Here is one coming straight from Will L. from 2013: I just want to take a moment to specifically address the notion that Arachidonic Acid (ArA) should be taken alone, without fish oil, for maximum anabolic effect. While this may be true for some individuals, we at Molecular Nutrition have found through years of trial and error that fish oil can augment the anabolic effects of ArA in many individuals. This is why we added Omega-3 EFA's to X-Factor Advanced. A recent study may help explain why there may be such synergy. The study in question examined the metabolic effects of fish oil supplementation in young men. As part of this, the researchers measured prostaglandin (PG) levels. As you may know, PGF2-alpha is a prostaglandin produced from arachidonic acid, and is the PG primarily related to protein synthesis and muscle growth. It is what we're looking for more of when taking ArA. The researchers must have expected a reduction in PGF2-alpha after fish oil, given its known competitive nature with ArA. However, the opposite occurred. Fish oil resulted in a substantial increase in PGF2-alpha. What is probably going on is that the omega-3 EFA's in fish oil are displacing membrane-bound ArA, causing it to enter circulation where it is available for PG synthesis. So instead of being counterproductive, taking fish oil alongside ArA may actually cause you to have a greater increase in the serum level of muscle-building prostaglandins. Whatever the exact mechanism, we are not noticing the inhibition everyone expected. It probably isn't this way for everyone, or at least I speculate. I'd imagine those that have already been taking high doses of fish oil might have already done a good job of lowering membrane-bound ARA. I would say this type of user should probably run ArA alone. Otherwise, taking some fish oil might help you get more out of your next run of ArA.
Reference: Metabolism, 2013 Mar 20. pii: S0026-0495(13)00051-6. doi: 10.1016/j.metabol.2013.02.004.
[Epub ahead of print] Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men.
Yes it's his opinion, but he does have his reasoning behind it and does address some of the caveats possible with continuing fish oil with ArA supplementation for some individuals. I'm sure he has much more thoughts and references for his opinions but again, best to ask him directly. I'm just sharing info here. Additional things to think about: What if you are one of those that falls into the demographic in which fish oil supplementation actually will increase your inflammation response? Now what would be the optimal dosing procedure for such an individual? How does one even tell which kind of dosing would be best with them? Just a reminder that there are variables at play in real world practice which are not evident when looking at things in isolated scenarios. Personally, and this is ENTIRELY PERSONAL ANECDOTE (which I've mentioned probably on AM a time or two and a few times over on the other board), so THIS IS NOT A CLAIM, but I found DOMS usually kicks in quicker and stronger when I've used XFA. That's just an n=1 experience, but that is what I have personally observed through multiple ArA cycles.
