Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic. So, I started looking in the literature for NATURAL versions of GHRP to use. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2). This was an amazing find! I could now legally sell a supplement that had the same effect as GHRP-2 without being illegal! Understand, that this peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor! Amazing find, but I couldn't stop there.
GHRH is the other receptor that allows for LARGE increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. Luckily, we found an amazing GHRH stimulating supplement that I included in GHenerate to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph details the GHRH agonist I found!
Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!