Serotonin Syndrome?

bell1986

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
 
Bintherduntht

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
Hmm good question. I'm on SSRIs as well. I always thought that serotonin syndrome is uncommon and that it would only happen if you were on SSRIs and took something dumb like ecstasy that works alot on serotonin or other drugs that work on serotonin with SSRIs. I think lithium is pretty "hard" on your system. But I do not know the answer and would love to hear what other people think. I have always wondered what it would take to get serotonin syndrome, what it feels like, the outcome etc.
 
bell1986

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Hmm good question. I'm on SSRIs as well. I always thought that serotonin syndrome is uncommon and that it would only happen if you were on SSRIs and took something dumb like ecstasy that works alot on serotonin or other drugs that work on serotonin with SSRIs. I think lithium is pretty "hard" on your system. But I do not know the answer and would love to hear what other people think. I have always wondered what it would take to get serotonin syndrome, what it feels like, the outcome etc.
Their is a video of a girl online that has serotonin syndrome and it don't look fun! Can really mess you up and can also be fatal. Their is a channel on youtube called nootropics expert and he says in his 5-htp video NOT to mix an ssri with 5-htp. His friend did and died Scary how easy these ingredients are too pick up as well.

It does say in the leaflet not to mix with Lithium. So my own fault for not reading it proper. I have binned the lithium tablets. Thankfully nothing has happened
 

jarrellt67

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Their is a video of a girl online that has serotonin syndrome and it don't look fun! Can really mess you up and can also be fatal. Their is a channel on youtube called nootropics expert and he says in his 5-htp video NOT to mix an ssri with 5-htp. His friend did and died Scary how easy these ingredients are too pick up as well.

It does say in the leaflet not to mix with Lithium. So my own fault for not reading it proper. I have binned the lithium tablets. Thankfully nothing has happened
I'm surprised it says that about lithium as there are many studies where it's used effectively as an adjunct (at high pharmaceutical doses, not the small doses used with lithium orotate) to SSRIs.
 
3clipseGT

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If you had serotonin syndrome you would for sure know it I think. If after two weeks you havnt had any bad interactions id say you are fine. Not saying you should keep taking it, if it says not to id stay away from it.

I had taken an SSRI and had the worst experience possible. I was up for about 3 days, extremely agitated and antsy, hot and cold sweats etc. I looked up serotonin syndrome and had quite a lot of the sides associated with it.
 
bell1986

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If you had serotonin syndrome you would for sure know it I think. If after two weeks you havnt had any bad interactions id say you are fine. Not saying you should keep taking it, if it says not to id stay away from it.

I had taken an SSRI and had the worst experience possible. I was up for about 3 days, extremely agitated and antsy, hot and cold sweats etc. I looked up serotonin syndrome and had quite a lot of the sides associated with it.
See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
 
3clipseGT

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See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
I think that just sounds like an SSRI and not so much an interaction. Some people of course respond differently than others.

My issue happened the minute I took the SSRI, it started immediately.
 
Bintherduntht

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What does it feel like? What are the symptoms? Obviously this is a very hard question to figure out
 

kisaj

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Not sure how common it is, but I don't think very. I know a couple of guys that take SSRIs and were taking SAM-e and 5HTP for years not knowing that it can have an interaction. Not recommended, but I don't think the chance of it happening are high.
 
DR.D

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See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
You sound like you're flirting with SS, but you haven't crossed the line quite yet. I'm sorry if you already mentioned it and I didn't see, but what SSRI are you taking? Some are more prone to cause SS that others, but it's not common. Lithium is very serotonergic though, so I'd guess cutting that was probably a good idea that should eliminate your symptoms.

But yes, just as 3clipseGT mentioned, you'd probably know if you had it, because it's characterized by unstable vitals, hot/cold, tired/shaky, etc.. And consciousness is disturbed as well, so any abnormal mentality would give it away.
 
HIT4ME

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Dr.D pretty much jas my thoughts. You could possibly be flirting with SS, but if it was full blown it would be serious. However, it doesn't usually just come on unless you do something pretty dramatic from what I have read - it is typically from the build up of seratonin over time. This is part of the reason it may be missed - someone shows up in am ER and their drugs haven't been changed in years, so it doesn't raise a red flag.

Also, I could be wrong, but I believe you would be more likely to get hit with SS if you were older, sick, etc. Our body, when young and healthy, can adjust to a bunch that isn't ideal.

Beyond that, um, it is summer and waking up sweating is maybe just normal? Maybe it is a bout of indigestion?

I would still play it safe and take a break.
 
DR.D

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Dr.D pretty much jas my thoughts. You could possibly be flirting with SS, but if it was full blown it would be serious. However, it doesn't usually just come on unless you do something pretty dramatic from what I have read - it is typically from the build up of seratonin over time. This is part of the reason it may be missed - someone shows up in am ER and their drugs haven't been changed in years, so it doesn't raise a red flag.

Also, I could be wrong, but I believe you would be more likely to get hit with SS if you were older, sick, etc. Our body, when young and healthy, can adjust to a bunch that isn't ideal.

Beyond that, um, it is summer and waking up sweating is maybe just normal? Maybe it is a bout of indigestion?

I would still play it safe and take a break.
Yes, you make some good points, HIT4ME. I have used almost all the available SSRIs before but never felt threatened with SS. Luvox was probably the best and cleanest, but some of them like Celexa seemed to promote Agranulocytosis almost as bad and as rapidly as M1T!

I've honestly never experienced SS or known anyone using SSRIs who has, but I have heard of it happening from time to time and mostly associate it with excessive use of serotonergic stims like X or other designer club drugs.

As far as waking up sweating, that personally reminds me of high carb intake right before bed.
 
bell1986

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It is Fluoxetine i curently use (Prozac) been on ot for about 10 month so well past the settling in stage.

I have stopped the Lithium. I really was getting some scary side effects. The other night laying in bed my heart rate was sitting at 122bpm and i was warm but shaking. Was in the house myself to lol i have ditched that stuff and i just take the Fluoxetine. No point taking both as they both work similarly anyway.

Just gotta be careful with some OTC ingredients. I think some pre workouts that hit serotonin receptors could also cause grief for people on SSRI's. That's a guess though but just seems viable
 
Ape McGrapes

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I've been on Lexapro(SSRI) for four years now, and it was the best decision for my mental health, that I ever made.

I've mixed Lexapro with a good deal of drugs. Marijuana, LSD, Cocaine, etc. I personally believe it is hard to get serotonin syndrome, but ecstacy/molly and DXM are two drugs that are more than likely to cause it. Dont chance it with those two. As far as LSD, which does work on Serotonin, I never noticed any negative effects, its def still works for me. At most; the potency might be slightly diminished, but I can't say I've really noticed it.
 
bell1986

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I've been on Lexapro(SSRI) for four years now, and it was the best decision for my mental health, that I ever made.

I've mixed Lexapro with a good deal of drugs. Marijuana, LSD, Cocaine, etc. I personally believe it is hard to get serotonin syndrome, but ecstacy/molly and DXM are two drugs that are more than likely to cause it. Dont chance it with those two. As far as LSD, which does work on Serotonin, I never noticed any negative effects, its def still works for me. At most; the potency might be slightly diminished, but I can't say I've really noticed it.
Ah ok I just didn't have a good reaction with this Pre Workout. I have looked over the ingredients and none really should interfere with serotonin? I think Fluoxetine is one of the milder SSRI's as well?

You notice a difference with the lexapro? I was anxious about going on an SSRI but after that initial settling in period (First 4-6 weeks) i have noticed an improvement with my anxiety etc so any help is a bonus . You will know yourself how debilitating it can make you become when it does strike. That's good you have found one that suits you though. I hear if people having to trial loads of different types to find the one that suits them.
 
Bintherduntht

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When I was on prozac things were pretty cool. But after awhile I dunno I started feeling way to "up."

Then they put me on Zoloft for PTSD, depression, and anxiety. I've been on that 5 years now. It works great for what its made for, but fuk it has THE WORST sexual side effects. If I wasnt on test, i would probably have ED and wouldn't be able to ejaculate. Right after I take it, sex is out of the question. But if its been a couple hours then Im good to go. But damn it really kills the boner. But it really helps the depression ptsd and anxiety
 
DR.D

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When I was on prozac things were pretty cool. But after awhile I dunno I started feeling way to "up."

Then they put me on Zoloft for PTSD, depression, and anxiety. I've been on that 5 years now. It works great for what its made for, but fuk it has THE WORST sexual side effects. If I wasnt on test, i would probably have ED and wouldn't be able to ejaculate. Right after I take it, sex is out of the question. But if its been a couple hours then Im good to go. But damn it really kills the boner. But it really helps the depression ptsd and anxiety
Yohimbine fixed my Zoloft problems (50-200mg/d), but it might aggravate the PTSD though.
 
HIT4ME

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Yohimbine fixed my Zoloft problems (50-200mg/d), but it might aggravate the PTSD though.
This actually made me think.
.we often use agmatine in this hobby of ours. Agmatine may have some effects here, mainly making things more potent.
 
rtmilburn

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
True serotonin syndrome is incredibly uncommon. It can happen for sure but it RARE
 

jarrellt67

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This actually made me think.
.we often use agmatine in this hobby of ours. Agmatine may have some effects here, mainly making things more potent.
Agmatine did seem to potentiate the effects of Zoloft when I was taking it. It also seemed to help some with the loss in libido.
 

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