Best Nootropic For Mood And Happiness

muscleupcrohn said:
Meh. 200mg of 50% Alpha-GPC is only 100mg Alpha-GPC, which is a pretty low dose. 200mg of NALT is also a very small dose, and, IMO, inferior to l-tyrosine. 100mg of 20% PS is only 20mg, which is also a very small dose. Also, does guarana not have caffeine? I️ read that they can have 2-4.5% caffeine, which is only ~10mg caffeine, but this is an extract, so can have more or less. Do that claim caffeine free?
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No sorry, my bad. I meant to say stim free/low stim.
How much Alpha-GPC would you recommend for overall cognitive health?
 
Slims said:
No sorry, my bad. I meant to say stim free/low stim.
How much Alpha-GPC would you recommend for overall cognitive health?
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At least 200mg of actual Alpha-GPC, preferably 250-300mg. All these labels listing 50% Alpha-GPC means doubling that to 400mg (200mg) or 500-600mg (250-300mg). Honestly, even double dosed, the profile isn’t all that impressive IMO, and 400mg theanine is a bit much IMO.
 
Mood And Happiness comes down to high levels of Dopamine, Serotonin, Phenylethylamine, and for some GABA, Opioid, Endocannabinoid, Nicotinic receptor activity.
 
NeuroTropic said:
Mood And Happiness comes down to high levels of Dopamine, Serotonin, Phenylethylamine, and for some GABA, Opioid, Endocannabinoid, Nicotinic receptor activity.
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If only fixing depression was that easy. Neurotransmitters do play a roll but that line of thinking is out-dated.
 
pbandy1 said:
I would argue the same for "mood and happiness".
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It's highly complex..I have been in a "good" mood and generally happy, while at the same time knowing the undercurrent of depression could cut my legs out from under me at any moment.
 
For me it's omega-3s l-theanine and 5-HTP along with some dmae at times for a little increased focus and cognition.
And depending on how bad the depression is I'm a tweak it with this or that. Maybe some l-dopa extracts, I get 99%. Along with brain awake by Irwin Naturals which I really like because it's not super strong but if I want to I can take more than a single dose. And believe it or not choline is a very good and cheap nootropic that can help with mood more than I realized in the past and mixed with piracetam and dmae it can be one damn good nootropic stack but not the best for depression so I usually adding l-theanine always as it keeps you focused but keeps the depression under the blanket. Sometimes some kratom. Oh and although it's not normally considered for its antidepressant properties or nootropic properties I do believe acetyl-l-carnitine really does help with mood and focus with an added bonus of helping mobilize fat tissue for energy. Alcar is a staple of mine so I kind of forgot about it. Feel free to message me if you would like to go over any of this because I know I'm kind of talking about it in random order. Best of luck and feel better my man.
 
pbandy1 said:
If only fixing depression was that easy. Neurotransmitters do play a roll but that line of thinking is out-dated.
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Some drugs can have long term remission in depression like ketamine or mushrooms but everyone's neurochem is different.

What's outdated is thinking everyone is the same, responds identically, and only 1 approach works.

Depression has many factors but many of those neurotransmitters or their receptors are low and/or down-regulated in people who are depressed. Reversing those in depression will make a difference but unless the underlying causes are addressed they are not a cure just helping correct the imbalances so you can enjoy life.
 
NeuroTropic said:
Mood And Happiness comes down to high levels of Dopamine, Serotonin, Phenylethylamine, and for some GABA, Opioid, Endocannabinoid, Nicotinic receptor activity.
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So what supplements/ingredients would you recommend or use to increase and balance these chemicals/hormones? To create the nest Mood And Happiness stack?

Also, How effective is Ginko? It keeps popping up in researching Cognitive Health but it's very rarely mentioned or listed in nootropic supplements/products.
 
InItForGainz said:
So what supplements/ingredients would you recommend or use to increase and balance these chemicals/hormones? To create the nest Mood And Happiness stack?

Also, How effective is Ginko? It keeps popping up in researching Cognitive Health but it's very rarely mentioned or listed in nootropic supplements/products.
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Really depends on your age, goals, diet, etc.

You can do any number of stacks like 5-HTP, Silexan, or Kanna for Serotonin, L-DOPA, dopamine agonists, deprenyl, or dopamind for Dopamine and/or PEA, L-Theanine, PharmGABA, Kava, Phenibut, Picamilon, etc best as needed for GABA, Kratom as needed for opioid, CBD/THC from Hemp for endocannabinoid, Nicotine, Cytisine, or galantamine for Nicotinic ACh receptors. Some people also like Arecoline which is a muscarinic ACh agonist.

Gingko pharmaceutical grade extracts in clinically studied doses (240-600 mg) is solid for cognition in younger and older adults but not so much an effect on mood.

Brain-derived neurotrophic factor is also worth mentioning as a brand new and far more exciting target for both cognition and mood. It's been linked a main factor in exercise and feeling positive. Also how some antidepressant drugs work. Definitely worth looking at as this approach literally regenerates brain cells, builds new ones, and more through neurogenesis so a NeuroAnabolic effect.
 
NeuroTropic said:
Brain-derived neurotrophic factor is also worth mentioning as a brand new and far more exciting target for both cognition and mood. It's been linked a main factor in exercise and feeling positive. Also how some antidepressant drugs work. Definitely worth looking at as this approach literally regenerates brain cells, builds new ones, and more through neurogenesis so a NeuroAnabolic effect.
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BDNF really does interest me in regards to cognitive enhancement. Although studies on increasing BDNF through supplementation seem very hit and miss/inconclusive.
I've seen studies with choline, high doses of vitamin B-12, Lion's Mane mushroom, Omega-3, Bacopa monnieri, Blueberry extracts etc. But again, Non of which are conclusive.
 
InItForGainz said:
BDNF really does interest me in regards to cognitive enhancement. Although studies on increasing BDNF through supplementation seem very hit and miss/inconclusive.
I've seen studies with choline, high doses of vitamin B-12, Lion's Mane mushroom, Omega-3, Bacopa monnieri, Blueberry extracts etc. But again, Non of which are conclusive.
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7,8-DHF works very well as a BDNF agonist. It's my favorite current nootropic or Neuroanabolic.

NeuroFactor is also clinically proven to raise BDNF levels in healthy adults (143% above normal).

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Everything else I don't think will do much with BDNF.




Lion's mane is one of the few solid ones for NGF which is another important NeuroTrophins (neurochemicals that repair brain/nerve damage and enhance cognitive systems) but only if it's standardized for Hericenones.
 
NeuroTropic said:
7,8-DHF works very well as a BDNF agonist. It's my favorite current nootropic or Neuroanabolic.

NeuroFactor is also clinically proven to raise BDNF levels in healthy adults (143% above normal).

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Everything else I don't think will do much with BDNF.




Lion's mane is one of the few solid ones for NGF which is another important NeuroTrophins (neurochemicals that repair brain/nerve damage and enhance cognitive systems) but only if it's standardized for Hericenones.
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I noticed nothing from 78dhf after months of use. But I did notice some enhancement from lions mane. And deff got itchy which I hear is peripheral nerve stimulation/healing.
 
bigdavid said:
I noticed nothing from 78dhf after months of use. But I did notice some enhancement from lions mane. And deff got itchy which I hear is peripheral nerve stimulation/healing.
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Since everyone's receptors are different your dosage may vary. Typically if you're not seeing results your dose is probably too low. I notice best results around 100 mg myself but I plan to go higher sometime.

Interesting which brand did you use? I was looking at which ones have the most hericenones to get assured Nerve Growth Factor stimulation.
 
Nootropimax is good

Numbs emotions a bit which allows more stable focus and opens up my mind to do way more work

Pretty decent on mood
 
NeuroTropic said:
Since everyone's receptors are different your dosage may vary. Typically if you're not seeing results your dose is probably too low. I notice best results around 100 mg myself but I plan to go higher sometime.

Interesting which brand did you use? I was looking at which ones have the most hericenones to get assured Nerve Growth Factor stimulation.
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Well the cost of doing 100 daily (I did 60 usually) was cost prohibitive for me. Especially when I can take Zoloft and get just as high if not higher increases in BDNF. And there are many other drugs and supplements that increase BDNF. Sure they aren’t direct agonists of the receptor, but I don’t think BDNF agonism by itself is very helpful IME

As far as lions mane I used Host Defense
 
bigdavid said:
Well the cost of doing 100 daily (I did 60 usually) was cost prohibitive for me. Especially when I can take Zoloft and get just as high if not higher increases in BDNF. And there are many other drugs and supplements that increase BDNF. Sure they aren’t direct agonists of the receptor, but I don’t think BDNF agonism by itself is very helpful IME

As far as lions mane I used Host Defense
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From what I've read, it seems Host Defense isn't a very good brand. Since the mycelium can't be separated from the brown rice it's grown on, companies that use it just blend the two together. So, there's no telling how much of the product in the capsule is mycelium and how much is the brown rice substrate. In fact, if you look at the "other ingredients" portion of the label, it even mentions the brown rice. Companies that sell Nammex fruited bodies seem to be better in that you're getting the actual stated quantity of mushroom. The mycelium may have benefits that the fruited body doesn't but again, how much are you really getting in a product like Host Defense.
 
jarrellt67 said:
From what I've read, it seems Host Defense isn't a very good brand. Since the mycelium can't be separated from the brown rice it's grown on, companies that use it just blend the two together. So, there's no telling how much of the product in the capsule is mycelium and how much is the brown rice substrate. In fact, if you look at the "other ingredients" portion of the label, it even mentions the brown rice. Companies that sell Nammex fruited bodies seem to be better in that you're getting the actual stated quantity of mushroom. The mycelium may have benefits that the fruited body doesn't but again, how much are you really getting in a product like Host Defense.
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Yeah I understand and honestly didn’t expect much from the product. But I have taken other drugs or supplements that increase NGF peripherally and the feeling of that itchyness and slight increase in my subjective temp is consistent and also happened with this product. I prob won’t buy it again and wouldn’t look for any other companies either. It just is too pricey for what it does IMO
 
bigdavid said:
Well the cost of doing 100 daily (I did 60 usually) was cost prohibitive for me. Especially when I can take Zoloft and get just as high if not higher increases in BDNF. And there are many other drugs and supplements that increase BDNF. Sure they aren’t direct agonists of the receptor, but I don’t think BDNF agonism by itself is very helpful IME

As far as lions mane I used Host Defense
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Not everyone can afford an effective dose of novel chemicals unfortunately. I know many people can see effects from just 20 mg. 7,8-DHF doesn't increase BDNF so you can't compare it to Zoloft based on BDNF levels. It's a BDNF mimic so you can only really compare them based on the degree of nerve regrowth or neurogenesis.
 
bigdavid said:
Yeah I understand and honestly didn’t expect much from the product. But I have taken other drugs or supplements that increase NGF peripherally and the feeling of that itchyness and slight increase in my subjective temp is consistent and also happened with this product. I prob won’t buy it again and wouldn’t look for any other companies either. It just is too pricey for what it does IMO
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Agree. I've tried both (mycelium products and fruited body only products) and wasn't too impressed with either. Reishi isn't bad though. There's even this study (Invalid Link Removed) which seems to indicate it's better than Lion's Mane with regard to NGF.
 
NeuroTropic said:
Not everyone can afford an effective dose of novel chemicals unfortunately. I know many people can see effects from just 20 mg. 7,8-DHF doesn't increase BDNF so you can't compare it to Zoloft based on BDNF levels. It's a BDNF mimic so you can only really compare them based on the degree of nerve regrowth or neurogenesis.
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While your technically right I would just say I can notice a difference mentally on Zoloft in terms of cognition, independent of mood. For some reason it is the only SSRI that doesn’t negatively impact cognition in some fashion (some other ones are also minor but still have negative effects) and I think a lot of that has to do with it increasing BDNF and also slightly affecting dopamine. You’re right it’s a different category I am just thinking comparatively for end result it’s not worth it for me when I can get Zoloft for $5 a month
 
jarrellt67 said:
From what I've read, it seems Host Defense isn't a very good brand. Since the mycelium can't be separated from the brown rice it's grown on, companies that use it just blend the two together. So, there's no telling how much of the product in the capsule is mycelium and how much is the brown rice substrate. In fact, if you look at the "other ingredients" portion of the label, it even mentions the brown rice. Companies that sell Nammex fruited bodies seem to be better in that you're getting the actual stated quantity of mushroom. The mycelium may have benefits that the fruited body doesn't but again, how much are you really getting in a product like Host Defense.
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Yeah there's no testing of Hericenones with Host Defense it's basically placebo. Nammex isn't any better. If you want a standardized one that's been clinically studied Amycenone is the clear choice.
 
NeuroTropic said:
Yeah there's no testing of Hericenones with Host Defense it's basically placebo. Nammex isn't any better. If you want a standardized one that's been clinically studied Amycenone is the clear choice.
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Yeah, I've seen the Mushroom Wisdom Amyloban product...it's really expensive.
 
bigdavid said:
While your technically right I would just say I can notice a difference mentally on Zoloft in terms of cognition, independent of mood. For some reason it is the only SSRI that doesn’t negatively impact cognition in some fashion (some other ones are also minor but still have negative effects) and I think a lot of that has to do with it increasing BDNF and also slightly affecting dopamine. You’re right it’s a different category I am just thinking comparatively for end result it’s not worth it for me when I can get Zoloft for $5 a month
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Well yeah it's an SSRI and raises Serotonin so you should feel an effect from mood. 7,8-DHF doesn't effect Serotonin anywhere near as much as an SSRI, if you're depressed you may be low in serotonin so it's helping correct a deficiency. I'd have to see how zoloft compares to 7,8-DHF in studies head on but the research so far shows impressive effects for 7,8-DHF. I would not advise Zoloft for healthy people looking for BDNF effects though the side effects of discontinuation syndrome and withdrawal brain zaps I hear can be hell.
 
jarrellt67 said:
Yeah, I've seen the Mushroom Wisdom Amyloban product...it's really expensive.
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If you take the full dose of 6 tablets. I think a good approach is taking it for 1 month full then lowering it to 1-3 daily afterwards if you need some serious levels of NGF and want the best quality. Even 1-2 a day is giving you a guaranteed quantified amount of it's NGF actives. With others you have no idea if they have any hericenones at all and could be doing nothing.
 
NeuroTropic said:
If you take the full dose of 6 tablets. I think a good approach is taking it for 1 month full then lowering it to 1-3 daily afterwards if you need some serious levels of NGF and want the best quality. Even 1-2 a day is giving you a guaranteed quantified amount of it's NGF actives. With others you have no idea if they have any hericenones at all and could be doing nothing.
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Thanks for the advice. Might give it a try sometime to see how it compares to the others I've tried.
 
muscleupcrohn said:
Meh. 200mg of 50% Alpha-GPC is only 100mg Alpha-GPC, which is a pretty low dose. 200mg of NALT is also a very small dose, and, IMO, inferior to l-tyrosine. 100mg of 20% PS is only 20mg, which is also a very small dose. Also, does guarana not have caffeine? I️ read that they can have 2-4.5% caffeine, which is only ~10mg caffeine, but this is an extract, so can have more or less. Do that claim caffeine free?
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Helpful!
 
Anyone ever try albizia?


Ps- love my reishi and ****ake extracts. Not sure if they help with mood or not but I will try tonight as I'm in a sh1t mood.
 
NeuroTropic said:
Solid doses just alot of caps.
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jarrellt67 said:
Really nice formula but $80/bottle...too expensive for what's in it (unless it can be found cheaper at other distributers).
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I'd just build it from OL ashwagandha in place of Rhodiola and let tyrosine is dirt cheap if you know where to look. Same for other ingredients. And you may find that a decent dose of cheap green tea extract and let tyrosine works just fine. Play with single ingredients and then stack for what you like would be my input. That's what I've always done.
If you're stateside look in places like puritan dot com and on ebay with vitamins because (your worth it). Both super cheap and have decent products.
 
Nearly every store I've ever asked what is great for social enhancement all reply with a basic Phenibut.

What conclusions have experienced users come to? Seems like too many options!
 
AdelV said:
Nearly every store I've ever asked what is great for social enhancement all reply with a basic Phenibut.

What conclusions have experienced users come to? Seems like too many options!
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Phenibut is good when used not very often. Its been like six months or so since I used it until recently. I didnt get much out of it, didnt knock me out for sleep like I desired, maybe because its five years old, although i would think itd still be good. I didnt feel much; although i used to. The only way to know is try something and see if it works for you.

Piracetam may have worked, I really dont know. Sulbutiamine, maybe.
 
AdelV said:
Nearly every store I've ever asked what is great for social enhancement all reply with a basic Phenibut.

What conclusions have experienced users come to? Seems like too many options!
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Phenibut is so good man. But strictly for occasional use. Makes you feel awful if you use it consecutive days
 
AdelV said:
What dosage if using before heading out?

It would only be used once a week or every blue moon to be honest.
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1 g is the sweet spot for me I can get away with a little less. Consecutive days does have negative effects. If I just take it once in awhile I feel awesome the next day. So I take it multiple days I start getting Moody and irritable and feel extremely tired when it wears off. But yeah I vote pheni as well.
 
AdelV said:
What dosage if using before heading out?

It would only be used once a week or every blue moon to be honest.
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As Godstrength mentioned 1g is usually the sweet spot for most, however at 1g I always get a slight hangover feel the next day. 500mg however treats me amazing and I feel great the next day. I take it occasionally before going out on a Saturday night and it makes me 10x more social. I would say start at 500mg the first few times then bump up to 1g as needed.
 
Phenibut never worked for me and made me so foggy the next day at any amount. That being said, something that can only be used 1-2x weekly seems very limiting for most people looking for a mood boost or anxiolytic properties. I've never quite understood where it would fit in. The only thing I would compare it to for "as needed" purposes would be propanolol, but it doesn't have effects on physical symptoms, so again, not sure how it would be used.

What are the applications?
 
I have also had that day after affect of euphoria post dosage of 1 gram phenibut the night before. However, it does not seem to always be the case. It also seems to work better sometimes than others for knocking me out. I wonder if there are variables that influence absorption? I always do empty stomach..
 
Ricky10 said:
I have also had that day after affect of euphoria post dosage of 1 gram phenibut the night before. However, it does not seem to always be the case. It also seems to work better sometimes than others for knocking me out. I wonder if there are variables that influence absorption? I always do empty stomach..
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Well I think it affects gaba levels so primarily depends where they are when it is taken imo. For example when I feel extremely stressed and mentally tired and take it it seems to work better as gaba levels are probably low. Phenibut is a gaba agonist. I think that is where the feel goods come from after taking it and also why taking it regularly it doesn't work as well.
 
kisaj said:
Phenibut never worked for me and made me so foggy the next day at any amount. That being said, something that can only be used 1-2x weekly seems very limiting for most people looking for a mood boost or anxiolytic properties. I've never quite understood where it would fit in. The only thing I would compare it to for "as needed" purposes would be propanolol, but it doesn't have effects on physical symptoms, so again, not sure how it would be used.

What are the applications?
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To try and answer your question...it is kind of like having a mild benzo on hand for occasional use. I am always on benzos so that is a mute point for me. I usually take it as a last resort if I can’t sleep. On the other hand I am going to take some right now as my fiancé has been acting like a a crazy beeaatch!

So applications could be acute anxiety, sleepless nights, and crazy beeaatch stress relief.
 
Godstrength said:
Well I think it affects gaba levels so primarily depends where they are when it is taken imo. For example when I feel extremely stressed and mentally tired and take it it seems to work better as gaba levels are probably low. Phenibut is a gaba agonist.
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Exactly, sometimes I take it after a night of drinking when I can’t sleep, along with my Klonopin. All three of which are GABA agonists.

Note: I do not advise the above behavior
 
Ricky10 said:
Exactly, sometimes I take it after a night of drinking when I can’t sleep, along with my Klonopin. All three of which are GABA agonists.

Note: I do not advise the above behavior
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Alcohol klonapin and phenubit!!! **** how are you alive. I'm being serious!! I've had friends die from mixing small amount of a benzo with alcohol. Yes it was a good amount of alcohol but nothing that would have killed them by itself.
 
rtmilburn said:
Alcohol klonapin and phenubit!!! **** how are you alive. I'm being serious!! I've had friends die from mixing small amount of a benzo with alcohol. Yes it was a good amount of alcohol but nothing that would have killed them by itself.
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I’ve mixed 1g with plenty of booze before (stupid I know) with no ill effects apart from
Sleeping for like 15 hours straight haha
 
horizons said:
I only use it during the day

It can last up to or over 24 hours

Some phenibut can be bad quality too
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I have only bought SNS, and this bottle is six months old or less. I just took one gram.
I might pass out, or I may just forget all about what was bringing me down and actually end up having a good day....possibly both!
 
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