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New E-pharm product: URSOBOLIC !

Force of Green said:
Nice! Japan must be a really fun, interesting and cultural place. I was intrigued by some of the places I saw in that movie 'Lost in Translation' with Bill Murray and Scarlette Johansen. How do you like Japan?
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Japan is great! Foods good. I'm learning Judo here too. Perhaps when I start taking ursobolic I'll see I notice any blood glucose changes in my meals. I'll probably add that to my log when I start it. If anything it'll show a good way to dose this thing. :)
 
Not being a smart ass just saw this thread a link and document (on mindandmuscle forum) and saw it say dna damage, couldnt get access to read its content so just asked for thoughts either way, if this dna issue has been already discussed/cleared i apologise.

Thoughts on ursolic acid? (pa new product) p4 post 68 by Bill. (mindandmuscleforum)
 
This report/study is massive, i didnt want to copy and paste the whole thing it goes into results etc etc


Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and
caspase-dependent human endothelial cell apoptosis, and accelerates
atherosclerotic plaque formation in vivo


Barbara Messnera,1, Iris Zeller a,1, Christian Plonerb, Sandra Frotschnigc, Thomas Ringerd,
Anneliese Steinacher-Nigischa, Andreas Ritsche, Günther Laufera, Christian Huckd, David Bernharda,∗
a Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
b Department of Plastic and Reconstructive Surgery, Medical University Innsbruck, Innsbruck, Austria
c Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Medical University Innsbruck, Innsbruck, Austria
d Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University Innsbruck, Innsbruck, Austria
e Department of Medicine, Medical University Innsbruck, Innsbruck, Austria
a r t i c l e i n f o


Article history:
Received 24 September 2010
Received in revised form 18 April 2011
Accepted 23 May 2011
Available online xxx
Keywords:
Ursolic acid
Triterpene
Endothelial
Atherosclerosis
Cell death
DNA-damage
P53
BAK
BCLXL
IL-5
Therapy
a b s t r a c t

Objective: The plant derived triterpene ursolic acid (UA) has been intensively studied in the past; mainly
as an anti-cancer compound and for its cardiovascular protective properties. Based on the controversy
of reports suggesting anti-angiogenic and cytotoxic effects of UA on one side and cardiovascular and
endothelial protective effects on the other side, we decided to assess UA effects on primary human
endothelial cells in vitro and atherosclerotic plaque formation in vivo.
Methods and results: Our in vitro analyses clearly show that UA inhibits endothelial proliferation and is
a potent inducer of endothelial cell death. UA causes DNA-damage, followed by the activation of a P53-,
BAK-, and caspase-dependent cell-death pathway. Oral application of UA in APO E knockout mice potently
stimulated atherosclerotic plaque formation in vivo, which was correlated with decreased serum levels
of the athero-protective cytokine IL-5.

Conclusions: Due the potent endothelial cell death inducing activity of UA, a systemic application of UA in
the treatment of cardiovascular diseases seems unfavourable. UA as an anti-angiogenesis, anti-cancer and
– locally applied – cardiovascular drug may be helpful. The DNA damaging activity of UA may however
constitute a serious problem.
 
There was mention of Anabeta and like I said, it's a product I intend trying. Just not right at the moment. There was never a total diversion of topic onto another brands product. There may have been 1 post (maybe even me) talking about using the product and PES's great track record of products, but nothing that you are hinting to. Calm down Pat.
 
Mission1 said:
Right now I feel Anabeta is the best natural muscle builder because of my experience with it. Not saying that ursobolic won't be better but time will tell. I'm stacking both and I'm day 13.
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Anabeta has a recommended dose of four caps per day. With Ursobolic, the minimum dosage is 9 caps per day. People aren't even sure if that is an effective dosage yet based on the logs I have seen. More and more people are going up to 18 caps and over each day. That is one hell of an expensive supplement!. I'm sure its good and everything and plan on buying some but I have to wait and actually put some money away for it. Patrick did say he was working on trying to get more in one capsule though. I'd need 10 bottles to run it for 60 days at the max dosage. That will cost me around $140. So that is what I plan on doing sometime in the future if I can get the extra money together.
 
T-Bone said:
Anabeta has a recommended dose of four caps per day. With Ursobolic, the minimum dosage is 9 caps per day. People aren't even sure if that is an effective dosage yet based on the logs I have seen. More and more people are going up to 18 caps and over each day. That is one hell of an expensive supplement!. I'm sure its good and everything and plan on buying some but I have to wait and actually put some money away for it. Patrick did say he was working on trying to get more in one capsule though. I'd need 10 bottles to run it for 60 days at the max dosage. That will cost me around $140. So that is what I plan on doing sometime in the future if I can get the extra money together.
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You're 100% right. I guess it boils down to how patient you are, how much you're willing to spend, do you think the benefits outweigh the cost (matter of opinion), etc. If it does what it says and people are recomping like crazy at the max dose, the results sound better than anavar, but without the side effects including, but not limited to HTPA suppression.
 
if it can reduce the fat in a significant way without being catabolic, then $140 is worth it. if its results are the same as a fat burner, then yes it is expensive. so far I've seen one person report losing 8lbs over 3 weeks. I'm still not convinced but very hopeful.
 
L1AM said:
is it true that this can cause impotency?
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I haven't heard anything in that regard and just did an extensive internet search and could find no studies to suggest that ursobolic could cause impotence
 
L1AM said:
is it true that this can cause impotency?
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There is a big difference between impotency and low sperm motility. Where did you read/hear it can cause impotency? :aargh:
 
as far as atherosclerosis goes -im sure alot of AS contribute also--but you could take 200/300 mg of ALA as a support supp --it stops LDL from tuning into plaque
 
Force of Green said:
There was mention of Anabeta and like I said, it's a product I intend trying. Just not right at the moment. There was never a total diversion of topic onto another brands product. There may have been 1 post (maybe even me) talking about using the product and PES's great track record of products, but nothing that you are hinting to. Calm down Pat.
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hey i am calm i was just making a statement to make sure things on this board stay on track. i wasnt accusing anyone of any violations specificaly
 
Just increased ursobolic to 5 a day. Noticed wasn't as hungry. Had a great arm workout. I think 5 could be my sweet spot. I definitely feel my Anabeta kicking in hard with great pumps, veins , and strength increasing everyday. It's a win win for me. Loving it!
 
miniarnold said:
Read that on bb.com also and they were also saying it causes infertility.

is serious dna damage possible from this?
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It may be possible, however I don't have US $ 31.50 to buy the abstract from PubMed to get all the details as I spent it on Ursobolic.
 
L1AM said:
bodybuilding .com

Don't know why anyone would make something like that up but it's good to know that its not an issue.
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AAAHHH! that explains it.
 
miniarnold said:
Read that on bb.com also and they were also saying it causes infertility.

is serious dna damage possible from this?
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How many posts can you possibly make about the whole infertility thing???
 
ursabolic

given patricks record and his great production of products to benefit everyone,i believe he would have let us know up front about potential problems with any of his products,have a little faith
truthornothin said:
How many posts can you possibly make about the whole infertility thing???
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willib said:
given patricks record and his great production of products to benefit everyone,i believe he would have let us know up front about potential problems with any of his products,have a little faith
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Did you mean to quote me? Or the user I quoted. I have the utmost faith in Patrick and his products, see my log Invalid Link Removed
 
There is a guy on PHF forum that upped his dosage to 45 caps a day!. WTF?????. More is always better right?. Plus he is taking OEP. Dude is gonna be Jacked and Ripped!. :omfg::head:


Seriously though I wonder what he is smokin?
 
willib said:
i was just backing u up my friend,also have alot of faith in patrick
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ok......but your post made it sound like I am questioning Pat on this and I'm not just wanted to clarify. I am having great results by the way at 9 caps a day
 
T-Bone said:
There is a guy on PHF forum that upped his dosage to 45 caps a day!. WTF?????. More is always better right?. Plus he is taking OEP. Dude is gonna be Jacked and Ripped!. :omfg::head:


Seriously though I wonder what he is smokin?
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that just seems stupid. I started today with 10 caps/day, I just cant bring myself to do 18, plus I didnt order more yet, so Im running 10 day for a few weeks, I'll post here in a few days and let you know what I think.
 
RoadBlocK said:
that just seems stupid. I started today with 10 caps/day, I just cant bring myself to do 18, plus I didnt order more yet, so Im running 10 day for a few weeks, I'll post here in a few days and let you know what I think.
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LOL that is probably extreme...everyone knows I'm all in on experimenting, but diminishing returns (not to mention common sense) come into play at some point.
 
rampage jackson said:
LOL that is probably extreme...everyone knows I'm all in on experimenting, but diminishing returns (not to mention common sense) come into play at some point.
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diminishing returns, now theres a term more people need to ****in learn the definition of, way too much of the more is better crowd online lately for my tastes, I see people recommending a gram of test or more, if you're not a pro, and you need that much test to grow, there is something else wrong with that picture. lol, I will stick with my 10 caps a day and keep my fingers crossed.
 
Sorry patrick Arnold if I somehow took the thread away from where it should be going. :)
I will be running a ursobolic log in about four weeks. After my transaderm sponsored log.

A quick question on thoughts about using this while on a PH/DS like epi for recomp?
 
Sorry patrick Arnold if I somehow took the thread away from where it should be going. :)
I will be running a ursobolic log in about four weeks. After my transaderm sponsored log.

A quick question on thoughts about using this while on a PH/DS like epi for recomp?
 
I've read a few logs and so far it doesn't look like this product is doing anything amazing, especially for the price. Think I'll hold off on a purchase until I see the price go down or someone starts seeing amazing fat loss/muscle gain worthy of the price.
 
mattrag said:
Sorry patrick Arnold if I somehow took the thread away from where it should be going. :)
I will be running a ursobolic log in about four weeks. After my transaderm sponsored log.

A quick question on thoughts about using this while on a PH/DS like epi for recomp?
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i see no reason why it would be inappropriate to use like that
 
rampage jackson said:
LOL that is probably extreme...everyone knows I'm all in on experimenting, but diminishing returns (not to mention common sense) come into play at some point.
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I agree, there is going to be a point where more isn't going to do anything, there will be a saturation point. I am having great results thus far. I haven't eaten this much food since I was much younger with no ill effects. I still have my abs. I wanted to bounce this off Patrick, I don't always log it in my log, I'll have to start, but I drink a lot of coffee and all my coffee has a lot of half and half, I know substances are dissolve more easily as temperatures go up. Also that ursolic acid dissolves in fat better than water. I usually was my Ursobolic down with coffee. I wonder it the hot half and half i.e. milkfat is helping with the absorption for me. This came to mind this morning as I belched 15 min after taking it and no smoke cloud like others report. This suggests to me that my dose is dissolving and not lying around as powder.
 
Mission1 said:
Just increased ursobolic to 5 a day. Noticed wasn't as hungry. Had a great arm workout. I think 5 could be my sweet spot. I definitely feel my Anabeta kicking in hard with great pumps, veins , and strength increasing everyday. It's a win win for me. Loving it![/QUOTE]how does ursobolic compare to the "neuro stim" feeling you get from DHT compounds . Does it have enough "juice" to get you thru a tough workout on its own? or is it better to Be used as a PCT to give your liver a break from METH"S
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I really can't answer only because I'm stacking Anabeta and ursobolic together. I would say at this point use it as part of your pct to see how much better you recover from your other cycles. Or give it a solo run when your body has returned back to its natural state.
 
due to the recent ARSENIC IN APPLE JUICE-SCARE --i was looking at the source of the ursolic acid [loquat] a chinese apple tree -and i guess they use arsenic as a pesticide over there--so if UA is basically loquat peel extract and its loaded with arsenic --that would not be good--just sayin:thumbsup:
 
skull said:
due to the recent ARSENIC IN APPLE JUICE-SCARE --i was looking at the source of the ursolic acid [loquat] a chinese apple tree -and i guess they use arsenic as a pesticide over there--so if UA is basically loquat peel extract and its loaded with arsenic --that would not be good--just sayin:thumbsup:
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Although it states its from loquat i beleive PA said that it was not extracted from loquat but they didnt have time to change the labels.
 
T-Bone said:
I've read a few logs and so far it doesn't look like this product is doing anything amazing, especially for the price. Think I'll hold off on a purchase until I see the price go down or someone starts seeing amazing fat loss/muscle gain worthy of the price.
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Its good to be skeptical, and sometimes its good to wait and see how things turn out before making up your mind, but are you really gonna focus that much on price as your reasoning, I give you more credit than that, I mean cmon, 3 bottles would cost you about 45 bucks and you could run 12/day for a month, I have no vested interest in it at all, so it doesnt matter to me if you try it or not, but over the past year, there have been alot of "new" things that cost the same or have been alot more expensive that people were diving into.

Im at 10/day, I'll let you know if I see anything amazing or not.
 
3clipseGT said:
Although it states its from loquat i beleive PA said that it was not extracted from loquat but they didnt have time to change the labels.
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----point being that its some kind of fruit tree that china uses arsenic for a pesticide--maybe the extract process somehow gets rid of arsenic?
 
3clipseGT said:
Although it states its from loquat i beleive PA said that it was not extracted from loquat but they didnt have time to change the labels.
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It was extracted from Rosemary
 
skull said:
----point being that its some kind of fruit tree that china uses arsenic for a pesticide--maybe the extract process somehow gets rid of arsenic?
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I definitely see what your saying. Im pretty sure when PA test it, it checks for levels of metals and contaminates i beleive. I know PA said when he uses one of his machines it checks for this stuff.
 
truthornothin said:
I agree, there is going to be a point where more isn't going to do anything, there will be a saturation point. I am having great results thus far. I haven't eaten this much food since I was much younger with no ill effects. I still have my abs. I wanted to bounce this off Patrick, I don't always log it in my log, I'll have to start, but I drink a lot of coffee and all my coffee has a lot of half and half, I know substances are dissolve more easily as temperatures go up. Also that ursolic acid dissolves in fat better than water. I usually was my Ursobolic down with coffee. I wonder it the hot half and half i.e. milkfat is helping with the absorption for me..
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it probably is helping
 
skull said:
Mission1 said:
Just increased ursobolic to 5 a day. Noticed wasn't as hungry. Had a great arm workout. I think 5 could be my sweet spot. I definitely feel my Anabeta kicking in hard with great pumps, veins , and strength increasing everyday. It's a win win for me. Loving it![/QUOTE]how does ursobolic compare to the "neuro stim" feeling you get from DHT compounds . Does it have enough "juice" to get you thru a tough workout on its own? or is it better to Be used as a PCT to give your liver a break from METH"S
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you wont get that feeling from the stuff
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Im taking 1 or 2 servings of Ursoblic daily with Coffee and half and half as well, + 3 grams of fish oil.
 
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