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DCP 2.0

Rodja said:
How the **** did I miss this release!? I remember beta testing DCP 1.0 back in Winter '06.
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Get on Rodja!

soitgoes said:
whoops, bought 4 bottles and some alphamine

;)
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DCP 2.0 + Alphamine sounds great

MidwestBeast said:
Super stoked about this.

And the intro price is ridiculous.
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Price is unbelievable. People should be eating this up.

I can't wait to get my hands on a bottle and give it a go to really see its versatility.
 
dsade said:
I see the jealous competition down vote train has hit the product ratings at Nutraplanet.
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I'm not trying to play devil's advocate here but what about the others who voted and gave the product a 5 star review with out even trying the product yet? Isn't that the same? It's really a shame either way because you have the haters and the nut huggers voting without even trying the product and giving it a fair chance.

I really am looking forward to reading some honest unbiased reviews soon to see if this is a good product or not.
 
RickyBDragon said:
I'm not trying to play devil's advocate here but what about the others who voted and gave the product a 5 star review with out even trying the product yet? Isn't that the same? It's really a shame either way because you have the haters and the nut huggers voting without even trying the product and giving it a fair chance.

I really am looking forward to reading some honest unbiased reviews soon to see if this is a good product or not.
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Absolutely. I'm not a fan of either. Shame that's how it goes on retail sites though. I think that's why AM ended up putting up the "Product Review" section.
 
dsade said:
I see the jealous competition down vote train has hit the product ratings at Nutraplanet.
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Someone really loves you Matt. Every product you release is hit with the one star attack bandwagon before release. "Matt has a new product not out yet. To the 1 star mobile! We must attack early and often!"
 
New study posted.....it would be a VERY good idea to combine DCP with Vanillean.

Invalid Link Removed 2013 Apr 21. [Epub ahead of print]
[h=1]Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation.[/h]Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.
[h=3]Source[/h]Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, 400042, China.

[h=3]Abstract[/h]Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid deposition and coincides often with cardiometabolic diseases. Several dietary factors attenuate NAFLD. Here, we report beneficial effects of chronic dietary capsaicin intake on NAFLD which is mediated by the transient receptor potential vanilloid 1 (TRPV1) activation. The results showed that TRPV1 activation by capsaicin reduced free fatty acids (FFAs) induced the intracellular lipid droplets in HepG2 cells and prevented fatty liver in vivo. Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor δ (PPARδ) in wild-type (WT) mice. This effect was absent in TRPV1[SUP]-/-[/SUP] mice. Dietary capsaicin did not affect lipogenesis, as indicated by the detection of hepatic fatty acid synthase (FAS), sterol regulatory element-binding protein-1 (SREBP-1), PPARα, and liver X receptor (LXR) in mice. Importantly, TRPV1 causes PPARδ activation which significantly increased the expression of autophagy-related proteins, such as light chain 3 (LC3)II, Beclin1, Atg5, and Atg7 in HepG2 cells. In the in vivo study, TRPV1 activation by dietary capsaicin enhanced hepatic PPARδ and autophagy-related proteins and reduced hepatic enzymes and inflammatory factor in WT but not TRPV1[SUP]-/-[/SUP] mice. TRPV1 activation by dietary capsaicin prevents NAFLD through PPARδ-dependent autophagy enhancement in mice. Dietary capsaicin may represent a beneficial intervention in populations at high risk for NAFLD.


PMID:23605066 [PubMed - as supplied by publisher]
 
LXR and RXR are my research goals for the summer. Might have to hit you up.
 
dsade said:
LXR and RXR are my research goals for the summer. Might have to hit you up.
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Fun. Lotta awesome implications in the research, if you're willing to connect the dots. My thesis is on the interplay of nuclear receptors with proliferation/regeneration pathways. Very fascinating, especially in the liver, intestine and macrophages of all things.
 
Resolve said:
Fun. Lotta awesome implications in the research, if you're willing to connect the dots. My thesis is on the interplay of nuclear receptors with proliferation/regeneration pathways. Very fascinating, especially in the liver, intestine and macrophages of all things.
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Deep Stuff.
 
More research indicating activity of PPAR delta and osteoblasts. Again I will be working up a more in-depth writeup to cover the interplay between the PPAR-delta angle and Carnitine Fumarate choice for DCP 2.0 as the month continues.

Invalid Link Removed

Invalid Link Removed 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31.
[h=1]PPARβ/δ governs Wnt signaling and bone turnover.[/h]Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.
[h=3]Source[/h]1] Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nürnberg, Erlangen, Germany. [2] Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen-Nürnberg, Erlangen, Germany.

[h=3]Abstract[/h]Peroxisome proliferator-activated receptors (PPARs) act as metabolic sensors and central regulators of fat and glucose homeostasis. Furthermore, PPARγ has been implicated as major catabolic regulator of bone mass in mice and humans. However, a potential involvement of other PPAR subtypes in the regulation of bone homeostasis has remained elusive. Here we report a previously unrecognized role of PPARβ/δ as a key regulator of bone turnover and the crosstalk between osteoblasts and osteoclasts. In contrast to activation of PPARγ, activation of PPARβ/δ amplified Wnt-dependent and β-catenin-dependent signaling and gene expression in osteoblasts, resulting in increased expression of osteoprotegerin (OPG) and attenuation of osteoblast-mediated osteoclastogenesis. Accordingly, PPARβ/δ-deficient mice had lower Wnt signaling activity, lower serum concentrations of OPG, higher numbers of osteoclasts and osteopenia. Pharmacological activation of PPARβ/δ in a mouse model of postmenopausal osteoporosis led to normalization of the altered ratio of tumor necrosis factor superfamily, member 11 (RANKL, also called TNFSF11) to OPG, a rebalancing of bone turnover and the restoration of normal bone density. Our findings identify PPARβ/δ as a promising target for an alternative approach in the treatment of osteoporosis and related diseases.


PMID:23542786 [PubMed - in process]
 
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Matt,

Sir, a question for you. On Wednesday I begin daily fasts for a month, for religious reasons. Being in the Northern hemisphere I have my pre-fast meal at 1:30am, I then fast for approx 21 hours and break my fast with a meal at 10pm, so two meals in 24 hours. I will be training at 8:30 pm, so that soon after I finish I will be able to eat. With that in mind, would two capsules of DCP 2.0 with each meal (four in total) be enough? Also I'm intending to lose as much fat as possible during this month. Is there anything else you can suggest supplement wise. I already have eviscerate and green coffee extract.

Thanks.
 
I'm not Matt, but Vanillean could be a supplement you could add.

I'd like to hear Matt's response as well. Is 3/3 a possibility?

Please let us know how it goes for you.
 
testosteronet said:
I'm not Matt, but Vanillean could be a supplement you could add.

I'd like to hear Matt's response as well. Is 3/3 a possibility?

Please let us know how it goes for you.
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Thanks mate. It is a possibility - but I just wondered whether it will yield better results since I'm only eating twice a day within a four hour window.
 
I would actually concentrate on fasting and preworkout doses. You will find the best results with those (the fasted doses will be the equivalent of a pre-bed dose, with a massive and quick shift from glycogen to fatty acids as bodyfuel.
 
dsade said:
I would actually concentrate on fasting and preworkout doses. You will find the best results with those (the fasted doses will be the equivalent of a pre-bed dose, with a massive and quick shift from glycogen to fatty acids as bodyfuel.
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I can't eat or drink anything from 1:30am until 10pm, so I can't dose pre-workout as I'm training at 8pm. The only times I can does is post workout once I've broken my fast at 10pm and another one around 1:00 or 1:30 before I begin my fast. Should I do 3 on 3 or would 2 on 2 be sufficient? nd would there be any benefit in adding Vanillean?
 
There is a definite thermogenic benefit to adding Vanillean, for sure.

Is there some kind of loophole you can exploit? Technincally these are food supplements, not food...and you might be allowed small sips of water?

If you can do 3/3 you will notice a better effect vs 2/2 for sure.
 
dsade said:
There is a definite thermogenic benefit to adding Vanillean, for sure.

Is there some kind of loophole you can exploit? Technincally these are food supplements, not food...and you might be allowed small sips of water?

If you can do 3/3 you will notice a better effect vs 2/2 for sure.
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Thanks mate. Nothing can enter the central cavity regardless of its form or composition. I'll go 3 and 3 then. My intention is that for 1.30am meal it will be only protein and fat, so hopefully the DCP will help burn fat for the day rather than stored carbohydrates.
 
saggy321 said:
Thanks mate. Nothing can enter the central cavity regardless of its form or composition. I'll go 3 and 3 then. My intention is that for 1.30am meal it will be only protein and fat, so hopefully the DCP will help burn fat for the day rather than stored carbohydrates.
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Can you please let us know how the 3/3 dosing scheme works for you. I'd be interested in your thought and results.
 
testosteronet said:
Can you please let us know how the 3/3 dosing scheme works for you. I'd be interested in your thought and results.
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Will do. I have a feeling this is gonna be kick ass! I sitting at around 12%, so a month of 21 hours fasts with DCP 2.0 should shred me up pretty well! I may keep a log if there's enough interest.
 
Definitely interested in following a log.
 
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