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Serotonin & Dopamine...

AndroRage

AndroRage

Well-known member
I've reading a lot about to improve and two things which are mentioned quite a lot seem to be serotonin and dopamine. My question is which products/supplements are most effective at optimising these brain chemicals to improve mood regarding anxiety/depression etc

Just generally anything which makes you have used and it has improves your well being and made you feel good.

It can be something you have experience with or has been proven/validated to work by science.

Someone I know advised of 5-HTP

Thanks in advance
 
Honestly, when it comes to neurological ailments, especially depression, anxiety, etc., it's always best to seek medical assistance.
 
aaronuconn said:
Honestly, when it comes to neurological ailments, especially depression, anxiety, etc., it's always best to seek medical assistance.
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I didn't say I specifically have depression or abnormalities regarding neurological aliments. What I'm looking for is something to increase the feel good feeling in these winter months.
 
5-HTP has been hit or miss with me. Sometimes I feel better, other times I crash worse. I've read about some brands that combine 5-HTP & L-Tryptophan, haven't tried though.

Vitamin D3 seems to help & is cheap.

B12 sublingual always gives me a little extra boost - I hear the B12 shot is great
 
get out and go ice fishin! thatll boost your spirits and give you some lean protonz for your diet :)
actually
you can look to products like L-dopa and PEa's to boost your mood. I will tell you though that people rave about the good mood that intimidate puts them in after a restful sleep.
 
I have went through a bottle of bsl growth and noticed a huge improvement in my mood and well being. I think a restful nights sleep works wonders.
 
low dose oral selegiline plus, 1 cap dopadex plus 1 cap of pikatropin would be real ideal to aid in depression
 
aaronuconn said:
Honestly, when it comes to neurological ailments, especially depression, anxiety, etc., it's always best to seek medical assistance.
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I disagree, if he seeks medical help they are just going to put him on something like Lexapro or Prozac which are just going to cause more of a problem.
 
infraredline said:
I disagree, if he seeks medical help they are just going to put him on something like Lexapro or Prozac which are just going to cause more of a problem.
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So seeking guidance from us is a better call? It's irresponsible for us to give him advice on a subject that isn't just black and white, as Synapsin alluded to.
 
When I came off anti depressants in 2010, I did lots of research RE this. I determined that using the following would be best, and it worked for about 3 months to help the coming off and restoration of natural healthy levels of serotonin and dopamine:

50mg 5htp at bed

1000mg l tyrosine (500mg caps) dosed in AM and afternoon on empty stomach

200mg SAM E dosed empty stomach in AM

After a while, I began to experience serotonin syndrome sides and dropped the 5htp. I've used the tyrosine and Sam e as listed above for the last 3 years daily. I sometimes use a sleep aid with 5htp but never take more than 25mg or else I get sides.
 
aaronuconn said:
So seeking guidance from us is a better call? It's irresponsible for us to give him advice on a subject that isn't just black and white, as Synapsin alluded to.
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I think doing research on his own is best, part of that includes coming here and seeing what had worked for others.
 
i'm a big fan of 5htp, when i take sleep supplements with 5 htp i usually start to feel better overall within a week or two....i don't suffer with seasonal depression during the winter months or depression overall but a good boost in well being is always fun, look into Lights Out, should really help

people have also reported a boost in well being from DAA, NMDA being a better choice, look into Intimidate SRT, maybe even stack it with Lights Out or 5 htp

Mood Support:

When we activate our NMDA receptors, our body releases Pregnenolone. Pregnenolone helps us feel rested and happy very quickly. Intimidate SRT™ may help support your mood and your workouts will help you maintain a positive attitude!*

heres part of the write up from Intimidate SRT
 
Maybe I should have been more specific in my initial post, to clarify I don't have depression or any specific or underlying health problem related to the former. I was merely asking for something for promotion of well being as I have a stressful job and and it can be mentally and emotionally draining in combination with these winter months.
 
andrew732 said:
low dose oral selegiline plus, 1 cap dopadex plus 1 cap of pikatropin would be real ideal to aid in depression
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I was actually reading up on a l-dopa supplement as I believe it also has growth hormone elevating properties which i was looking for a separate supplement for also. What kind of dowse would be use for dwell good and what dose for gh elevation?

Thanks for you response
 
Alasel said:
Maybe I should have been more specific in my initial post, to clarify I don't have depression or any specific or underlying health problem related to the former. I was merely asking for something for promotion of well being as I have a stressful job and and it can be mentally and emotionally draining in combination with these winter months.
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i read that you weren't depressed, i do know some people that just don't like the cold winter and the dark nights....my recommendations are what i've either used or plan on using to help feel better overall.....the logs of people using intimidate srt notice mood boost, not to mention the other benefits it offers
 
Young Gotti said:
i read that you weren't depressed, i do know some people that just don't like the cold winter and the dark nights....my recommendations are what i've either used or plan on using to help feel better overall.....the logs of people using intimidate srt notice mood boost, not to mention the other benefits it offers
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No I noticed that you noticed, other posters seemed to misinterpret, maybe I should have been clearer. Thanks for your response, will look into intimidate.
 
What are you talking about Aaron? Of course we know more than a medical professional. I googled supplements to help depression for a FULL 5 minutes today :D

In all seriousness, vitamin d3 supplementation is my preferred supplement of choice to 'prevent' seasonal depression. That and l dopa. I like l dopa
 
You SNS guys make some great points about seeking medical advice for these things. In fact, to show my appreciation, I will consult a physician before taking any of your products just as you advise. I know that my doctor as well as most others will be eager to give me their blessing to take products that are widely known by most MDs like DAA, agmatine, x-gels.
Thanks so much for caring.
 
Vj63 said:
You SNS guys make some great points about seeking medical advice for these things. In fact, to show my appreciation, I will consult a physician before taking any of your products just as you advise. I know that my doctor as well as most others will be eager to give me their blessing to take products that are widely known by most MDs like DAA, agmatine, x-gels.
Thanks so much for caring.
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It does say to do so on the bottle :D

Forgive us for not misrepresenting ourselves as MD's, but when someones psycholoigcal welfare is at stake, board members need more than 5 minutes google before handing out advice over prescription medication.
 
God it seems like you guys go the doctor for every little ****ing thing. I couldn't imagine spending so much time getting tests done and asking questions, etc. you don't need a doctors visit for every supplement you take....seriously....you guys think doctors give great advice. It's because of a doctors advice that I almost died and experience pain on a daily basis. Had he not been involved in my life I would be fine. Believe me doctors are OFTEN wrong
 
JD261985 said:
God it seems like you guys go the doctor for every little ****ing thing. I couldn't imagine spending so much time getting tests done and asking questions, etc. you don't need a doctors visit for every supplement you take....seriously....you guys think doctors give great advice. It's because of a doctors advice that I almost died and experience pain on a daily basis. Had he not been involved in my life I would be fine. Believe me doctors are OFTEN wrong
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Wrong and you've misinterpreted the responses thus far. As company reps, we must be mindful that our posts are not taken as medical advice. It was misinterpreted as to what OP was after (it was taken as though he was suffering from depression) and we are in no position to offer medical advice.

You must be aware that depression is multi factorial and if OP did indeed have it, then without proper assessment, people making generalised 'medical' statements could potentially make things worse.

OP has made it clear he does not have depression so suggestions thus far could be warranted.
 
OP, my recommendation for the winter months is vitamin D3. If you're looking for a quality L-Dopa product, I would check out Dopadex Invalid Link Removed
 
JD261985 said:
God it seems like you guys go the doctor for every little ****ing thing. I couldn't imagine spending so much time getting tests done and asking questions, etc. you don't need a doctors visit for every supplement you take....seriously....you guys think doctors give great advice. It's because of a doctors advice that I almost died and experience pain on a daily basis. Had he not been involved in my life I would be fine. Believe me doctors are OFTEN wrong
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Wow There are bad mechanics too, do you assume every one of them are bad because of it? And the doctor recommendation thing is basically associated with almost anything to do with the health industry and rightfully so.
 
Phenibut. /thread.

EDIT-im sorry pregenolone is NOT released in response to the NMDA receptors being stimulated but pregenolone sulfate is.

Invalid Link Removed

Example study. Read the first two lines.
 
EatMoar said:
Phenibut. /thread.

EDIT-im sorry pregenolone is NOT released in response to the NMDA receptors being stimulated but pregenolone sulfate is.

Invalid Link Removed

Example study. Read the first two lines.
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Do you happen to have a pdf of the study? I see what the abstract says happens in retinal cells, but even then it is not clear. Pregenolone modulate NMDARs, but I haven't seen anything that shows that synthesis occurs after NMDAR activation.
 
Aleksandar37 said:
Do you happen to have a pdf of the study? I see what the abstract says happens in retinal cells, but even then it is not clear. Pregenolone modulate NMDARs, but I haven't seen anything that shows that synthesis occurs after NMDAR activation.
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I can snag it when I get home. But the abstract says the synthesis increases after NMDAR activation.
 
Vj63 said:
You SNS guys make some great points about seeking medical advice for these things. In fact, to show my appreciation, I will consult a physician before taking any of your products just as you advise. I know that my doctor as well as most others will be eager to give me their blessing to take products that are widely known by most MDs like DAA, agmatine, x-gels.
Thanks so much for caring.
Click to expand...
would you rather them be like the iforce reps and constantly pimp every iforce supp for every question lol?
 
EatMoar said:
I can snag it when I get home. But the abstract says the synthesis increases after NMDAR activation.
Click to expand...

Abstracts have a funny tendency to sound much more exciting and significant than the data actually shows. Also, the abstract says they only used retinal cells.
 
Alasel said:
I was actually reading up on a l-dopa supplement as I believe it also has growth hormone elevating properties which i was looking for a separate supplement for also. What kind of dowse would be use for dwell good and what dose for gh elevation?

Thanks for you response
Click to expand...
2 caps of analyzed supplements dopadex should definitely do the trick, you could add a little huperzine-a to attentuate the effects
 
Aleksandar37 said:
OP, my recommendation for the winter months is vitamin D3. If you're looking for a quality L-Dopa product, I would check out Dopadex Invalid Link Removed
Click to expand...

i agree, vitamin d is great for mood enhancement and aids in dopamine + serotonin synthesis
 
rhoadx said:
would you rather them be like the iforce reps and constantly pimp every iforce supp for every question lol?
Click to expand...

This. Products like x-gels, agmatine, etc, aren't used to treat issues that may be as serious as mental health issues, regardless of how insignificant the OP and others may think they are. I would have thought that people would prefer helpful responses by people that aren't just out to pimp products for the sake of helping the bottom line out.
 
Synapsin said:
This. Products like x-gels, agmatine, etc, aren't used to treat issues that may be as serious as mental health issues, regardless of how insignificant the OP and others may think they are. I would have thought that people would prefer helpful responses by people that aren't just out to pimp products for the sake of helping the bottom line out.
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lmao, i don't even know how to respond to this nonsense...i'll just let it go
 
Jiigzz said:
What are you talking about Aaron? Of course we know more than a medical professional. I googled supplements to help depression for a FULL 5 minutes today :DIn all seriousness, vitamin d3 supplementation is my preferred supplement of choice to 'prevent' seasonal depression. That and l dopa. I like l dopa
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This illustrates just how correct you are about giving advise.

My wife is an endocrinologist. I also had to learn about treatment of osteoporosis back when we tried 7 HRT bellwether cases in Reno and in Philadelphia. Understanding D3 was a piece of this process.

The feel good from the sun comes from an opioid B-endorphin via stimulation of POMC. Not sure D really produces any feel good reaction similar to the UV production of B-endorphin feel good response.

The belief that large doses of d will make a normal person feel any better or any different is perhaps bunk. Large doses of D3 theoretically could have opposite impact if raises blood calcium. I think the d feel good may be a bit psychosomatic.

A lot of us eating decent amounts of tuna, salmon and etc. and with younger skin may be at optimal levels. Taking mega doses with optimal levels may lead to hypercalcemia. K may help plumbing and redirect calcium.
 
5htp - legendary, make sure its a good supplier and start low (50mg) increasing if needed. ALWAYS perks me up when im being a grumpy a$$ this time of year. Within 2 weeks you forget the need for it.

Also, if stressed, try some calming - Im grumpy from that too - so I take Kalms or other supermarket versions

L-dopa arrived today! A MUST for 5htp users as it depletes dopamine. Together, you feel GREEEEAAAT. I couldn't wait for my usa shipment so I bought USP Powerfull from the uk.


Don't go to the doc, he'll refer you for chemicals that don't fix the issue or natural option will be 5htp anyway!
 
Clean gene said:
Well said!
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I agree that many times SSRIs are handed up absent proper testing resulting in an exacerbation of the problem, especially if the problem is xy axis related. Docs are getting a little better these days regarding the SSRIs.

Telling someone (especially younger white males) to take D3 without knowing their baseline, however, is perhaps no better than a GP prescribing an SSRI to someone depressed because of jacked hormones. Even with baseline tests, a low D and high blood calcium could be indicative of a parathyroid. Low D3 prohibits intestines from absorbing more calcium to protect the body from high blood calcium levels. Ingesting more D3 could be very, very bad even if you have low D-25 without a full understanding of the bigger picture.

The point here is that a healthy younger individual eating a proper diet will generally have homeostasis with D3 and calcium levels. The lower range D25 blood level was also recently reduced from 30ng to 20ng. I doubt very seriously most, if any of you, need or will benefit from D supplements if you are less than 30, male, or non-Hispanic white. Candidly, unless you are some 65 year old granny with jacked hormones, have Parkinson's, MS et al., vitamin D will perhaps do nothing for you. So much misinformation or manipulation of data employed to promote D.
 
996ttelise said:
I agree that many times SSRIs are handed up absent proper testing resulting in an exacerbation of the problem, especially if the problem is xy axis related. Docs are getting a little better these days regarding the SSRIs.

Telling someone (especially younger white males) to take D3 without knowing their baseline, however, is perhaps no better than a GP prescribing an SSRI to someone depressed because of jacked hormones. Even with baseline tests, a low D and high blood calcium could be indicative of a parathyroid. Low D3 prohibits intestines from absorbing more calcium to protect the body from high blood calcium levels. Ingesting more D3 could be very, very bad even if you have low D-25 without a full understanding of the bigger picture.

The point here is that a healthy younger individual eating a proper diet will generally have homeostasis with D3 and calcium levels. The lower range D25 blood level was also recently reduced from 30ng to 20ng. I doubt very seriously most, if any of you, need or will benefit from D supplements if you are less than 30, male, or non-Hispanic white. Candidly, unless you are some 65 year old granny with jacked hormones, have Parkinson's, MS et al., vitamin D will perhaps do nothing for you. So much misinformation or manipulation of data employed to promote D.
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This probably needs a cooper or synapsin response but remember there is vitamin D and vitamin D3 supplements and,during colder winter months it should be almost mandatory to get extra d3 in the system considering the sun is the main source of it.

The safe UL is noted at around 10,000iu and there are so many benefits with supplementing with d3, if deficiet, that doing so in winter should be paramount.

Can I ask you what basis you lay the claim that supplementing with it is not needed given the plethora of data on the subject showing benefits?
 
Jiigzz said:
This probably needs a cooper or synapsin response but remember there is vitamin D and vitamin D3 supplements and,during colder winter months it should be almost mandatory to get extra d3 in the system considering the sun is the main source of it.
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Almost mandatory? According to whom? Supplement companies, vitamin companies, health food stores, homeopathic companies et al. I do know a few DOs and GPs that used to make such statements, but have since backed off.

In healthy individuals, blood levels of cholecalciferol naturally peak in the fall, build up in your system and help production of d throughout the winter months. Again, if you are a young, white male that ingests a healthy diet, you are most likely in a state of homeostasis with regard to d and calcium regulation throughout the winter months.

Unlike the body's conversion of sun, taking d supplements can cause hypercalcemia. The body will down regulate D in a state of hypercalcemia to impede the small intestine's absorption of more calcium to guard against further hypercalcemia. The body can and will maintain this homeostasis with natural d production, but cannot with supplemental vitamin d.

Guess what? Hypercalcemia due to unnecessary ingestion of supplemental d can cause: depression, memory loss, apathy and irritability.

I primarily took issue with your feel good comments regarding taking supplemental d. The feel good reaction from the sun is not a result of vitamin d. The sun's feel good comes from an opioid B-endorphin through stimulation of POMC.
 
996ttelise said:
So much misinformation or manipulation of data employed to promote __________.
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I know you put "vit D" in there when you typed it, but let's just be real and fill in the blank with whatever you want
this forum is great, but ppl sure stretch the credibility of this or that study etc when attempting to "prove a point"
I get a chuckle almost daily
 
996ttelise said:
Almost mandatory? According to whom? Supplement companies, vitamin companies, health food stores, homeopathic companies et al. I do know a few DOs and GPs that used to make such statements, but have since backed off.

In healthy individuals, blood levels of cholecalciferol naturally peak in the fall, build up in your system and help production of d throughout the winter months. Again, if you are a young, white male that ingests a healthy diet, you are most likely in a state of homeostasis with regard to d and calcium regulation throughout the winter months.

Unlike the body's conversion of sun, taking d supplements can cause hypercalcemia. The body will down regulate D in a state of hypercalcemia to impede the small intestine's absorption of more calcium to guard against further hypercalcemia. The body can and will maintain this homeostasis with natural d production, but cannot with supplemental vitamin d.

Guess what? Hypercalcemia due to unnecessary ingestion of supplemental d can cause: depression, memory loss, apathy and irritability.

I primarily took issue with your feel good comments regarding taking supplemental d. The feel good reaction from the sun is not a result of vitamin d. The sun's feel good comes from an opioid B-endorphin through stimulation of POMC.
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Cooper is a, at least to my knowledge, a proponent of supplemental vit D3.
mr.cooper69 Synapsin De__eB

If this is true, which the overwhelming doesnt support, then I want to hear it from these guys.
 
snagencyV2.0 said:
I know you put "vit D" in there when you typed it, but let's just be real and fill in the blank with whatever you want
this forum is great, but ppl sure stretch the credibility of this or that study etc when attempting to "prove a point"
I get a chuckle almost daily
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You're being ignorant if you feel all studies are biased to make you buy product.
 
Jiigzz said:
You're being ignorant if you feel all studies are biased to make you buy product.
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what? jigzz, I am shocked by your own lack of thought in that post
where the hell did I say anything remotely resembling what you accuse me of?
I think you need some sleep buddy
 
mr.cooper69 said:
What's nonsense about it? Agmatine is a confirmed neurotransmitter in the human body and ArA excess is implicated in all sorts of neurological conditions.
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I know eh? I saw his post and figured no point in getting into a pointless argument.

About vit D: people tend to be more deficient than they think, but not everybody is and its quite easy to take care of. Vit D should realistically be taken by people who have had blood tests showing they are deficient, although it won't hurt most people to supplement vit D. Supplementing it when you don't need it, however, is pointless.
 
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