Pregnolone and DHEA

Insomnia is a classic sign of the beginning of over training.

I am really surprised that you run preg at that high of a dose and had no side effects related to e2. That would keep me awake for days, btw.
 
Did the same thing to me at 50-100mg Preg, crazy insomnia! And super hot, sweating in 60 degree A/C which felt like torture haha talk about an imbalance!
 
kisaj said:
It's weird that I have been hearing and reading so much about this lately because I had to call my endo today to update insurance info and he quickly ran through my charts on the phone. He asked if we had ever discussed adding this in and I said no, that we found a good protocol with my test cyp injects and I felt really good. He tells me that I am mid range and that he think I could feel even better if I were in the top range for DHEA and now wants me to take sublingual DHEA 25mg 2xd and 50mg of pregnolone and then run labs in a month.

I just picked the stuff up that he recommended, so I guess we'll be seeing how this works out.
Click to expand...

test or TRT ONLY covers testosterone... there are MANY other factors that you lose out on if you dont add prengn or DHEA IMO.
I would NEVER rec or do HRT without daily Pregnolone and/or DHEA.. EVER.. if you have to pick only one then get Pregnolone, but i rec both also..
there is a whole chain reaction of hormones before the hormone testosterone. ist good to take the "mother" hormones before test so your body can use and convert whats needed/used to.
an HRT of only testosterone shots/creams is not an optimal HRT.

good luck! : )

PS. took my DHEA and preng, no ****... 5 min ago! haha.
 
I take about 50-100mg preng ed btw
 
UCSMiami said:
daily? for how long now?
Click to expand...

like 2 or 3 years now. sometimes i miss a day ( busy) but 5-6 days out of the week i take it. i was on hrt alone for a couple years before that, and i felt a lil better after adding it in i think.
I been using LG's M1D and the preng for a year now since i had a BUNCH of M1D and it is DHEA, with less chance to go to estogen. seems to work well. when im out ill prob go back to simple DHEA and compare.
 
kisaj said:
Insomnia is a classic sign of the beginning of over training.

I am really surprised that you run preg at that high of a dose and had no side effects related to e2. That would keep me awake for days, btw.
Click to expand...

I just checked and my Estradiol was 21.7pg/ml using Roche methodology and the scale is 7.6 - 42.6. I was still consuming 100mg of Pregnenolone. I looked at my consumption/refill rate in the period before bloodwork and it works out to approx. one capsule every 1.75 days since January1st.
 
UCSMiami said:
daily? for how long now?
Click to expand...

I take 100 mgs of preg everyday. Life extension brand. Been doing it for almost 3 months now. My E2 is elevated and recently started arimidex. I don't think it's from the preg tho. It's been elevated since I've been on trt which was started last October.
 
Does anyone know if pregnenolone can affect your TSH number? I had a value of 1.55 about a year ago and just had it tested again and it came back as 0.74. The only supplement change I made during that time was taking Bacopa and Ashwagandha (replaced them with rhodiola about 2 months ago) and started taking pregnenolone (10 to 20 mg of sublingual tablets each day) a little over a month ago.
 
jarrellt67 said:
Does anyone know if pregnenolone can affect your TSH number? I had a value of 1.55 about a year ago and just had it tested again and it came back as 0.74. The only supplement change I made during that time was taking Bacopa and Ashwagandha (replaced them with rhodiola about 2 months ago) and started taking pregnenolone (10 to 20 mg of sublingual tablets each day) a little over a month ago.
Click to expand...

Do you mean FSH? If so, I believe this drops significantly because you are injecting test. It's a natural occurrence in the body from injecting test since your body isn't making it.
 
sammpedd88 said:
Do you mean FSH? If so, I believe this drops significantly because you are injecting test. It's a natural occurrence in the body from injecting test since your body isn't making it.
Click to expand...

No, TSH (Thyroid Stimulating Hormone). I'm not injecting test...just taking pregnenolone since it helps with energy and focus.
 
I have been considering supplementing with Pregnelonone and DHEA. However, my recent blood tests indicate that my DHEA Unconjugated is almost twice as high as the top of the range for normal. However, my DHEA-S is borderline low (4.75 where normal is 3.59-11.91).

Can anyone tell me which of these two measurements is the one to go by? I would guess the DHEA-S, but I'm a bit alarmed by the astronomical unconjugated DHEA.
 
vkg1 said:
I have been considering supplementing with Pregnelonone and DHEA. However, my recent blood tests indicate that my DHEA Unconjugated is almost twice as high as the top of the range for normal. However, my DHEA-S is borderline low (4.75 where normal is 3.59-11.91).

Can anyone tell me which of these two measurements is the one to go by? I would guess the DHEA-S, but I'm a bit alarmed by the astronomical unconjugated DHEA.
Click to expand...

You really want them both because they work together. Are you taking fish oil, l-dopa, or lots of vitamin E? They are known to lower dheas numbers. Unless you are out of range, I wouldn't be too concerned about it, but you could always ask your endo.
 
kisaj said:
You really want them both because they work together. Are you taking fish oil, l-dopa, or lots of vitamin E? They are known to lower dheas numbers. Unless you are out of range, I wouldn't be too concerned about it, but you could always ask your endo.
Click to expand...
That is VERY helpful. I had NO IDEA fish oil reduced DHEA. Since I regularly use fish oil, l-dopa, and vitamin E - that explains a lot.Thank you.
 
kisaj said:
You really want them both because they work together. Are you taking fish oil, l-dopa, or lots of vitamin E? They are known to lower dheas numbers. Unless you are out of range, I wouldn't be too concerned about it, but you could always ask your endo.
Click to expand...

My doc put me on vitamin E about three months ago and started taking pregnenolone at the same time. My DHEA levels were good then. Having labs done soon. Since I've been taking vitamin E and my DHEA levels were good, but in the low end, you're saying vitamin E could drop it? Maybe that's why I feel like something is missing! I may ask if I can bump up my lab work!
 
I'm saying it is possible. When I was tested, I was asked if I was taking vitamin e, fish oil, or l-dopa and told to stop several weeks beforehand as it can lower real numbers. I did a lot of researching and discussed with my endo and it appears there is conflicting information on DHEA and vitamin e as it can protect against oxidative stress, but it was of the opinion of his office and the lab that it can interfere with test numbers and make them lower.

Would I ever say to stop taking vitamin e or fish oil? No. Just saying to be aware for testing purposes.
 
kisaj said:
I'm saying it is possible. When I was tested, I was asked if I was taking vitamin e, fish oil, or l-dopa and told to stop several weeks beforehand as it can lower real numbers. I did a lot of researching and discussed with my endo and it appears there is conflicting information on DHEA and vitamin e as it can protect against oxidative stress, but it was of the opinion of his office and the lab that it can interfere with test numbers and make them lower. Would I ever say to stop taking vitamin e or fish oil? No. Just saying to be aware for testing purposes.
Click to expand...

Oh I'm not saying I should stop the vitamin e. Just wondering if it has lowered my DHEA. Something has happened in the last month. My libido is not as high as it was an erections are not as strong. I started arimidex a few weeks ago and things were going good with it but still not where I want to be. I'm hoping I can get my blood work moves up and see what is going on.
 
Oh, well that is a huge variable. Adding any AI and seeing a drop in libido is usually due to e2 going too low. Make sure you get your e2 level checked.
 
kisaj said:
Oh, well that is a huge variable. Adding any AI and seeing a drop in libido is usually due to e2 going too low. Make sure you get your e2 level checked.
Click to expand...

I was feeling like that before the AI. I'm having a tough time because the only symptoms I show when I'm high is bloating and anxiety. No sensitive nipples or gyno or any other classic signs. No clue what I would feel like too low. I only take .25 E3D.
 
Some good info being posted in this thread lately. I had no idea about fish oil, l-dopa, and vitamin E affecting DHEA levels
 
kisaj said:
Oh, well that is a huge variable. Adding any AI and seeing a drop in libido is usually due to e2 going too low. Make sure you get your e2 level checked.
Click to expand...

I've also followed that protocol in the famous post on here by a guy that have his recommendation on arimidex and watching your morning wood. Not sure if that is working for me or not.
 
Morning wood is only a small indicator of test and e2 levels. REM actually has more to do with morning wood.
 
That's the point. You can't tell, which is why using it as a gauge for anything hormonal is not a good method. I was getting morning wood every day and had 200 levels of test and high estrogen.
 
kisaj said:
That's the point. You can't tell, which is why using it as a gauge for anything hormonal is not a good method. I was getting morning wood every day and had 200 levels of test and high estrogen.
Click to expand...

Interesting.....you're like the Yoda of this forum!
 
UCSMiami said:
Damn. I thought morning wood was the el cheapo test for free T.
Click to expand...

Combined with sexual function, it's a decent indicator/gauge only while on TRT imo.

For example, I had good morning wood while my test levels were in the 300's before starting TRT. My e2 was balanced for that level, but they both were definitely not optimal levels at all.
 
kisaj said:
You really want them both because they work together. Are you taking fish oil, l-dopa, or lots of vitamin E? They are known to lower dheas numbers. Unless you are out of range, I wouldn't be too concerned about it, but you could always ask your endo.
Click to expand...

No, I am just trying to eat healthy and take multi-vitamin and zinc. I'm not quite sure what you mean when you say you want them both. My values for one are high and the other low. I'm wondering which is the better indicator for whether or not I should consider supplementing DHEA. Do you know which test is considered more reliable or more appropriate to make this determination from?
 
vkg1 said:
No, I am just trying to eat healthy and take multi-vitamin and zinc. I'm not quite sure what you mean when you say you want them both. My values for one are high and the other low. I'm wondering which is the better indicator for whether or not I should consider supplementing DHEA. Do you know which test is considered more reliable or more appropriate to make this determination from?
Click to expand...

I think what he meant by both was both DHEA and pregnenolone. They work together.
 
vkg1 said:
No, I am just trying to eat healthy and take multi-vitamin and zinc. I'm not quite sure what you mean when you say you want them both. My values for one are high and the other low. I'm wondering which is the better indicator for whether or not I should consider supplementing DHEA. Do you know which test is considered more reliable or more appropriate to make this determination from?
Click to expand...

I'm saying you want both DHEA serum and DHEA-s serum. My endo was more concerned with the result of the DHEA-S number because elevated or low numbers indicate other issues. These tests are usually included with others (SHBG, test, preg, cortisol, etc..) for a complete workup.

Determining if you should supplement would be a decision between you and your doc.
 
Thanks guys, but all credit goes to Onlychevy6 from my standpoint. I was only researching it on my own until he started talking about it with his experience and that made me start the discussion with my doc and endo. I just happen to get a little crazy with my research and discussions with doctors and pass along what I learn.

It's a great community that fosters an environment where we can all learn from each other.
 
Definitely helps to have folks who have been there and done that to draw knowledge and perspective from. I've been mulling my own journey into TRT for years now. Currently use HCG but it seems to be waning in effect.

Sublingual preg should be here by Fri. Currently use Dermacrine with mixed results and want to see what preg as a standalone can do.
 
bioman said:
Definitely helps to have folks who have been there and done that to draw knowledge and perspective from. I've been mulling my own journey into TRT for years now. Currently use HCG but it seems to be waning in effect. Sublingual preg should be here by Fri. Currently use Dermacrine with mixed results and want to see what preg as a standalone can do.
Click to expand...

Speaking of sublingual pregnenolone, anyone know if there is a greater benefit from it versus an oral capsule?
 
goodvibes said:
This kisaj dude know his endocrine & steroids. I've learned quite a lot trolling from this forum and reading from the likes of this gentleman.
Click to expand...

Yeah, he is a good dude and he now reps for the best supplement company in the business.
 
sammpedd88 said:
Speaking of sublingual pregnenolone, anyone know if there is a greater benefit from it versus an oral capsule?
Click to expand...

Yes, far better absorption with the sublingual form. Nobody should be using oral preg or dhea. Use sublingual s or transdermals.
 
ELROCK said:
Yes, far better absorption with the sublingual form. Nobody should be using oral preg or dhea. Use sublingual s or transdermals.
Click to expand...

Why no go on the oral pregnenolone? I took oral 100mg and my progesterone levels increased. Same result with much less mg if taken sublingually?
 
You must log in or register to reply here.
Back
Top