Good preliminary news for those who consume a bit of Aspartame and Sucralose through powdered supplements. I believe there has historically been concern over artificial sweeteners, such as Aspartame and Sucralose, and their effect on gut health and insulin sensitivity due to previous animal studies. The below study was done on humans.
“In a preliminary study intended to evaluate the impact that these two common NNSs would have on the trillions of gut bacteria present in the digestive tract, 17 healthy participants between the ages of 18 and 45 years old who had a BMI of 20-25 underwent two 14-day periods in which they took a daily dose of aspartame, and then sucralose, and had their fecal samples collected for analysis of changes to their microbiome and short-chain fatty acid production. The researchers used an aspartame dose that was 14% of Health Canada’s Acceptable Daily Intake (ADI), since the aspartame ADI would equate to the content found in 20 servings of Diet Coke, and approximately 20% of the ADI for sucralose, as the ADI for it represents 14 servings of diet iced tea. The dosages used in the study were reflective of about three cans of diet soda per day, making the dosage level high but reasonable and realistic. Additionally, the participants were prohibited from drinking more than two cups of caffeinated drinks, and no more than 10 mL of alcohol, and any probiotic supplements or foods containing probiotics were off limits.”
“Fecal sampling indicated that there were no changes to the six short-chain fatty acids evaluated in any of the study participants, the authors wrote, and, additionally, there were no measurable impacts on gut microbiota.”
“Additionally, neither of the NNSs used in the study had any measurable effect on glucose metabolism or insulin sensitivity, the authors said.”
Quote from above found here: https://www.nutraceuticalsworld.com/contents/view_breaking-news/2020-11-11/common-sugar-substitutes-have-no-impact-on-gut-microbiome-study-reports/
Full text study found here: https://www.mdpi.com/2072-6643/12/11/3408/htm
“In a preliminary study intended to evaluate the impact that these two common NNSs would have on the trillions of gut bacteria present in the digestive tract, 17 healthy participants between the ages of 18 and 45 years old who had a BMI of 20-25 underwent two 14-day periods in which they took a daily dose of aspartame, and then sucralose, and had their fecal samples collected for analysis of changes to their microbiome and short-chain fatty acid production. The researchers used an aspartame dose that was 14% of Health Canada’s Acceptable Daily Intake (ADI), since the aspartame ADI would equate to the content found in 20 servings of Diet Coke, and approximately 20% of the ADI for sucralose, as the ADI for it represents 14 servings of diet iced tea. The dosages used in the study were reflective of about three cans of diet soda per day, making the dosage level high but reasonable and realistic. Additionally, the participants were prohibited from drinking more than two cups of caffeinated drinks, and no more than 10 mL of alcohol, and any probiotic supplements or foods containing probiotics were off limits.”
“Fecal sampling indicated that there were no changes to the six short-chain fatty acids evaluated in any of the study participants, the authors wrote, and, additionally, there were no measurable impacts on gut microbiota.”
“Additionally, neither of the NNSs used in the study had any measurable effect on glucose metabolism or insulin sensitivity, the authors said.”
Quote from above found here: https://www.nutraceuticalsworld.com/contents/view_breaking-news/2020-11-11/common-sugar-substitutes-have-no-impact-on-gut-microbiome-study-reports/
Full text study found here: https://www.mdpi.com/2072-6643/12/11/3408/htm