How's it coming along? Really looking forward to this. I would love to beta test
We are closer than you may think :-D. I will post a thread for beta testers very soon.How's it coming along? Really looking forward to this. I would love to beta test
You and me both brotha... so yea can't wait!I would hate to be a tester for this
^^Reverse psychology
We are marketing it as a standalone but don't get me wrong it is going to be a magnificent addition to any PCT.is it only for PCT or can be used alone ?
Yeah, Resveratrol is expensive right now and the bioavailability just isn't there. I see the price coming down a lot over the next couple of years though which is a great thing.i'm itching on this too, just to save me some $ over the cost of taking 1g of resveratrol a day. I think its around $2 a day which irritates me.
Looking forward to trying this also, Anyone else get sleepy after taking resveratrol, if so just wondering what might cause this.
Honestly, not sure what percentage in product I was taking.I thought I was the only one. it makes sleepy, But it does not do that to my wife. Do you take the 50% herb or the 99% pure extract? the 50% will do that more then the pure 99% powder.
Yea looks like a solid addition to the supplement world.On a side note I can't wait for this one to come out. WIth an increase in bioavailability and a drop in price I think a lot more bb's will venture into using this for PCT.
Waiting on labels to print, don't you worry, it's coming! We might be doing a pre sale soon.Thats a good question, where the hell is the Acetyl-Resveratrol?
This is very speculative. You can't go off of "oral dosages" because not only are they different for everyone but they differ depending on other substances that are taken along side it. The only true way to see whether something would work in the body is to know the molar amounts of it in that specific tissue. Studies go off of the molar quantities to gauge effectiveness. For instance some actions of resveratrol are effective in the 5 uM range while some are 10 times that. There are limited studies that state the molar quantities in tissues after specific orally administered dosages. It is also a little different for rats and humans which is why it is hard to take a lot away from that. What I can say is that the health benefits of resveratrol are very clearly stated and that this really could be the next big thing for big pharma.This is just speculation based on various opinions I've read, but i believe health benefits are seen with a low dose, such as 250 mg of trans-resveratrol daily. I myself haven't noticed much with such a low dose, but in the long-term it should be very beneficial as an anti-cancer/ anti-aging supplement.
For PCT, I was taking 1 gram daily of 98& trans-resveratrol with piperine for more bioavailabilty. I definately had more stamina and I could feel a marked improvment with libido after two weeks. I also dropped some boday fat, which was a nice side effect.
Honestly, you will want to exceed 1 gram dialy of the 98& resveratrol or 2 grams of the 50% extract for a good PCT.
With Ibe's new acetylated product coming, dosage can be smaller with much better bioavailabily. This is what I have been waiting for.
Hope that helps.
Yeah, Resveratrol is expensive right now and the bioavailability just isn't there. I see the price coming down a lot over the next couple of years though which is a great thing.
You should see how amazing this stuff is though in the most recent studies.
No I am not confusing them. Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation (def. straight from text). With that being said conjugation is simply the act of changing the molecule. Therefore when the more conjugation taking place the less bioavailability of the compound that is being administered. The quicker you make it through the first pass of the liver the better. We are hoping that due to the increased lipophilicity that the compound will absorb fast enough that it can reach systemic circulation in larger amounts than regular resveratrol. Esterase and other enzymes will still degrade it but it is also possible that it gets degraded back into trans-resveratrol (trihydroxy form) after first pass. There are actually a lot of pharmaceutical companies attempting to do the same thing.You're confusing bioavailbility and conjugation. Plasma spikes are considerable, but it is quickly conjugated in the liver.
Honestly, I do not trust any of the in vitro studies. If you read through most of the in vitro studies, they come to find that action in the body is completely different. You are isolating the molecule from the rest of the body. For instance they will culture intestinal cells and then add resveratrol. This is a very small system and does not take into account the many other cell types and millions of enzymes. There are limited in vivo studies, yes, but we are just going by the research we have done. They passed on acetyl resveratrol not because it doesn't work but because the application they are using it for had better options. For instance, anti-tumor properties. Acetyl Resveratrol had anti-tumor properties slightly higher than regular Res, but trimethoxy res had anti-tumor properties 10 times higher than regular res. However, trimethoxy res had absolutely no antioxidant effects. You have to find a middle ground.A plasma spike is seen prior to first pass. Is it bioavailable?
Sirtis had access to acetyl-resv and passed on it. As you know, there is virtually no in vitro activity with the acetyl form. Also, the acetyl is an NCE and therefore is not a natural product, rendering legal issues related to its sale.
A plasma spike is seen prior to first pass. Is it bioavailable?
Sirtis had access to acetyl-resv and passed on it. As you know, there is virtually no in vitro activity with the acetyl form. Also, the acetyl is an NCE and therefore is not a natural product, rendering legal issues related to its sale.
Don't trust it, why is that? It's likely cleaved intracellularly and active in vivo, but you don't have the data.Honestly, I do not trust any of the in vitro studies.
My brother's fund was a seed/mezz investor in Sirtis. Are you suggesting that 501 is the tri-acetyl? Show you? A shame you're not privy to the data. 501 is not the tri-acetyl. It's micronized resveratrol in HPMC and DOSS.Passed it on show me the research and also you are referring to the 4-acetyl not tri-acetyl and also yes tri-acetylreveratrol is found in food. the 4-acetyl is not..nuff said.
My brother's fund was a seed/mezz investor in Sirtis. Are you suggesting that 501 is the tri-acetyl? Show you? A shame you're not privy to the data. 501 is not the tri-acetyl. It's micronized resveratrol in HPMC and DOSS.
"Passed it on show me the research" Which is nearly indecipherable, but I mentioned that Sirtis passed on the acetyl.Are you even from this country? what the heck are you talking about? where in any of mine or LMD did we say anything about 501. stop putting words in my month. I suggest you back off before things get ugly.
"Passed it on show me the research" Which is nearly indecipherable, but I mentioned that Sirtis passed on the acetyl.
SIRTIS and SRT-501 you phucking twit. Sirtis owns the data on the acetyl and they passed in favor of 501. I don't expect you to understand what you're attempting to bring to market. It's not as though you've phucked up before...
tren or epi, which is it?
Or what, another internet threat? You're woefully out of your depth. Please hold the trenbolone in your tri-acetyl product. The fact that you can't get the data proves how pathetically small-time you are. I have no interest in showing you sh^t.attempting to bring to the market? I am bringing to the market, I know what 501 is jack ass but what the heck does that have to do with my product? I asked you to back what you are trying to say but instead you come back and call me twit? Do you know who you are dealing with? Did'nt I warn you to back off? don't come on my forum and try to start sh*t me buddy. where is that research I ask one more time?
Or what, another internet threat? You're woefully out of your depth. Please hold the trenbolone in your tri-acetyl product. The fact that you can't get the data proves how pathetically small-time you are. I have no interest in showing you sh^t.
My apologies for the "twit" comment. It was a typo; I meant to type "twat"I knew you did'nt know what you were talking about. you showed your motive by not being an aldult and keeping it science but instead you call me a twit and bring up epi. it was nice chatting with you now come back and see us you here.
My apologies for the "twit" comment. It was a typo; I meant to type "twat"
LOL.....this thread got nasty quick. :saw:So anyways.. this ready yet? :afro:
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