Ordered 2 bottles this morning. Not trying to be "that guy" but do you believe it'll be shipped within the next week?
I know you stated that the ace inhibition isn't the only or even main way EC works. But I'm not sure how ace inhibition would build muscle at all? I would love to learn how it does tho. But as far as I know they aren't as other than you I've never heard that prescription ace inhibitors helping gains. Also no one has ever claimed that natural ace inhibitors like celery seed extract being anabolic
Ace inhibitors have several ways in which they help us build muscle as well as reduce bodyfat.
I did write a bit about this in the product writeup but there is alot going on with regards to ACEi.
Ill try to sit down and write something cohesive and extensive when I get home tonight. For now here are a few quotes from some studies that show just a few of the ways ACIs work.
"ACE inhibitors can also enhance whole-body glucose disposal and glucose transport activity in skeletal muscle"
"ACE inhibitors acutely enhance glucose uptake in insulin-resistant skeletal muscle via two mechanisms. One mechanism involves the action of bradykinin, acting through bradykinin B(2) receptors, to increase nitric oxide (NO) production and ultimately enhance glucose transport. A second mechanism involves diminution of the inhibitory effects of ATII, acting through AT(1) receptors, on the skeletal muscle glucose transport system. The acute actions of ACE inhibitors on skeletal muscle glucose transport are associated with upregulation of insulin signaling, including enhanced IRS-1 tyrosine phosphorylation and phosphatidylinositol-3-kinase activity, and ultimately with increased cell-surface GLUT-4 glucose transporter protein. Chronic administration of ACE inhibitors or AT(1) antagonists to insulin-resistant rodents can increase protein expression of GLUT-4 in skeletal muscle"
"it has been suggested that ACE inhibitor-induced positive effects may also be mediated by direct action on the skeletal muscle"
" treatment with ACE inhibitors was associated with better performance and muscular outcomes and genetic studies also support the hypothesis that the ACE system may be involved in physical performance and skeletal muscle function."
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And ACEIs increase fat loss. Again Ill get more into detail later tonight. Ive got to get to the warehouse and get your guys product moving out!
Study Shows Blood Pressure Drugs May Help Reduce Body Fat
April 28, 2008 -- Some popular blood pressure medications may help you lose weight and body fat, according to a study done in mice.
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers are blood pressure drugs that block key steps in a system that helps control blood pressure and reduce fluid buildup in the body. This pathway is known as the renin-angiotensin system. Previous studies have suggested that the renin-angiotensin system plays a role in body fat and obesity.
Michael Mathai and colleagues in Australia examined mice that were missing a gene that encodes for angiotensin-converting enzyme, a key protein for the renin-angiotensin system. They discovered that those without the gene weighed 20% less.
The lightweight mice also had about 50% less body fat than their heavyweight counterparts, particularly in the belly area. However, both groups of mice seemed to eat and exercise the same amount, leading researchers to theorize that the slimmer mice might have a faster metabolism.
The researchers found that the ACE-deficient mice not only broke down fats faster in the liver, they processed blood sugars more quickly than the other mice, making them less likely to develop diabetes.
The study results demonstrate that an ACE deficiency leads to reduction in body fat accumulation in mice and suggests that drugs that affect the renin-angiotensin system, such as ACE inhibitors, might spark weight loss, especially in the midsection.
Thanks bro. I work really hard on our products. I do love the research and dev part but what is my favorite is seeing the products work well and you guys happy and reaching your goals. Im super excited about FD2. Im SUPER excited just to see you guys get to use it and see how great it really is.
I will be running It solo with the basics, whey, creatine, pre, vitamins, fish oil.. This is my first go at a natural anabolic so I am going to take it solo and see how I react. Obviously nothing to report thus far but will start a log shortly for those interested.
Definitely an interesting formula, and EC has some real potential. Could you point me to the actual 2-week EC study referenced earlier? I'd love to read it.Thanks bro. I work really hard on our products. I do love the research and dev part but what is my favorite is seeing the products work well and you guys happy and reaching your goals. Im super excited about FD2. Im SUPER excited just to see you guys get to use it and see how great it really is.
On day 3 of FD2 and the glycogen retention is no joke. I'm looking very full right now. The only thing that has me worried is the quercetin. Every time I have tried taking quercetin in the past I seem to develop arthritic joint pain from it over time. Crossing my fingers that this doesn't happen here because I can tell already that this stuff has incredible potential on a lean bulk.
On day 3 of FD2 and the glycogen retention is no joke. I'm looking very full right now. The only thing that has me worried is the quercetin. Every time I have tried taking quercetin in the past I seem to develop arthritic joint pain from it over time. Crossing my fingers that this doesn't happen here because I can tell already that this stuff has incredible potential on a lean bulk.
Does anyone know if there are any contraindications in taking forskolin with fd2?
Day 6 and muscular endurance is up! Hit 15 for 205 on squats and it felt nice!
Product goes good with practically anything. But I do suggest to run it solo at first to see how it treats you then add if you feel be on your next run. It's great solo so no need to stack at first.
I'm just adding OLs Endure on workout days for some extra (-)epi to be absorpted and extra pumpsso I know Follidrone 2.0 will be the main cause for any benefits.
Yea that's light. Can't wait to see what u and others think.
Going to run folli 2 for 16 weeks soon and see how it goes.
$hit! That's going to be a good ass run! Are you going to log that? That would be sick to see the transformation from day one to day 112!
Agreed. I'm going to log mine for 12 weeks when I do it most likely.
Day three and noticing an increase in endurance. Slight increase in pump during workouts but the added endurance is definite. I feel great all the way till failure. Can't wait to see how this pans out in the next coming weeks.
So is 12 weeks the commonality?
I only have one bottle, didn't want to invest in multiple not knowing how epi, ec etc would effect me. But it seems there is absolutely no reason you cant run this for multiple weeks, so from the looks of it most plan for 8-12 weeks.
Glad to hear, thanks for the help. I ordered 3 thinking id run 3 seperate runs but now im rethinking this decision. Just as it's very new i was preparing cautiously. Best of luck!
If you have three bottles, from what I've learned in the few threads on follidrone 2.0 I have no reservations from advising you to go ahead and run it for 12 weeks. The overall benefits from this in the long run have huge possibilities. Backed by scientific studies.. Great dosing of ingredients, backed by stand up guy (brundel) , go ahead and go the 12 weeks. Don't forget to let us know how it all goes either! I'd love to see how this effects different people.
Im not the best for it tbh. I've realized i stack too many products to give an honest review. I've used everything i use solo besides follidrone 2.0 obviously but still not sure if its a fair judge, may finish my 8 week natty cycle then test it solo for fair review.
$hit! That's going to be a good ass run! Are you going to log that? That would be sick to see the transformation from day one to day 112!
Are the gains seen and gained on fd2 likely to be short term and hard to keep?.
Are the gains seen and gained on fd2 likely to be short term and hard to keep?.
Idk for sure but I think it might be. My logic behind saying that is ace-031 gains and follistatin-344 are hard to keep. Although they are drastic gains in short periods of time. Whereas you can take this for a long time and solidify those gains. But idk