This has to be true. MY friend failed a drug test for amphetamines and the only thing he was talking as oep. THIS IS NO BS.
For the purposes of clarity, allow me to explain why this is chemically impossible. And for the organic chemistry aficionados reading this post, I apologize for anything I may muddle.
In terms of OEP and causing a false positive for amphetamines, the charge most seem to make is in reference to 1,3-dimethylamylamine, which is entirely impossible. Some basic chemistry may significantly clarify this issue. Methamphetamine is simply the N-methyl derivative of alpha-methylphenethylamine (amphetamine). In both of these compounds, we can notice several functional groups, owing to the parent homologue of phenethylamine. These are the phenyl group, the ethyl group, and the amine group.
The first functional group, the phenyl, constitutes the base ring of all amphetamine derivatives, and is a six carbon benzene ring where each carbon serves as a point for an additional functional group to bond to. In this case, the carbon at position one is bonded to the second functional group, the ethyl, and the other five are saturated with hydrogen atoms. Therefore, we read the chemical structure of the phenyl group in phenethylamine as (C6 [six carbons] H5 [five hydrogen atoms])
The second functional group, the ethyl, is a structural unit where two carbons atoms are fused together by a single bond, and each carbon atom then shares a single bond with three hydrogen atoms. In the case of phenethylamine, the ethyl group is bound to the phenyl group at the first carbon, in the position where the third hydrogen atom would normally be. Ethyl groups will always share this bond with another functional group, which is why we read ethyl as (C2 [two carbons] H5 [five hydrogen atoms – as the functional bond takes the place of the sixth hydrogen atom]).
The final functional group, the amine, is a simple nitrogen atom which shares two single bonds to hydrogen atoms. We thus read it is (NH2). We describe amphetamine and phenethylamine as homologues, as the only structural difference between the two is that, with phenethylamine, the amine is bound to ethyl group where the third hydrogen would normally be.
Dimethylamylamine, then, is clearly different from amphetamine, and this is easily recognized as it does not share our key functional groups. It lacks the benzene ring, first and foremost, which is present in all phenethylamine substitutions, possesses a pentyl as opposed to an ethyl as the second alkyl group, and in reality shares only the amine functional group. (Being a sympathomimetic amine, however, is not sufficient enough to call these compounds “structurally similar” by any means.)
Most importantly, though, is that phenyl groups cannot be developed in metabolism, essentially meaning that all substances that have phenyl ring-containing compounds already had the phenyl ring in their structure prior to ingestion. As 1,3-dimethylamylamine clearly does not, and is not produced from any compounds which possess such a ring, it is quite literally chemically impossible for the 1,3-dimethylamylamine in OEP to result as a false positive for methamphetamine.
Hopefully that was informative.
