Q&A for K1NGSLAYER

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The long awaited release of K1NGSLAYER is almost here. Almost unthinkable that we were able to improve upon OR1GIN, the revolutionary natty muscle builder. xtyler NoAddedHmones created a masterpiece!

https://www.stack3d.com/2018/01/k1ngs-slayer-intro.html
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OFFICIAL K1NGSLAYER WRITE-UP

The ranking of K1NG is associated with wealth, power and prestige. The most enviable position in the land, the alpha male and the most powerful. That position is typically is bestowed upon birth preventing the masses from achieving that status. However, for those that aspire to be the best there is only one other way to become the best …slay the K1NG! Olympus Labs can prepare you for that battle to become the best version of yourself. The transition from a mere mortal into a DemiGod is within reach with K1NGSLAYER.

K1NGSLAYER is actually an enhancement of the revolutionary muscle builder ORIG1N which provided strength, recovery and body composition benefits unlike any other natural supplement. As you may recall, ORIG1N targeted unique pathways including ghrelin secretion, myogenesis and insulin growth factor 1 (IGF-1 signalling). We made a very slight change to the formula, but a very significant one which targets these same pathways to a larger degree. In addition, the new innovative compound in K1NGSLAYER, Korean Mistletoe Extract has been shown to augmentat myogenin expression(a key transcription factor required for regulation of skeletal muscle differentiation), as well as suppressing Atrogin-1 expression ( akey gene induced early during the atrophy process and involved in skeletal muscle atrophy)..

K1NGSLAYER contains four effective ingredients supported by clinical data to induce significant muscle anabolism, where the clinical dose of 2g of Korean Mistletoe Extract replaces Robuvit®. The remaining components of the formula is essentially unchanged; 750mg of Hesperidin Methyl Chalcone, 600mg of Gentian Root extract and 300mg of Atractylodis Lanceae extract (20% Atractylodin). Gentian Root significantly improves digestion and nutrient uptake. Hesperidin and Rikkun****o are potent stimulators of ghrelin secretion, the link connecting somatic growth and body composition with energy metabolism. Korean Mistletoe Extract is another innovative ingredient that Olympus Labs brings to the supplement industry. It has incredible potential as a stimulator of myogenesis, mitochondrial function and IGF-1 receptor signalling. Those pathways ultimately result in increased endurance, increases in skeletal muscle mass and reduction of muscle breakdown. It is quite amazing to have all these properties in one ingredient at the magnitude that KME provides, let alone one that is completely natural.

The combination of these four ingredients in K1NGSLAYER will provide nothing short of exceptional results. As always, Olympus Labs builds our formulations on thorough research and sound science which is reflected in the complete dosing of each ingredient.. In fact, K1NGSLAYER contains doses on the high end or higher than clinical studies so you can rest assured you will experience maximize muscle anabolism. In order to build your ultimate physique you need the ultimate muscle builder and that is K1NGSLAYER.

Prior to discussing the detailed benefits of the ingredients in K1NGSLAYER it would be beneficial to understand the importance of the key pathways targeted.

Ghrelin Secretion
Ghrelin is an endogenous ligand, GHS-R1a, of the growth hormone secretagogue receptor that can cause a significant increase in appetite. In fact, Ghrelin is the only hormone that exhibits this appetite enhancement, or orexigenic effect, following peripheral administration. In addition, ghrelin exhibits a variety of actions, including stimulation of growth hormone secretion, gastric motility, and gastric acid secretion, as well as induction of a positive energy balance. This hormone, predominantly expressed and secreted by the stomach, has a dual action on GH secretion and food intake. It is believed to be the link connecting somatic growth and body composition with energy metabolism.

Insulin Growth Factor 1 (IGF-1)
Insulin Growth Factor 1 (IGF-1), identified in 1957, is a small peptide consisting of 70 amino acids which share some structural similarities to insulin. The IGF-1 receptor gene is expressed by almost all tissues and cells during prenatal development. THe activated IGF-1 receptor is capable of phosphorylating other substances leading to protein kinases which regulate cellular pathways. Research in both children and adults has demonstrated that IGF-1 raises serum alkaline phosphatase, which is an indicator of osteoblastic activity and linked to muscle development. Although different than growth hormone, IGF-1 receptor signalling has been proven to result in muscle growth.

Korean Mistletoe Extract
Mistletoe is a semi-parasitic plant that grows on various trees and that has been used for centuries to treat several human ailments. It is believed to have anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. There are several extracts of Mistletoe and the chemical composition of them depends on the species of the host tree, harvest time and extract preparation. Recent research has focused on Korean mistletoe extract (KME) for use as a treatment for the prevention and reversal of muscle wasting conditions. The research on KME is nothing short of exceptional and quite beneficial for athletes. It has been shown to increase endurance exercise by potentiating mitochondrial function and increase muscle hypertrophy while preventing muscle atrophy. It induced those results by stimulating myogenesis,phosphorylation of Akt signaling pathway(THE anabolic machinery) PGC-1α and GLUT4 expression (linked to insulin secretion and sensitivity, perfect partner for higher IGF-1 expression stimulated by Hesperidin and Rikkun****o) and inhibited atrogin-1. Although KME is derived from a semi-parasitic plant, clinical studies in humans have found no negatives side effects. In fact, studies have shown it has been well tolerated and there have been no indications of liver or kidney toxicity.

A randomized controlled trial examined whether a combination of Korean mistletoe extract (KME) supplement and exercise affected muscle mass, muscle function, and targeted molecular expressions. Sixty-seven subjects were assigned to placebo, low-dose (1 g/d), or high-dose (2 g/d) of KME for 12 weeks. The body composition was significantly changed in the high-dose group during the intervention period as determined by skeletal muscle mass, fat free mass, soft lean mass, skeletal muscle index, fat-free mass index, percent body fat, and fat mass to lean mass ratio. Knee strength measurements demonstrated a significant effect in the KME groups compared to the placebo group, which was more pronounced after adjusting for age, gender, protein, and energy intake. The dynamic balance ability was remarkably improved in the high-dose group over a 12-week period as determined a fast walk and ordinary walk test. Consistent with these results, RT-PCR, multiplex analyses, and immunocytofluorescence staining revealed that a high-dose KME supplementation was effective for suppressing intracellular pathways related to muscle protein degradation, but stimulating those related to myogenesis. In particular, significant differences were found in atrogin-1 mRNA, myogenin mRNA and insulin growth factor 1 receptor phosphorylation at a single administration and a 12-week administration. These results suggest that KME supplementation together with resistance exercise may be useful in suppressing the age-related loss of muscle mass and strength.

A clinical study examined the expression pattern of several genes concerned with muscle physiology in C2C12 myotubes (mice) cells to identify whether KME inhibits muscle atrophy or promotes muscle hypertrophy. KME induced the mRNA expression of SREBP-1c, PGC-1α, and GLUT4, known positive regulators of muscle hypertrophy, in C2C12 cells. On the contrary, KME reduced the expression of Atrogin-1, which is directly involved in the induction of muscle atrophy. In animal models, KME mitigated the decrease of muscle weight in denervated mice. The expression of Atrogin-1 was also diminished in those mice. Moreover, KME enhanced the grip strength and muscle weight in long-term feeding mice. These results suggest that KME has beneficial effects on muscle atrophy and muscle hypertrophy.

An study was conducted to examine whether KME could increase mitochondrial activity and exert an anti-fatigue effect in mice. KME treatment significantly increased the mitochondrial oxygen consumption rate (OCR) in L6 cells and increased the expression of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and silent mating type information regulation 2 homolog 1 (SIRT1), two major regulators of mitochondria function, in C2C12 cells. In the treadmill test, KME-treated mice could run 2.5-times longer than chow-fed control mice. Additionally, plasma lactate levels of exhausted mice were significantly lower in the KME-treated group. In addition, the swimming time to exhaustion of mice treated with KME was prolonged by as much as 212% in the forced-swim test. Liver and kidney histology was similar between the KME-treated and phosphate-buffered saline-treated animals, indicating that KME was nontoxic. These results show that KME induces mitochondrial activity, possibly by activating PGC-1α and SIRT1, and improves the endurance of mice, strongly suggesting that KME has great potential as a novel mitochondria-activating agent.

Hesperidin
Hesperidin is a flavanone glycoside or a sugar molecule consisting of the flavone hesperitin bound to the disaccharide rutinose. It is naturally occurring in citrus fruits including oranges, tangerines and grapefruits. Hesperidin has been shown to influence several biological functions, including inhibiting tumor development and the proliferation of human cancer cells, as well as the destruction of cancer cells. It also has antibacterial, antiviral, and antifungal properties. In vivo studies have shown that hesperidin may also play a role in ghrelin secretion from the stomach through antagonism of the serotonin receptors.

A study with mouse muscle cells was performed to assess the in vivo and in vitro effect of hesperidin on myogenic differentiation (muscle tissue formation). The cells were analyzed in the presence and absence of hesperidin for the in vitro portion of the study using several lab testing methods, including reporter gene assays, immunoblotting, RT-PCR and DNA pull-down assays. In vivo, the effects of hesperidin were assessed using the freeze injury-induced muscle regeneration model in mice and daily injections of hesperidin for 6 days. Hesperidin promoted myogenic differentiation, in a dose-dependent manner, by increasing myogenin gene expression. Myogenin is a gene transcriptor in mice that plays a critical role in the development of functional skeletal muscle. Hesperidin increased myogenin and muscle creatine kinase gene expression during myogenic differentiation from C3H10T1/2 mesenchymal stem cells in a MyoD-dependent manner and accelerated in vivo muscle regeneration induced by muscle injury. These results indicate hesperidin can play a beneficial role in promoting muscle regeneration, following injury.

Gentian root
Gentian root is a a herbal bitter that is derived from the perennial, Gentiana lutea L. It has traditionally been used in the treatment of digestive disorders and is an ingredient of many proprietary medicines. It contains secoiridoid glucosides which are some of the most bitter compounds known and is used as a scientific basis for measuring bitterness. Gentiana lutea is known to have several biological effects, such as anti-oxidant, anti-tumor and hepatoprotective properties. Recent clinical research into Gentian root and other bitter compounds found that observed improvements in digestion and appetite may at least be partly ascribed to the bitter tonic effect. The increase in appetite that Gentian root provides can be attributed to its ability to stimulate ghrelin secretion. If you want grow you will need to get those macros in and the significant improvement in digestion that Gentiana lutea provides will make larger meals more tolerable. At the substantial dosage included in OR1GIN it will be extremely effective in that regard.

Atractylodin
Atractylodin is a derivative of the Atractylodes herb, a member of the Asteraceae family. It can be found in Rikkun****o, a Japanese herbal medicine. It has been traditionally used as treatment for several conditions including diarrhea, atrophy and flaccidity, arthralgia (joint pain) due to wind and dampness and loss of appetite. Similar to Gentian root, the effect on appetite that Atractylodin causes is indicative of ghrelin secretion. As detailed in the study below, Atractylodin has been shown to be effective with hesperidin induced ghrelin receptor signaling.
Active components of rikkun****o, hesperidin and atractylodin, were given to tumor-bearing rats to determine their efficacy as a treatment for cancer anorexia–cachexiaé It is a syndrome that results in decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortality in cancer patients. Corticotropin-releasing factor (CRF) decreased the plasma level of acyl ghrelin, and its receptor antagonist, α-helical CRF, increased food intake of these rats. The serotonin 2c receptor (5-HT2cR) antagonist SB242084 decreased hypothalamic CRF level and improved anorexia, gastrointestinal (GI) dysmotility and body weight loss. The ghrelin receptor antagonist (D-Lys3)-GHRP-6 worsened anorexia and hastened death in tumor-bearing rats. Ghrelin attenuated anorexia–cachexia in the short term, but failed to prolong survival, as did SB242084 administration. In addition, the herbal medicine rikkun****o improved anorexia, GI dysmotility, muscle wasting, and anxiety-related behavior and prolonged survival in animals and patients with cancer. The appetite-stimulating effect of rikkun****o was blocked by (D-Lys3)-GHRP-6
Active components of rikkun****o, hesperidin and atractylodin potentiated ghrelin secretion and receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats. Our study demonstrates that the integrated mechanism underlying cancer anorexia–cachexia involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF through the 5-HT2cR. Potentiation of ghrelin receptor signaling may be an attractive treatment for anorexia, muscle wasting and prolong survival in patients with cancer anorexia–cachexia.

Conclusion
It is time for you to become the master of your own destiny. It is time to breakthrough genetic limitations or other barriers. K1NGSLAYER eradicates all obstacles to becoming bigger and stronger. The holy grail of natural muscle builders just got more powerful with the innovative new compound; Korean Mistletoe Extract. K1NGSLAYER will deliver results that are unbelievable from a natural supplement. By stimulating key pathways linked to muscle; ghrelin secretion, myogenesis, IGF-1 receptor signalling and mitochondrial function K1NGSLAYER is undoubtedly the K1NG of natural muscle builders.

The first noticeable benefit you will experience from K1NGSLAYER will likely be the improved digestion, nutrient uptake and muscle recovery. While that is amazing on its own it will get so much better from there with improved body composition due to increased energy metabolism. The key aspect of all the aforementioned benefits is they will occur to a significant degree, certainly more than any natural muscle builder on the market.
To make the most gains in the gym you need the best supplements and Olympus Labs provides the Innovation, Value and Results you need. Forge your destiny with K1NGSLAYER!

References:
1. Camina JP et al. Endocrine. 2003 Oct;22(1):5-12. Regulation of ghrelin secretion and action.
2. Z Laron et al. Mol Pathol. 2001 Oct; 54(5): 311–316. Insulin-like growth factor 1 (IGF-1): a growth hormone
3. NJ Lima, et al. Experimental Gerontology. Volume 87, Part A, January 2017, Pages 48-56. A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial.
4. J Jeong, et al. BMC Complementary and Alternative Medicine. January 2017. 17:68. https://doi.org/10.1186/s12906-017-1575-9é. Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy.
5. HY Jung, et al. Journal of Medicinal Food. Vol. 15: , Issue. 7, : Pages. 621-628. July 2012. https://doi.org/10.1089/jmf.2010.1469. Korean Mistletoe (Viscum album coloratum) Extract Improves Endurance Capacity in Mice by Stimulating Mitochondrial Activity.
6. Suzuki H et al. Recent Pat Food Nutr Agric. 2014;6(1):60-3. Hesperidin potentiates ghrelin signaling.
7. Hana J et al. Br J Pharmacol. 2011 Jun; 163(3): 598–608. doi: 10.1111/j.1476-5381.2011.01243.x. Hesperidin promotes MyoD-induced myogenic differentiation in vitro and in vivo.
Gentiana lutea Yellow Gentian PFAF Plant Database
8. Olivier DK et al. J Ethnopharmacol. 2013 Jun 3;147(3):676-9. doi: 10.1016/j.jep.2013.03.059. Epub 2013 Mar 30. Bitterness values for traditional tonic plants of southern Africa.
9.Kusar A et al. Human & Experimental Toxicology (2006) 25: 599-604. Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance.
10. McMullen MK et al. J Ethnopharmacol. 2014 Jul 3;154(3):719-27. doi: 10.1016/j.jep.2014.04.041. Epub 2014 May 5. Bitter tastants alter gastric-phase postprandial haemodynamics.
Atractylodes (Cang Zhu) | Chinese Herbs Healing
11. S Takiguchi et al. Gastric Cancer (2013) 16:167–174. DOI 10.1007/s10120-012-0164-3. Effect of rikkun****o, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels
in gastric cancer patients after gastrectomy.
12. N Fujitsuka et al. Transl Psychiatry. 2011 Jul; 1(7): e23. Published online 2011 Jul 26. doi: 10.1038/tp.2011.25. Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
 
Woody

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Cannot. Wait.
 
xtyler

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We did it again. As if Urolithin-B wasn't enough.

At this rate we won't even need to lift anymore.

WHO'S YOUR FRIGGIN DADDY?

Olympus Labs for the win once again. Undisputed innovation leaders. Period.
 
JulzRulz

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From my understanding it will be perfect on cycle and during PCT.

Looking forward to the release. ?
 
iamyourfather

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Q&A for K1NGSLAYER

very nice! how long shoud KS be run at least and is there a max. time?

EDIT: could it be that the DOI of reference #4 isnt correct? i cant find it
 
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Sub'ed.....you guys are killing my bank account. I guess if I end up homeless being jacked should make me less of a target
 
Woody

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Sub'ed.....you guys are killing my bank account. I guess if I end up homeless being jacked should make me less of a target
You'll have first dibs at all the good dumpsters, too
 
Oconns28

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Would you guys please just sponsor me already!! I'll be your guinea pig!! Lol
 
iamyourfather

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Q&A for K1NGSLAYER

and people, please tell us your experiences, in a short summary to keep this thread KS focused, with the OG Or1gin, so others (and I) can know what to expect with this new supplement. (in an even stronger way?)
i think that would be good thing for all people new to these ingredients and sitting on the fence for KS =)
 
VO2Maxima

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Great formula R&D team, and nice write-up G.

I can't wait to get my hands on this one. Nor can I wait for all you guys to experience it!
 
xtyler

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From my understanding it will be perfect on cycle and during PCT.

Looking forward to the release. ��
Yessir, any-time.

very nice! how long shoud KS be run at least and is there a max. time?
No minimum and you can run it for months and months without a break.
 
Oconns28

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What does "almost here" mean lol. I've been contemplating starting to cut but getting bigger is much more fun!
 
Danes

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1. What is Rikkunsh1to whole plant ? :D
2. Why is Actractylodin named as Rikkunsh1to ?
"Gentian Root significantly improves digestion and nutrient uptake. Hesperidin and Rikkun****o are potent stimulators of ghrelin secretion"...

Rikkunsh1to = KAMPO medicine made of 8 plants/herbs
 
Mowglisml

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We did it again. As if Urolithin-B wasn't enough.

At this rate we won't even need to lift anymore.

WHO'S YOUR FRIGGIN DADDY?

Olympus Labs for the win once again. Undisputed innovation leaders. Period.
My massacr3 log might just turn into a year long run with all these new drops
 
muscleupcrohn

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It's still the gentian extract like what was used in Origin? The label looks like it only says "root" compared to the old label that said 10:1 extract.
 
chedapalooza

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I like the straight forward bolus dosing. Since my largest meal is post workout and Is minimum 1400cals I very much look forward to seeing how this product will affect me with gains, fat loss, and digestion. On top of Glycøshield I’ll have no excuses not to look like I work out, finally
 
TreatnHerRigt

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What would be the optimal way to take this?
When Bulking/Cutting/Recomp?

Because i plan to start a cut soon, and this sounds pretty awesome!
 
TrainerTone

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I was planning to start my cut beginning of April but might have to push it back to May now just so I can give K1ngslayer a run!! Super exc1ted for this, especially after reading that write up!!
 
NoAddedHmones

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What would be the optimal way to take this?
When Bulking/Cutting/Recomp?

Because i plan to start a cut soon, and this sounds pretty awesome!
Will actually benefit in any circumstance. I tested while at maintenance calories and recomp effects were really noticeable within a few weeks. If you have used Orig1n then you will experience the same digestion, recovery and workout performances that it provided.
 
Danes

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Will actually benefit in any circumstance. I tested while at maintenance calories and recomp effects were really noticeable within a few weeks. If you have used Orig1n then you will experience the same digestion, recovery and workout performances that it provided.
Digestion on Or1gin was insane! I could eat a lot of red meat and still my stomach felt great
 
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this gonna be so synergistic with ames1a
 
muscleupcrohn

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Digestion on Or1gin was insane! I could eat a lot of red meat and still my stomach felt great
I noticed this when I used it too. Same with other product I used that also had gentian. Is this the same gentian extract as in Origin? The old label said 10:1 extract and the new one only says root, but maybe it’s just a labeling thing?
 
NoAddedHmones

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I noticed this when I used it too. Same with other product I used that also had gentian. Is this the same gentian extract as in Origin? The old label said 10:1 extract and the new one only says root, but maybe it’s just a labeling thing?
It is the exact same
 
big_jewels

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Sweet ! just in time as i'm finishing off my last 2 bottles of OG Or1gin.
 
Ricky10

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I had previously seen the data and researched the benefits of Korean Mistletoe and suspected it would not be long before somebody utilized this ingredient. Congrats to OL for bringing it to the table!
 
NoAddedHmones

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I had previously seen the data and researched the benefits of Korean Mistletoe and suspected it would not be long before somebody utilized this ingredient. Congrats to OL for bringing it to the table!
We had worked on getting the right source and extract for months...
 
xtyler

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We had worked on getting the right source and extract for months...
Yep. Finding the correct plant material ain't easy as most would assume. Same goes for extraction process.
 
TheMrMuscle

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Good job! Im one week into my 3 bottles or Or1gin so by the time i run out people should have been getting their hand on K1ngslayer. Hopefully it will be available in the EU by then as well so that i can move on to that.
 
xtyler

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Good job! Im one week into my 3 bottles or Or1gin so by the time i run out people should have been getting their hand on K1ngslayer. Hopefully it will be available in the EU by then as well so that i can move on to that.
Count on it ;)
 
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Looking forward to stacking this for a natural cycle in my PCT.
 
brundel

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I have a question.
Rikkun****o isnt a plant. Its a chinese medicine comprised of 8 ingredients. Can you explain how you have Rikkun****o whole plant if its not a plant?

"
Rikkun****o, a Kampo medicine, is often prescribed for upper gastrointestinal disorders such as functional dyspepsia (FD), gastroesophageal reflux, and anorexia [1–3] and is prepared by compounding eight of the following crude drugs: Atractylodis lanceae rhizoma, Ginseng radix, Pinellia tuber, Hoelen, Zizyphi fructus, Aurantii nobilis pericarpium, Glycyrrhizae radix, and Zingiberis rhizome. "

https://www.hindawi.com/journals/ecam/2014/519035/

And how is it standardized for 20% atractlodin if its 8 plants?
 
NoAddedHmones

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I have a question.
Rikkun****o isnt a plant. Its a chinese medicine comprised of 8 ingredients. Can you explain how you have Rikkun****o whole plant if its not a plant?

"
Rikkun****o, a Kampo medicine, is often prescribed for upper gastrointestinal disorders such as functional dyspepsia (FD), gastroesophageal reflux, and anorexia [1–3] and is prepared by compounding eight of the following crude drugs: Atractylodis lanceae rhizoma, Ginseng radix, Pinellia tuber, Hoelen, Zizyphi fructus, Aurantii nobilis pericarpium, Glycyrrhizae radix, and Zingiberis rhizome. "

https://www.hindawi.com/journals/ecam/2014/519035/

And how is it standardized for 20% atractlodin if its 8 plants?
Hi thanks for the series of rhetorical questions, its obviously a labelling error, as you know. We moved from a freeze dried oil in Orig1n to a 20% extract of atractylodis lanceae.
 
brundel

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Hi thanks for the series of rhetorical questions, its obviously a labelling error, as you know. We moved from a freeze dried oil in Orig1n to a 20% extract of atractylodis lanceae.
Not meant to be problematic. A reasonable question I assume someone else would ask if I didn't.
Korean mistletoe is interesting.
Is it 2g of 1:1 whole plant? Not a bad choice.
 
NoAddedHmones

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Q&A for K1NGSLAYER

Not meant to be problematic. A reasonable question I assume someone else would ask if I didn't.
Korean mistletoe is interesting.
Is it 2g of 1:1 whole plant? Not a bad choice.
No, it is 2g of the whole plant extract from a korean sourced mistletoe (no an easy thing to source) and extracted in the same process as the referenced study.
 

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