LucasBagoDoce
Member
- Awards
- 0
@sns8778 how’s that tribulus aquaticus project going, Steve?
From the jump, I’m someone who values uniqueness and innovation from supplement companies. There’s a whole myriad of companies that offer products that are superfluous (transdermal products where oral bioavailability is good) or unoriginal (everyone and their sister putting out an Ursolic Acid product). For the latter, it’s irritating, but I get it, if there’s an efficacious product and a venn diagram of consumers the hope is that while there are some who are aware of multiple companies shilling their own version, there is the non overlapping portion who are unaware or brand loyal. With Oleanolic acid, incinderine has a promising inclusion of it in their formula. Unfortunately, it’s kitchen a sink approach, including stimulants that may deter some people and mask the comparative efficacy of the compound. I think they were spot on for using phospholipids to increase bioavailability however. What I appreciate about SNS is that you’ll include promising compounds in formulas as well as offer it individually, allowing people more control of what they take. With Maslinic acid, Ideally, I’m thinking a transdermal may provide better bioavailability over a phospholipid carrier. Being of the same class of compounds as Ursolic Acid, Maslinic acid offers similar recompositional effects as well as skeletal muscle hypertrophy. This makes it interesting as a possible compound to stack with ursolic acid. Furthermore, the sufficient variance in structure may provide for more beneficial effects in some individuals over others (e.g. better responders). I’ve attached several publications below.I'm open to suggestions. I would be curious to hear your reasoning for those. I think I know where you're going with the idea, but curious if its what I'm thinking.
The project is in process.@sns8778 how’s that tribulus aquaticus project going, Steve?
Thank you for the links and also for the kind words.From the jump, I’m someone who values uniqueness and innovation from supplement companies. There’s a whole myriad of companies that offer products that are superfluous (transdermal products where oral bioavailability is good) or unoriginal (everyone and their sister putting out an Ursolic Acid product). For the latter, it’s irritating, but I get it, if there’s an efficacious product and a venn diagram of consumers the hope is that while there are some who are aware of multiple companies shilling their own version, there is the non overlapping portion who are unaware or brand loyal. With Oleanolic acid, incinderine has a promising inclusion of it in their formula. Unfortunately, it’s kitchen a sink approach, including stimulants that may deter some people and mask the comparative efficacy of the compound. I think they were spot on for using phospholipids to increase bioavailability however. What I appreciate about SNS is that you’ll include promising compounds in formulas as well as offer it individually, allowing people more control of what they take. With Maslinic acid, Ideally, I’m thinking a transdermal may provide better bioavailability over a phospholipid carrier. Being of the same class of compounds as Ursolic Acid, Maslinic acid offers similar recompositional effects as well as skeletal muscle hypertrophy. This makes it interesting as a possible compound to stack with ursolic acid. Furthermore, the sufficient variance in structure may provide for more beneficial effects in some individuals over others (e.g. better responders). I’ve attached several publications below.
Maslinic Acid Attenuates Denervation-Induced Loss of Skeletal Muscle Mass and Strength
Maslinic acid (MA) is a pentacyclic triterpene abundant in olive peels. MA reportedly increases skeletal muscle mass and strength in older adults; however, the underlying mechanism is unknown. This study aimed to investigate the effects of MA on denervated ...www.ncbi.nlm.nih.govMaslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases
Maslinic acid (MA) is a pentacyclic triterpene acid, which exists in many plants, including olive, and is highly safe for human beings. In recent years, it has been reported that MA has anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, neuroprotective ...www.ncbi.nlm.nih.govMaslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy
ABSTRACT. Maslinic acid, a naturally occurring pentacyclic triterpene in more than 30 plants (including olives), reportedly increases human muscle mass andacademic.oup.comMaslinic Acid Promotes Hypertrophy Induced by Functional Overload in Mouse Skeletal Muscle - PubMed
Nutritional supplements are sometimes important for athletes to improve their sports performance and maintain their condition. Maslinic acid (MA) is a type of compound with a pentacyclic triterpene structure extracted from olives, and has a strong anti-inflammatory effect and improves metabolic...pubmed.ncbi.nlm.nih.govUrsolic Acid and Maslinic Acid: Novel Candidates for Counteracting Muscle Loss and Improving Body Composition
A considerable amount of progress has been made recently in our understanding of the distinct set of genes and signaling pathways that mediate skeleta…www.sciencedirect.com
That has been a thought but when I mentioned it awhile back, it didn't seem to get much interest. But am definitely open to this one and it will also be included in a formula in next years upcoming anti-aging/longevity products.Spermidine
it gets destroyed by stomach acid. some drug companies sell it in a ph cap, but anectdotal testimonies indicate benefit anyway at least from the 4-8x concentrations. there are much more potent and hardier enzymes out there@sns8778 Have been doing some research on pancreatin. Wondering what your thoughts on it are?
Appreciate the feedback, was not finding much feedback on it.it gets destroyed by stomach acid. some drug companies sell it in a ph cap, but anectdotal testimonies indicate benefit anyway at least from the 4-8x concentrations. there are much potent and hardier enzymes out there
it's pretty mindblowing to think this could come out anyday nowThe project is in process.
I think a lot of people don't realize but with companies and contract manufacturers that follow GMP guidelines, it takes on average a minimum of 12 weeks to bring out a new product and there can be more delays depending on shipping of raws and components.
Everything is in and its in the production lineup. Label text is done and ready to go to print whenever it needs to.
Naming suggestions have been all over the place - Prime XT, Primadrol, Primaldrol, Prima-Plex, and P-Plex (which was an old CEL name).
I think that it is a good ingredient in a combination digestive enzyme formula, but probably not something I would use separately outside of one.@sns8778 Have been doing some research on pancreatin. Wondering what your thoughts on it are?
We don't have a product named Creatine XT. Are you referring to the Creatine HCI Caps and Powder?is creatine xt powder discontinued? it isnt on the homepage anymore. I was a non-responder on monohydrate, micronized monohydrate but noticed increased energy, stronger pulse, improved reaction time, randomly having less time between sets using higher doses. recently switched to creatine xt. dont imagine i will ever see increased strength from it, but i have a need for alot of non-stim energy and creatine hcl is now a staple. creatine xt has the best pricepoint ive seen
It won't be any day now, but it won't be long either. It will likely go into capsulation next week, so I suppose I have to finalize a name for it this week haha.it's pretty mindblowing to think this could come out anyday now
No problem at all. I'm always open to and appreciative of ingredient suggestions and discussion.@sns8778 I really appreciate you taking the time to honestly address my recommendation. To clarify, I’d leave the Ursa transdermal alone. When I meant stacking, I should’ve elucidated that I was more so opting for a separate transdermal formulation involving Maslinic and/or Oleanolic acid. I also understand your perspective insofar as viewing these compounds as ancillary/secondary, although I would disagree arguing that that perspective is based on a pragmatic cautionary lack of user evidence. I say this because I’m wholly aware that you’d be pushing a product without any feedback on their potential efficacy. Thus it’s safer for you to pair them with things which have some positive reviews and potentially isolate these two as independent products in the future should the forumulation exceed expectations. Granted, logistically, I have no idea how much wiggle room you have for uncharted supplements, as the ones I’ve mentioned. From my perspective, barring logistics, you have everything, but user data, in favor of beta testing a transdermal, scientific studies, and structural homology (similarity) to an already established product, as well as the potential of a temporary monopoly on these compounds should you move forward with them. As always, I appreciate you taking the time, and am always open to discuss further.
phew. yeah it didnt come up in search or the baseline dropdown, only caps but i just found it in all products. thanksWe don't have a product named Creatine XT. Are you referring to the Creatine HCI Caps and Powder?
If so, we still offer them.
Creatine HCl - 120 caps | Serious Nutrition Solutions
SNS Creatine HCl can be cost effectively used by those looking for an Ultra-Concentrated form of Creatine that doesn’t require any loading and that does NOT cause the bloating and fluid retention that is normally associated with some other forms of Creatine.seriousnutritionsolutions.com
Creatine HCl - 120 caps | Serious Nutrition Solutions
SNS Creatine HCl can be cost effectively used by those looking for an Ultra-Concentrated form of Creatine that doesn’t require any loading and that does NOT cause the bloating and fluid retention that is normally associated with some other forms of Creatine.seriousnutritionsolutions.com
No problem at all. On my end, it does come up on the Baseline Series flyout menu.phew. yeah it didnt come up in search or the baseline dropdown, only caps but i just found it in all products. thanks
Been reading and hearing some talk about protein absorption can be improved with supplementation. Pancreatin production reduced with age. Pancreatin enzymes are used by white blood cells to help combat infection/disease. Also see some talk about supplementation over 10,000 mgs can possibly reduce or eliminate cancer cells.I think that it is a good ingredient in a combination digestive enzyme formula, but probably not something I would use separately outside of one.
If you do use it, I would suggest the NOW Foods brand for it.
I'm curious though and always open to conversation, what are your thoughts on it? And what interest in it?
Was the trib aquaticus purported to increase strength/performance outside of any hormonal changes? Ie, not just being test/estrogen-mediated?It won't be any day now, but it won't be long either. It will likely go into capsulation next week, so I suppose I have to finalize a name for it this week haha.
That is correct. The natural strength and performance aspects from it are supposed to not be related to being hormonal.Was the trib aquaticus purported to increase strength/performance outside of any hormonal changes? Ie, not just being test/estrogen-mediated?
Thanks for explaining, and no worries at all - I'm always open to discussion on supplements and ingredients.Been reading and hearing some talk about protein absorption can be improved with supplementation. Pancreatin production reduced with age. Pancreatin enzymes are used by white blood cells to help combat infection/disease. Also see some talk about supplementation over 10,000 mgs can possibly reduce or eliminate cancer cells.
now like I said most of this is talk or things I’ve read, but not any real research or anything I’ve seen. I don’t have the first clue about any of it but it sounds intriguing so I was curious if there is actually anything to it or nah.
I'm sorry but I haven't completed the write up and I don't have time to go into a ton of details on it right at this moment, but it was discussed in this thread within the last few pages unless I'm getting confused with another thread. If I'm not mistaken, @thescience posted some things about it in the last couple pages.So what is the mechanism of action?
That’s kinda what I was wondering, thanks for taking the time to explain and detail it out!Thanks for explaining, and no worries at all - I'm always open to discussion on supplements and ingredients.
On the subject of cancer cells, I'm not sold on Pancreatin helping with that because there would be a lot of if's in that equation; I think that's something to keep up with future research on, but I don't think its anything solid, at least not at this time.
On the subject of protein absorption - protein absorption can be improved through supplementation, but normally doesn't need to be improved as most people don't have a hard time absorbing it.
The real benefit would come moreso from improving protein synthesis, which things like Phosphatidic Acid XT and Pepti-Plex do.
And this is where some companies try to be slick with their marketing and intentionally use tricky and deceptive wording to make it out like the benefits of increased protein synthesis would come along with increased protein absorption, because ingredients to help with protein absorption are exponentially less expensive than ones that help improve protein synthesis.
Ironically, one of the best things that you could likely use to increase protein absorption is something that you likely already take if you use our products, and that is AstraGin, as it has been shown to increase amino acid absorption.
You're very welcome. I'm glad to help in any way that I can.That’s kinda what I was wondering, thanks for taking the time to explain and detail it out!
so yeah safe to say non-hormonal. i ran it without interruption for years and had to stop cold turkey when it was no longer produced and i experienced zero negative sides. you could still buy it for a while as stock ran out from other vendors, and at one point i had like a two year supply on hand. USPlabs never stated a definitive method of action, but speculated it could be due to glucocorticoid suppression or calpain inhibition. definitly was not an anti-estrogen; ive had a few of those and always react the same way. no increase in libido or alpha feeling, just a huge raw increase in strength that came out of nowhere after three weeks; i literally added 90lbs to my bench one day at ten reps because my normal routine felt lightSo what is the mechanism of action?
i found it in the dropdown; i just assumed it would be alphabetically above or below the caps, really didnt pay enough attentionNo problem at all. On my end, it does come up on the Baseline Series flyout menu.
We are in the process of updating the website and I think we'll be doing away with some of the series assortment because we have so many products now that cross over into more than one type or category.
No worries at all. I think the dropdown goes left to right and it just happened to bounce it down one row at the moment. Next one added, it'll balance out.i found it in the dropdown; i just assumed it would be alphabetically above or below the caps, really didnt pay enough attention
I have heard a few accounts of it just being a strength/performance booster when used continuously just like that. Most were reading anonymous anecdotes online, BUT one was a Pro Middleweight (231lb class) strongman who was probably the only natty pro middleweight there was (strongman is entirely untested for PEDs in America & most of the world). This guy would save his stockpiled trib aqua for the final 4 weeks before a contest & swore by it.so yeah safe to say non-hormonal. i ran it without interruption for years and had to stop cold turkey when it was no longer produced and i experienced zero negative sides. you could still buy it for a while as stock ran out from other vendors, and at one point i had like a two year supply on hand. USPlabs never stated a definitive method of action, but speculated it could be due to glucocorticoid suppression or calpain inhibition. definitly was not an anti-estrogen; ive had a few of those and always react the same way. no increase in libido or alpha feeling, just a huge raw increase in strength that came out of nowhere after three weeks; i literally added 90lbs to my bench one day at ten reps because my normal routine felt light
oh yeah it has to be taken every day for the accumulative effect. usplabs had this chart on the box indicating at what stage people start feeling what effects, which i think is important for some people to see as they would just try popping some in for a preworkout effectI have heard a few accounts of it just being a strength/performance booster when used continuously just like that. Most were reading anonymous anecdotes online, BUT one was a Pro Middleweight (231lb class) strongman who was probably the only natty pro middleweight there was (strongman is entirely untested for PEDs in America & most of the world). This guy would save his stockpiled trib aqua for the final 4 weeks before a contest & swore by it.
He also had awesome natty genetics, as he’s one of only a few guys who have ever won the World’s Strongest Man under 105kg/231lb, so this is just something to take with a grain of salt. I’m talking doing 405lb axle split jerks and repping 700 on deads natural.
He won that title when he finally cashed in his natty card, and it was very obvious when he did, so you knew he really had been natty when he was cycling the tribulus in.
Anyway, it’s enough hype that I’m intrigued!
I think that's important for a lot of things - I think way too many people have unrealistic expectations with supplements in general and also they take things that need to be taken daily for best results and then take a dose before a workout and then complain that they don't see a benefit from it.oh yeah it has to be taken every day for the accumulative effect. usplabs had this chart on the box indicating at what stage people start feeling what effects, which i think is important for some people to see as they would just try popping some in for a preworkout effect
When we get the website updates done, I do hope to be able to offer some type of subscription program.I was just thinking of something I could probably use, subscription. Lol.
I'm gonna text you my list and send ya money tomorrow I think.Or you can just always tell me what to send you and I can take care of it
That should be a great stack.I'm gonna text you my list and send ya money tomorrow I think.
probably going to go with
December:
Alpha Gel + phosphatidic Acid XT
January
XPG Epiandro + anabolic effect + anabolic xt + phosphatidic XT.
it's gonna be a capsule marathon but a helluva a run for 6-8 weeks.
I might do that since I could throw in the Anabolic Effect while taking a break from the epi, then it's fully ramped up by january when I'm going hard.You could start if in December if you wanted to, or however works, if you wanted to do that.
I think that would be great. The results start pretty quick but really seem to kick in the best in week 3 and then get better by the week.I might do that since I could throw in the Anabolic Effect while taking a break from the epi, then it's fully ramped up by january when I'm going hard.
Transdermally: Chlorogenic acid & KaempferolNo problem at all. I'm always open to and appreciative of ingredient suggestions and discussion.
Any suggestions as to what you think would make from another or some other ingredient pairings to go along with these?
I'll be glad to check on those. I've never had anyone mention them for topical application, but glad to check and see if they would be good candidates for a topical.Transdermally: Chlorogenic acid & Kaempferol
Sounds cool. I would tryI'll be glad to check on those. I've never had anyone mention them for topical application, but glad to check and see if they would be good candidates for a topical.
Yes. There are a lot of exciting things Focus XT related coming up very soon.Hi Steve,
Have you considered Focus XT or a related nootropic in a capsule format? I added Focus XT to a long drive this summer and really liked it, powered almost all the way from Chicago back to NC. Thinking about end of the year travel and would be very convenient to throw caps in the backpack, or have them whenever needed in my desk, etc. There’s a ton of capsule nootropics out there but hard to find one I trust!
Wow, that’s awesome. Is it a rearranged formula to fit caps? Or I’ll just wait and find out when it’s launched?Yes. There are a lot of exciting things Focus XT related coming up very soon.
I'll go ahead and say that a capsule version is finalized and the label is actually being worked on now.
Priority #1 is getting the flavored version back in stock, but the capsule version shouldn't be too far behind.
There would be some alternations to the formula so that it would be suitable for a capsule.Wow, that’s awesome. Is it a rearranged formula to fit caps? Or I’ll just wait and find out when it’s launched?