New on TRT.... High Estrogen - Arimidex Dosage advice

[getalpha]

Hey All,

Okay dont get me started.... my anti-aging Dr said to go to my GP for the arimidex since they gave me the reandron (nebeido) which he believes has got my E all high.

E is 211 pmol/l

Dr scripted me Arimidex ($38 thankyou Australian medication subsidy)

BUT Said take 1mg EVERY DAY for 30 days.....

From what I read, that will crush my E bad.

Can someone please give me confirmation on how to tackle this?

I took 1mg today

I'll be getting bloods again on Monday (will post other bloods in another thread later).

Then will get bloods done again in 2 weeks time.

Thanks

 

[hitest]

I don't have first hand experience but from what I've read it is best to start with very low doses of arimidex and slowly creep up on it all the while monitoring your E2 levels. If it were me I wouldn't start with any more than .5mg/week and give it some time to stabilize before retesting. If this doesn't bring it down much I would increase by another .5mg. After that I would switch to .25mg increases if needed. This could take a while but better than overshooting.

 

[The Matrix]

Hey All,Okay dont get me started.... my anti-aging Dr said to go to my GP for the arimidex since they gave me the reandron (nebeido) which he believes has got my E all high.E is 211 pmol/lDr scripted me Arimidex ($38 thankyou Australian medication subsidy)BUT Said take 1mg EVERY DAY for 30 days.....From what I read, that will crush my E bad.Can someone please give me confirmation on how to tackle this?I took 1mg todayI'll be getting bloods again on Monday (will post other bloods in another thread later).Then will get bloods done again in 2 weeks time.Thanks

tell ur.Dr.Its.over kill.25 mgs every 3 days is good

 

[getalpha]

Thanks for the advice guys.

The Matrix, is this still suitable even though my E is currently high?

What should I do givne I've already taken a 1mg tablet, just take .25mgs in 3 days time and keep up with that?

Cheers

 

[hitest]

Thanks for the advice guys.

The Matrix, is this still suitable even though my E is currently high?

What should I do givne I've already taken a 1mg tablet, just take .25mgs in 3 days time and keep up with that?

Cheers

That 1mg is 12 days worth at .25mg/3days. I'd wait this long before the next .25mg dose.

 

[EasyEJL]

That 1mg is 12 days worth at .25mg/3days. I'd wait this long before the next .25mg dose.

eh yeah, but its a suicide inhibitor, and a half life of only 2-3 days. with E2 being so high to start (thats over 3x top of normal) you can probably do .25mg E3D starting in 4-5 days. I still wish I could find more documentation on aromatase production rates.

 

[getalpha]

Thanks EasyEJL

I was thinking similar to this, given E is so high at the moment.

I'll do that, and get bloods tested in a few weeks.

How long does it take to start showing an effect from this?

Is it worth dosing high first few days (1mg per day x 3 days) then .25mg E3D?

 

[EasyEJL]

Thanks EasyEJL

I was thinking similar to this, given E is so high at the moment.

I'll do that, and get bloods tested in a few weeks.

How long does it take to start showing an effect from this?

Is it worth dosing high first few days (1mg per day x 3 days) then .25mg E3D?

hmm an effect from splitting the testosterone dose, or the arimidex? The testosterone splitting should level out in 3-4 weeks. The arimidex should show some pretty immediate results because it is a suicide inhibitor. so the molecules of arimidex bind with molecules of the aromatase enzyme rendering them useless. at a 1 mg dosage, you more or less should almost entirely get rid of active aromatase in the body, unless you have really high bodyfat. thats why the dosages are suggested for small doses with days inbetween as more in a shorter span of time will keep estrogen literally at 0, which isn't any better than being high.

 

[getalpha]

Bodyfat at the moment is high, in the 20's

Sorry I was referring to the Arimidex dosing and how long effect takes.

I did notice the nipples were not as sore or sensitive almost immediately, still sensitive though.

 

[EasyEJL]

Bodyfat at the moment is high, in the 20's

Sorry I was referring to the Arimidex dosing and how long effect takes.

I did notice the nipples were not as sore or sensitive almost immediately, still sensitive though.

well, the arimidex will more or less stop new creation of estrogen, but circulating estrogen will have to slowly disappear as its used. so it may be a few days to a week before its mostly gone.

 

[getalpha]

Can I help the body rid it better?

Will DIM and Resveratol actually help with this?

I've read about them but how effective they are I do not know.

Also, I believe D Aspartic Acid is responsible for increasing Aromatize and dumping a bunch of T into E so quickly.

Don't think my E would be this high if it were just the normal TRT, so removing that as of today.

 

[EasyEJL]

really everything i've seen deals with inhibiting aromatase as for medical purposes its about the long run, so doing that and creating less estrogen is easier than trying to manage already created estrogen. Probably does make sense to drop the DAA though.

 

[getalpha]

Yeah dropped all supplements today.

Just doing the TRT so I can see where my body sits with it.

Thought about DIM to help metabolize some of the high E quicker through the liver, given that I won't be aromatizing much with the arimidex.

Is this worth doing?

How long should I expect with just arimidex to bring levels that high down?

 

[pmgamer18]

I don't think there are to many men on TRT as long as I have been on it over 30 yrs and I have done Arimidex and it's not a suicide inhibitor Aromasin is. Arimidex will block the Aromatase from making more Estradiol E2 Aromasin will kill Aromatase.

After many yrs on Arimidex I have found if your levels are over 50 pg/ml your 211 is = to 57 pg/ml so I tell men they need to start on .5 mgs every other day to get this down. You will know it's down when your Rem Sleep wood starts back up. Here is a copy of a file I made on how to do this. As for DIM when you get your levels down you might be able to keep them down on Indolplex/DIM.
=====================================================================
How To Take Arimdex and not go down on your Estradiol to Low.

What I found is if you go to low taking arimidex, it's the length of time your to low, if your too low say for 8 weeks it can take your body a longer time to make more Estradiol. Bottom line is to know how not to go to low. Keep a log on your dose and how you feel men going to low can't get it up taking Viagra. I went to low when I first tried Arimidex and did not know about going to low or how one feels to low, so I was low a good 8 weeks. I did not know I was low until my next labs.

The best gage I have found to control your Estradiol levels is to gage your night time and morning wood. At good levels or what I call the sweet spot you get your night time and morning wood back so strong it will wake you up and you can hang a coat on it.

Most men do good taking .25 mgs or 1/4 of a 1mg. pill, I use a pill cutter to cut the small pill in half then I stand it on the cut end and use a single edge razor to cut this in half. A good way to take arimidex is by how high your levels are. I tested over 90 pg/ml so we tried doing .5 mgs every other day after 8 weeks my next set of labs showed it did not move below 90, test said >90. So we did .5 mgs. every day in about 2 weeks I got some strong night time and morning wood back after not having them for many yrs.

I kept doing this dose and in 8 weeks my next set of labs said <20 back in the day labs were like this they did not have to good labs we have today they could not read lower the 20. My Dr. told me this looks to low to stop taking the Arimidex. The one thing I noticed was my wood stopped and stopping the Arimidex my wood came back in about 7 weeks my next test at 8 weeks was 24 pg/ml. So we went back on the Arimidex but the Dr. told me to take .5 mgs every 3 days I was on this dose not a week and lost wood. This is when I figured out going to low you lose wood. And the longer your too low the longer it takes to get levels back up.

I stopped the arimidex right away and got my wood back in 4 days. I then after playing with the dose for a time found the best dose is .25mgs every 2 to 3 days.

So lets say your labs are less the 50 pg/ml if your take .5 mgs you can go down so dam fast your miss the sweet spot of your wood and go to low. It's best with lower levels 50 and under to do less Arimidex .25mgs every 2 days if later your lose wood when it comes back go to every 3 days.

I have found estradiol is the hardest hormone to control, it goes up or down from month to month some times I need .25mgs every 2 days other times I need .25mgs everyday most of the time I do well on every 3 days.

So between wood and labs I do great and so do most of the men I have told this to. I keep a log on how much I am taking and how I feel. Doing this and reading back in my log I was able to tell when I was going to high or to low my Dr. lets me dose my arimidex by how I feel.

Over the yrs. I have posted this story until I am blue in the face.

 

[getalpha]

Thanks heaps mate, yeah I read this in another thread actually that you posted and it made alot of sense.

At one point I was getting awesome wood, the damn thing would wake me up middle of the night.

Lost that, I've only just got back half wood in the mornings, so the Arimidex is already working, I'll go in for bloods on Monday anyhow and then again in 2 weeks from then.

So are you on Arimidex now or Aromasin?

 

[pmgamer18]

I am on Aromasin now I feel this works the best and no sides no rebound effec on Estradiol and I can handle high levels of Estraidol most men do well taking a half a pill every 2 to 3 days.

Thanks heaps mate, yeah I read this in another thread actually that you posted and it made alot of sense.

At one point I was getting awesome wood, the damn thing would wake me up middle of the night.

Lost that, I've only just got back half wood in the mornings, so the Arimidex is already working, I'll go in for bloods on Monday anyhow and then again in 2 weeks from then.

So are you on Arimidex now or Aromasin?

 

[getalpha]

Yeah, I'll get it in control using Arimidex first since thats what I've been scripted.

Then I'll look at doing a switch over to Aromasin.

I dont know anything about Arimidex sides yet, dont think I've got any but will check into potentials.

 

[pmgamer18]

The sides I seen are going to low easy and the dam rebound effect I would take it in the morning go to low and by bedtime be to high again.

Yeah, I'll get it in control using Arimidex first since thats what I've been scripted.

Then I'll look at doing a switch over to Aromasin.

I dont know anything about Arimidex sides yet, dont think I've got any but will check into potentials.

 

[getalpha]

Right.... Fun times ahead then

I notice in the mornings I get slightly sensitive nipples again, but shortly after taking it, that goes away.

 

[pmgamer18]

Listen once you lean to read your body you can keep your Estradiol in the Zone and feel dam good if your not sure how your doing just ask me I can help been helping men with this for many yrs.

Right.... Fun times ahead then

I notice in the mornings I get slightly sensitive nipples again, but shortly after taking it, that goes away.

 

[EasyEJL]

I hadn't realized what your normal scale was, I was thinking the normal american scales. I was more or less where you are at when my testosterone was in the 270s and really now that i've dropped a lot of fat don't think its any higher while on trt

 

[pmgamer18]

Here is a copy of a file I made on not going to low on Arimidex and it works the same for DIM and Aromasin you need to gage this by your Rem Sleep Wood.
==================================================================
How To Take Arimdex and not go down on your Estradiol to Low.

What I found is if you go to low taking arimidex, it's the length of time your to low, if your too low say for 8 weeks it can take your body a longer time to make more Estradiol. Bottom line is to know how not to go to low. Keep a log on your dose and how you feel men going to low can't get it up taking Viagra. I went to low when I first tried Arimidex and did not know about going to low or how one feels to low, so I was low a good 8 weeks. I did not know I was low until my next labs.

The best gage I have found to control your Estradiol levels is to gage your night time and morning wood. At good levels or what I call the sweet spot you get your night time and morning wood back so strong it will wake you up and you can hang a coat on it.

Most men do good taking .25 mgs or 1/4 of a 1mg. pill, I use a pill cutter to cut the small pill in half then I stand it on the cut end and use a single edge razor to cut this in half. A good way to take arimidex is by how high your levels are. I tested over 90 pg/ml so we tried doing .5 mgs every other day after 8 weeks my next set of labs showed it did not move below 90, test said >90. So we did .5 mgs. every day in about 2 weeks I got some strong night time and morning wood back after not having them for many yrs.

I kept doing this dose and in 8 weeks my next set of labs said <20 back in the day labs were like this they did not have to good labs we have today they could not read lower the 20. My Dr. told me this looks to low to stop taking the Arimidex. The one thing I noticed was my wood stopped and stopping the Arimidex my wood came back in about 7 weeks my next test at 8 weeks was 24 pg/ml. So we went back on the Arimidex but the Dr. told me to take .5 mgs every 3 days I was on this dose not a week and lost wood. This is when I figured out going to low you lose wood. And the longer your too low the longer it takes to get levels back up.

I stopped the arimidex right away and got my wood back in 4 days. I then after playing with the dose for a time found the best dose is .25mgs every 2 to 3 days.

So lets say your labs are less the 50 pg/ml if your take .5 mgs you can go down so dam fast your miss the sweet spot of your wood and go to low. It's best with lower levels 50 and under to do less Arimidex .25mgs every 2 days if later your lose wood when it comes back go to every 3 days.

I have found estradiol is the hardest hormone to control, it goes up or down from month to month some times I need .25mgs every 2 days other times I need .25mgs everyday most of the time I do well on every 3 days.

So between wood and labs I do great and so do most of the men I have told this to. I keep a log on how much I am taking and how I feel. Doing this and reading back in my log I was able to tell when I was going to high or to low my Dr. lets me dose my arimidex by how I feel.

Over the yrs. I have posted this story until I am blue in the face.

I hadn't realized what your normal scale was, I was thinking the normal american scales. I was more or less where you are at when my testosterone was in the 270s and really now that i've dropped a lot of fat don't think its any higher while on trt

 

[getalpha]

Can DIM really have that much of an effect that it can lower E too much?

What is the best brand of DIM I saw someone (think it was you pmgamer18) tell someone else to check their PM's for the brand that you get the most results from.

Also thanks for the offer of help pmgamer, appreciate it.

One thing I am learning is how to read your body and what is hormonal.

I thought I was getting tired again because it was not enough T, so when I saw my T levels I was shocked, but then saw E and it made sense.

 

[pmgamer18]

If you can't get a Dr. to give you Arimidex or Aromasin and I feel Aromasin is the best for to much E2 don't call E or Estrogen it's called Estraidol E2 so when your talking to your Dr. make sure you get this right or you will have the wrong labs.

As for DIM the best kind comes in Tablets that you can cut up and is called Indolplex/DIM it only needs to say Indolplex on the lable.

High Estradiol levels will undo any good TRT dose for use you can get ED, have trouble reaching an orgasm, get BPH, feel hot and sweat allday and night, look red on your face and upper body, get sore and hard nipples, have hot flash's and if you have a panic problem this will set one off. Some men say they can't get a good workout in the gym muscle will not pump up.

Men lose there Rem Sleep Wood with high Estradiol levels and if they take something to bring it down and go to low it will kill your wood you can't get it up taking Viagra when this happens stop what your taking until your RSW comes back then go back on what your taking but take less or go from every 2 days to every 3 days on Arimidex or Aromasin.

Can DIM really have that much of an effect that it can lower E too much?

What is the best brand of DIM I saw someone (think it was you pmgamer18) tell someone else to check their PM's for the brand that you get the most results from.

Also thanks for the offer of help pmgamer, appreciate it.

One thing I am learning is how to read your body and what is hormonal.

I thought I was getting tired again because it was not enough T, so when I saw my T levels I was shocked, but then saw E and it made sense.

 

[getalpha]

GAH FRUSTRATING

Okay here

30/08/2011 - Day before injection

Oestradiol 211 pmol/L (55-165)
SHBG 21 nmol/L (10-70)
Testosterone 29.8 nmol/L (11-40)
Calculated FTE 858 pmol/L (260-740)

05/09/2011 - start of 5th day post injection

Oestradiol < 37 pmol/L
SHBG 19 nmol/L
Testosterone 38.2 nmol/L
Calculated FTE 1190 pmol/L

So.... I well and truly crashed my estrogen from high.... to low

I suspect it is to do with the following.

1. D Aspartic Acid, increased my aromatize ability abnormally
2. Stopped D Aspartic Acid - Started Arimidex to lower aromatize
3. Body cleared D Aspartic Acid within 3 to 5 days, thus bringing my aromatize to normal.... but now with Arimidex even lower

===== Crashed E

End result.... have stopped Arimidex as of today (dammit took .5mg this morning)

I dont think I will need arimidex going forward but we shall see, since thats pretty quick for the estrogen to be lowered, I'd say I should be fine on DIM

I'll be leaving all of it for about 1 week, where I will test pre testosterone shot next week, and 3 to 4 days post testosterone shot then go from there.

Can anyone else please give me some further guidance here or tweaks to the plan.

 

[pmgamer18]

Yes you E2 is very low so just stop takeing any meds or supplements stop them until you get some Rem Sleep Wood back when your sleeping they will come back and be very strong so much so they will wake you up. Then go back on what your doing but do less.
==============================================================
How To Take Arimdex and not go down on your Estradiol to Low.

What I found is if you go to low taking arimidex, it's the length of time your to low, if your too low say for 8 weeks it can take your body a longer time to make more Estradiol. Bottom line is to know how not to go to low. Keep a log on your dose and how you feel men going to low can't get it up taking Viagra. I went to low when I first tried Arimidex and did not know about going to low or how one feels to low, so I was low a good 8 weeks. I did not know I was low until my next labs.

The best gage I have found to control your Estradiol levels is to gage your night time and morning wood. At good levels or what I call the sweet spot you get your night time and morning wood back so strong it will wake you up and you can hang a coat on it.

Most men do good taking .25 mgs or 1/4 of a 1mg. pill, I use a pill cutter to cut the small pill in half then I stand it on the cut end and use a single edge razor to cut this in half. A good way to take arimidex is by how high your levels are. I tested over 90 pg/ml so we tried doing .5 mgs every other day after 8 weeks my next set of labs showed it did not move below 90, test said >90. So we did .5 mgs. every day in about 2 weeks I got some strong night time and morning wood back after not having them for many yrs.

I kept doing this dose and in 8 weeks my next set of labs said <20 back in the day labs were like this they did not have to good labs we have today they could not read lower the 20. My Dr. told me this looks to low to stop taking the Arimidex. The one thing I noticed was my wood stopped and stopping the Arimidex my wood came back in about 7 weeks my next test at 8 weeks was 24 pg/ml. So we went back on the Arimidex but the Dr. told me to take .5 mgs every 3 days I was on this dose not a week and lost wood. This is when I figured out going to low you lose wood. And the longer your too low the longer it takes to get levels back up.

I stopped the arimidex right away and got my wood back in 4 days. I then after playing with the dose for a time found the best dose is .25mgs every 2 to 3 days.

So lets say your labs are less the 50 pg/ml if your take .5 mgs you can go down so dam fast your miss the sweet spot of your wood and go to low. It's best with lower levels 50 and under to do less Arimidex .25mgs every 2 days if later your lose wood when it comes back go to every 3 days.

I have found estradiol is the hardest hormone to control, it goes up or down from month to month some times I need .25mgs every 2 days other times I need .25mgs everyday most of the time I do well on every 3 days.

So between wood and labs I do great and so do most of the men I have told this to. I keep a log on how much I am taking and how I feel. Doing this and reading back in my log I was able to tell when I was going to high or to low my Dr. lets me dose my arimidex by how I feel.

Over the yrs. I have posted this story until I am blue in the face.

GAH FRUSTRATING

Okay here

30/08/2011 - Day before injection

Oestradiol 211 pmol/L (55-165)
SHBG 21 nmol/L (10-70)
Testosterone 29.8 nmol/L (11-40)
Calculated FTE 858 pmol/L (260-740)

05/09/2011 - start of 5th day post injection

Oestradiol < 37 pmol/L
SHBG 19 nmol/L
Testosterone 38.2 nmol/L
Calculated FTE 1190 pmol/L

So.... I well and truly crashed my estrogen from high.... to low

I suspect it is to do with the following.

1. D Aspartic Acid, increased my aromatize ability abnormally
2. Stopped D Aspartic Acid - Started Arimidex to lower aromatize
3. Body cleared D Aspartic Acid within 3 to 5 days, thus bringing my aromatize to normal.... but now with Arimidex even lower

===== Crashed E

End result.... have stopped Arimidex as of today (dammit took .5mg this morning)

I dont think I will need arimidex going forward but we shall see, since thats pretty quick for the estrogen to be lowered, I'd say I should be fine on DIM

I'll be leaving all of it for about 1 week, where I will test pre testosterone shot next week, and 3 to 4 days post testosterone shot then go from there.

Can anyone else please give me some further guidance here or tweaks to the plan.