If joint issues exist when you go onto Gharine/MK, it would be advisable to add in a joint builder formula. Increased GH will trigger growth - everywhere. For joints to repair they need specific compounds such as msm, glucosamine, collagen etc. The more growth you get the greater the demand for said nutrients. Don't just assume that no pain means effective healing is taking place, specific nutrients will be required - unless your diet will provide adequate nutrition in that regard.
My joint pain disappeared on MK, reappeared when the cycle ended. Next time I will increase the dose of Now Joint Support powder &/or one of the tablet/capsule products such as Vital Labs Joyful Joints or Infinite Labs (the turmeric is great) if anti-inflammatory ingredients are needed. I will run MK much, much longer next time.