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Ok, guys - here is the writeup covering the updated formula.
BMP 2.0 Write Up
Intro
EvoMuse released the original BMP formula almost a year ago and it became extremely popular with tons of great user feedback, fully delivering on the muscle building hype. During this time however, we’ve found a way to make BMP even better while still keeping it just as cost-effective. If you’re familiar with the original formula, you’ll notice quite a few similarities, but also a few key changes that we’re confident will give users even better results.
BMP, for the sake of our new groundbreaking formula, stands for Body Modify- Phenotype.
For the sake of the physiology it happens to be targeting, it stands for Bone Morphogenetic Protein.
Based on new research, it turns out that a pathway once thought to only regulate bone growth/turnover is actually tightly and crucially linked to muscle growth as well. Since this research began to surface, we’ve been watching it like a hawk and researching ingredients that might take advantage of this pathway. Now that more and more data have confirmed the previous conclusions, we are confident that EvoMuse BMP is about to dig its heels in as a serious player in the toolbox for natural and assisted bodybuilders.
Much of the research we have access to at this point is looking at bone anabolism as opposed to muscle, as the BMP-muscle link is such a new area. So we will have to extrapolate a bit and look at implications of the ingredients’ effects on bone growth through BMP, knowing that the same pathway is going to target muscle growth as well. At this point, when we find something that targets bone growth through supporting the BMP pathway, we can assume increased rates of muscle growth will accompany.
Definitions
Since this is quite a dense topic, it will be exponentially easier to understand, and flow through reading the write-up if several terms/concepts are at least superficially understood. Scan through these definitions first, and then refer back to them as you go through the write-up as you need clarification.
Bone Morphogenetic Proteins (BMPs)
BMPs are a class of growth factors belonging to the Transforming Growth Factor beta (TGF-b) superfamily. Another, contrasting part of this superfamily is the myostatin/activin subfamily.
These two subfamilies have directly opposing functions on muscle mass, namely that BMPs are anabolic and myostatin is catabolic. Originally it was thought that BMPs were responsible, solely, for bone and cartilage formation, but recently it has been discovered that they are also key players in skeletal muscle growth.
Interestingly, BMPs are actually dominant over myostatin signaling; when levels are high they win the anabolic/catabolic battle. BMPs are divided into specific proteins, namely BMP2, BMP4, and BMP7.
BMP’s promote chondrocyte proliferation AND hypertrophy, and SMAD signaling (see below) regulates chondrocyte hypertrophy (1). BMP’s are unique in that they not only induce differentiation of mesenchymal stem cells to osteoblasts, and they also enhance the function of the osteoblast once differentiated (2).
A 2013 study published in the journal Nature Genetics provided some compelling conclusions about BMP and muscle tissue (3).
BMP signaling is the fundamental signal for hypertrophy.
Inhibiting BMP signaling causes atrophy, abolishes myostatin deficient mice from gaining the enormous amount of muscle they normally do, and increases the negative effect from fasting.
BMP plays a critical role in adult muscle growth.
Now we’ll take a look at the specific types of BMPs.
BMP2
BMP2 plays a major role in bone and cartilage formation, as well as osteoblast differentiation. Differentiation is an important point here, as will be discussed below. BMP2 is the secondary target of this formula, with BMP7 being the primary target.
BMP4
BMP4, while still important, is comparatively our lowest priority of the three for targeting muscle growth. Like the other BMPs it is involved in bone and cartilage development, although more specifically for teeth and limbs, as well as being a key player during embryonic development.
BMP7
BMP7 is our priority target for muscle growth. It is a major player in osteoblast differentiation as well as the induction of SMAD1 and SMAD5 (see below).
SMADs
SMADs are a family of nine proteins that live inside the cell, which fall into one of three categories (receptor-regulated, common-mediator, or inhibitory). The first two classes help to mediate BMP by bringing the extracellular signal into the nucleus of the cell where they trigger gene transcription downstream.
SMAD4, which makes up the entirety of the common-mediator class, is a helper protein for SMAD1/2/3/5/8/9, which make up the receptor-regulated class. Once BMPs hit the cell membrane, this triggers the phosphorylation of SMAD1/5/8; they then form a complex with SMAD4 and are translocated to the nucleus. SMADs basically act as an executive assistant to BMPs.
Chondrocyte
This is just a cartilage cell. That was easy.
Chondrogenesis
The formation of cartilage. Another gimmie.
Mesenchymal Stem Cell (MSC)
MSC’s are stem cells located in connective tissue throughout the body, which can differentiate down different pathways into chondrocytes, osteoblasts, or adipocytes.
Osteoblast
Formed from MSC’s, these cells, once grouped together are responsible for synthesizing bone. Since bone is a dynamic tissue, these cells are constantly working in anabolic opposition to the catabolic osteoclasts.
Osteoclast
A catabolic bone cell, osteoclasts oppose osteoblasts and encourage bone resorption (the process of breaking down bones which pushes calcium into the blood).
Wnt Signaling Pathways
These pathways are made up of proteins that function in a way similar to SMADs, helping pass signals from outside to inside a cell, as well as regulating b-catenin from the cytoplasm to the nucleus. This pathway is also responsible for regulating calcium inside the cell, as well as aiding in differentiation and proliferation.
Notch Signaling Pathway
This pathway involves cell to cell communication; for example when one cell expresses a specific trait, this pathway can be used to switch that trait off in a neighboring cell to allow a process of many cells gathering together to form large structures. It is also upstream of several differentiation processes, and encourages the osteoblast pathway from stem cells (4).
Proliferation
Proliferation is simply the increase in cell number through the process of cell division.
Differentiation
This is the process where a non-specific stem cell becomes a specific type of cell, like an osteoblast.
Feel smarter? Good. Time to break down the ingredients in the formula and see what this stuff is all about.
BMP 2.0 Write Up
Intro
EvoMuse released the original BMP formula almost a year ago and it became extremely popular with tons of great user feedback, fully delivering on the muscle building hype. During this time however, we’ve found a way to make BMP even better while still keeping it just as cost-effective. If you’re familiar with the original formula, you’ll notice quite a few similarities, but also a few key changes that we’re confident will give users even better results.
BMP, for the sake of our new groundbreaking formula, stands for Body Modify- Phenotype.
For the sake of the physiology it happens to be targeting, it stands for Bone Morphogenetic Protein.
Based on new research, it turns out that a pathway once thought to only regulate bone growth/turnover is actually tightly and crucially linked to muscle growth as well. Since this research began to surface, we’ve been watching it like a hawk and researching ingredients that might take advantage of this pathway. Now that more and more data have confirmed the previous conclusions, we are confident that EvoMuse BMP is about to dig its heels in as a serious player in the toolbox for natural and assisted bodybuilders.
Much of the research we have access to at this point is looking at bone anabolism as opposed to muscle, as the BMP-muscle link is such a new area. So we will have to extrapolate a bit and look at implications of the ingredients’ effects on bone growth through BMP, knowing that the same pathway is going to target muscle growth as well. At this point, when we find something that targets bone growth through supporting the BMP pathway, we can assume increased rates of muscle growth will accompany.
Definitions
Since this is quite a dense topic, it will be exponentially easier to understand, and flow through reading the write-up if several terms/concepts are at least superficially understood. Scan through these definitions first, and then refer back to them as you go through the write-up as you need clarification.
Bone Morphogenetic Proteins (BMPs)
BMPs are a class of growth factors belonging to the Transforming Growth Factor beta (TGF-b) superfamily. Another, contrasting part of this superfamily is the myostatin/activin subfamily.
These two subfamilies have directly opposing functions on muscle mass, namely that BMPs are anabolic and myostatin is catabolic. Originally it was thought that BMPs were responsible, solely, for bone and cartilage formation, but recently it has been discovered that they are also key players in skeletal muscle growth.
Interestingly, BMPs are actually dominant over myostatin signaling; when levels are high they win the anabolic/catabolic battle. BMPs are divided into specific proteins, namely BMP2, BMP4, and BMP7.
BMP’s promote chondrocyte proliferation AND hypertrophy, and SMAD signaling (see below) regulates chondrocyte hypertrophy (1). BMP’s are unique in that they not only induce differentiation of mesenchymal stem cells to osteoblasts, and they also enhance the function of the osteoblast once differentiated (2).
A 2013 study published in the journal Nature Genetics provided some compelling conclusions about BMP and muscle tissue (3).
BMP signaling is the fundamental signal for hypertrophy.
Inhibiting BMP signaling causes atrophy, abolishes myostatin deficient mice from gaining the enormous amount of muscle they normally do, and increases the negative effect from fasting.
BMP plays a critical role in adult muscle growth.
Now we’ll take a look at the specific types of BMPs.
BMP2
BMP2 plays a major role in bone and cartilage formation, as well as osteoblast differentiation. Differentiation is an important point here, as will be discussed below. BMP2 is the secondary target of this formula, with BMP7 being the primary target.
BMP4
BMP4, while still important, is comparatively our lowest priority of the three for targeting muscle growth. Like the other BMPs it is involved in bone and cartilage development, although more specifically for teeth and limbs, as well as being a key player during embryonic development.
BMP7
BMP7 is our priority target for muscle growth. It is a major player in osteoblast differentiation as well as the induction of SMAD1 and SMAD5 (see below).
SMADs
SMADs are a family of nine proteins that live inside the cell, which fall into one of three categories (receptor-regulated, common-mediator, or inhibitory). The first two classes help to mediate BMP by bringing the extracellular signal into the nucleus of the cell where they trigger gene transcription downstream.
SMAD4, which makes up the entirety of the common-mediator class, is a helper protein for SMAD1/2/3/5/8/9, which make up the receptor-regulated class. Once BMPs hit the cell membrane, this triggers the phosphorylation of SMAD1/5/8; they then form a complex with SMAD4 and are translocated to the nucleus. SMADs basically act as an executive assistant to BMPs.
Chondrocyte
This is just a cartilage cell. That was easy.
Chondrogenesis
The formation of cartilage. Another gimmie.
Mesenchymal Stem Cell (MSC)
MSC’s are stem cells located in connective tissue throughout the body, which can differentiate down different pathways into chondrocytes, osteoblasts, or adipocytes.
Osteoblast
Formed from MSC’s, these cells, once grouped together are responsible for synthesizing bone. Since bone is a dynamic tissue, these cells are constantly working in anabolic opposition to the catabolic osteoclasts.
Osteoclast
A catabolic bone cell, osteoclasts oppose osteoblasts and encourage bone resorption (the process of breaking down bones which pushes calcium into the blood).
Wnt Signaling Pathways
These pathways are made up of proteins that function in a way similar to SMADs, helping pass signals from outside to inside a cell, as well as regulating b-catenin from the cytoplasm to the nucleus. This pathway is also responsible for regulating calcium inside the cell, as well as aiding in differentiation and proliferation.
Notch Signaling Pathway
This pathway involves cell to cell communication; for example when one cell expresses a specific trait, this pathway can be used to switch that trait off in a neighboring cell to allow a process of many cells gathering together to form large structures. It is also upstream of several differentiation processes, and encourages the osteoblast pathway from stem cells (4).
Proliferation
Proliferation is simply the increase in cell number through the process of cell division.
Differentiation
This is the process where a non-specific stem cell becomes a specific type of cell, like an osteoblast.
Feel smarter? Good. Time to break down the ingredients in the formula and see what this stuff is all about.