shaddow
Well-known member
Subscrizzled fo' shizzle! :lol:
Sweet. I'm not the only one subscrizzlin' up in this beeeitch!After quite a Hiatus I have returned in time to subscrizzle.
:head:
Subscrizzled fo' shizzle! :lol:
Sweet. I'm not the only one subscrizzlin' up in this beeeitch!After quite a Hiatus I have returned in time to subscrizzle.
*Saved for final review*
Little use for this, but want to see some additional real world feedback on these compounds (mainly ellagic and Androsterone because aromatase inhibitors fascinate me).
Is it safe for me to assume that a big part of your review/thoughts of this product will be seen if you add it to your PCT (if you still are planning your uber log in the future). Or do you already have your pct planned/staple pct supplements?
Whats up John? You know I wouldn't miss this. I'm following along bud with a keen interest as this product seems pretty intriguing.
Cheers to ya Brutha Man!:cheers:
found this statement in another forum:BTW - I've always known androsterone to be a metabolite of testosterone and DHEA, but when did it start to be used as an AI? What type of an AI is it?
found this statement in another forum:
Androsterone is a steroid metabolite of testosterone with weak androgenic properties. Specifically, it is the 3-hydroxyl, 17-keto isomer, of testosterone. Androsterone has no known anti-estrogenic properties. Supplementation with excess amounts of androsterone will undoubtedly trigger the negative feedback within the HPTA leading to lower natural testosterone levels. For someone coming off a steroid cycle, supplementing with Formadrol will probably prolong their recovery until supplementation ceases.
and this answer from lg:
Androsterone has LOTS of studies showing anti-aromatase effects. Daidzin has been shown in studies to stimulate growth. Your paper on Female mice with their overaries removed isn't really relevant and they used synthetic equol at that in the study. So, clearly it doesn't appear to have much merit in the conversion rate. ATD is in there which is also good as an AI.
"Androsterone is a steroid metabolite of testosterone with weak androgenic properties. Specifically, it is the 3-hydroxyl, 17-keto isomer, of testosterone. Androsterone has no known anti-estrogenic properties. Supplementation with excess amounts of androsterone will undoubtedly trigger the negative feedback within the HPTA leading to lower natural testosterone levels. For someone coming off a steroid cycle, supplementing with Formadrol will probably prolong their recovery until supplementation ceases."
I will go point by point to show that you don't know everything.
You say "Androsterone has no known anti-estrogenic properties"
1: J Clin Endocrinol Metab. 1984 Mar;58(3):467-72.Links
The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.Perel E, Stolee KH, Kharlip L, Blackstein ME, Killinger DW.
To determine if the 5 alpha-reduced androgen metabolites formed within the breast carcinoma cells could influence aromatase activity, the MD line was further studied. After 24-h preincubation with AND, DHT, or 5 alpha-A-dione at concentrations of 10(-6), 10(-7), and 10(-8) M, [3H]androstenedione was added to the culture medium, and aliquots were removed at 0, 4, 8, and 24 h. An 8-h incubation period was found to be optimum for inhibition studies. In comparison to control levels of estrone (2.5%) and estradiol (0.35%) formation, inhibition of aromatization was evident with all three compounds at 10(-8) M, with 5 alpha-A-dione producing the greatest inhibition (50%). At 10(-7) M, inhibition ranged from 45% (ANDROSTERONE) to 70% (5 alpha-A-dione), and at 10(-6) M, inhibition was greater than 90% for each compound. 5 alpha-A-dione produced slightly greater inhibition than ANDROSTERONE or DHT at each concentration tested. Since each of these compounds was capable of inhibiting aromatization, the cumulative effect of these 5 alpha-reduced metabolites could be an important factor in the intracellular regulation of aromatase activity.
Aromatase activity in the breast and other peripheral tissues and its therapeutic regulation.Killinger DW, Perel E, Daniilescu D, Kharlip L, Blackstein ME.
Department of Medicine, University of Toronto, Ontario, Canada.
Using cultured breast carcinoma cells, it was shown that estrogen formation was stimulated by cortisol (10(-6) M) and inhibited by endogenous 5 alpha-reduced androgens: 5 alpha-androstene-dione greater than androsterone greater than dihydrotestosterone greater than epiandrosterone greater than 3 alpha- and 3 beta- androstanediol.
but then another statement from the op as an answer:
Those studies had to do with substrate availability. In the human body, endogenous testosterone production will not be suppressed systemically for this to occur. And unless you are developing a topical androsterone cream, neither of those studies were relevant to what we were discussing. Specifically, I said androsterone has no anti-estrogenic properties.
The studies you mentioned display the obvious: 5a-reduced androgens cannot convert to estrogen via the aromatase enzyme. Without a subtrate for estrogen production (IN A CLOSED SYSTEM [en vitro]), estrogen levels will go down. Your logic is that if one supplements with a 5a-reduced androgen, then estrogenic symptoms will not occur. I think you now see the flaw in your argument. In retrospect, I do apologize for the title of this thread.
DAY 1
Weight: 211 lbs
Libido: Baseline
Aggression: Baseline
Overall mood: Baseline
Strength: N/A
I took my first dose of this about 1 hour ago. I will say that i did experience a "Mild" buzz upon immediately taking this sublingual product. My tongue also went a bit numb for a few minutes.
The taste was ok. At first pretty sweet, then bitter, but very tolerable. Please note i only took the PM dose today. I have enough T-911 for almost 3 weeks total.
i hope your strength picks up tomorrow...N/A pift..
i bet trauma will finally be picking up the green 10lb dumbells instead of those pink 5 pounders he's been stuck on for yrs now. :lol:
YEAH BOI!! GET EM DUMPLIN'!! LIGHT WEIGHT BABY, LIGHT WEIGHT!!
i bet trauma will finally be picking up the green 10lb dumbells instead of those pink 5 pounders he's been stuck on for yrs now. :lol:
YEAH BOI!! GET EM DUMPLIN'!! LIGHT WEIGHT BABY, LIGHT WEIGHT!!
found this statement in another forum:
Androsterone is a steroid metabolite of testosterone with weak androgenic properties. Specifically, it is the 3-hydroxyl, 17-keto isomer, of testosterone. Androsterone has no known anti-estrogenic properties. Supplementation with excess amounts of androsterone will undoubtedly trigger the negative feedback within the HPTA leading to lower natural testosterone levels. For someone coming off a steroid cycle, supplementing with Formadrol will probably prolong their recovery until supplementation ceases.
and this answer from lg:
Androsterone has LOTS of studies showing anti-aromatase effects. Daidzin has been shown in studies to stimulate growth. Your paper on Female mice with their overaries removed isn't really relevant and they used synthetic equol at that in the study. So, clearly it doesn't appear to have much merit in the conversion rate. ATD is in there which is also good as an AI.
"Androsterone is a steroid metabolite of testosterone with weak androgenic properties. Specifically, it is the 3-hydroxyl, 17-keto isomer, of testosterone. Androsterone has no known anti-estrogenic properties. Supplementation with excess amounts of androsterone will undoubtedly trigger the negative feedback within the HPTA leading to lower natural testosterone levels. For someone coming off a steroid cycle, supplementing with Formadrol will probably prolong their recovery until supplementation ceases."
I will go point by point to show that you don't know everything.
You say "Androsterone has no known anti-estrogenic properties"
1: J Clin Endocrinol Metab. 1984 Mar;58(3):467-72.Links
The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.Perel E, Stolee KH, Kharlip L, Blackstein ME, Killinger DW.
To determine if the 5 alpha-reduced androgen metabolites formed within the breast carcinoma cells could influence aromatase activity, the MD line was further studied. After 24-h preincubation with AND, DHT, or 5 alpha-A-dione at concentrations of 10(-6), 10(-7), and 10(-8) M, [3H]androstenedione was added to the culture medium, and aliquots were removed at 0, 4, 8, and 24 h. An 8-h incubation period was found to be optimum for inhibition studies. In comparison to control levels of estrone (2.5%) and estradiol (0.35%) formation, inhibition of aromatization was evident with all three compounds at 10(-8) M, with 5 alpha-A-dione producing the greatest inhibition (50%). At 10(-7) M, inhibition ranged from 45% (ANDROSTERONE) to 70% (5 alpha-A-dione), and at 10(-6) M, inhibition was greater than 90% for each compound. 5 alpha-A-dione produced slightly greater inhibition than ANDROSTERONE or DHT at each concentration tested. Since each of these compounds was capable of inhibiting aromatization, the cumulative effect of these 5 alpha-reduced metabolites could be an important factor in the intracellular regulation of aromatase activity.
Aromatase activity in the breast and other peripheral tissues and its therapeutic regulation.Killinger DW, Perel E, Daniilescu D, Kharlip L, Blackstein ME.
Department of Medicine, University of Toronto, Ontario, Canada.
Using cultured breast carcinoma cells, it was shown that estrogen formation was stimulated by cortisol (10(-6) M) and inhibited by endogenous 5 alpha-reduced androgens: 5 alpha-androstene-dione greater than androsterone greater than dihydrotestosterone greater than epiandrosterone greater than 3 alpha- and 3 beta- androstanediol.
but then another statement from the op as an answer:
Those studies had to do with substrate availability. In the human body, endogenous testosterone production will not be suppressed systemically for this to occur. And unless you are developing a topical androsterone cream, neither of those studies were relevant to what we were discussing. Specifically, I said androsterone has no anti-estrogenic properties.
The studies you mentioned display the obvious: 5a-reduced androgens cannot convert to estrogen via the aromatase enzyme. Without a subtrate for estrogen production (IN A CLOSED SYSTEM [en vitro]), estrogen levels will go down. Your logic is that if one supplements with a 5a-reduced androgen, then estrogenic symptoms will not occur. I think you now see the flaw in your argument. In retrospect, I do apologize for the title of this thread.
DAY 1
Weight: 211 lbs
Libido: Baseline
Aggression: Baseline
Overall mood: Baseline
Strength: N/A
I took my first dose of this about 1 hour ago. I will say that i did experience a "Mild" buzz upon immediately taking this sublingual product. My tongue also went a bit numb for a few minutes.
The taste was ok. At first pretty sweet, then bitter, but very tolerable. Please note i only took the PM dose today. I have enough T-911 for almost 3 weeks total.
Late but subbed. Got to love a numb tounge I have not had that since I last did Arggg wrong type of board to mention that:head:
You got buzzed & a numb tongue, damn maybe it's laced with coke :icon_lol:
take 2 ed and wait for third day, results really kicked in for me then. some serious effects.
Good to hear you're enjoying it T. I'm definitely impressed on how fast some of these effects have seemed to kick in. I'm really looking forward to the next few days.
can you put some light on the Androsterone discussion that ziquor began on this thread, or at least bring someone to help us understand better the use of an androgen in a test booster product, don't get me wrong but this product interests me as a pct one and that question is relevant for me.Androsterones kick in QUICK in pill form so bein sublingual this does NOT surprise me.
I was hounding at Eric before this even came out to make a sublingual version of like MMV2 or 1-androsterone, but so far to no avail.
Keep up the work T... Your logs are always a good read..... on the john that is.
HAHA.. how was that for a pun, and joke in one?
Adams
I was hounding at Eric before this even came out to make a sublingual version of like MMV2 or 1-androsterone, but so far to no avail.
john, the aggression didn't kick in for me till around 3rd or 4th day. if you are feeling this on day2 get ready to be a aggressive sob. libido is insane on this, if you haven't felt it yet it should be heading your way. i am done with my samples, only had 6 days, but i am very curious how this pans out on a longer run.:thumbsup:DAY 2
Weight: 211 lbs
Libido: Nothing to report as of yet. Remains at baseline.
Agression: I've literally been a prick all day today. I began to notice it about an hour after my morning dose. This continued throughout the day. Road rage was VERY bad on my way home from work. :aargh:
Overall Mood: See above, nothing but irritability and aggression today. I did seem to have highs and lows with it throughout the day though.
Strength: Nothing of any significance to note thusfar, however if i'm already demonstrating andro sides it should be coming soon.
Dosing: 1 sublingual tab at 0700 and 1800.
Narrative:
So, i took my first dose upon rising today at 0700. Literally within about 15 minutes, i again noticed the same "buzz-like" feeling, however it was more pronouced. I equate it to how i feel when i take a benadryl. Kind of spacey and relaxed, yet fun all in one. :lol: This lasted for about 20-30 minutes. Shortly after that, the aggressive tendencies began to take effect. This was not good today because i had to sit through nursing orientation at my hospital ALL DAY LONG.
Needless to say, i had a great workout today. I did bi's/back for today's workout. I have a feeling by day 3-4 this stuff is very going to pick it up a notch. I say this because i'm in shock it kicked in this fast already.
can you put some light on the Androsterone discussion that ziquor began on this thread, or at least bring someone to help us understand better the use of an androgen in a test booster product, don't get me wrong but this product interests me as a pct one and that question is relevant for me.
yeah , very good log,nice structured and easy to read , fantastic T1.
Tell me, are you planning on doing blood work in the end ?
thanks , look forward to see them:study:Lemme see what i can find, Eric hasnt been on all day but the next time he is let me see if i can get him to link me to some studies. :thumbsup:
yeah , very good log,nice structured and easy to read , fantastic T1.
Tell me, are you planning on doing blood work in the end ?
sounds good buddy....what is this upcoming cycle looking like.
i am still doing some research for mine...i NEED to hoop on very very soon!
Oh.....it's going to be ballz to the wall.
T1 shall be making it a 12-14 weeker for some SERIOUS gains!
:bb3:
i am planning on doing the tampa classic next year but need some more mass...thats about the time i was going to run mine. never cycled so i should get some phenominal gains with my genitics (knock on wood):head:
Good to hear. It sounds like you and J need to get over to tampa once and a while so we can do a "Ballz to the wall" training session, WOOT, WOOT!
I'm SO ready for a major bulker as is. We shall bring it brother, FLORIDA STYLE!!!
Yea bro we should definately get down and tear the gym up!
Oh.....it's going to be ballz to the wall.
T1 shall be making it a 12-14 weeker for some SERIOUS gains!
:bb3:
wow, a 12-14 week menstrual cycle? :toofunny:
lol.