I got the e-mail rolling along when I read Judo's post over at stakedcops Log and I have an answer now, gonna let u guys have it out on that one, here goes
"Questions 1-3
These cannot be quantitatively answered because there is no negative control, and in order to make even qualitative inferences, one would need to take a biopsy of the brain or testicles. (be my guest, somebody might pay you for the study)
As far as I can tell, DAA almost exclusively promotes the release of GnRH (Gonadotropin-releasing hormone) which is responsible for LH (Luteinizing-hormone) production which is THEN responsible for steroidogenesis. With all these steps and with all the communication that has to occur,
I doubt anything will get accumulated to astronomical levels unless somebody has a medical condition.
Questions 4 and 5
If you are talking about calcium influx into a neuron then the limiting factor will become glycine, the ion channel is BOTH ligand and voltage dependent.
NMDA would have to bind AND glycine for calcium to enter the neuron, so even if there is an excess of NDMA it won't effect calcium ion influx into the cell unless there is also an excess of glycine as well. Glycine does not act exclusively as a neurotransmitter/hormone like DAA does so it
will not necessarily accumulate in the brain more if you eat a ton of glycine.
Secondly, the channel is voltage dependent, so if the charge inside the neuron reaches a certain point due to calcium buildup there will be a repulsion effect (think of sticking the same pole of two magnets together)
I will say this.
Since DAA is not active directly and must be metabolized, the body's negative feedback system
will likely kick in before anything accumulates to dangerous levels.
I hope this covers the information you wanted to cover."
I have been sitting on my butt reading and reading for quite awhile on all sorts of aspartame and glutamate and what nots (Dolly Parton's movie 9-5 playing n the background :/ .....twice) and i havent been thrown off of having my two packets of sweetener in the morning yet.
I have found on my own research, (even researching in Italian) a lot of evidence that back up the claims on the increased production of testosterone and it is used in Italy for fertility treatments. The truth
I've seen is there seems to be a lot of info out there that verifies it really does what it's being marketed for in the supps industry and not much research on the negative effects although it does seem to be riding on the research done on aspartame.
this is me, I'm like u guys, I do bodywork not a scientist.
Now I've always had some ideas on the "increase" in neurological disorders (the quotation isn't because I don't believe it, it's because I haven't read up on like per capita or anything, so I'm not sure on it, or at least I haven't been convinced yet either way, but i will read up...anyway)
alleged causes:
plastic bowls, pill containers and water bottles etc... (basically a lot of plastic stuff)
tampons
fluorescent lights
wireless devices
*sunblock may cause chemical cancer
ok any way lots of stuff.....
Now I have no idea which way this goes in terms of the current discussion LOL but u know it's info that's out there.
I'm gonna stay away from google for awhile
well I'm sure more questions will pop up so lets keep reading