Serotonin Syndrome?

bell1986

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
 
Bintherduntht

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
Hmm good question. I'm on SSRIs as well. I always thought that serotonin syndrome is uncommon and that it would only happen if you were on SSRIs and took something dumb like ecstasy that works alot on serotonin or other drugs that work on serotonin with SSRIs. I think lithium is pretty "hard" on your system. But I do not know the answer and would love to hear what other people think. I have always wondered what it would take to get serotonin syndrome, what it feels like, the outcome etc.
 
bell1986

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Hmm good question. I'm on SSRIs as well. I always thought that serotonin syndrome is uncommon and that it would only happen if you were on SSRIs and took something dumb like ecstasy that works alot on serotonin or other drugs that work on serotonin with SSRIs. I think lithium is pretty "hard" on your system. But I do not know the answer and would love to hear what other people think. I have always wondered what it would take to get serotonin syndrome, what it feels like, the outcome etc.
Their is a video of a girl online that has serotonin syndrome and it don't look fun! Can really mess you up and can also be fatal. Their is a channel on youtube called nootropics expert and he says in his 5-htp video NOT to mix an ssri with 5-htp. His friend did and died Scary how easy these ingredients are too pick up as well.

It does say in the leaflet not to mix with Lithium. So my own fault for not reading it proper. I have binned the lithium tablets. Thankfully nothing has happened
 

jarrellt67

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Their is a video of a girl online that has serotonin syndrome and it don't look fun! Can really mess you up and can also be fatal. Their is a channel on youtube called nootropics expert and he says in his 5-htp video NOT to mix an ssri with 5-htp. His friend did and died Scary how easy these ingredients are too pick up as well.

It does say in the leaflet not to mix with Lithium. So my own fault for not reading it proper. I have binned the lithium tablets. Thankfully nothing has happened
I'm surprised it says that about lithium as there are many studies where it's used effectively as an adjunct (at high pharmaceutical doses, not the small doses used with lithium orotate) to SSRIs.
 
3clipseGT

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If you had serotonin syndrome you would for sure know it I think. If after two weeks you havnt had any bad interactions id say you are fine. Not saying you should keep taking it, if it says not to id stay away from it.

I had taken an SSRI and had the worst experience possible. I was up for about 3 days, extremely agitated and antsy, hot and cold sweats etc. I looked up serotonin syndrome and had quite a lot of the sides associated with it.
 
bell1986

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If you had serotonin syndrome you would for sure know it I think. If after two weeks you havnt had any bad interactions id say you are fine. Not saying you should keep taking it, if it says not to id stay away from it.

I had taken an SSRI and had the worst experience possible. I was up for about 3 days, extremely agitated and antsy, hot and cold sweats etc. I looked up serotonin syndrome and had quite a lot of the sides associated with it.
See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
 
3clipseGT

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See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
I think that just sounds like an SSRI and not so much an interaction. Some people of course respond differently than others.

My issue happened the minute I took the SSRI, it started immediately.
 
Bintherduntht

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What does it feel like? What are the symptoms? Obviously this is a very hard question to figure out
 

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Not sure how common it is, but I don't think very. I know a couple of guys that take SSRIs and were taking SAM-e and 5HTP for years not knowing that it can have an interaction. Not recommended, but I don't think the chance of it happening are high.
 
DR.D

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See i have been waking up during the night and soaked in sweat? Very disturbed dreams. I have stopped the lithium. I was laying down the other day and i felt spaced out. No sure if this was mild serotonin syndrome?
You sound like you're flirting with SS, but you haven't crossed the line quite yet. I'm sorry if you already mentioned it and I didn't see, but what SSRI are you taking? Some are more prone to cause SS that others, but it's not common. Lithium is very serotonergic though, so I'd guess cutting that was probably a good idea that should eliminate your symptoms.

But yes, just as 3clipseGT mentioned, you'd probably know if you had it, because it's characterized by unstable vitals, hot/cold, tired/shaky, etc.. And consciousness is disturbed as well, so any abnormal mentality would give it away.
 
HIT4ME

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Dr.D pretty much jas my thoughts. You could possibly be flirting with SS, but if it was full blown it would be serious. However, it doesn't usually just come on unless you do something pretty dramatic from what I have read - it is typically from the build up of seratonin over time. This is part of the reason it may be missed - someone shows up in am ER and their drugs haven't been changed in years, so it doesn't raise a red flag.

Also, I could be wrong, but I believe you would be more likely to get hit with SS if you were older, sick, etc. Our body, when young and healthy, can adjust to a bunch that isn't ideal.

Beyond that, um, it is summer and waking up sweating is maybe just normal? Maybe it is a bout of indigestion?

I would still play it safe and take a break.
 
DR.D

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Dr.D pretty much jas my thoughts. You could possibly be flirting with SS, but if it was full blown it would be serious. However, it doesn't usually just come on unless you do something pretty dramatic from what I have read - it is typically from the build up of seratonin over time. This is part of the reason it may be missed - someone shows up in am ER and their drugs haven't been changed in years, so it doesn't raise a red flag.

Also, I could be wrong, but I believe you would be more likely to get hit with SS if you were older, sick, etc. Our body, when young and healthy, can adjust to a bunch that isn't ideal.

Beyond that, um, it is summer and waking up sweating is maybe just normal? Maybe it is a bout of indigestion?

I would still play it safe and take a break.
Yes, you make some good points, HIT4ME. I have used almost all the available SSRIs before but never felt threatened with SS. Luvox was probably the best and cleanest, but some of them like Celexa seemed to promote Agranulocytosis almost as bad and as rapidly as M1T!

I've honestly never experienced SS or known anyone using SSRIs who has, but I have heard of it happening from time to time and mostly associate it with excessive use of serotonergic stims like X or other designer club drugs.

As far as waking up sweating, that personally reminds me of high carb intake right before bed.
 
bell1986

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It is Fluoxetine i curently use (Prozac) been on ot for about 10 month so well past the settling in stage.

I have stopped the Lithium. I really was getting some scary side effects. The other night laying in bed my heart rate was sitting at 122bpm and i was warm but shaking. Was in the house myself to lol i have ditched that stuff and i just take the Fluoxetine. No point taking both as they both work similarly anyway.

Just gotta be careful with some OTC ingredients. I think some pre workouts that hit serotonin receptors could also cause grief for people on SSRI's. That's a guess though but just seems viable
 
Ape McGrapes

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I've been on Lexapro(SSRI) for four years now, and it was the best decision for my mental health, that I ever made.

I've mixed Lexapro with a good deal of drugs. Marijuana, LSD, Cocaine, etc. I personally believe it is hard to get serotonin syndrome, but ecstacy/molly and DXM are two drugs that are more than likely to cause it. Dont chance it with those two. As far as LSD, which does work on Serotonin, I never noticed any negative effects, its def still works for me. At most; the potency might be slightly diminished, but I can't say I've really noticed it.
 
bell1986

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I've been on Lexapro(SSRI) for four years now, and it was the best decision for my mental health, that I ever made.

I've mixed Lexapro with a good deal of drugs. Marijuana, LSD, Cocaine, etc. I personally believe it is hard to get serotonin syndrome, but ecstacy/molly and DXM are two drugs that are more than likely to cause it. Dont chance it with those two. As far as LSD, which does work on Serotonin, I never noticed any negative effects, its def still works for me. At most; the potency might be slightly diminished, but I can't say I've really noticed it.
Ah ok I just didn't have a good reaction with this Pre Workout. I have looked over the ingredients and none really should interfere with serotonin? I think Fluoxetine is one of the milder SSRI's as well?

You notice a difference with the lexapro? I was anxious about going on an SSRI but after that initial settling in period (First 4-6 weeks) i have noticed an improvement with my anxiety etc so any help is a bonus . You will know yourself how debilitating it can make you become when it does strike. That's good you have found one that suits you though. I hear if people having to trial loads of different types to find the one that suits them.
 
Bintherduntht

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When I was on prozac things were pretty cool. But after awhile I dunno I started feeling way to "up."

Then they put me on Zoloft for PTSD, depression, and anxiety. I've been on that 5 years now. It works great for what its made for, but fuk it has THE WORST sexual side effects. If I wasnt on test, i would probably have ED and wouldn't be able to ejaculate. Right after I take it, sex is out of the question. But if its been a couple hours then Im good to go. But damn it really kills the boner. But it really helps the depression ptsd and anxiety
 
DR.D

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When I was on prozac things were pretty cool. But after awhile I dunno I started feeling way to "up."

Then they put me on Zoloft for PTSD, depression, and anxiety. I've been on that 5 years now. It works great for what its made for, but fuk it has THE WORST sexual side effects. If I wasnt on test, i would probably have ED and wouldn't be able to ejaculate. Right after I take it, sex is out of the question. But if its been a couple hours then Im good to go. But damn it really kills the boner. But it really helps the depression ptsd and anxiety
Yohimbine fixed my Zoloft problems (50-200mg/d), but it might aggravate the PTSD though.
 
HIT4ME

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Yohimbine fixed my Zoloft problems (50-200mg/d), but it might aggravate the PTSD though.
This actually made me think.
.we often use agmatine in this hobby of ours. Agmatine may have some effects here, mainly making things more potent.
 
rtmilburn

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Hi guys. Wasn't sure where to post this so thought i would add it to this section.

Was looking through a few of the supplements i have played around with and i came across this interaction.....

I take an SSRI. I always knew to stay away from 5-htp/tyroptophan but i wasn't aware that.. St John's wort was also a major interaction? I have St John's wort at home but very rarely have tried it.

But the biggest concern for me was... Lithium (Lithium Orotate) this has been shown to have a major interaction with an SSRI and can cause serotonin syndrome. I have been taking both daily for the last 2 weeks :/ I suppose i should have checked before hand but even looking through both the Lithium Packaging and the SSRI box it doesn't state what you should avoid when you are taking an SSRI.

Is serotonin syndrome un-common? Would you show signs before anything major became apparent?

Thanks
True serotonin syndrome is incredibly uncommon. It can happen for sure but it RARE
 

jarrellt67

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This actually made me think.
.we often use agmatine in this hobby of ours. Agmatine may have some effects here, mainly making things more potent.
Agmatine did seem to potentiate the effects of Zoloft when I was taking it. It also seemed to help some with the loss in libido.
 
Bintherduntht

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Agmatine did seem to potentiate the effects of Zoloft when I was taking it. It also seemed to help some with the loss in libido.
Is that due to the N.O. effects? If so, can I use citruline malate? Or it needs to be agmatine? Zoloft is great for me, its just those sexual sides. Its depressing actually when you take it and have problems!
 

jarrellt67

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Is that due to the N.O. effects? If so, can I use citruline malate? Or it needs to be agmatine? Zoloft is great for me, its just those sexual sides. Its depressing actually when you take it and have problems!
I think it might be due to the NO effects because citrulline also seemed to help with the sexual side effects (but it didn't seem to potentiate the anti-anxiety effects of zoloft).
 
HIT4ME

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Is that due to the N.O. effects? If so, can I use citruline malate? Or it needs to be agmatine? Zoloft is great for me, its just those sexual sides. Its depressing actually when you take it and have problems!
I believe it has more to do with agmatine's effects on NMDA and alpha-2 receptors.
 
HIT4ME

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I think it might be due to the NO effects because citrulline also seemed to help with the sexual side effects (but it didn't seem to potentiate the anti-anxiety effects of zoloft).
NO effects relax endothelial tissue and will have this effect due to increased blood flow. It isn't all that far off from Viagra's mode of action (inhibiting pde). This is what makes it a good pump supp.
 
Bintherduntht

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I believe it has more to do with agmatine's effects on NMDA and alpha-2 receptors.
Speaking of NMDA... I told my psychiatrist about the sexual sides. So she put me on wellbutrin and said that should help. Wellbutrin acts on NMDA correct? I think it increases norepinephrine. I don't understand how too much serotonin would prevent your junk to work. I read it has to do with being TOO calm. Like when your having sex you have that edgy/stimulated feeling. But after I take zoloft I just lose focus, calm down, kind of zone out lol. I cannot keep my mind on sex or anything a few hours after I take it. I think "ah who cares." It's like being fukkin chemically castrated! LikeI said though it works wonders for the ptsd, anxiety and depression. But not being able to "score a goal" makes me that much more depressed! I've read that is why a lot of people switch from zoloft to something else. If I wasn't on test... I stopped cruising for about a year and it was horrible! I thought about sex like 1-5% of the time when normally its more like 70%. Just wanted to sleep all day.
 
HIT4ME

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Speaking of NMDA... I told my psychiatrist about the sexual sides. So she put me on wellbutrin and said that should help. Wellbutrin acts on NMDA correct? I think it increases norepinephrine. I don't understand how too much serotonin would prevent your junk to work. I read it has to do with being TOO calm. Like when your having sex you have that edgy/stimulated feeling. But after I take zoloft I just lose focus, calm down, kind of zone out lol. I cannot keep my mind on sex or anything a few hours after I take it. I think "ah who cares." It's like being fukkin chemically castrated! LikeI said though it works wonders for the ptsd, anxiety and depression. But not being able to "score a goal" makes me that much more depressed! I've read that is why a lot of people switch from zoloft to something else. If I wasn't on test... I stopped cruising for about a year and it was horrible! I thought about sex like 1-5% of the time when normally its more like 70%. Just wanted to sleep all day.
I have a BIG lack of knowledge here. I honestly know just enough about SSRIs to believe that the theories are far from accurate and it seems to me like either these theories have huge holes or my knowledge of these theories has large holes.

In a discussion with a doctor friend of mine he said his experience has been that maybe 50% of the time the drugs work as the theories suggest and other times they are off...so we probably do have plenty to learn.

Having said that, a quick google search indicates that Wellbutrin is a reuptake inhibitor for dopamine, nor adrenaline and seratonin. I know there is a class of drugs known as a SNRI - Seritonin/Norepinephrine Reuptake Inhibitors and I would guess this is Wellbutrin's classification.

I could be wrong about a lot of that though.....
 
rtmilburn

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I have a BIG lack of knowledge here. I honestly know just enough about SSRIs to believe that the theories are far from accurate and it seems to me like either these theories have huge holes or my knowledge of these theories has large holes.

In a discussion with a doctor friend of mine he said his experience has been that maybe 50% of the time the drugs work as the theories suggest and other times they are off...so we probably do have plenty to learn.

Having said that, a quick google search indicates that Wellbutrin is a reuptake inhibitor for dopamine, nor adrenaline and seratonin. I know there is a class of drugs known as a SNRI - Seritonin/Norepinephrine Reuptake Inhibitors and I would guess this is Wellbutrin's classification.

I could be wrong about a lot of that though.....
Best description I've seen of welbutrin I saw on reddit it so here it is

Simple terms.
Your brain uses two reuptake transporters to control dopamine and norepinephrine.

In the frontal lobe, dopamine is controlled by NET thus by blocking NET you get more dopamine and more norepinephrine in the frontal lobe.

In the basal ganglia, the part of the brain that integrates various thoughts from other parts of the brain, such as your logical cognition, as well as the goal part of the brain, the emotions you are expering, and your current senses, the basal ganglia makes your legion of thoughts into one purpose, one concept, goal, and action. In this part of the brain dopamine is controlled by DAT. Thus when you increase the dopamine in this area you get emotional benefits or emotional side effects depending if this area was in balance before or out of balance.



Strattera is a strong blocker of NET thus more dopamine in the frontal lobe, but not the emotional brain, but more norepinephrine everywhere.

Wellbutrin is a weaker inhibitor of NET but it also inhibits DAT and this can cause emotional side effects or benefits such as treating depression. Wellbutrin also has some antiinflammatory properties and it temporary modifies a subtype of acetylcholine receptors, another major neurotransmitter

The ADHD stimulants also block NET and DAT but at higher levels. Usually this means they are better ADHD meds but all this extra stuff wellbutrin does (not involving NET and DAT) may make it a better fit for some people and some type of issues like depression.

Now I been saying the abbreviations NET and DAT without explaining the names on purpose. The reason why is the names confuse people for they assume a connection that is not there.
Both NET and DAT do reuptake of multiple neurotransmitters such as Dopamine, Norepinephrine, Adreanline, etc.
But DAT is called the Dopamine transporter for the brain uses DAT to move dopamine around in the emotional brain and the striatum, and some hormone areas. Humans are special for we have a well developed prefrontal cortex and it is kinda an accident that we are using dopamine for new purposes such as thinking and executive function for most animals do not plan their actions out in the future in a deliberate manner where they create theories in their mind space, reject bad ones without moving, and then much later perform the action
NET is the norepinephrine transporter and it is the transporter used most of the time for norepinephrine. In the frontal lobe we use NET to move dopamine around and place it within the nerve cell after use. Given similar levels of dopamine and norepinephrine the NET reuptake protein will actually grab dopamine first over norepinephrine for dopamine has a higher affinity for NET over norepinephrine.
Finding the best drug for you, your adhd, and your other conditoons is trial and error. Just like a mechanic does not have a single screwdriver but 6 different types plus multiple sizes we have multiple meds for adhd. All those screwdrivers may do similar things but sometimes you need a flathead, a phillips, but we also have things like a fearson screwdriver, torqx screwdriver, hexagon, etc.
 
Ricky10

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Best description I've seen of welbutrin I saw on reddit it so here it is
I have had some great experiences on Wellbutrin in the past, and I have been thinking about switching off my Prozac to try it out again for quite some time now.

In the meantime, have you come across any natural supplements that inhibit NET and/or DAT in your research?
 

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I have had some great experiences on Wellbutrin in the past, and I have been thinking about switching off my Prozac to try it out again for quite some time now.

In the meantime, have you come across any natural supplements that inhibit NET and/or DAT in your research?
Man, I tried switching back to Wellbutrin again recently but ran into the same problems - too much anxiety and a rash developing (within 24-48 hours) all across my chest and arms. Sucks because it's great for improving mood and giving you motivation to actually get something done.
 
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Bintherduntht

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Best description I've seen of welbutrin I saw on reddit it so here it is
So wellbutrin will either make you better, or worse depending on how you brain was before you started it?

I felt it mostly in the first week. After I would take it, felt like I had a cup of coffee. Now, not so mich
 
Ricky10

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Man, I tried switching back to Wellbutrin again recently but ran into the same problems - too much anxiety and a rash developing (within 24-48 hours) all across my chest and arms. Sucks because it's great for improving mood and giving you motivation to actually get something done.
I agree that it is great for motivation and positive mood...particularly in the beginning stages! I could certainly use the extra pep in my step instead of relying so much on stims etc. It also made me rather temperamental/irritable and more outspoken at those moments. That was kind of nice though because there are certainly times I need to be more assertive anyway.

Too bad it didn’t work out for you :confused:
Not really sure it will for me again either
 
HIT4ME

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This is where I would suspect agmatine may help - it has the ability to avoid tolerance/escalation of some drugs. Not sure if it would do that with wellbutrin, but it may.
 
Ricky10

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So wellbutrin will either make you better, or worse depending on how you brain was before you started it?

I felt it mostly in the first week. After I would take it, felt like I had a cup of coffee. Now, not so mich
It certainly can intensify your emotions and it’s a much better drug for depression than it is for anxiety.

The first week was the honeymoon stage for me, and I experienced a few days of profound euphoria. Unfortunately, that tapered away into something much less notable. Mood boost was certainly still there though.
 

jarrellt67

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This is where I would suspect agmatine may help - it has the ability to avoid tolerance/escalation of some drugs. Not sure if it would do that with wellbutrin, but it may.

Supposedly a 10-fold increase but I never noticed it making a difference (with antidepressant effects or tolerance) when I tried the two together (wellbutrin felt the same with or without the agmatine).
 

jarrellt67

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It certainly can intensify your emotions and it’s a much better drug for depression than it is for anxiety.

The first week was the honeymoon stage for me, and I experienced a few days of profound euphoria. Unfortunately, that tapered away into something much less notable. Mood boost was certainly still there though.
Yeah, that honeymoon period was great. It's the reason I end up trying it again and again (even with my obvious allergic reaction)...never did capture that initial feeling again though. Still a great medication though. I get a similar (albeit less) feeling from low dose modafinil.
 
HIT4ME

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Supposedly a 10-fold increase but I never noticed it making a difference (with antidepressant effects or tolerance) when I tried the two together (wellbutrin felt the same with or without the agmatine).
Yeah, I wouldn't expect it to be an acute or noticable effect. What I would expect is that if a certain dose worked for you and you took agmatine, that dose would continue to work for longer than if you did not take the agmatine.

So if x amount if Wellbutrin works great for 2 months andthen you need z amount after to get the same effect, then agmatine and x dose from the beginning would probably prevent the escalation to z dose.
 

jarrellt67

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Yeah, I wouldn't expect it to be an acute or noticable effect. What I would expect is that if a certain dose worked for you and you took agmatine, that dose would continue to work for longer than if you did not take the agmatine.

So if x amount if Wellbutrin works great for 2 months andthen you need z amount after to get the same effect, then agmatine and x dose from the beginning would probably prevent the escalation to z dose.
Yeah, I think I somewhat misunderstood your comment. I don't think I tried both together long enough to tell if it had the result you describe...I was more focused on whether it increased the antidepressant effects.
 
HIT4ME

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Yeah, I think I somewhat misunderstood your comment. I don't think I tried both together long enough to tell if it had the result you describe...I was more focused on whether it increased the antidepressant effects.
Yeah, understandable though. I think agmatine does have some mild anxiety relieving effects...but I would expect that it would be unnoticeable alongside something that a pharma company is using.

I wonder if anyone has noticed any effects of TUDCA on their wellbutrin use? I have a few things that I think may play a role...TUDCA has ER repair capabilities and I wonder if this may kind of "repair" things in the brain so that these drugs could continue to function.
 
HIT4ME

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Bintherduntht

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It certainly can intensify your emotions and it’s a much better drug for depression than it is for anxiety.

The first week was the honeymoon stage for me, and I experienced a few days of profound euphoria. Unfortunately, that tapered away into something much less notable. Mood boost was certainly still there though.
Thats exactly what happened with me! First week i felt great and energized. Then I just felt regular again lol. Is it actually working? Haha. I do feel less depressed since starting it though
 
Ricky10

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Yeah, that honeymoon period was great. It's the reason I end up trying it again and again (even with my obvious allergic reaction)...never did capture that initial feeling again though. Still a great medication though. I get a similar (albeit less) feeling from low dose modafinil.
Same here, I think I went back on it like 3 times after the my initial run. I never got that feeling back again either. Since it has been so long now (over 10 years) since I have used it, maybe it will happen again!
I could be interpreting that wrong, but it looks like they exposed cells to a toxic concentration of bupropion and then noted cell toxicity as a result :LOL:
Thats exactly what happened with me! First week i felt great and energized. Then I just felt regular again lol. Is it actually working? Haha. I do feel less depressed since starting it though
In theory, it shouldn’t be at its full therapeutic effect until 4-6 weeks. The initial week is is just a peculiar bonus! The only reason I ended up completely quitting after a few rounds of it is because I was still dealing with the issues that threw me into depression and debilitating anxiety in the first place. Under those conditions, I opted to give up the stimulation of Wellbutrin for the more calming effects of Prozac.

How long have you been on it?
 
Bintherduntht

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Same here, I think I went back on it like 3 times after the my initial run. I never got that feeling back again either. Since it has been so long now (over 10 years) since I have used it, maybe it will happen again!

I could be interpreting that wrong, but it looks like they exposed cells to a toxic concentration of bupropion and then noted cell toxicity as a result :LOL:

In theory, it shouldn’t be at its full therapeutic effect until 4-6 weeks. The initial week is is just a peculiar bonus! The only reason I ended up completely quitting after a few rounds of it is because I was still dealing with the issues that threw me into depression and debilitating anxiety in the first place. Under those conditions, I opted to give up the stimulation of Wellbutrin for the more calming effects of Prozac.

How long have you been on it?
At least 6-8 months. With all the damn meds the VA has me on my memory is a bit foggy lol. But yea prob 6-8 months
 
KingErgogenic

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When I was taking ashwaghanda , it made me feel like death. That’s just my experience.

I almost sued KSM66. The OWNER of the entire company called me... Becaue I believe they have spiked their product with an SSRI.

I have evidence from all these people:
Screen Shot 2019-05-06 at 4.37.24 pm.png
Screen Shot 2019-06-23 at 2.31.04 pm.png
Screen Shot 2019-06-23 at 2.31.11 pm.png
Screen Shot 2019-06-30 at 1.50.33 pm.png
Screen Shot 2019-07-02 at 1.09.03 pm.png
Screen Shot 2019-07-07 at 4.50.21 pm.png
Screen Shot 2019-07-07 at 4.57.18 pm.png
Screen Shot 2019-07-10 at 3.32.09 pm.png


If I see another guy get negatively affected by Ashwagandha I am going to lose my fucking mind... It has been 2 years since I used it and I am still dealing with the PSSD symptoms.

Guys, look out for your mates!!! KSM-66 can really mess you up.
 

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jarrellt67

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I almost sued KSM66. The OWNER of the entire company called me... Becaue I believe they have spiked their product with an SSRI.

I have evidence from all these people:
View attachment 186372View attachment 186374View attachment 186375View attachment 186376View attachment 186377View attachment 186379View attachment 186380View attachment 186381

If I see another guy get negatively affected by Ashwagandha I am going to lose my fucking mind... It has been 2 years since I used it and I am still dealing with the PSSD symptoms.

Guys, look out for your mates!!! KSM-66 can really mess you up.
You're lucky not to be sued for claiming they put a ssri in the product. Good lord dude, your sensationalist reaction and posts on reddit (lokzo55), anytime someone mentions a negative reaction to ashwagandha, are ridiculous. Some people just don't react well to a supplement but to claim it caused pssd symptoms for two years is just plain nuts.
 
HIT4ME

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I could be interpreting that wrong, but it looks like they exposed cells to a toxic concentration of bupropion and then noted cell toxicity as a result :LOL:
Yes, the result isn't the interesting part - it is the caspase-3 inhibition reducing the stress, suggesting that bupropion induces toxicity through ER stress.

I wonder if this is also part of the mechanism by which the honeymoon period is lost...maybe taking it with something that helps avoid ER stress will allow it to work longer....
 

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