Can anyone comment on Propionyl-L-Carnitine's effectiveness as a fat loss supplement?
You are confusing ALCAR with AICARALCAR would be a better option via AMPK stimulation.
PLCAR is quite difficult to come by (if I recall) and would be best used for: elevate muscle carnitine, energy production, testosterone like effects, and fatigue.
It will do almost nothing for fat loss.Can anyone comment on Propionyl-L-Carnitine's effectiveness as a fat loss supplement?
Possibly and aware of AlCAR and AMPK activation.You are confusing ALCAR with AICAR
There is more ways to increase insulin sensitivity then ampk, ampk is only one of MANY ways to increase insulin sensitivity. I'm pretty sure alcar does nothing to ampkPossibly and aware of AlCAR and AMPK activation.
Correct me if I'm wrong, but ALCAR ability to increase insulin sensitivity, would cause the activation of AMPK?
I haven't seen any data to suggest ALCAR will have any tangible fat loss effects, you are right though it has been shown to improve insulin sensitivity in pre-diabetic/non-healthy people. But in context for a normal person, wouldn't count on it to doing Mucho en absoluto.Possibly and aware of AlCAR and AMPK activation.
Correct me if I'm wrong, but ALCAR ability to increase insulin sensitivity, would cause the activation of AMPK?
Believe me, I am well aware of more effective ways to increase insulin sensitivity. Although ALCAR may not stimulate AMPK directly, I am thinking it may through other mechanisms. Again, I could certainly be wrong.There is more ways to increase insulin sensitivity then ampk, ampk is only one of MANY ways to increase insulin sensitivity. I'm pretty sure alcar does nothing to ampk
I haven't seen any data to suggest ALCAR will have any tangible fat loss effects, you are right though it has been shown to improve insulin sensitivity in pre-diabetic/non-healthy people. But in context for a normal person, wouldn't count on it to doing Mucho en absoluto.
I wasn't trying to say you didn't know your stuff or anything like that if it came off that way I'm sorry. If you find anything on it effecting ampk I would love to see it!Believe me, I am well aware of more effective ways to increase insulin sensitivity. Although ALCAR may not stimulate AMPK directly, I am thinking it may through other mechanisms. Again, I could certainly be wrong.
Oh I agree 100% on ALCAR and fat loss. Certainly wouldn't be something I would recommend in that department.
All good. Wasn't trying to come off as pissed or thinking you thought that, lol.I wasn't trying to say you didn't know your stuff or anything like that if it came off that way I'm sorry. If you find anything on it effecting ampk I would love to see it!
Haha OK sweet, ya I agree there is much better option for ampk; although I do think that carnitine derivatives like PLCAR and ALCAR are very good supps. I'm curious to what makes you think it might effect ampk? Wanna walk me through your thinking?All good. Wasn't trying to come off as pissed or thinking you thought that, lol.
I haven't found anything showing it directly, so my comment on ALCAR and AMPK directly may not be 100% correct. That being said, far better options for AMPK activation anyways.
Effective fat loss supplement ?noCan anyone comment on Propionyl-L-Carnitine's effectiveness as a fat loss supplement?
I prefer GPLCNoAddedHmones Synapsin Jiigzz Danes kbayne and whoever else
what are your guys thoughts on acetyl-l-carnitine arginate? Overall as a supplement, as a nootropics, and specifically on its ability to increase/mimic NGF.(this one has me intrigued! As the results were 3 fold of what regular acetyl-l-carnitine produced)
I know gplc is better for bodybuilding purposes and pumps.I prefer GPLC
GPLC would be superior as a nootropic.I know gplc is better for bodybuilding purposes and pumps.
Although isn't acetyl-l-carnitine arginate superior for NGF production and mimicking? And as a nootropics too? Or is gplc just as good for that?
To be honest, I really dont know dont use that eitherI know gplc is better for bodybuilding purposes and pumps.
Although isn't acetyl-l-carnitine arginate superior for NGF production and mimicking? And as a nootropics too? Or is gplc just as good for that?
The NGF increase, isnt that in rats?I know gplc is better for bodybuilding purposes and pumps.
Although isn't acetyl-l-carnitine arginate superior for NGF production and mimicking? And as a nootropics too? Or is gplc just as good for that?
The studies was done on ratsThe NGF increase, isnt that in rats?
If I remember right, I have seen some "old" rat studies long time agoThe studies was done on rats
Pretty much. I wanted to drop about 1% bf as I'm already around 6%. I have a PL comp coming up soon and was trying to avoid going into a deficit that would inhibit my recovery from workouts. I have EC on hand, but I understand that it will do very little for fat loss if not used in tandem with a caloric deficitAre you trying to go the non stim route?
You want to drop 1% body fat without going into a caloric deficit? Not sure that is going to happen, and a carnitine salt sure as heck isn't going to do any help. Going beyond that, not much of anything is going to drop you 1% BF without going into a caloric deficit.So the carnitines are pretty much useless as fat loss agents? Any other supplements that can promote lipolysis absent of a caloric deficit?
Thanks as always you are very helpful/insightful! Always love hearing your thoughts and learning from you. What would you say is an optimal dose for PLCAR 1g?Some of my original notes on PLCAR....not sure if the PubMed Study numbers are still good and I'm catatonic from an extremely long week...
PLCAR increases carbohydrate/glucose metabolism. (7554119)
PLCAR causes dilation of blood vessels, especially those in adipose tissue - possibly by increasing production of prostaglandins (pgf2-a?) (10359944)
PLCAR increases energy expenditure (9139943)
PLCAR relieves Pyruvate DeHydrogenase inhibition caused by elevated ratio of Acetyl-CoA:CoA. The propionate ester is severed in the mitochondria, and replaced with an acetyl group (thus lowering the ratio). .(10826498)
PLCAR increases plasma levels of ATP and adenosine. (9546959)
When the propionate is severed in the mitochondria, it is converted easily, and without energy consumption, into Succinate, a VERY important Krebs intermediate. (15591005)
A gram is a great dose and provides a noticeable kick in energy. I started designing an energy drink using PLCAR but the stuff doesn't exactly taste deliciousThanks as always you are very helpful/insightful! Always love hearing your thoughts and learning from you. What would you say is an optimal dose for PLCAR 1g?
Lol I bet PLCAR isn't necessarily delectable, not to mention the other stuff you used, and knowing you they unusual but bad a$$. If you ever need a beta tester or taste tester I'm in!!! LolA gram is a great dose and provides a noticeable kick in energy. I started designing an energy drink using PLCAR but the stuff doesn't exactly taste delicious
You got yourself a dealLol I bet PLCAR isn't necessarily delectable, not to mention the other stuff you used, and knowing you they unusual but bad a$$. If you ever need a beta tester or taste tester I'm in!!! Lol
Sweet!!!You got yourself a deal
People need to stop worrying about the damn taste and worry about the products effectiveness.A gram is a great dose and provides a noticeable kick in energy. I started designing an energy drink using PLCAR but the stuff doesn't exactly taste delicious
Totally agree!!!!People need to stop worrying about the damn taste and worry about the products effectiveness.
With an energy drink? You know it wouldn't sell well outside of the bodybuilding community. Even within it, it would be a niche group that would buy it (AM crowd, etc)People need to stop worrying about the damn taste and worry about the products effectiveness.
Yeah, that was the conclusion I came to. HUGE minimums and it wouldn't sell outside of the fitness markets. Personally, I think MONSTER energy tastes like ass, but enough people like it to have made them all a fortune. I can make one way more effective, but would never be able to move through the minimums.With an energy drink? You know it wouldn't sell well outside of the bodybuilding community. Even within it, it would be a niche group that would buy it (AM crowd, etc)
It's an effective fat burner as part of a formula...a damn good one at that...but fat burning is a complicated process where quite a few factors need to be functioning ideally. PLCAR serves a semi-critical role in fat burning, one that you notice more when you're NOT taking it.So if it's not very effective as a fat burner, what is it effective with? I understand that it does promote nitric oxide production, and I get a noticeable uptick in energy levels after taking around 2 g.
Honestly if you can get it to be decent tasting I think it could be HUGE hit!!! With the right marketing. Market towards gamers but not to direct either leaving who you are marketing to more inclusive.Yeah, that was the conclusion I came to. HUGE minimums and it wouldn't sell outside of the fitness markets. Personally, I think MONSTER energy tastes like ass, but enough people like it to have made them all a fortune. I can make one way more effective, but would never be able to move through the minimums.
You guys want me to offer some bulk PLCAR? This is something i can offer near or slightly above cost.
Want to add that this is a really untouched market. These gamers buy poo ton of montsers and barely effective energy drinks. Companies are barely starting to market to this group but they are in powders. Make a canned product, in the $3 price range, and get it into Walmart ,gas station, etc. It would kill it as your stuff is very very effective and the gamers would cling to it, then the niche market like us(AMers) would love it too, also truckers, etc. I'm telling you with your genius in this area would make a killing if you can get the price point right!!!!Honestly if you can get it to be decent tasting I think it could be HUGE hit!!! With the right marketing. Market towards gamers but not to direct either leaving who you are marketing to more inclusive.
PLCAR literally blew my socks off the first time I tried it. Having been taking ALCAR for a couple of years before that, I figure that the ester couldn't make that much of a difference between the acetyl and the priopionate, but it really does.Want to add that this is a really untouched market. These gamers buy poo ton of montsers and barely effective energy drinks. Companies are barely starting to market to this group but they are in powders. Make a canned product, in the $3 price range, and get it into Walmart ,gas station, etc. I would kill it as you stuff is very very effective and the gamers would cling to it and then the niche market like us(AMers) would love it too, also truckers, etc. I'm telling you with your genius in this area would make a killing if you can get the price point right!!!!
Haha SOOOOOOO true. I'm excited to try it! I do think it could be a big hit, with the right marketingPLCAR literally blew my socks off the first time I tried it. Having been taking ALCAR for a couple of years before that, I figure that the ester couldn't make that much of a difference between the acetyl and the priopionate, but it really does.
The PLCAR affects the body's energy levels dramatically, while ALCAR supercharges your brain.
Tell you what...I'll go ahead with the formula I have made up. It won't be in a can, it won't be carbonated, and it's doubtful the flavor will be anything approaching final, but if you guys like it I have some people I might be able to pitch the idea too.
Every single energy drink out there is the same exact crappy assed formula (imagine that...people in this industry only have the brains to copy others).
I'll make up some powdered samples that you can evaluate for effects.
Excluding energy drinks. Now those need to taste good IMO. Those are something (for the most part) someone is going to sip on, not slam.With an energy drink? You know it wouldn't sell well outside of the bodybuilding community. Even within it, it would be a niche group that would buy it (AM crowd, etc)
You don't like the Monster Zero huh?Yeah, that was the conclusion I came to. HUGE minimums and it wouldn't sell outside of the fitness markets. Personally, I think MONSTER energy tastes like ass, but enough people like it to have made them all a fortune. I can make one way more effective, but would never be able to move through the minimums.
You guys want me to offer some bulk PLCAR? This is something i can offer near or slightly above cost.
Nice, that should be great.PLCAR literally blew my socks off the first time I tried it. Having been taking ALCAR for a couple of years before that, I figure that the ester couldn't make that much of a difference between the acetyl and the priopionate, but it really does.
The PLCAR affects the body's energy levels dramatically, while ALCAR supercharges your brain.
Tell you what...I'll go ahead with the formula I have made up. It won't be in a can, it won't be carbonated, and it's doubtful the flavor will be anything approaching final, but if you guys like it I have some people I might be able to pitch the idea too.
Every single energy drink out there is the same exact crappy assed formula (imagine that...people in this industry only have the brains to copy others).
I'll make up some powdered samples that you can evaluate for effects.
Excluding energy drinks. Now those need to taste good IMO. Those are something (for the most part) someone is going to sip on, not slam.
But I agree, if something doesn't taste good, its not going to sell.
You don't like the Monster Zero huh?
Bulk PLCAR would be solid IMO, as it is hard to come by now days.
Sign me up!PLCAR literally blew my socks off the first time I tried it. Having been taking ALCAR for a couple of years before that, I figure that the ester couldn't make that much of a difference between the acetyl and the priopionate, but it really does.
The PLCAR affects the body's energy levels dramatically, while ALCAR supercharges your brain.
Tell you what...I'll go ahead with the formula I have made up. It won't be in a can, it won't be carbonated, and it's doubtful the flavor will be anything approaching final, but if you guys like it I have some people I might be able to pitch the idea too.
Every single energy drink out there is the same exact crappy assed formula (imagine that...people in this industry only have the brains to copy others).
I'll make up some powdered samples that you can evaluate for effects.
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