TUDCA/NAC?

StanleyG said:
IMO NAC should be your on cycle support run at 1200mgs/day. UDCA (I dont use TUDCA, I use UDCA) Should be on hand should your liver enzymes become elevated and out of range in spite of your NAC prevention measures. Running both IS overkill and would likely, believe it or not, reduce the effectiveness of what you are taking. As crazy as it sounds you do not want you liver to metabolize things TOO efficiently or it can become counter productive. You want your enzymes in range, not to low either. UDCA is more of a treatment for elevated liver enzymes, NAC is a prevention.
Best of Luck.
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Incorrect on every count, not sure where you read this bs man. NAC doesn't improve liver metabolic rate (a function of CYP induction) and neither does TUDCA/UDCA. One reduces oxidative stress (liver cell death) and the other prevents bile acid buildup. Absolutely NOTHING to do with metabolism of compounds. And there is NOTHING wrong with having enzymes "too low," which only indicates that cells aren't dying. In medicine, both NAC and UDCA are used for treatment only, not prevention. But if knowingly taking toxic compounds, prevention is ALWAYS more prudent than treating after the fact. Finally, taking both isn't overkill since they act completely differently. Please educate yourself before spreading misinformation to the board.

I can vouch for OL TUDCA btw based on labwork with that being the only change. And I can vouch for CEL as well having been affiliated in the past and having seen the QC measures that go into their products
 
mr.cooper69 said:
Incorrect on every count, not sure where you read this bs man. NAC doesn't improve liver metabolic rate (a function of CYP induction) and neither does TUDCA/UDCA. One reduces oxidative stress (liver cell death) and the other prevents bile acid buildup. Absolutely NOTHING to do with metabolism of compounds. And there is NOTHING wrong with having enzymes "too low," which only indicates that cells aren't dying. In medicine, both NAC and UDCA are used for treatment only, not prevention. But if knowingly taking toxic compounds, prevention is ALWAYS more prudent than treating after the fact. Finally, taking both isn't overkill since they act completely differently. Please educate yourself before spreading misinformation to the board.

I can vouch for OL TUDCA btw based on labwork with that being the only change. And I can vouch for CEL as well having been affiliated in the past and having seen the QC measures that go into their products
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How much Nac is needed to make any significant difference in AST/ALT levels?
 
Olympus Labs said:
That's funny considering the owner of Omega Sports has vouched for our product in the past. It's also more funny, that a respected member like cooper has used our TUDCA multiple times and vouched for it's quality as well.

Direct from the owner of Omega:
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The owner of Omega is also owns the manufacturer you use...so of course he will vouch
 
mr.cooper69 said:
Incorrect on every count, not sure where you read this bs man. NAC doesn't improve liver metabolic rate (a function of CYP induction) and neither does TUDCA/UDCA. One reduces oxidative stress (liver cell death) and the other prevents bile acid buildup. Absolutely NOTHING to do with metabolism of compounds. And there is NOTHING wrong with having enzymes "too low," which only indicates that cells aren't dying. In medicine, both NAC and UDCA are used for treatment only, not prevention. But if knowingly taking toxic compounds, prevention is ALWAYS more prudent than treating after the fact. Finally, taking both isn't overkill since they act completely differently. Please educate yourself before spreading misinformation to the board.

I can vouch for OL TUDCA btw based on labwork with that being the only change. And I can vouch for CEL as well having been affiliated in the past and having seen the QC measures that go into their products
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If you think UDCA's effect on choleostasis is not going to improve its metabolism of ingested sunstamces (btw I am well aware of the cyp enzyme function in this process) you are sadly mistaken. Dont talk down to me, I probably have forgotten more than you will ever know.
NAC for prevention , UDCA for treatment. It works. Both together is unnecessary and yes to a degree (albeit a small one) can be counterproductive.
You can sell **** and talk **** as far as I can tell, I KNOW **** and share what I know.
 
StanleyG said:
If you think UDCA's effect on choleostasis is not going to improve its metabolism of ingested sunstamces (btw I am well aware of the cyp enzyme function in this process) you are sadly mistaken. Dont talk down to me, I probably have forgotten more than you will ever know.
NAC for prevention , UDCA for treatment. It works. Both together is unnecessary and yes to a degree (albeit a small one) can be counterproductive.
You can sell **** and talk **** as far as I can tell, I KNOW **** and share what I know.
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The arrogance in the midst of your utter ignorance is hilarious. Go ahead and save your UDCA for when you have symptomatic cholestasis, but don't jeopardize the health of the board with your doctorate in broscience
 
TUDCA is TUDCA where ever I can get it cheaper per gram I will buy.

I made this thread for help now it's just turned into a fight on which company can advertise out their product the best.
 
StanleyG said:
IMO NAC should be your on cycle support run at 1200mgs/day. UDCA (I dont use TUDCA, I use UDCA) Should be on hand should your liver enzymes become elevated and out of range in spite of your NAC prevention measures. Running both IS overkill and would likely, believe it or not, reduce the effectiveness of what you are taking. As crazy as it sounds you do not want you liver to metabolize things TOO efficiently or it can become counter productive. You want your enzymes in range, not to low either. UDCA is more of a treatment for elevated liver enzymes, NAC is a prevention.
Best of Luck.
Click to expand...

NAC will only stimulate glutathione synthesis to assist in repleting stores. This mechanism is only of benefit when hepatic glutathione are depleted and glutathione transferase mediated conjugation cannot occur efficiently.
What it seems like you are saying is that the compound you are taking the protection for will have its metabolism affected. This is not true- the rate of elimination would not be changed by increasing glutathione levels- at this stage of metabolism (phase II) the elimination rate is dictated by the affinity of the parent compound or active metabolites for conjugation enzymes (glutathione transferase, sulfur transferase, ect) or the induction of these enzymes. Glutathione only acts as a cofactor.

Although the mechanism of action of UDCA for treating cholestasis is not completely understood- any potential interactions at the hepatic level are unlikely. In vivo studies show very little affect on CYP activity- and what was identified in in vitro (induce CYP3A4) was nullified in the later in vivo research. Besides this- the OP was taking a 17 alpha-alkylated compound- which are somewhat resistant to phase I metabolism-which makes this redundant anyway.
 
Quote Originally Posted by Bicep View Post
TUDCA is TUDCA where ever I can get it cheaper per gram I will buy.

I made this thread for help now it's just turned into a fight on which company can advertise out their product the best.

Hmm, not really correct. mr.cooper69 is imo setting the record straight about Tudca and quite possibly stopping people from dosing incorrectly and harming themselves. Nothing wrong with the companies mentioned, just buy from a reputable source, (not ebay).
 
Bicep said:
Ebay does sell reputable companys
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I should of been clearer, I was referring to buying from unknown sellers as there are counterfeit supplements on Ebay.

Also, I understand that TUDCA is best stored in a fridge so I'd at least make sure you're buying stock that has a long expiry date and has been stored properly.
 
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