav TG, Kanaujia PK. Direct radioimmunoassay for the measurement of serum testosterone using 3H as label. J Immunoassay Immunochem. 2007;28(2):127-36.
• Basu A, Shrivastav TG One step enzyme linked immunosorbent assay for direct estimation of serum cortisol. J Immunoassay. 2000 Feb;21(1):39-50.
• Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, and Ryuichi Ajisaka Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Am J Physiol Endocrinol Metab 294: E961-E968, 2008.
• Davison SL, Bell R (April 2006). "Androgen physiology". Semin. Reprod. Med. 24 (2): 71–7.
• Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency.
• Cailleux-Bounacer A, Rohmer V, Lahlou N, Lefebvre H, Roger M, Kuhn JM.
• Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men. Int J Androl. 2007 Oct 11.
• Kunelius P, Lukkarinen O, Hannuksela ML, Itkonen O, Tapanainen. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. JSJ Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.
• de Lignieres B. Transdermal dihydrotestosterone treatment of 'andropause'. Ann Med. 1993 Jun;25(3):235-41.
• Sakhri S, Gooren LJ. Safety aspects of androgen treatment with 5alpha-dihydrotestosterone. Andrologia. 2007 Dec;39(6):216-22.
• Boada LD, Fernández L, Zumbado M, Luzardo OP, Chirino R, Díaz-Chico BN.
• Identification of a specific binding site for the anabolic steroid stanozolol in male rat liver microsomes. J Pharmacol Exp Ther. 1996 Dec;279(3):1123-9.
• Fernández L, Chirino R, Boada LD, Navarro D, Cabrera N, del Rio I, Díaz-Chico BN. Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes. Endocrinology. 1994 Mar;134(3):1401-8.
• Guillon G. Experiment with mesterolone in male fertility disorders Z Hautkr. 1975 Apr 1;50(7):293-7.
• Szöllösi J, Falkay GY, Sas M. Mesterolone treatment of patients with pathospermia. Int Urol Nephrol. 1978;10(3):251-6.
• Nikkanen V. Plasma cholesterol, triglycerides, FSH and testosterone levels of normolipemic male patients with decreased fertility treated with mesterolone. Andrologia. 1979 Jan;11(1):33-6.
• Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD.
• The hormone response to a synthetic androgen (mesterolone) in oligospermia.
• Clin Endocrinol (Oxf). 1977 May;6(5):339-45.
• Christiansen, K. in Testosterone Action, Deficiency, and Substitution, Nieschlag, E. and Behre, H.M. eds. Springer-Verlag, New York, 107-142, 1998.
Rosie Chee
The Female Terminator
The "more" has been added to this thread.
ETA is 4-5 weeks, with a great price for a 110-count bottle.
grila jujitsu
Well-known member
because this compound is a dht derivative, will people who are from suffering mpb notice more shedding on this compound?
Flyboy
Member
I really don't see how this is possible...
In terms of hairloss there is pretty much nothing worse than flooding your body with DHT. Maybe it won't show until a little further down the line, maybe 4-5 weeks isn't long enough to make a big difference... who knows.
Cheers for the info though, but I think i'll have to sit this one out until I hear more on it from that front, i've spent too long getting my hair back!
grila jujitsu
Well-known member
thanks easy! I think i will wait and see a few others run it too. just so i can be sure!
you guys have a great product! I am sure of this!
Thanks,
GJJ
Outside Backer
Well-known member
ok, i know ive posted this a few times
i felt the same way about DHT however you like me we were thinking wrong
there are literally dozens of studies out there that show DHT's effects on hairline prostate etc arent as bad as initially thought
even pat arnold recently posted a paper saying dht has the bad rap and is actually beneficial
with that being said yes we posted the studies showing what i just stated
yes i have a receding hairline
and yes if ur going bald nothing u can do with stop this
5 weeks on this compound during initial trials didnt change anything in my
bp hairline, prostate, nothing of that nature
donorrell
Board Sponsor
In general, It think this one appears to be easy on the follicles. However, I think its a lot more about the individual's genetics. I've taken some high DHT stuff back in the day (way back) and stayed on too long (way too long) and never lost a single hair. My next door neighbor is 10 years younger and wouldn't know a PH or steroid if it hit him in the head and he's bald as a billiard ball.
This is much more about the individual that the compound, ESPECIALLY IF TAKEN AS DIRECTED. Sounds like you just lost the hair gene lottery.
Flyboy
Member
indeed, although because i caught it early i've been able to keep it at bay somewhat.... i know people younger than me who are a lot worse off!
I'm actually back to a point where i'm reasonably happy with my hair, and if i could run something which wouldn't screw up my progress i would in a heartbeat.
I'll definitely follow along on the feedback for this one, see how it works in the wild among the mpb prone.
In the mean time, good luck with it guys!
I'm actually back to a point where i'm reasonably happy with my hair, and if i could run something which wouldn't screw up my progress i would in a heartbeat.
I'll definitely follow along on the feedback for this one, see how it works in the wild among the mpb prone.
In the mean time, good luck with it guys!
nunes
Well-known member
seeing the graph of the lean mass gained on 2 weeks , I really didn't expect that epistane was so week when compared with the others, especially when we look at epi anabolic : androgenic ratio, I don't have the numbers here but I thought that the anabolic number was above 1000
donorrell
Board Sponsor
nunes
Well-known member
dont know if this was already asked but does appnut manufactures the steroid or import the raws from china?
Rosie Chee
The Female Terminator
He sure is!!! :thumbsup:
AN imports the raw materials and then chemically alters them.
donorrell
Board Sponsor
Raws are imported, but there are numerous steps after that they undergo here to yeild a finished compound.
SamBoz19
Well-known member
To add on...there is a lot more work then one might think that goes into making a compound.
Cheers!:cheers:
JBerto
Active member
IMO, DHT has a role in hairloss.
I've MPB and i started losing hair years ago (i lost a lot of hair), then i went to the dermatologist and I started using Finasteride... and the hairloss stopped!!!
Until then, i use Finasteride every day (i'm using it for years!!). Finasteride blocks Testosterone -> DHT, and my hairloss stopped when i started using Finasteride, so IMO DHT has an important role in hairloss. Of course, they're other factors (genetic, etc.), but DHT is one of them.
I started using hormonals last year (january, 2008) and then i add minoxidil (so now i'm using Finasteride + Minoxidil ED to keep my hair). I used H-Drol, Bold, and Oxandrolone but though i'm genetically predisposed to MPB, I didn't suffer any hairloss with none of them (they are hormonals, but none of them are DHT related). That's why i think DHT is the main culprit of hairloss.
xtraflossy
Board Supporter
ohhhhhhhh,.. new stuff :food:
In
In
Chub
Well-known member
Did you get a chance to test? Can't remember seeing your name mentioned as a tester but do remember from your workout log you saying you were trying something brand new
Vitruvian
O.G. Appnut
EasyEJL
Never enough
you may have to buy new shirts? thats the biggest catch. seriously.
TexasLifter89
Well-known member
ha REAL FUN!
TexasLifter89
Well-known member
oh boy....
Rosie Chee
The Female Terminator
Did you get a chance to test? Can't remember seeing your name mentioned as a tester but do remember from your workout log you saying you were trying something brand new
No, Sean wasn't a tester (there were just the 2 affiliated with AN).
The ONE is a prohormone...And there's no catch
ETA is 4-5 weeks.
SamBoz19
Well-known member
Did you get a chance to test? Can't remember seeing your name mentioned as a tester but do remember from your workout log you saying you were trying something brand new
Yes...I've tried other products that were new, but this wasn't one of them.
When I run this...expect a more thorough breakdown...my log isn't dead...I've just taken a hiatus away from it due to personal matters and just falling on hard times. I'll resume things when I start my cycle of "The ONE". So stay tuned.
Cheers!:cheers:
Chub
Well-known member
Yes...I've tried other products that were new, but this wasn't one of them.
When I run this...expect a more thorough breakdown...my log isn't dead...I've just taken a hiatus away from it due to personal matters and just falling on hard times. I'll resume things when I start my cycle of "The ONE". So stay tuned.
Cheers!:cheers:
Thats defo one log i won't miss! Can't wait for logs to pop up, it does seem like a truely epic product
Outside Backer
Well-known member
labido was nuts
i wanted to rock that ass all the time, very sexually aggressive
i wanted to rock that ass all the time, very sexually aggressive
donorrell
Board Sponsor
He locked himself in the bathroom a lot...:nutkick:
TexasLifter89
Well-known member
haha