EvoMuse BMP - Body Modify:Phenotype Writeup

I recently ordered this from a site that didn't say "out of stock" so I took the chance. Turns out it was indeed out of stock. Decided to leave that part of the order pending (it was part of an order, the rest shipped). Any idea on time frame? The site told me they did not currently have an eta.

Not urgent, I can afford to wait but would like some idea on how long I'd be waiting
 
DNasteee said:
I recently ordered this from a site that didn't say "out of stock" so I took the chance. Turns out it was indeed out of stock. Decided to leave that part of the order pending (it was part of an order, the rest shipped). Any idea on time frame? The site told me they did not currently have an eta.

Not urgent, I can afford to wait but would like some idea on how long I'd be waiting
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The powder (non capped) version is in stock.
 
DNasteee said:
I recently ordered this from a site that didn't say "out of stock" so I took the chance. Turns out it was indeed out of stock. Decided to leave that part of the order pending (it was part of an order, the rest shipped). Any idea on time frame? The site told me they did not currently have an eta.

Not urgent, I can afford to wait but would like some idea on how long I'd be waiting
Click to expand...

We don't have a solid production date right now, unfortunately.
 
I bought the bmp powder and i want to take it with Olympus labs trump 1hr pre work is there any reason not to do this?
 
josun said:
I bought the bmp powder and i want to take it with Olympus labs trump 1hr pre work is there any reason not to do this?
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im not familiar with the product....link?
 
Triumph? If it's that that I'm thinking of you should be fine. Similar to E9 in some ways but obviously different in others
 
kwinslow said:
Hey guys,
For the powder. It says 825 grams twice a day. Does anyone know what this converts into when speaking about teaspoon/tablespoon? I am awaiting my delivery but was trying to figure out ahead of getting it. Much appreciated.
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825 grams??? How many scoops per serving?
 
Negncic said:
825 grams??? How many scoops per serving?
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I believe each scoop is one serving. The BMP pouches come with a plastic scoop inside. I just fill "00" size capsules and consider each cap a serving.
 
GreenMachineX said:
When will BMP be back in stock on the shopify store?
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I'll check this morning for you how many I held back as backup for messed up orders. Since those are pretty much resolved, I'll go ahead and let the stock go.
 
dsade said:
I'll check this morning for you how many I held back as backup for messed up orders. Since those are pretty much resolved, I'll go ahead and let the stock go.
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Awesome. Looking to get 4 or 5 pounces to go with my DCP/Epitome/Testruction stack for the next 2 months.
 
one of my bmp bags had a small hole and now it's like a brick :(
 
GreenMachineX said:
Just ordered 5 pouches!
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They're almost gone and I can't seem to get an accurate tracking update. Starting to irritate me, as my own pouch is getting light. BMP and Brite (and now DCP) are what saved my physique and my sanity when both should have been rapidly deteriorating.
 
dsade said:
They're almost gone and I can't seem to get an accurate tracking update. Starting to irritate me, as my own pouch is getting light. BMP and Brite (and now DCP) are what saved my physique and my sanity when both should have been rapidly deteriorating.
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I haven't even looked at Brite yet. If I do, I'm afraid I'll put out another hundred or so and I already have Evomuse products falling out of the cupboard, as well as spending just way too much money.

You weren't running Testruction or MyoElite in that downtime?
 
GreenMachineX said:
I haven't even looked at Brite yet. If I do, I'm afraid I'll put out another hundred or so and I already have Evomuse products falling out of the cupboard, as well as spending just way too much money.

You weren't running Testruction or MyoElite in that downtime?
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I just found half a bottle of MyoElite, but I'm out of the gym for another 2 weeks for the gallbladder. Testruction I'm running as a baseline mental/TRT type thing. I didn't really factor that into the equation. Good question, but I don't really want to stop taking it to find out how much of an effect that's having
 
I've found you can just smash it back into smaller pieces every so often. I literally used a hammer to break mine up, and put it in a new ziploc bag as this makes it much easier to remove each dose than the smaller bags the BMP comes in.
 
dsade said:
I just found half a bottle of MyoElite, but I'm out of the gym for another 2 weeks for the gallbladder. Testruction I'm running as a baseline mental/TRT type thing. I didn't really factor that into the equation. Good question, but I don't really want to stop taking it to find out how much of an effect that's having
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Gotcha.
Does BMP aid in injury healing? I've got a couple new and old aches and pains ruining my workouts, just trying to put together a good injury stack. Already taking Genoflex at 1.5x the recommended dose.
 
GreenMachineX said:
Gotcha.
Does BMP aid in injury healing? I've got a couple new and old aches and pains ruining my workouts, just trying to put together a good injury stack. Already taking Genoflex at 1.5x the recommended dose.
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BMP-2 and cartilage:

Cell Tissue Res. 2005 May;320(2):269-76. Epub 2005 Mar 19.
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
Sekiya I1, Larson BL, Vuoristo JT, Reger RL, Prockop DJ.
Author information
Abstract

The human adult stem cells from bone marrow stroma referred to as mesenchymal stem cells or marrow stromal cells (MSCs) are of interest because they are easily isolated and expanded and are capable of multipotential differentiation. Here, we examined the ability of recombinant human bone morphogenetic protein (BMP)-2, -4, and -6 to enhance in vitro cartilage formation of MSCs. Human MSCs were isolated from bone marrow taken from normal adult donors. The cells were pelleted and cultured for 21 days in chondrogenic medium containing transforming growth factor beta3 and dexamethasone with or without BMP-2, -4, or -6. All the BMPs tested increased chondrogenic differentiation as assayed by immunohistochemistry and by the size and weight of the cartilage synthesized. However, BMP-2 was the most effective. Microarray analyses of approximately 12,000 genes and reverse transcription-polymerase chain reaction assays established that the critical genes for cartilage synthesis were expressed in the expected time sequence in response to BMP-2. The tissue engineering of autologous cartilage derived from MSCs in vitro for transplantation will be a future alternative for patients with cartilage injuries. To obtain large amounts of cartilage rich in proteoglycans, the use of BMP-2 is recommended, instead of BMP-4 or -6.

PMID:
15778851
DOI:
10.1007/s00441-004-1075-3

[PubMed - indexed for MEDLINE]
 
dsade said:
BMP-2 and cartilage:

Cell Tissue Res. 2005 May;320(2):269-76. Epub 2005 Mar 19.
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
Sekiya I1, Larson BL, Vuoristo JT, Reger RL, Prockop DJ.
Author information
Abstract

The human adult stem cells from bone marrow stroma referred to as mesenchymal stem cells or marrow stromal cells (MSCs) are of interest because they are easily isolated and expanded and are capable of multipotential differentiation. Here, we examined the ability of recombinant human bone morphogenetic protein (BMP)-2, -4, and -6 to enhance in vitro cartilage formation of MSCs. Human MSCs were isolated from bone marrow taken from normal adult donors. The cells were pelleted and cultured for 21 days in chondrogenic medium containing transforming growth factor beta3 and dexamethasone with or without BMP-2, -4, or -6. All the BMPs tested increased chondrogenic differentiation as assayed by immunohistochemistry and by the size and weight of the cartilage synthesized. However, BMP-2 was the most effective. Microarray analyses of approximately 12,000 genes and reverse transcription-polymerase chain reaction assays established that the critical genes for cartilage synthesis were expressed in the expected time sequence in response to BMP-2. The tissue engineering of autologous cartilage derived from MSCs in vitro for transplantation will be a future alternative for patients with cartilage injuries. To obtain large amounts of cartilage rich in proteoglycans, the use of BMP-2 is recommended, instead of BMP-4 or -6.

PMID:
15778851
DOI:
10.1007/s00441-004-1075-3

[PubMed - indexed for MEDLINE]
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Found a new staple!
 
whats the best way to take this? it doesn't seem to really dissolve in anything, like it doesn't taste horrible but is a bit tedious to take down.

appreciate the response which said the dosing and scoop size lol.

is it easiest to just cap the lot and take it that way?
 
scump said:
whats the best way to take this? it doesn't seem to really dissolve in anything, like it doesn't taste horrible but is a bit tedious to take down.

appreciate the response which said the dosing and scoop size lol.

is it easiest to just cap the lot and take it that way?
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I just cap it using an empty capsule and a business card. If that's not handy I just toss it into my mouth and chase it. It's a tiny scoop only twice per day, so it's not that bad.
 
GreenMachineX said:
With meals or doesn't matter? Pre workout?
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1 dose should be close to workout, other dose doesn't matter. I haven't found food to make much difference.
 
GreenMachineX said:
I haven't even looked at Brite yet. If I do, I'm afraid I'll put out another hundred or so and I already have Evomuse products falling out of the cupboard, as well as spending just way too much money.

You weren't running Testruction or MyoElite in that downtime?
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Brite is a long term thing. Should be a staple in any stack.
 
dsade said:
I just cap it using an empty capsule and a business card. If that's not handy I just toss it into my mouth and chase it. It's a tiny scoop only twice per day, so it's not that bad.
Click to expand...

ah cheers will give that a go.

Thanks man.
 
unitas27 said:
I believe each scoop is one serving. The BMP pouches come with a plastic scoop inside. I just fill "00" size capsules and consider each cap a serving.
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I get about 400-500 mg when I weighed a scoop, so I've been taking about 2 scoops?
Too much?
 
Not sure if placebo or not, but this was only thing I added to my typical pre-workout regimen today.. and my pump was crazy. SO excited to run this for 30 days
 
I've just been placing in a cup, adding some water on top, swishing it around and chasing down with more water. I agree it tastes pretty awful, the worst part is when a clump of it gets stuck somewhere in your mouth, so that you can taste it over and over again. I think this still beats the hassle of capping it though.
 
dsade said:
Sorry I missed this...It looks like keeping your vitamin K intake at a reasonable recommended level will prevent calcification in the VSMCs and act as a protective agent. but it/s dependent upon the MK4 form.

I would say that overall a normal intake of Vitamin K (the below indicates dairy and meat as sources) will be protective without inhibiting BMP-2's contribution to muscle growth.

Invalid Link Removed


Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30.
Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.
Wallin R1, Schurgers L, Wajih N.
Author information
Abstract
INTRODUCTION:

The transformation of smooth muscle cells (VSMCs) in the vessel wall to osteoblast like cells is known to precede arterial calcification which may cause bleeding complications. The vitamin K-dependent protein MGP has been identified as an inhibitor of this process by binding BMP-2, a growth factor known to trigger the transformation. In this study, we determined if the vitamin K-dependent Gla region in MGP by itself can inhibit the growth factor activity of BMP-2 and if menaquinone-4 (MK4) regulates gene expression in VSMCs.
MATERIALS AND METHODS:

A synthetic gamma-carboxyglutamic acid (Gla) containing peptide covering the Gla region in human MGP was used to test its ability to inhibit BMP-2 induced transformation of mouse pro-myoblast C2C12 cells into osteoblasts. MK4 was tested by microarray analysis as a gene regulatory molecule in VSMCs.
RESULTS AND CONCLUSIONS:

The results show that the Gla - but not the Glu-peptide inhibited the transformation which provide evidence that the Gla region in MGP is directly involved in the BMP-2/MGP interaction and emphasizes the importance of the vitamin K-dependent modification of MGP. From the data obtained from the microarray analysis, we focused on two quantitatively altered cDNAs representing proteins known to be associated with vessel wall calcification. DT-diaphorase of the vitamin K-cycle, showed increased gene expression with a 4.8-fold higher specific activity in MK4 treated cells. Osteoprotegrin gene expression was down regulated and osteoprotegrin protein secretion from the MK4 treated cells was lowered to 1.8-fold. These findings suggest that MK4 acts as an anti-calcification component in the vessel wall.

PMID:
18234293
[PubMed - indexed for MEDLINE]
PMCID:
PMC2529147
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I'm getting 500% vitamin K from my multi; think that's too much?
Vitamin K (200 mcg as Vitamin K1 and 200 mcg as Vitamin K2)?
 
8 left in stock
 
I got my pouches of BMP. It was still loose powder so didn't have to break it up. There was a lot of powdered residue on the outside of the bags and inside the envelope. When I ripped the bag open I got a face full of bmp hah. Anyway, took my first dose. A little bitter but I've had much worse. Took it just like I do Brite, water in mouth, drop in ____, swallow, chase.
 
Rand0m said:
I got my pouches of BMP. It was still loose powder so didn't have to break it up. There was a lot of powdered residue on the outside of the bags and inside the envelope. When I ripped the bag open I got a face full of bmp hah. Anyway, took my first dose. A little bitter but I've had much worse. Took it just like I do Brite, water in mouth, drop in ____, swallow, chase.
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I guess that's one way to dose it.
 
GreenMachineX said:
Any chance BMP could increase red blood cells and subsequently hemoglobin/hematocrit?
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I would think if this messes with bone marrow at all it could increase RBC. In theory at least. I don't know enough about how this stuff works to say much more.

A lot of other things can increase RBC too...hypoxia / sleep apnea are fairly common.
 
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