In general, one should avoid alcohol, or take it in moderation, if at all. As you know, the consumption of alcohol triggers the production of two highly reactive and toxic metabolites, malondialdehyde and acetaldehyde. These potent free-radical agents produce a chain of effects that range from compromising of liver function to central-nervous-system damage (mostly via accumulation of alcohol in nerve cells leading to (diabetic) neuropathy), and immune-system problems. Although taking compounds such as N-Acetyl-Cysteine (with three times more Vitamin C prevent N-Acetyl-Cysteine oxidation), Grape Seed Extract/Silymarin/Resveratrol (for hepatic support and antioxidant shield), and Benfotiamine, fat-soluble Vitamin B1 [(Thiamine) for blood sugar support and protection from oxidative stress] may help alleviate related problems, alcohol use with Y-RD and PRIME is hardly justified. Alcohol may neutralize the broad effects (CNS and beyond) from Y-RD and neutralize the anti-oxidant impact of PRIME. Furthermore, as is well known, (excessive) alcohol impairs fertility via reduction in testosterone production and inhibition of sperm production and sperm function. On top of this, alcohol stimulates estrogen receptor sites, including estradiol, one of the most potent forms of estrogen. This is especially observable in cases of existing gynecomastia. Alcohol, on its own, under certain conditions, can produce gynecomastia.