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What is Triazole™?

Classic love it!
 
Another little tidbit for you fellas:

One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!
 
Another little tidbit for you fellas:

One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!

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when is this comming after pct i will through this in.

i always run 2 pcts after inj cycles.
1st being clomid nolva for 4 weeks then i do a OTC pct rightb after which will be this product with some natty test booster. and powerfull ( prolactin i used tren)
 
How does triazole and activate extreme compare to the original NHA stack using the rebound reloaded with 6 bromo? What can one expect?
 
How does triazole and activate extreme compare to the original NHA stack using the rebound reloaded with 6 bromo? What can one expect?

Based on the user bloodwork, this should be as good in terms of testosterone boosting, but EVEN BETTER when you consider that there will be no negative side effect on your sex drive.
 
It seems through the old logs that 6-bromo had a great effect on recomposition, users reported gaining on the average 3-4 lbs., while having a smaller waste. will triazole have this same effect?

Also, off subject. Is the new glucophase still in development or has that project been eliminated?
 
It seems through the old logs that 6-bromo had a great effect on recomposition, users reported gaining on the average 3-4 lbs., while having a smaller waste. will triazole have this same effect?

We certainly hope. You can follow along with a guy running a log on bodyspace here: Invalid Link Removed

He is running quite a low calorie diet during, so the scale will likely only be going down, but he showed us some progress pics after just two weeks:

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His strength is still climbing for the most part.

Also, off subject. Is the new glucophase still in development or has that project been eliminated?

http://anabolicminds.com/forum/driven-sports/156396-welcome-driven-sports-2.html#post2508334
 
Another morsel for you guys:

Prunella Vulgaris is a highly esteemed traditional medicinal herb that is affectionately known as “heal-all”. It gets this name thanks to the diversity of ailments it has been purported to fix. These include anti-inflammatory and anti-bacterial effects, its ability to reduce fevers, stomach problems and even lower blood pressure. More recently, new research into its effects on cancer and diabetes have come to light. Prunella Vulgaris has been demonstrated to have anti-estrogenic properties through its effect in activating the Aryl hydrocarbon receptor (AHR) which can interfere with estrogen. Further proof of this effect is displayed in its effect on inhibiting the estrogen-induced enzyme, CYR61, which has recently been suggested as a biomarker for prostate cancer.


Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod. 2009 Feb;80(2):375-83.
 
Some more studies on Prunella for those interested.

Immune modulatory effects of Prunella vulgaris L.
Int J Mol Med. 2005 Mar;15(3):491-6.
Prunella vulgaris has a wide array of biological effects exhibiting numerous therapeutic potentials. Its anti-microbial effects including anti-viral and anti-bacterial effects are, presently, receiving increasing attention. While its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects or actions remain unknown. In view of the fact that polysaccharides isolated from medicinal herbs often function as biological response modifier of body immunity, we hypothesized that the anti-microbial effect of polysaccharides isolated from Prunella vulgaris is probably also mediated via immune modulation. We have isolated four polysaccharides containing fractions from Prunella vulgaris, one of the fractions, PV2, could markedly stimulate the production of superoxide and nitrite representing nitric oxide from murine macro****e RAW264.7 and brain macro****e BV2 cells. The amount of nitrite and superoxide produced after PV2 stimulation was as high as that seen in stimulation using bacterial endotoxin lipopolysaccharide (LPS), and this stimulatory response is dose-dependent. In addition to monocyte/macro****e, PV2 also stimulated the proliferation of splenocytes. In this study, we have shown that the polysaccharides isolated from Prunella vulgaris have marked immune stimulatory effects, which may bring about the anti-microbial effects of Prunella vulgaris.

A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells.
J Ethnopharmacol. 2004 Jul;93(1):63-8.
Herpes simplex viruses are pathogenic. With the emergence of drug-resistant strains of Herpes simplex virus, new antiviral agents, especially those with different modes of action, are urgently needed. Prunella vulgaris L. (Labiatae), a perennial plant commonly found in China and Europe, has long been used as a folk medicine to cure ailments. In this study, a polysaccharide fraction was prepared from Prunella vulgaris, and its effects on the expressions of Herpes simplex virus-1 and Herpes simplex virus-2 antigens in their host Vero cells were investigated with flow cytometry. The Herpes simplex virus antigen increased time-dependently in the infected cells, and Prunella vulgaris reduced its expression. The effective concentrations of Prunella vulgaris with 50% reductions of the Herpes simplex virus-1 and Herpes simplex virus-2 antigens were 20.6 and 20.1 microg/ml, respectively. The novelty of Prunella vulgaris is that it also reduces the antigen expression of acyclovir-resistant strain of Herpes simplex virus-1. After incubations with 25-100 microg/ml of Prunella vulgaris the Herpes simplex virus antigen-positive cells were reduced by 24.8-92.6%, respectively, showing that this polysaccharide fraction has a different mode of anti-Herpes simplex virus action from acyclovir. Results from this study show that Prunella vulgaris is effective against both the Herpes simplex virus-1 and Herpes simplex virus-2 infections, and flow cytometry offers a quantitative and highly reproducible anti-Herpes simplex virus drug-susceptibility assay.

Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats.
Pharmacol Res. 2004 Aug;50(2):123-30.
The study tested the effects of phenolics-rich extracts from the plants Silybum marianum (silymarin) and Prunella vulgaris on blood and liver antioxidant status and lipoprotein metabolism. These results indicate that silymarin and Prunella vulgaris improve antioxidant status in blood and liver and positively affect plasma lipoprotein profile in an experimental model of dietary induced hypertriglyceridemia.

Biological activities of Prunella vulgaris extract.
Phytother Res. 2003 Nov;17(9):1082-7.
The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(II) and Fe(III) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB(4) in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of Prunella vulgaris.

Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte.
Life Sci. 2002 Aug 30;71(15):1779-91.
An increasing portion of patients with HIV infection and/or AIDS cannot use currently FDA-approved anti-HIV drugs, including the reverse transcriptase and protease inhibitors, due to the adverse effects and the emergence of drug resistance. Thus, it is essential to develop new anti-HIV agents with a target different from the HIV reverse transcriptase and protease. Using a conformation-specific monoclonal antibody NC-1, we previously established a high throughput screening assay for identification of small molecular organic compounds that disrupt the HIV-1 gp41 six-helix bundle formation, a critical step of membrane fusion between the HIV and the target cell. In the present study, we used this assay to screen for inhibitors of the gp41 six-helix bundle formation from aqueous extracts of nine Chinese medicinal herbs with antiviral activity. We found that the extracts of two herbs, Prunella vulgaris and Rhizoma cibotte, showed potent inhibitory activity. The inhibitory activity of these two herb extracts significantly decreased after they were passed through polyamide resin mini-columns, which are able to bind polyphenols including tannin, an HIV-1 inhibitor with multiple mechanisms of action. The bound polyphenols were eluted from the polyamide columns and also showed potent inhibitory activity on the gp41 six-helix bundle formation. Tannin purchased from different commercial sources inhibited the gp41 six-helix bundle formation in a manner similar to the polyphenols isolated from the herb extracts. These results suggest that tannin may be one of major inhibitors of the HIV-1 gp41 six-helix bundle formation in the herb extracts and that tannin may inhibit HIV-1 entry by disrupting the gp41 six-helix bundle formation.

Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model.
Immunopharmacol Immunotoxicol. 2001 Aug;23(3):423-35.
We studied the effect of aqueous extract of Prunella vulgaris (Labiatae) on immediate-type allergic reactions. Prunella vulgaris (0.005 to 1 g/kg) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/ 80 in rats. When Prunella vulgaris was given as pretreatment, at concentrations ranging from 0.005 to 1 g/kg, the serum histamine levels induced by compound 48/ 80 were reduced in a dose-dependent manner. Prunella vulgaris (0.001 to 1 g/kg) inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Prunella vulgaris also inhibited the histamine release induced by compound 48/80 or anti-DNP IgE from the rat peritoneal mast cells (RPMC). The level of cyclic AMP in RPMC, when Prunella vulgaris was added, significantly increased, compared with that of normal control. Moreover, Prunella vulgaris (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis factor-alpha production from RPMC. These results indicate that Prunella vulgaris inhibits immediate-type allergic reactions in rats.

Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
Planta Med. 2000 May;66(4):358-60.
The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic acid, and 2 alpha-hydroxyursolic acid. One of these compounds, 2 alpha,3 alpha-dihydroxyursolic acid, demonstrated significant inhibition on the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 microM. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macro****es, RAW 264.7 cells, ursolic acid and 2 alpha-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 microM, respectively).
 
Another little tidbit for you fellas:

One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!

Here is a scan of the bloodwork in question.


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Test subject 04 pre-set blood work series (5/13/2010):
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Test subject 04 post-set of blood work series (6/15/2010):
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Thats an increase in total testosterone of roughly 90%, an increase in free testosterone of roughly 100% while keeping estrogen levels below the testing thresh hold.
 
Those results were strictly for Triazole correct? I can't imagine what the addition of ActX would add to this....
 
We certainly hope. You can follow along with a guy running a log on bodyspace here: Invalid Link Removed

He is running quite a low calorie diet during, so the scale will likely only be going down, but he showed us some progress pics after just two weeks:

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His strength is still climbing for the most part.

It is up on some things and holding steady on just about everything else. I checked my weight and after 2 weeks I am actually up 2lbs. 228 at start and Im sitting at 230 even as of yesterday.


http://anabolicminds.com/forum/driven-sports/156396-welcome-driven-sports-2.html#post2508334

Those results were strictly for Triazole correct? I can't imagine what the addition of ActX would add to this....

We'll see in a couple weeks. Ill have my post blood work done after running the 2.

I can't wait to use this combo when Im eating closer to 4-5k cals a day. Im getting excited just thinking about it. haha!
 
Hey guys the presale is up on Nutra......please tell me it is not really $67.99 per bottle????

That has got to be a mistype right?

Mr.50

***Edit*** Its not exactly a pre-sale its more of a notice of release at the end of September
 
Hey guys the presale is up on Nutra......please tell me it is not really $67.99 per bottle????

That has got to be a mistype right?

Mr.50

***Edit*** Its not exactly a pre-sale its more of a notice of release at the end of September


Matt said it should sell for around the same price as Activate Xtreme.
 
Those results were strictly for Triazole correct? I can't imagine what the addition of ActX would add to this....
Correct those are just for Triazole. Tom will be the first one to post blood work of the stack.

Hey guys the presale is up on Nutra......please tell me it is not really $67.99 per bottle????

That has got to be a mistype right?

Mr.50

***Edit*** Its not exactly a pre-sale its more of a notice of release at the end of September
That is the MSRP, I doubt that will be the price. All we have control over is the MSRP.
 
Correct those are just for Triazole. Tom will be the first one to post blood work of the stack.

That is the MSRP, I doubt that will be the price. All we have control over is the MSRP.

Ah I see....makes sense...wonder what Nutra will be asking??

Mr.50
 
dumb question = what is msrp?
 
Look at the other prices and work out a general pattern. The black text is always the MSRP, the red text always the actual price. The actualy price tends to be 60-75% of the MSRP.

Got it. Thanks and I am sure you guys are right. I had a knee jerk reaction...

Mr.50
 
ahhh ok thanks ROBBOE, im def going to use this as my part 2 pct. dude one of the dude who posted pics after just 2 weeks ^ top of the page, looks better after 2 weeks then most ppl who cut for 2 months.
 
Test Subject (T.S.) 02- blood work. "It was great seeing the fat loss aspect of this formula due to the drastically lower estrogen and higher testosterone. It gave a great confidence boost!"

Pre-set taken on
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Post estrogen levels went down at least 57%*

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Post free testosterone went up 98% and total testosterone went up 75%

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*assuming that estrogen went down the min to a level of 49
 
IT;S NOT 70$ READ THE WHOLE THREAD!
 
woooooooooooow impressive results! wooow guy went from ****ty 388 to a crazy 700 wooooooow
 
Awesome - thats all I can say :lol:

//CC
 
Triazole™ also introduces CAPE, an all-natural SERM (selective estrogen receptor modulator) found in bee propolis extract. Propolis is a resin that bees use for structural support of their hive, but recent research has shown it to have numerous health benefits. These include reducing inflammation, strengthening the immune system and being excellent for heart health. While propolis contains many constituents, it is only CAPE that was demonstrated to displace estrogen from the estrogen receptor. If CAPE is occupying the estrogen receptor, then the estrogen hormone has no way to bind to it itself making CAPE a novel SERM! In addition, CAPE has been shown to downregulate estrogen receptor expression, or in other words, reduce the amount of estrogen receptors.

One other exciting property of CAPE that has been shown recently in research is its effect inhibiting a highly pro-inflammatory signalling molecule called NF-kB. Scientists are investigating compounds that can achieve this because inhibition of NF-kB signalling has potential therapeutic application in cancer and other inflammatory diseases.

Jung BI, Kim MS, Kim HA, Kim D, Yang J, Her S, Song YS. Caffeic acid phenethyl ester, a component of beehive propolis, is a novel selective estrogen receptor modulator. Phytother Res. 2010 Feb;24(2):295-300.
 
Test Subject 03- blood work taken on 5/15/10 and 6/17/10 "Everything is still great. Strength and aggression have both made noticeable leaps over the past 11 days. Also, I have been in a consistent carb-rich caloric surplus and I'm not holding much water. On ActX, my mood was noticeably different, almost euphoric. Right now I'm not feeling that, but rather, controllable aggression. It might be hard to understand, but it's MUCH better.

Pre set levels of: Est 70 TT 485

Post set levels of: Est <50* TT 717


Estrogen decreased a min. of 30%* and total testosterone increased 48%.

*assuming that estrogen went down the min to a level of 49
 
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My sentiments....
 
I'm getting anxious!! I have just under 2 weeks left of Triazole/ActX until I get my blood work. I wanna know NOW!! haha
 
Test Subject 03- blood work taken on 5/15/10 and 6/17/10 "Everything is still great. Strength and aggression have both made noticeable leaps over the past 11 days. Also, I have been in a consistent carb-rich caloric surplus and I'm not holding much water. On ActX, my mood was noticeably different, almost euphoric. Right now I'm not feeling that, but rather, controllable aggression. It might be hard to understand, but it's MUCH better.

Pre set levels of: Est 70 TT 485

Post set levels of: Est <50* TT 717


Estrogen decreased a min. of 30%* and total testosterone increased 48%.

*assuming that estrogen went down the min to a level of 49


Matt there is no potential for a false positive increase in Test with this compound is there? I remember one of the compounds that came out a few years ago (cant remember if it was ATD or what) seemed to have fantastic results on paper but there was a concern that in testing it caused a false positive for elevated test but as a substitute substrate for testosterone.

Mr.50
 
Matt there is no potential for a false positive increase in Test with this compound is there? I remember one of the compounds that came out a few years ago (cant remember if it was ATD or what) seemed to have fantastic results on paper but there was a concern that in testing it caused a false positive for elevated test but as a substitute substrate for testosterone.

Mr.50

ATD metabolites caused the false positive. There are no steroidal-structured metabolites from anything in Triazole that will do this.
 
I'll be testing this with hormone tests in conjunction with Act-X for those interested. Trying to get as much info on this stuff for you guys as possible.
 
Test Subject 07- blood work. "Day 11 update- My mood is better than ever, having had no problems with waking up very early, managing a 10 hour job everyday and then going to workout after or do cardio. My sessions are getting better and better, which is pretty remarkable. Added reps and weight to most compound exercises. I think this product may aid in pumps, but not 100% sure yet."


Pre- set testosterone levels of:
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Post total testosterone went up 120% from 407 to 896 and free test went up 257% from 74.3 to 265.2!!!Invalid Link Removed
 
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