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Seth Roberts' Book ANABOLIC PHARMACOLOGY

Props to Seth on the book.. I'm really enjoying the content thus far... the science behind the reasoning is awesome but I do have a question. Following your thought process, increasing SHBG during a cycle is an effective way of combating side effects related to them? And if you agree what sort of compounds do that?
 
dexter87 said:
Props to Seth on the book.. I'm really enjoying the content thus far... the science behind the reasoning is awesome but I do have a question. Following your thought process, increasing SHBG during a cycle is an effective way of combating side effects related to them? And if you agree what sort of compounds do that?
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Increasing may not necesarily be the right word but rather stemming the decrease in SHBG. Androgens decrease SHBG while estrogen increases it (these are only two factors of course). Driving estrogen levels too low will decrease SHBG. Tamoxifen is known to increase SHBG.
 
Checked it ou
t at tha a classic book looks really good nice work

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In order for a muscle to contract, all of the fibers in that muscle must contract.
This is known as the all or none principle of muscle contraction.
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I thought that the all-or-none principle was that a muscle fiber was either fully contracting or not contracting... not that "all of the fibers in that muscle must contract."
 
chim_chim said:
I thought that the all-or-none principle was that a muscle fiber was either fully contracting or not contracting... not that "all of the fibers in that muscle must contract."
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To be completely technical, the all-or-none principal states that there is no gradation in response (of a nerve or muscle fiber) but rather any stimulus above a threshold produces a full response. Most muscles (in humans anyway) consist of fibers that run the full length of the muscle and are serviced by a single motor end plate. Entire muscles and groups of muscles can produce a graded response due to a concept called recruitment. The statement in the book is a simplification of the concept so as not to confuse the reader because the discussion of this aspect of the book could fill a book in its own right.
 
I think the all-or-none principle was slightly confusing the way you stated it. Anyways as I go through the book, I have been writing down everything that jumps out at my like typos, missing words, etc. Enjoying my read-through tho :thumbsup:
 
Steveoph said:
I think the all-or-none principle was slightly confusing the way you stated it. Anyways as I go through the book, I have been writing down everything that jumps out at my like typos, missing words, etc. Enjoying my read-through tho :thumbsup:
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That is the consequence sometimes of trying to simplify a complex theory into a sentence or two. There are many areas that I would like to expand and I would like to include some more advanced concepts.

Hopefully there weren't a lot of typos -- I noticed one in the fluoxymesterone profile. I appreciate any heads up anyone wants to give on typos.
 
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